Compositions And Methods For Inhibiting Expression Of GSK-3 Genes

ABSTRACT

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 (GSK-3), and methods of using the dsRNA to inhibit expression of GSK-3.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation of U.S. patent application Ser. No. 13/615,164, filed Sep. 13, 2012 (allowed), which is a continuation of U.S. patent application Ser. No. 13/003,740 filed Jul. 13, 2009 (abandoned), which is a 371 national phase of PCT patent application serial number PCT/US2009/050432, filed Jul. 13, 2009, which claims the benefit of U.S. Provisional Application No. 61/080,153, filed Jul. 11, 2008, which are hereby incorporated in their entirety by reference.

STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT

None.

SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 23, 2015, is named 29133_US_CRF_sequencelisting.txt, and is 4,165,632 bytes in size.

FIELD OF THE INVENTION

The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting Glycogen Synthase Kinase-3 alpha and/or beta (GSK-3 alpha and/or beta), and methods of using the dsRNA to inhibit expression of GSK-3. alpha and/or beta.

BACKGROUND OF THE INVENTION

Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine kinase. It functions as a key regulator of numerous signaling pathways. It phosphorylates and inactivates glycogen synthase, a key enzyme in glycogen metabolism. It has also been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. Two isoforms of GSK-3 have been reported in mammals: an approximately 51 kDa GSK-3 alpha form and an approximately 47 kDa GSK-3 beta form. These two isoforms exhibit about 98% homology in their kinase domains. Other regions share less homology: they share only about 36% identity in the last 76 C-terminal amino acid residues.

Double-stranded RNA molecules (dsRNA) have been shown to block gene expression in a highly conserved regulatory mechanism known as RNA interference (RNAi). WO 99/32619 (Fire et al.) disclosed the use of a dsRNA of at least 25 nucleotides in length to inhibit the expression of genes in C. elegans. dsRNA has also been shown to degrade target RNA in other organisms, including plants (see, e.g., WO 99/53050, Waterhouse et al.; and WO 99/61631, Heifetz et al.), Drosophila (see, e.g., Yang, D., et al., Curr. Biol. (2000) 10:1191-1200), and mammals (see WO 00/44895, Limmer; and DE 101 00 586.5, Kreutzer et al.).

SUMMARY OF THE INVENTION

The invention provides compositions containing double-stranded ribonucleic acid (dsRNA) targeted to a GSK-3 gene and methods for inhibiting the expression of a GSK-3 gene in a cell or mammal. The composition can inhibit GSK-3 alpha and/or GSK-3 beta. A composition that inhibits both can do so, e.g., by including a dsRNA that targets both GSK-3 alpha and GSK-3 beta, or by including a first dsRNA that inhibits GSK-3 alpha and a second dsRNA that inhibits GSK-3 beta. The composition can also include a dsRNA which inhibits both and a second which inhibits only one of the isoforms.

The invention also provides compositions and methods for treating manic depression (bipolar disorder).

Other disorders, e.g., pathological conditions and diseases caused by the expression of a GSK-3 gene, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS and nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, bipolar disorder, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), are also provided. The dsRNAs described herein can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.

In one embodiment the invention provides a double-stranded ribonucleic acid (dsRNA), having a sense strand and an antisense strand, the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to an mRNA encoding a GSK-3 gene, and wherein said region of complementarity is less than 30 nucleotides in length. In some embodiments, the second sequence includes a region complementary to the GSK-3 gene sequences NM_(—)019884, NM_(—)00103166, :NM_(—)002093, or NM_(—)019827. In other embodiments, the second sequence includes a region complementary to at least 15 nucleotides of a target sequence described herein, e.g., in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. The second sequence can include a region complementary to a target sequence described in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.

The antisense strand of the dsRNA of the invention can include at least 15 nucleotides of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In one embodiment, the antisense strand includes one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. In another embodiment, the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.

The sense strand can include at least 15 nucleotides of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. For example, the sense strand can include or can consist of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.

In some embodiments, the dsRNA of the invention consists of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 and the antisense strand consists of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Further embodiments include the duplexes disclosed herein, e.g., huGSKA-3, huGSKB-11, AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, or AD-18844.

The dsRNA of the invention can include at least one modified nucleotide. Disclosed herein are exemplary modified sequences, but one of skill can readily design duplexes with different set of modifications using the sequences and teachings herein. The modified nucleotides can be, e.g., a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, or a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group. The modified nucleotide(s) can be a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide. In one embodiment the dsRNA of the invention includes at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.

The region of complementarity of the dsRNA of the invention is less than 30 nucleotides, e.g., at least 15 nucleotides in length, or, e.g., between 19 and 21 nucleotides in length, or, e.g., 19 nucleotides in length.

Disclosed and claimed herein are methods for inhibiting expression of a GSK-3 gene. In one embodiment, administration of the dsRNA inhibits expression of GSK3 by more than 40%. In another embodiment the dsRNA exhibits an IC50 of less than or equal to 10 nM in suppressing GSK3. Alternatively, the dsRNA exhibits an IC50 of less than or equal to 1.0 nM in suppressing GSK3.

Also included in the invention are cells and vectors comprising the dsRNA of the invention.

Further contemplated is a pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising a dsRNA of the invention.

Methods of inhibiting GSK-3 expression in a cell are included in the invention. The methods include (a) introducing into the cell the dsRNA of the invention; and (b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.

Also included is a method of treating a disorder mediated by GSK-3 expression comprising administering to a human in need of such treatment a therapeutically effective amount of a dsRNA of the invention, including treatment of manic depression.

BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS

These and other features, aspects, and advantages of the present invention will become better understood with regard to the following description, and accompanying drawings, where:

FIG. 1 is a graph illustrating the results of GSK3α mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.

FIG. 2 is a graph illustrating the results of GSK3β mRNA suppression in HT22 cells 24 hours after 37.5 nM siRNA transfection.

FIG. 3 is a graph illustrating the dose dependence of GSK3α mRNA suppression after siRNA transfection of HT22 cells.

FIG. 4 is a graph illustrating the dose dependence of GSK3 β mRNA suppression after siRNA transfection of HT22 cells.

FIG. 5 is a western blot illustrating protein levels after siRNA transfection in HT22 cells.

FIG. 6 is a graph illustrating GSK3β mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18844 into the nucleus accumbens.

FIG. 7 is a graph illustrating GSK3α mRNA suppression in mouse nucleus accumbens after 14 day infusion of AD-18826 into the nucleus accumbens.

DETAILED DESCRIPTION OF THE INVENTION

The invention provides dsRNAs and methods of using the dsRNAs for inhibiting the expression of a GSK-3 gene in a cell or a mammal where the dsRNA targets a GSK-3 gene. The invention also provides compositions and methods for treating pathological conditions and diseases, such as a metabolic disease or a cardiovascular disease, in a mammal caused by the expression of a GSK-3 gene. dsRNA directs the sequence-specific degradation of mRNA through a process known as RNA interference (RNAi).

The dsRNAs of the compositions featured herein include an RNA strand (the antisense strand) having a region which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an mRNA transcript of a GSK-3 gene. The use of these dsRNAs enables the targeted degradation of mRNAs of genes that are implicated in replication and or maintenance of cancer cells in mammals. Very low dosages of GSK-3 dsRNAs in particular can specifically and efficiently mediate RNAi, resulting in significant inhibition of expression of the GSK-3 gene. The methods and compositions of the invention containing the GSK-3 dsRNA are useful for treating pathological processes mediated by GSK-3 expression, e.g., manic depression, or other disorders described herein.

The following detailed description discloses how to make and use the compositions containing dsRNAs to inhibit the expression of a GSK-3 gene, as well as compositions and methods for treating diseases and disorders caused by the expression of these genes, such as manic depression. The pharmaceutical compositions featured in the invention include a dsRNA having an antisense strand comprising a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene, together with a pharmaceutically acceptable carrier. The compositions featured in the invention also include a dsRNA having an antisense strand having a region of complementarity which is less than 30 nucleotides in length, generally 19-24 nucleotides in length, and is substantially complementary to at least part of an RNA transcript of a GSK-3 gene.

Accordingly, certain aspects of the invention provide pharmaceutical compositions containing the GSK-3 dsRNA and a pharmaceutically acceptable carrier, methods of using the compositions to inhibit expression of a GSK-3 gene, and methods of using the pharmaceutical compositions to treat diseases caused by expression of the GSK-3 gene.

I. DEFINITIONS

For convenience, the meaning of certain terms and phrases used in the specification, examples, and appended claims, are provided below. If there is an apparent discrepancy between the usage of a term in other parts of this specification and its definition provided in this section, the definition in this section shall prevail.

“G,” “C,” “A” and “U” each generally stand for a nucleotide that contains guanine, cytosine, adenine, and uracil as a base, respectively. “T” and “dT” are used interchangeably herein and refer to a deoxyribonucleotide wherein the nucleobase is thymine, e.g., deoxyribothymine. However, it will be understood that the term “ribonucleotide” or “nucleotide” or “deoxyribonucleotide” can also refer to a modified nucleotide, as further detailed below, or a surrogate replacement moiety. The skilled person is well aware that guanine, cytosine, adenine, and uracil may be replaced by other moieties without substantially altering the base pairing properties of an oligonucleotide comprising a nucleotide bearing such replacement moiety. For example, without limitation, a nucleotide comprising inosine as its base may base pair with nucleotides containing adenine, cytosine, or uracil. Hence, nucleotides containing uracil, guanine, or adenine may be replaced in the nucleotide sequences of the invention by a nucleotide containing, for example, inosine. Sequences comprising such replacement moieties are embodiments of the invention.

As used herein, “GSK-3” refers to Glycogen Synthase Kinase-3, which is also known as DKFZp686D0638, GSK3, C86142, GSK-3beta, 7330414F15Rik, and 8430431H08Rik. GSK-3 alpha sequence can be found as NCBI GeneID:2931 (human) and 606496 (mouse) and RefSeq ID number: NM_(—)019884 (human) and NM_(—)001031667 (mouse). GSK-3 beta sequence can be found as NCBI GeneID:2932 (human) and 56637 (mouse) and RefSeq ID number: NM_(—)002093 (human) and NM_(—)019827 (mouse). A dsRNA featured in the invention can target a specific GSK-3 isoform, e.g. GSK-3 alpha or GSK-3 beta, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript. A dsRNA featured in the invention can target a specific GSK-3 beta isoform, e.g. GSK-3 beta 1 or GSK-3 beta 2, or a dsRNA of the invention can target both isoforms by binding to a common region of the mRNA transcript.

As used herein, “target sequence” refers to a contiguous portion of the nucleotide sequence of an mRNA molecule formed during the transcription of a GSK-3 gene, including mRNA that is a product of RNA processing of a primary transcription product.

As used herein, the term “strand comprising a sequence” refers to an oligonucleotide comprising a chain of nucleotides that is described by the sequence referred to using the standard nucleotide nomenclature.

As used herein, and unless otherwise indicated, the term “complementary,” when used to describe a first nucleotide sequence in relation to a second nucleotide sequence, refers to the ability of an oligonucleotide or polynucleotide comprising the first nucleotide sequence to hybridize and form a duplex structure under certain conditions with an oligonucleotide or polynucleotide comprising the second nucleotide sequence, as will be understood by the skilled person. Such conditions can, for example, be stringent conditions, where stringent conditions may include: 400 mM NaCl, 40 mM PIPES pH 6.4, 1 mM EDTA, 50° C. or 70° C. for 12-16 hours followed by washing. Other conditions, such as physiologically relevant conditions as may be encountered inside an organism, can apply. The skilled person will be able to determine the set of conditions most appropriate for a test of complementarity of two sequences in accordance with the ultimate application of the hybridized nucleotides.

This includes base-pairing of the oligonucleotide or polynucleotide comprising the first nucleotide sequence to the oligonucleotide or polynucleotide comprising the second nucleotide sequence over the entire length of the first and second nucleotide sequence. Such sequences can be referred to as “fully complementary” with respect to each other herein. However, where a first sequence is referred to as “substantially complementary” with respect to a second sequence herein, the two sequences can be fully complementary, or they may form one or more, but generally not more than 4, 3 or 2 mismatched base pairs upon hybridization, while retaining the ability to hybridize under the conditions most relevant to their ultimate application. However, where two oligonucleotides are designed to form, upon hybridization, one or more single stranded overhangs, such overhangs shall not be regarded as mismatches with regard to the determination of complementarity. For example, a dsRNA comprising one oligonucleotide 21 nucleotides in length and another oligonucleotide 23 nucleotides in length, wherein the longer oligonucleotide comprises a sequence of 21 nucleotides that is fully complementary to the shorter oligonucleotide, may yet be referred to as “fully complementary” for the purposes of the invention.

“Complementary” sequences, as used herein, may also include, or be formed entirely from, non-Watson-Crick base pairs and/or base pairs formed from non-natural and modified nucleotides, in as far as the above requirements with respect to their ability to hybridize are fulfilled. Such non-Watson-Crick base pairs includes, but not limited to, G:U Wobble or Hoogstein base pairing.

The terms “complementary”, “fully complementary” and “substantially complementary” herein may be used with respect to the base matching between the sense strand and the antisense strand of a dsRNA, or between the antisense strand of a dsRNA and a target sequence, as will be understood from the context of their use.

As used herein, a polynucleotide which is “substantially complementary to at least part of” a messenger RNA (mRNA) refers to a polynucleotide which is substantially complementary to a contiguous portion of the mRNA of interest (e.g., encoding a GSK-3) including a 5′ UTR, an open reading frame (ORF), or a 3′ UTR. For example, a polynucleotide is complementary to at least a part of a GSK-3 mRNA if the sequence is substantially complementary to a non-interrupted portion of an mRNA encoding a GSK-3.

The term “double-stranded RNA” or “dsRNA”, as used herein, refers to a complex of ribonucleic acid molecules, having a duplex structure comprising two anti-parallel and substantially complementary, as defined above, nucleic acid strands. In general, the majority of nucleotides of each strand are ribonucleotides, but as described in detail herein, each or both strands can also include at least one non-ribonucleotide, e.g., a deoxyribonucleotide and/or a modified nucleotide. In addition, as used in this specification, “dsRNA” may include chemical modifications to ribonucleotides, including substantial modifications at multiple nucleotides and including all types of modifications disclosed herein or known in the art. Any such modifications, as used in an siRNA type molecule, are encompassed by “dsRNA” for the purposes of this specification and claims. The two strands forming the duplex structure may be different portions of one larger RNA molecule, or they may be separate RNA molecules. Where the two strands are part of one larger molecule, and therefore are connected by an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′end of the respective other strand forming the duplex structure, the connecting RNA chain is referred to as a “hairpin loop”. Where the two strands are connected covalently by means other than an uninterrupted chain of nucleotides between the 3′-end of one strand and the 5′end of the respective other strand forming the duplex structure, the connecting structure is referred to as a “linker”. The RNA strands may have the same or a different number of nucleotides. The maximum number of base pairs is the number of nucleotides in the shortest strand of the dsRNA minus any overhangs that are present in the duplex. In addition to the duplex structure, a dsRNA may comprise one or more nucleotide overhangs.

As used herein, a “nucleotide overhang” refers to the unpaired nucleotide or nucleotides that protrude from the duplex structure of a dsRNA when a 3′-end of one strand of the dsRNA extends beyond the 5′-end of the other strand, or vice versa. “Blunt” or “blunt end” means that there are no unpaired nucleotides at that end of the dsRNA, i.e., no nucleotide overhang. A “blunt ended” dsRNA is a dsRNA that is double-stranded over its entire length, i.e., no nucleotide overhang at either end of the molecule.

The term “antisense strand” refers to the strand of a dsRNA which includes a region that is substantially complementary to a target sequence. As used herein, the term “region of complementarity” refers to the region on the antisense strand that is substantially complementary to a sequence, for example a target sequence, as defined herein. Where the region of complementarity is not fully complementary to the target sequence, the mismatches are most tolerated in the terminal regions and, if present, are generally in a terminal region or regions, e.g., within 6, 5, 4, 3, or 2 nucleotides of the 5′ and/or 3′ terminus.

The term “sense strand,” as used herein, refers to the strand of a dsRNA that includes a region that is substantially complementary to a region of the antisense strand.

“Introducing into a cell”, when referring to a dsRNA, means facilitating uptake or absorption into the cell, as is understood by those skilled in the art. Absorption or uptake of dsRNA can occur through unaided diffusive or active cellular processes, or by auxiliary agents or devices. The meaning of this term is not limited to cells in vitro; a dsRNA may also be “introduced into a cell”, wherein the cell is part of a living organism. In such instance, introduction into the cell will include the delivery to the organism. For example, for in vivo delivery, dsRNA can be injected into a tissue site or administered systemically. In vitro introduction into a cell includes methods known in the art such as electroporation and lipofection.

The terms “silence” and “inhibit the expression of” “down-regulate the expression of,” “suppress the expression of” and the like in as far as they refer to a GSK-3 gene, herein refer to the at least partial suppression of the expression of a GSK-3 gene, as manifested by a reduction of the amount of mRNA which may be isolated from a first cell or group of cells in which a GSK-3 gene is transcribed and which has or have been treated such that the expression of a GSK-3 gene is inhibited, as compared to a second cell or group of cells substantially identical to the first cell or group of cells but which has or have not been so treated (control cells). The degree of inhibition is usually expressed in terms of

$\frac{\left( {{mRNA}\mspace{14mu} i\; n\mspace{14mu} {control}\mspace{14mu} {cells}} \right) - \left( {{mRNA}\mspace{14mu} {in}\mspace{14mu} {treated}\mspace{14mu} {cells}} \right)}{\left( {{mRNA}\mspace{14mu} {in}{\mspace{11mu} \;}{control}\mspace{14mu} {cells}} \right)}{\bullet 100}\%$

Alternatively, the degree of inhibition may be given in terms of a reduction of a parameter that is functionally linked to GSK-3 gene transcription, e.g., the amount of protein encoded by a GSK-3 gene which is secreted by a cell, or the number of cells displaying a certain phenotype, e.g., apoptosis. In principle, GSK-3 gene silencing may be determined in any cell expressing the target, either constitutively or by genomic engineering, and by any appropriate assay. However, when a reference is needed in order to determine whether a given dsRNA inhibits the expression of the GSK-3 gene by a certain degree and therefore is encompassed by the instant invention, the assay provided in the Examples below shall serve as such reference.

For example, in certain instances, expression of a GSK-3 gene is suppressed by at least about 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, or 50% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 60%, 70%, or 80% by administration of the double-stranded oligonucleotide of the invention. In some embodiments, a GSK-3 gene is suppressed by at least about 85%, 90%, or 95% by administration of the double-stranded oligonucleotide of the invention.

As used herein in the context of GSK-3 expression, the terms “treat”, “treatment”, and the like, refer to relief from or alleviation of pathological processes mediated by GSK-3 expression. In the context of the present invention insofar as it relates to any of the other conditions recited herein below (other than pathological processes mediated by GSK-3 expression), the terms “treat”, “treatment”, and the like mean to relieve or alleviate at least one symptom associated with such condition, or to slow or reverse the progression of such condition, such as the slowing and progression of manic depression.

As used herein, the phrases “therapeutically effective amount” and “prophylactically effective amount” refer to an amount that provides a therapeutic benefit in the treatment, prevention, or management of pathological processes mediated by GSK-3 expression or an overt symptom of pathological processes mediated by GSK-3 expression. The specific amount that is therapeutically effective can be readily determined by ordinary medical practitioner, and may vary depending on factors known in the art, such as, e.g. the type of pathological processes mediated by GSK-3 expression, the patient's history and age, the stage of pathological processes mediated by GSK-3 expression, and the administration of other anti-pathological processes mediated by GSK-3 expression agents.

As used herein, a “pharmaceutical composition” comprises a pharmacologically effective amount of a dsRNA and a pharmaceutically acceptable carrier. As used herein, “pharmacologically effective amount,” “therapeutically effective amount” or simply “effective amount” refers to that amount of an RNA effective to produce the intended pharmacological, therapeutic or preventive result. For example, if a given clinical treatment is considered effective when there is at least a 25% reduction in a measurable parameter associated with a disease or disorder, a therapeutically effective amount of a drug for the treatment of that disease or disorder is the amount necessary to effect at least a 25% reduction in that parameter.

The term “pharmaceutically acceptable carrier” refers to a carrier for administration of a therapeutic agent. Such carriers include, but are not limited to, saline, buffered saline, dextrose, water, glycerol, ethanol, and combinations thereof. The term specifically excludes cell culture medium. For drugs administered orally, pharmaceutically acceptable carriers include, but are not limited to pharmaceutically acceptable excipients such as inert diluents, disintegrating agents, binding agents, lubricating agents, sweetening agents, flavoring agents, coloring agents and preservatives. Suitable inert diluents include sodium and calcium carbonate, sodium and calcium phosphate, and lactose, while corn starch and alginic acid are suitable disintegrating agents. Binding agents may include starch and gelatin, while the lubricating agent, if present, will generally be magnesium stearate, stearic acid or talc. If desired, the tablets may be coated with a material such as glyceryl monostearate or glyceryl distearate, to delay absorption in the gastrointestinal tract.

As used herein, a “transformed cell” is a cell into which a vector has been introduced from which a dsRNA molecule may be expressed.

II. DOUBLE-STRANDED RIBONUCLEIC ACID (DSRNA)

As described in more detail herein, the invention provides double-stranded ribonucleic acid (dsRNA) molecules for inhibiting the expression of a GSK-3 gene in a cell or mammal, e.g., in a human having manic depression, or another disorder described herein, where the dsRNA includes an antisense strand having a region of complementarity which is complementary to at least a part of an mRNA formed in the expression of a GSK-3 gene, and where the region of complementarity is less than 30 nucleotides in length, and where said dsRNA, upon contact with a cell expressing a GSK-3 gene, inhibits the expression of a GSK-3 gene, e.g., by at least 30% as assayed by, for example, a PCR or branched DNA (bDNA) based method. The dsRNA of the invention may further include one or more single-stranded nucleotide overhangs.

The dsRNA can be synthesized by standard methods known in the art as further discussed below, e.g., by use of an automated DNA synthesizer, such as are commercially available from, for example, Biosearch, Applied Biosystems, Inc.

The dsRNA includes two RNA strands that are sufficiently complementary to hybridize to form a duplex structure. One strand of the dsRNA (the antisense strand) includes a region of complementarity that is substantially complementary, and generally fully complementary, to a target sequence, derived from the sequence of an mRNA formed during the expression of the GSK-3 gene, the other strand (the sense strand) includes a region that is complementary to the antisense strand, such that the two strands hybridize and form a duplex structure when combined under suitable conditions. Generally, the duplex structure is between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the duplex is 19 base pairs in length. In another embodiment the duplex is 21 base pairs in length. When two different siRNAs are used in combination, the duplex lengths can be identical or can differ.

Similarly, the region of complementarity to the target sequence can be between 15 and 30, or between 25 and 30, or between 18 and 25, or between 19 and 24, or between 19 and 21, or 19, 20, or 21 base pairs in length. In one embodiment the region of complementarity is 19 nucleotides in length. In another embodiment the region of complementarity is 21 nucleotides in length. When two different siRNAs are used in combination, the region of complementarity can be identical or can differ.

Each strand of the dsRNA of invention is generally between 15 and 30, or between 18 and 25, or 18, 19, 20, 21, 22, 23, 24, or 25 nucleotides in length. In other embodiments, each is strand is 25-30 nucleotides in length. Each strand of the duplex can be the same length or of different lengths. When two different siRNAs are used in combination, the lengths of each strand of each siRNA can be identical or can differ.

The dsRNA of the invention can include one or more single-stranded overhang(s) of one or more nucleotides. In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. In another embodiment, the antisense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the sense strand. In further embodiments, the sense strand of the dsRNA has 1-10 nucleotides overhangs each at the 3′ end and the 5′ end over the antisense strand.

A dsRNAs having at least one nucleotide overhang can have unexpectedly superior inhibitory properties than the blunt-ended counterpart. In some embodiments the presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. A dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA can also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs can have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.

In one embodiment, the targeted GSK-3 gene is the human GSK-3 gene. In another embodiment, the targeted GSK-3 gene is a mouse gene. In some embodiments, the sense strand of the dsRNA includes a sense sequence from Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and the antisense sequence includes an antisense sequence of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7. Alternative antisense agents that target elsewhere in the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be determined using the target sequence and the flanking GSK-3 sequence.

The skilled person is well aware that dsRNAs comprising a duplex structure of between 20 and 23, but specifically 21, base pairs have been hailed as particularly effective in inducing RNA interference (Elbashir et al., EMBO 2001, 20:6877-6888). However, others have found that shorter or longer dsRNAs can be effective as well. In the embodiments described above, by virtue of the nature of the oligonucleotide sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, the dsRNAs of the invention can include at least one strand of a length of minimally 21 nt. It can be reasonably expected that shorter dsRNAs having one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 minus only a few nucleotides on one or both ends may be similarly effective as compared to the dsRNAs described above. Hence, dsRNAs having a partial sequence of at least 15, 16, 17, 18, 19, 20, or more contiguous nucleotides from one of the sequences of Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7, and differing in their ability to inhibit the expression of a GSK-3 gene in an assay as described herein below by not more than 5, 10, 15, 20, 25, or 30% inhibition from a dsRNA comprising the full sequence, are contemplated by the invention. Further dsRNAs that cleave within the target sequence provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 can readily be made using the GSK-3 sequence and the target sequence provided.

In addition, the siRNA agents provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 identify a site in a GSK-3 mRNA that is susceptible to siRNA based cleavage. As such the present invention further features siRNA agents that target within the sequence targeted by one of the agents of the present invention. As used herein a second siRNA agent is said to target within the sequence of a first siRNA agent if the second siRNA agent cleaves the message anywhere within the mRNA that is complementary to the antisense strand of the first siRNA agent. Such a second agent will generally consist of at least 15 contiguous nucleotides from one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 coupled to additional nucleotide sequences taken from the region contiguous to the selected sequence in the GSK-3 gene. For example, the last 15 nucleotides of SEQ ID NO:1 combined with the next 6 nucleotides from the target GSK-3 gene produces a single strand agent of 21 nucleotides that is based on one of the sequences provided in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7.

The dsRNA of the invention can contain one or more mismatches to the target sequence. In a preferred embodiment, the dsRNA of the invention contains no more than 3 mismatches. If the antisense strand of the dsRNA contains mismatches to a target sequence, it is preferable that the area of mismatch not be located in the center of the region of complementarity. If the antisense strand of the dsRNA contains mismatches to the target sequence, it is preferable that the mismatch be restricted to 5 nucleotides from either end, for example 5, 4, 3, 2, or 1 nucleotide from either the 5′ or 3′ end of the region of complementarity. For example, for a 23 nucleotide dsRNA strand which is complementary to a region of the GSK-3 gene, the dsRNA generally does not contain any mismatch within the central 13 nucleotides. The methods described within the invention can be used to determine whether a dsRNA containing a mismatch to a target sequence is effective in inhibiting the expression of a GSK-3 gene. Consideration of the efficacy of dsRNAs with mismatches in inhibiting expression of a GSK-3 gene is important, especially if the particular region of complementarity in a GSK-3 gene is known to have polymorphic sequence variation within the population.

In some embodiments the sense and/or antisense sequences of the dsRNA molecules featured herein can have the primary sequence shown in the tables with or without the modifications shown in the tables. In other embodiments the dsRNA molecule can differ by not more than 1, 2 or 3 bases from that provided in the tables.

In one embodiment, at least one end of the dsRNA has a single-stranded nucleotide overhang of 1 to 4, generally 1 or 2 nucleotides. dsRNAs having at least one nucleotide overhang have superior inhibitory properties than their blunt-ended counterparts. The presence of only one nucleotide overhang strengthens the interference activity of the dsRNA, without affecting its overall stability. dsRNA having only one overhang has proven particularly stable and effective in vivo, as well as in a variety of cells, cell culture mediums, blood, and serum. Generally, the single-stranded overhang is located at the 3′-terminal end of the antisense strand or, alternatively, at the 3′-terminal end of the sense strand. The dsRNA may also have a blunt end, generally located at the 5′-end of the antisense strand. Such dsRNAs have improved stability and inhibitory activity, thus allowing administration at low dosages, i.e., less than 5 mg/kg body weight of the recipient per day. Generally, the antisense strand of the dsRNA has a nucleotide overhang at the 3′-end, and the 5′-end is blunt. In another embodiment, one or more of the nucleotides in the overhang is replaced with a nucleoside thiophosphate.

Modifications

In yet another embodiment, the dsRNA is chemically modified to enhance stability. The nucleic acids of the invention may be synthesized and/or modified by methods well established in the art, such as those described in “Current protocols in nucleic acid chemistry”, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA, which is hereby incorporated herein by reference. Specific examples of preferred dsRNA compounds useful in this invention include dsRNAs containing modified backbones or no natural internucleoside linkages. As defined in this specification, dsRNAs having modified backbones include those that retain a phosphorus atom in the backbone and those that do not have a phosphorus atom in the backbone. For the purposes of this specification, and as sometimes referenced in the art, modified dsRNAs that do not have a phosphorus atom in their internucleoside backbone can also be considered to be oligonucleosides.

Preferred modified dsRNA backbones include, for example, phosphorothioates, chiral phosphorothioates, phosphorodithioates, phosphotriesters, aminoalkylphosphotriesters, methyl and other alkyl phosphonates including 3′-alkylene phosphonates and chiral phosphonates, phosphinates, phosphoramidates including 3′-amino phosphoramidate and aminoalkylphosphoramidates, thionophosphoramidates, thionoalkylphosphonates, thionoalkylphosphotriesters, and boranophosphates having normal 3′-5′ linkages, 2′-5′ linked analogs of these, and those) having inverted polarity wherein the adjacent pairs of nucleoside units are linked 3′-5′ to 5′-3′ or 2′-5′ to 5′-2′. Various salts, mixed salts and free acid forms are also included.

Representative U.S. patents that teach the preparation of the above phosphorus-containing linkages include, but are not limited to, U.S. Pat. Nos. 3,687,808; 4,469,863; 4,476,301; 5,023,243; 5,177,195; 5,188,897; 5,264,423; 5,276,019; 5,278,302; 5,286,717; 5,321,131; 5,399,676; 5,405,939; 5,453,496; 5,455,233; 5,466,677; 5,476,925; 5,519,126; 5,536,821; 5,541,316; 5,550,111; 5,563,253; 5,571,799; 5,587,361; and 5,625,050, each of which is herein incorporated by reference

Preferred modified dsRNA backbones that do not include a phosphorus atom therein have backbones that are formed by short chain alkyl or cycloalkyl internucleoside linkages, mixed heteroatoms and alkyl or cycloalkyl internucleoside linkages, or one or more short chain heteroatomic or heterocyclic internucleoside linkages. These include those having morpholino linkages (formed in part from the sugar portion of a nucleoside); siloxane backbones; sulfide, sulfoxide and sulfone backbones; formacetyl and thioformacetyl backbones; methylene formacetyl and thioformacetyl backbones; alkene containing backbones; sulfamate backbones; methyleneimino and methylenehydrazino backbones; sulfonate and sulfonamide backbones; amide backbones; and others having mixed N, O, S and CH2 component parts.

Representative U.S. patents that teach the preparation of the above oligonucleosides include, but are not limited to, U.S. Pat. Nos. 5,034,506; 5,166,315; 5,185,444; 5,214,134; 5,216,141; 5,235,033; 5,64,562; 5,264,564; 5,405,938; 5,434,257; 5,466,677; 5,470,967; 5,489,677; 5,541,307; 5,561,225; 5,596,086; 5,602,240; 5,608,046; 5,610,289; 5,618,704; 5,623,070; 5,663,312; 5,633,360; 5,677,437; and, 5,677,439, each of which is herein incorporated by reference.

In other preferred dsRNA mimetics, both the sugar and the internucleoside linkage, i.e., the backbone, of the nucleotide units are replaced with novel groups. The base units are maintained for hybridization with an appropriate nucleic acid target compound. One such oligomeric compound, an dsRNA mimetic that has been shown to have excellent hybridization properties, is referred to as a peptide nucleic acid (PNA). In PNA compounds, the sugar backbone of an dsRNA is replaced with an amide containing backbone, in particular an aminoethylglycine backbone. The nucleobases are retained and are bound directly or indirectly to aza nitrogen atoms of the amide portion of the backbone. Representative U.S. patents that teach the preparation of PNA compounds include, but are not limited to, U.S. Pat. Nos. 5,539,082; 5,714,331; and 5,719,262, each of which is herein incorporated by reference. Further teaching of PNA compounds can be found in Nielsen et al., Science, 1991, 254, 1497-1500.

Most preferred embodiments of the invention are dsRNAs with phosphorothioate backbones and oligonucleosides with heteroatom backbones, and in particular —CH₂—NH—CH₂—, —CH₂—N(CH₃)—O—CH₂— [known as a methylene (methylimino) or MMI backbone], —CH₂—O—N(CH₃)—CH₂—, —CH₂—N(CH₃)—N(CH₃)—CH₂— and —N(CH₃)—CH₂—CH₂— [wherein the native phosphodiester backbone is represented as —O—P—O—CH₂—] of the above-referenced U.S. Pat. No. 5,489,677, and the amide backbones of the above-referenced U.S. Pat. No. 5,602,240. Also preferred are dsRNAs having morpholino backbone structures of the above-referenced U.S. Pat. No. 5,034,506.

Modified dsRNAs may also contain one or more substituted sugar moieties. Preferred dsRNAs comprise one of the following at the 2′ position: OH; F; O-, S-, or N-alkyl; O-, S-, or N-alkenyl; O-, S- or N-alkynyl; or O-alkyl-O-alkyl, wherein the alkyl, alkenyl and alkynyl may be substituted or unsubstituted C₁ to C₁₀ alkyl or C₂ to C₁₀ alkenyl and alkynyl. Particularly preferred are O[(CH₂)_(n)O]_(m)CH₃, O(CH₂)_(n)OCH₃, O(CH₂)_(n)NH₂, O(CH₂)_(n)CH₃, O(CH₂)_(n)ONH₂, and O(CH₂)_(n)ON[(CH₂)_(n)CH₃)]₂, where n and m are from 1 to about 10. Other preferred dsRNAs comprise one of the following at the 2′ position: C₁ to C₁₀ lower alkyl, substituted lower alkyl, alkaryl, aralkyl, O-alkaryl or O-aralkyl, SH, SCH₃, OCN, Cl, Br, CN, CF₃, OCF₃, SOCH₃, SO₂CH₃, ONO₂, NO₂, N₃, NH₂, heterocycloalkyl, heterocycloalkaryl, aminoalkylamino, polyalkylamino, substituted silyl, an RNA cleaving group, a reporter group, an intercalator, a group for improving the pharmacokinetic properties of an dsRNA, or a group for improving the pharmacodynamic properties of an dsRNA, and other substituents having similar properties. A preferred modification includes 2′-methoxyethoxy (2′-O—CH₂CH₂OCH₃, also known as 2′-O-(2-methoxyethyl) or 2′-MOE) (Martin et al., Helv. Chim. Acta, 1995, 78, 486-504) i.e., an alkoxy-alkoxy group. A further preferred modification includes 2′-dimethylaminooxyethoxy, i.e., a O(CH₂)₂ON(CH₃)₂ group, also known as 2′-DMAOE, as described in examples herein below, and 2′-dimethylaminoethoxyethoxy (also known in the art as 2′-O-dimethylaminoethoxyethyl or 2′-DMAEOE), i.e., 2′-O—CH₂—O—CH₂—N(CH₂)₂, also described in examples herein below.

Other preferred modifications include 2′-methoxy (2′-OCH₃), 2′-aminopropoxy (2′-OCH₂CH₂CH₂NH₂) and 2′-fluoro (2′-F). Similar modifications may also be made at other positions on the dsRNA, particularly the 3′ position of the sugar on the 3′ terminal nucleotide or in 2′-5′ linked dsRNAs and the 5′ position of 5′ terminal nucleotide. DsRNAs may also have sugar mimetics such as cyclobutyl moieties in place of the pentofuranosyl sugar. Representative U.S. patents that teach the preparation of such modified sugar structures include, but are not limited to, U.S. Pat. Nos. 4,981,957; 5,118,800; 5,319,080; 5,359,044; 5,393,878; 5,446,137; 5,466,786; 5,514,785; 5,519,134; 5,567,811; 5,576,427; 5,591,722; 5,597,909; 5,610,300; 5,627,053; 5,639,873; 5,646,265; 5,658,873; 5,670,633; and 5,700,920, certain of which are commonly owned with the instant application, and each of which is herein incorporated by reference in its entirety.

DsRNAs may also include nucleobase (often referred to in the art simply as “base”) modifications or substitutions. As used herein, “unmodified” or “natural” nucleobases include the purine bases adenine (A) and guanine (G), and the pyrimidine bases thymine (T), cytosine (C) and uracil (U). Modified nucleobases include other synthetic and natural nucleobases such as 5-methylcytosine (5-me-C), 5-hydroxymethyl cytosine, xanthine, hypoxanthine, 2-aminoadenine, 6-methyl and other alkyl derivatives of adenine and guanine, 2-propyl and other alkyl derivatives of adenine and guanine, 2-thiouracil, 2-thiothymine and 2-thiocytosine, 5-halouracil and cytosine, 5-propynyl uracil and cytosine, 6-azo uracil, cytosine and thymine, 5-uracil (pseudouracil), 4-thiouracil, 8-halo, 8-amino, 8-thiol, 8-thioalkyl, 8-hydroxyl anal other 8-substituted adenines and guanines, 5-halo, particularly 5-bromo, 5-trifluoromethyl and other 5-substituted uracils and cytosines, 7-methylguanine and 7-methyladenine, 8-azaguanine and 8-azaadenine, 7-deazaguanine and 7-daazaadenine and 3-deazaguanine and 3-deazaadenine. Further nucleobases include those disclosed in U.S. Pat. No. 3,687,808, those disclosed in The Concise Encyclopedia Of Polymer Science And Engineering, pages 858-859, Kroschwitz, J. L, ed. John Wiley & Sons, 1990, these disclosed by Englisch et al., Angewandte Chemie, International Edition, 1991, 30, 613, and those disclosed by Sanghvi, Y S., Chapter 15, DsRNA Research and Applications, pages 289-302, Crooke, S. T. and Lebleu, B., Ed., CRC Press, 1993. Certain of these nucleobases are particularly useful for increasing the binding affinity of the oligomeric compounds of the invention. These include 5-substituted pyrimidines, 6-azapyrimidines and N-2, N-6 and 0-6 substituted purines, including 2-aminopropyladenine, 5-propynyluracil and 5-propynylcytosine. 5-methylcytosine substitutions have been shown to increase nucleic acid duplex stability by 0.6-1.2° C. (Sanghvi, Y. S., Crooke, S. T. and Lebleu, B., Eds., DsRNA Research and Applications, CRC Press, Boca Raton, 1993, pp. 276-278) and are presently preferred base substitutions, even more particularly when combined with 2′-O-methoxyethyl sugar modifications.

Representative U.S. patents that teach the preparation of certain of the above noted modified nucleobases as well as other modified nucleobases include, but are not limited to, the above noted U.S. Pat. No. 3,687,808, as well as U.S. Pat. Nos. 4,845,205; 5,130,30; 5,134,066; 5,175,273; 5,367,066; 5,432,272; 5,457,187; 5,459,255; 5,484,908; 5,502,177; 5,525,711; 5,552,540; 5,587,469; 5,594,121, 5,596,091; 5,614,617; and 5,681,941, each of which is herein incorporated by reference, and U.S. Pat. No. 5,750,692, also herein incorporated by reference.

Conjugates

Another modification of the dsRNAs of the invention involves chemically linking to the dsRNA one or more moieties or conjugates which enhance the activity, cellular distribution or cellular uptake of the dsRNA. Such moieties include but are not limited to lipid moieties such as a cholesterol moiety (Letsinger et al., Proc. Natl. Acid. Sci. USA, 199, 86, 6553-6556), cholic acid (Manoharan et al., Biorg. Med. Chem. Let., 1994 4 1053-1060), a thioether, e.g., beryl-S-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660, 306-309; Manoharan et al., Biorg. Med. Chem. Let., 1993, 3, 2765-2770), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20, 533-538), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J, 1991, 10, 1111-1118; Kabanov et al., FEBS Lett., 1990, 259, 327-330; Svinarchuk et al., Biochimie, 1993, 75, 49-54), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethyl-ammonium 1,2-di-O-hexadecyl-rac-glycero-3-Hphosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654; Shea et al., Nucl. Acids Res., 1990, 18, 3777-3783), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14, 969-973), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36, 3651-3654), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264, 229-237), or an octadecylamine or hexylamino-carbonyloxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277, 923-937).

Representative U.S. patents that teach the preparation of such dsRNA conjugates include, but are not limited to, U.S. Pat. Nos. 4,828,979; 4,948,882; 5,218,105; 5,525,465; 5,541,313; 5,545,730; 5,552,538; 5,578,717, 5,580,731; 5,591,584; 5,109,124; 5,118,802; 5,138,045; 5,414,077; 5,486,603; 5,512,439; 5,578,718; 5,608,046; 4,587,044; 4,605,735; 4,667,025; 4,762,779; 4,789,737; 4,824,941; 4,835,263; 4,876,335; 4,904,582; 4,958,013; 5,082,830; 5,112,963; 5,214,136; 5,082,830; 5,112,963; 5,214,136; 5,245,022; 5,254,469; 5,258,506; 5,262,536; 5,272,250; 5,292,873; 5,317,098; 5,371,241, 5,391,723; 5,416,203, 5,451,463; 5,510,475; 5,512,667; 5,514,785; 5,565,552; 5,567,810; 5,574,142; 5,585,481; 5,587,371; 5,595,726; 5,597,696; 5,599,923; 5,599,928 and 5,688,941, each of which is herein incorporated by reference.

It is not necessary for all positions in a given compound to be uniformly modified, and in fact more than one of the aforementioned modifications may be incorporated in a single compound or even at a single nucleoside within an dsRNA. The present invention also includes dsRNA compounds which are chimeric compounds. “Chimeric” dsRNA compounds or “chimeras,” in the context of this invention, are dsRNA compounds, particularly dsRNAs, which contain two or more chemically distinct regions, each made up of at least one monomer unit, i.e., a nucleotide in the case of an dsRNA compound. These dsRNAs typically contain at least one region wherein the dsRNA is modified so as to confer upon the dsRNA increased resistance to nuclease degradation, increased cellular uptake, and/or increased binding affinity for the target nucleic acid. An additional region of the dsRNA may serve as a substrate for enzymes capable of cleaving RNA:DNA or RNA:RNA hybrids. By way of example, RNase H is a cellular endonuclease which cleaves the RNA strand of an RNA:DNAduplex. Activation of RNase H, therefore, results in cleavage of the RNA target, thereby greatly enhancing the efficiency of dsRNA inhibition of gene expression. Consequently, comparable results can often be obtained with shorter dsRNAs when chimeric dsRNAs are used, compared to phosphorothioate deoxy dsRNAs hybridizing to the same target region. Cleavage of the RNA target can be routinely detected by gel electrophoresis and, if necessary, associated nucleic acid hybridization techniques known in the art.

In certain instances, the dsRNA may be modified by a non-ligand group. A number of non-ligand molecules have been conjugated to dsRNAs in order to enhance the activity, cellular distribution or cellular uptake of the dsRNA, and procedures for performing such conjugations are available in the scientific literature. Such non-ligand moieties have included lipid moieties, such as cholesterol (Letsinger et al., Proc. Natl. Acad. Sci. USA, 1989, 86:6553), cholic acid (Manoharan et al., Bioorg. Med. Chem. Lett., 1994, 4:1053), a thioether, e.g., hexyl-S-tritylthiol (Manoharan et al., Ann. N.Y. Acad. Sci., 1992, 660:306; Manoharan et al., Bioorg. Med. Chem. Let., 1993, 3:2765), a thiocholesterol (Oberhauser et al., Nucl. Acids Res., 1992, 20:533), an aliphatic chain, e.g., dodecandiol or undecyl residues (Saison-Behmoaras et al., EMBO J., 1991, 10:111; Kabanov et al., FEBS Lett., 1990, 259:327; Svinarchuk et al., Biochimie, 1993, 75:49), a phospholipid, e.g., di-hexadecyl-rac-glycerol or triethylammonium 1,2-di-O-hexadecyl-rac-glycero-3-H-phosphonate (Manoharan et al., Tetrahedron Lett., 1995, 36:3651; Shea et al., Nucl. Acids Res., 1990, 18:3777), a polyamine or a polyethylene glycol chain (Manoharan et al., Nucleosides & Nucleotides, 1995, 14:969), or adamantane acetic acid (Manoharan et al., Tetrahedron Lett., 1995, 36:3651), a palmityl moiety (Mishra et al., Biochim. Biophys. Acta, 1995, 1264:229), or an octadecylamine or hexylamino-carbonyl-oxycholesterol moiety (Crooke et al., J. Pharmacol. Exp. Ther., 1996, 277:923). Representative United States patents that teach the preparation of such dsRNA conjugates have been listed above. Typical conjugation protocols involve the synthesis of dsRNAs bearing an aminolinker at one or more positions of the sequence. The amino group is then reacted with the molecule being conjugated using appropriate coupling or activating reagents. The conjugation reaction may be performed either with the dsRNA still bound to the solid support or following cleavage of the dsRNA in solution phase. Purification of the dsRNA conjugate by HPLC typically affords the pure conjugate.

Vector Encoded siRNA Agents

In another aspect of the invention, GSK-3 specific dsRNA molecules that are expressed from transcription units inserted into DNA or RNA vectors (see, e.g., Couture, A, et al., TIG. (1996), 12:5-10; Skillern, A., et al., International PCT Publication No. WO 00/22113, Conrad, International PCT Publication No. WO 00/22114, and Conrad, U.S. Pat. No. 6,054,299). These transgenes can be introduced as a linear construct, a circular plasmid, or a viral vector, which can be incorporated and inherited as a transgene integrated into the host genome. The transgene can also be constructed to permit it to be inherited as an extrachromosomal plasmid (Gassmann, et al., Proc. Natl. Acad. Sci. USA (1995) 92:1292).

The individual strands of a dsRNA can be transcribed by promoters on two separate expression vectors and co-transfected into a target cell. Alternatively each individual strand of the dsRNA can be transcribed by promoters both of which are located on the same expression plasmid. In a preferred embodiment, a dsRNA is expressed as an inverted repeat joined by a linker polynucleotide sequence such that the dsRNA has a stem and loop structure.

The recombinant dsRNA expression vectors are generally DNA plasmids or viral vectors. dsRNA expressing viral vectors can be constructed based on, but not limited to, adeno-associated virus (for a review, see Muzyczka, et al., Curr. Topics Micro. Immunol. (1992) 158:97-129)); adenovirus (see, for example, Berkner, et al., BioTechniques (1998) 6:616), Rosenfeld et al. (1991, Science 252:431-434), and Rosenfeld et al. (1992), Cell 68:143-155)); or alphavirus as well as others known in the art. Retroviruses have been used to introduce a variety of genes into many different cell types, including epithelial cells, in vitro and/or in vivo (see, e.g., Eglitis, et al., Science (1985) 230:1395-1398; Danos and Mulligan, Proc. Natl. Acad. Sci. USA (1998) 85:6460-6464; Wilson et al., 1988, Proc. Natl. Acad. Sci. USA 85:3014-3018; Armentano et al., 1990, Proc. Natl. Acad. Sci. USA 87:61416145; Huber et al., 1991, Proc. Natl. Acad. Sci. USA 88:8039-8043; Ferry et al., 1991, Proc. Natl. Acad. Sci. USA 88:8377-8381; Chowdhury et al., 1991, Science 254:1802-1805; van Beusechem. et al., 1992, Proc. Nad. Acad. Sci. USA 89:7640-19; Kay et al., 1992, Human Gene Therapy 3:641-647; Dai et al., 1992, Proc. Natl. Acad. Sci. USA 89:10892-10895; Hwu et al., 1993, J. Immunol. 150:4104-4115; U.S. Pat. No. 4,868,116; U.S. Pat. No. 4,980,286; PCT Application WO 89/07136; PCT Application WO 89/02468; PCT Application WO 89/05345; and PCT Application WO 92/07573). Recombinant retroviral vectors capable of transducing and expressing genes inserted into the genome of a cell can be produced by transfecting the recombinant retroviral genome into suitable packaging cell lines such as PA317 and Psi-CRIP (Comette et al., 1991, Human Gene Therapy 2:5-10; Cone et al., 1984, Proc. Natl. Acad. Sci. USA 81:6349). Recombinant adenoviral vectors can be used to infect a wide variety of cells and tissues in susceptible hosts (e.g., rat, hamster, dog, and chimpanzee) (Hsu et al., 1992, J. Infectious Disease, 166:769), and also have the advantage of not requiring mitotically active cells for infection.

Any viral vector capable of accepting the coding sequences for the dsRNA molecule(s) to be expressed can be used, for example vectors derived from adenovirus (AV); adeno-associated virus (AAV); retroviruses (e.g., lentiviruses (LV), Rhabdoviruses, murine leukemia virus); herpes virus, and the like. The tropism of viral vectors can be modified by pseudotyping the vectors with envelope proteins or other surface antigens from other viruses, or by substituting different viral capsid proteins, as appropriate.

For example, lentiviral vectors of the invention can be pseudotyped with surface proteins from vesicular stomatitis virus (VSV), rabies, Ebola, Mokola, and the like. AAV vectors of the invention can be made to target different cells by engineering the vectors to express different capsid protein serotypes. For example, an AAV vector expressing a serotype 2 capsid on a serotype 2 genome is called AAV 2/2. This serotype 2 capsid gene in the AAV 2/2 vector can be replaced by a serotype 5 capsid gene to produce an AAV 2/5 vector. Techniques for constructing AAV vectors which express different capsid protein serotypes are within the skill in the art; see, e.g., Rabinowitz J E et al. (2002), J Virol 76:791-801, the entire disclosure of which is herein incorporated by reference.

Selection of recombinant viral vectors suitable for use in the invention, methods for inserting nucleic acid sequences for expressing the dsRNA into the vector, and methods of delivering the viral vector to the cells of interest are within the skill in the art. See, for example, Dornburg R (1995), Gene Therap. 2: 301-310; Eglitis M A (1988), Biotechniques 6: 608-614; Miller A D (1990), Hum Gene Therap. 1: 5-14; Anderson W F (1998), Nature 392: 25-30; and Rubinson D A et al., Nat. Genet. 33: 401-406, the entire disclosures of which are herein incorporated by reference.

Preferred viral vectors are those derived from AV and AAV. In a particularly preferred embodiment, the dsRNA of the invention is expressed as two separate, complementary single-stranded RNA molecules from a recombinant AAV vector having, for example, either the U6 or H1 RNA promoters, or the cytomegalovirus (CMV) promoter.

A suitable AV vector for expressing the dsRNA of the invention, a method for constructing the recombinant AV vector, and a method for delivering the vector into target cells, are described in Xia H et al. (2002), Nat. Biotech. 20: 1006-1010.

Suitable AAV vectors for expressing the dsRNA of the invention, methods for constructing the recombinant AV vector, and methods for delivering the vectors into target cells are described in Samulski R et al. (1987), J. Virol. 61: 3096-3101; Fisher K J et al. (1996), J. Virol, 70: 520-532; Samulski R et al. (1989), J. Virol. 63: 3822-3826; U.S. Pat. No. 5,252,479; U.S. Pat. No. 5,139,941; International Patent Application No. WO 94/13788; and International Patent Application No. WO 93/24641, the entire disclosures of which are herein incorporated by reference.

The promoter driving dsRNA expression in either a DNA plasmid or viral vector of the invention may be a eukaryotic RNA polymerase I (e.g. ribosomal RNA promoter), RNA polymerase II (e.g. CMV early promoter or actin promoter or U1 snRNA promoter) or generally RNA polymerase III promoter (e.g. U6 snRNA or 7SK RNA promoter) or a prokaryotic promoter, for example the T7 promoter, provided the expression plasmid also encodes T7 RNA polymerase required for transcription from a T7 promoter. The promoter can also direct transgene expression to the pancreas (see, e.g., the insulin regulatory sequence for pancreas (Bucchini et al., 1986, Proc. Natl. Acad. Sci. USA 83:2511-2515)).

In addition, expression of the transgene can be precisely regulated, for example, by using an inducible regulatory sequence and expression systems such as a regulatory sequence that is sensitive to certain physiological regulators, e.g., circulating glucose levels, or hormones (Docherty et al., 1994, FASEB J. 8:20-24). Such inducible expression systems, suitable for the control of transgene expression in cells or in mammals include regulation by ecdysone, by estrogen, progesterone, tetracycline, chemical inducers of dimerization, and isopropyl-beta-D1-thiogalactopyranoside (EPTG). A person skilled in the art would be able to choose the appropriate regulatory/promoter sequence based on the intended use of the dsRNA transgene.

Generally, recombinant vectors capable of expressing dsRNA molecules are delivered as described below, and persist in target cells. Alternatively, viral vectors can be used that provide for transient expression of dsRNA molecules. Such vectors can be repeatedly administered as necessary. Once expressed, the dsRNAs bind to target RNA and modulate its function or expression. Delivery of dsRNA expressing vectors can be systemic, such as by intravenous or intramuscular administration, by administration to target cells ex-planted from the patient followed by reintroduction into the patient, or by any other means that allows for introduction into a desired target cell.

dsRNA expression DNA plasmids are typically transfected into target cells as a complex with cationic lipid carriers (e.g. Oligofectamine) or non-cationic lipid-based carriers (e.g. Transit-TKO™). Multiple lipid transfections for dsRNA-mediated knockdowns targeting different regions of a single GSK-3 gene or two GSK-3 genes over a period of a week or more are also contemplated by the invention. Successful introduction of the vectors of the invention into host cells can be monitored using various known methods. For example, transient transfection. can be signaled with a reporter, such as a fluorescent marker, such as Green Fluorescent Protein (GFP). Stable transfection of ex vivo cells can be ensured using markers that provide the transfected cell with resistance to specific environmental factors (e.g., antibiotics and drugs), such as hygromycin B resistance.

The GSK-3 specific dsRNA molecules can also be inserted into vectors and used as gene therapy vectors for human patients. Gene therapy vectors can be delivered to a subject by, for example, intravenous injection, local administration (see U.S. Pat. No. 5,328,470) or by stereotactic injection (see e.g., Chen et al. (1994) Proc. Natl. Acad. Sci. USA 91:3054-3057). The pharmaceutical preparation of the gene therapy vector can include the gene therapy vector in an acceptable diluent, or can include a slow release matrix in which the gene delivery vehicle is imbedded. Alternatively, where the complete gene delivery vector can be produced intact from recombinant cells, e.g., retroviral vectors, the pharmaceutical preparation can include one or more cells which produce the gene delivery system.

III. PHARMACEUTICAL COMPOSITIONS COMPRISING DSRNA

In one embodiment, the invention provides pharmaceutical compositions comprising a dsRNA, as described herein, and a pharmaceutically acceptable carrier. The pharmaceutical composition comprising the dsRNA is useful for treating a disease or disorder associated with the expression or activity of a GSK-3 gene, such as pathological processes mediated by GSK-3 expression. Such pharmaceutical compositions are formulated based on the mode of delivery. One example is compositions that are formulated for systemic administration via parenteral delivery.

The pharmaceutical compositions featured herein are administered in dosages sufficient to inhibit expression of a GSK-3 gene. In general, a suitable dose of dsRNA will be in the range of 0.01 to 200.0 milligrams per kilogram body weight of the recipient per day, generally in the range of 1 to 50 mg per kilogram body weight per day. For example, the dsRNA can be administered at 0.01 mg/kg, 0.05 mg/kg, 0.5 mg/kg, 1 mg/kg, 1.5 mg/kg, 2 mg/kg, 3 mg/kg, 5.0 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg, 40 mg/kg, or 50 mg/kg per single dose.

The pharmaceutical composition may be administered once daily or the dsRNA may be administered as two, three, or more sub-doses at appropriate intervals throughout the day or even using continuous infusion or delivery through a controlled release formulation. In that case, the dsRNA contained in each sub-dose must be correspondingly smaller in order to achieve the total daily dosage. The dosage unit can also be compounded for delivery over several days, e.g., using a conventional sustained release formulation which provides sustained release of the dsRNA over a several day period. Sustained release formulations are well known in the art and are particularly useful for delivery of agents at a particular site, such as could be used with the agents of the present invention. In this embodiment, the dosage unit contains a corresponding multiple of the daily dose.

The skilled artisan will appreciate that certain factors may influence the dosage and timing required to effectively treat a subject, including but not limited to the severity of the disease or disorder, previous treatments, the general health and/or age of the subject, and other diseases present. Moreover, treatment of a subject with a therapeutically effective amount of a composition can include a single treatment or a series of treatments. Estimates of effective dosages and in vivo half-lives for the individual dsRNAs encompassed by the invention can be made using conventional methodologies or on the basis of in vivo testing using an appropriate animal model, as described elsewhere herein.

Advances in mouse genetics have generated a number of mouse models for the study of various human diseases, such as pathological processes mediated by GSK-3 expression. Such models are used for in vivo testing of dsRNA, as well as for determining a therapeutically effective dose.

The data obtained from cell culture assays and animal studies can be used in formulating a range of dosage for use in humans. The dosage of compositions featured in the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the methods featured in the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.

The dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by target gene expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.

Administration

The present invention also includes pharmaceutical compositions and formulations which include the dsRNA compounds of the invention. The pharmaceutical compositions of the present invention may be administered in a number of ways depending upon whether local or systemic treatment is desired and upon the area to be treated. Administration may be topical, pulmonary, e.g., by inhalation or insufflation of powders or aerosols, including by nebulizer; intratracheal, intranasal, epidermal and transdermal), oral or parenteral. Parenteral administration includes intravenous, intraarterial, subcutaneous, intraperitoneal or intramuscular injection or infusion; or intracranial, e.g., intrathecal or intraventricular, administration. In one embodiment, the pharmaceutical composition is administered intracranially, directly into the nucleus accumbens.

Pharmaceutical compositions and formulations for topical administration may include transdermal patches, ointments, lotions, creams, gels, drops, suppositories, sprays, liquids and powders. Conventional pharmaceutical carriers, aqueous, powder or oily bases, thickeners and the like may be necessary or desirable. Coated condoms, gloves and the like may also be useful. Preferred topical formulations include those in which the dsRNAs of the invention are in admixture with a topical delivery agent such as lipids, liposomes, fatty acids, fatty acid esters, steroids, chelating agents and surfactants. Preferred lipids and liposomes include neutral (e.g. dioleoylphosphatidyl DOPE ethanolamine, dimyristoylphosphatidyl choline DMPC, distearolyphosphatidyl choline) negative (e.g. dimyristoylphosphatidyl glycerol DMPG) and cationic (e.g. dioleoyltetramethylaminopropyl DOTAP and dioleoylphosphatidyl ethanolamine DOTMA). DsRNAs of the invention may be encapsulated within liposomes or may form complexes thereto, in particular to cationic liposomes. Alternatively, dsRNAs may be complexed to lipids, in particular to cationic lipids. Preferred fatty acids and esters include but are not limited arachidonic acid, oleic acid, eicosanoic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a C₁₋₁₀ alkyl ester (e.g. isopropylmyristate IPM), monoglyceride, diglyceride or pharmaceutically acceptable salt thereof. Topical formulations are described in detail in U.S. patent application Ser. No. 09/315,298 filed on May 20, 1999 which is incorporated herein by reference in its entirety.

Compositions and formulations for oral administration include powders or granules, microparticulates, nanoparticulates, suspensions or solutions in water or non-aqueous media, capsules, gel capsules, sachets, tablets or minitablets. Thickeners, flavoring agents, diluents, emulsifiers, dispersing aids or binders may be desirable. Preferred oral formulations are those in which dsRNAs of the invention are administered in conjunction with one or more penetration enhancers surfactants and chelators. Preferred surfactants include fatty acids and/or esters or salts thereof, bile acids and/or salts thereof. Preferred bile acids/salts include chenodeoxycholic acid (CDCA) and ursodeoxychenodeoxycholic acid (UDCA), cholic acid, dehydrocholic acid, deoxycholic acid, glucholic acid, glycholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium tauro-24,25-dihydro-fusidate and sodium glycodihydrofusidate. Preferred fatty acids include arachidonic acid, undecanoic acid, oleic acid, lauric acid, caprylic acid, capric acid, myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein, dilaurin, glyceryl 1-monocaprate, 1-dodecylazacycloheptan-2-one, an acylcarnitine, an acylcholine, or a monoglyceride, a diglyceride or a pharmaceutically acceptable salt thereof (e.g. sodium). Also preferred are combinations of penetration enhancers, for example, fatty acids/salts in combination with bile acids/salts. A particularly preferred combination is the sodium salt of lauric acid, capric acid and UDCA. Further penetration enhancers include polyoxyethylene-9-lauryl ether, polyoxyethylene-20-cetyl ether. DsRNAs of the invention may be delivered orally, in granular form including sprayed dried particles, or complexed to form micro or nanoparticles. DsRNA complexing agents include poly-amino acids; polyimines; polyacrylates; polyalkylacrylates, polyoxethanes, polyalkylcyanoacrylates; cationized gelatins, albumins, starches, acrylates, polyethyleneglycols (PEG) and starches; polyalkylcyanoacrylates; DEAE-derivatized polyimines, pollulans, celluloses and starches. Particularly preferred complexing agents include chitosan, N-trimethylchitosan, poly-L-lysine, polyhistidine, polyornithine, polyspermines, protamine, polyvinylpyridine, polythiodiethylaminomethylethylene P(TDAE), polyaminostyrene (e.g. p-amino), poly(methylcyanoacrylate), poly(ethylcyanoacrylate), poly(butylcyanoacrylate), poly(isobutylcyanoacrylate), poly(isohexylcynaoacrylate), DEAE-methacrylate, DEAE-hexylacrylate, DEAE-acrylamide, DEAE-albumin and DEAE-dextran, polymethylacrylate, polyhexylacrylate, poly(D,L-lactic acid), poly(DL-lactic-co-glycolic acid (PLGA), alginate, and polyethyleneglycol (PEG). Oral formulations for dsRNAs and their preparation are described in detail in U.S. application. Ser. No. 08/886,829 (filed Jul. 1, 1997), Ser. No. 09/108,673 (filed Jul. 1, 1998), Ser. No. 09/256,515 (filed Feb. 23, 1999), Ser. No. 09/082,624 (filed May 21, 1998) and Ser. No. 09/315,298 (filed May 20, 1999), each of which is incorporated herein by reference in their entirety.

Compositions and formulations for parenteral, intrathecal, intraventricular or intrahepatic administration may include sterile aqueous solutions which may also contain buffers, diluents and other suitable additives such as, but not limited to, penetration enhancers, carrier compounds and other pharmaceutically acceptable carriers or excipients.

Pharmaceutical compositions of the present invention include, but are not limited to, solutions, emulsions, and liposome-containing formulations. These compositions may be generated from a variety of components that include, but are not limited to, preformed liquids, self-emulsifying solids and self-emulsifying semisolids. Particularly preferred are formulations that target the liver when treating hepatic disorders such as hepatic carcinoma.

The pharmaceutical formulations of the present invention, which may conveniently be presented in unit dosage form, may be prepared according to conventional techniques well known in the pharmaceutical industry. Such techniques include the step of bringing into association the active ingredients with the pharmaceutical carrier(s) or excipient(s). In general, the formulations are prepared by uniformly and intimately bringing into association the active ingredients with liquid carriers or finely divided solid carriers or both, and then, if necessary, shaping the product.

The compositions of the present invention may be formulated into any of many possible dosage forms such as, but not limited to, tablets, capsules, gel capsules, liquid syrups, soft gels, suppositories, and enemas. The compositions of the present invention may also be formulated as suspensions in aqueous, non-aqueous or mixed media. Aqueous suspensions may further contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.

Emulsions

The compositions of the present invention may be prepared and formulated as emulsions. Emulsions are typically heterogenous systems of one liquid dispersed in another in the form of droplets usually exceeding 0.1 μm in diameter (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199; Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., Volume 1, p. 245; Block in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 2, p. 335; Higuchi et al., in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 301). Emulsions are often biphasic systems comprising two immiscible liquid phases intimately mixed and dispersed with each other. In general, emulsions may be of either the water-in-oil (w/o) or the oil-in-water (o/w) variety. When an aqueous phase is finely divided into and dispersed as minute droplets into a bulk oily phase, the resulting composition is called a water-in-oil (w/o) emulsion. Alternatively, when an oily phase is finely divided into and dispersed as minute droplets into a bulk aqueous phase, the resulting composition is called an oil-in-water (o/w) emulsion. Emulsions may contain additional components in addition to the dispersed phases, and the active drug which may be present as a solution in either the aqueous phase, oily phase or itself as a separate phase. Pharmaceutical excipients such as emulsifiers, stabilizers, dyes, and anti-oxidants may also be present in emulsions as needed. Pharmaceutical emulsions may also be multiple emulsions that are comprised of more than two phases such as, for example, in the case of oil-in-water-in-oil (o/w/o) and water-in-oil-in-water (w/o/w) emulsions. Such complex formulations often provide certain advantages that simple binary emulsions do not. Multiple emulsions in which individual oil droplets of an o/w emulsion enclose small water droplets constitute a w/o/w emulsion. Likewise a system of oil droplets enclosed in globules of water stabilized in an oily continuous phase provides an o/w/o emulsion.

Emulsions are characterized by little or no thermodynamic stability. Often, the dispersed or discontinuous phase of the emulsion is well dispersed into the external or continuous phase and maintained in this form through the means of emulsifiers or the viscosity of the formulation. Either of the phases of the emulsion may be a semisolid or a solid, as is the case of emulsion-style ointment bases and creams. Other means of stabilizing emulsions entail the use of emulsifiers that may be incorporated into either phase of the emulsion. Emulsifiers may broadly be classified into four categories: synthetic surfactants, naturally occurring emulsifiers, absorption bases, and finely dispersed solids (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).

Synthetic surfactants, also known as surface active agents, have found wide applicability in the formulation of emulsions and have been reviewed in the literature (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), Marcel Dekker, Inc., New York, N. Y., 1988, volume 1, p. 199). Surfactants are typically amphiphilic and comprise a hydrophilic and a hydrophobic portion. The ratio of the hydrophilic to the hydrophobic nature of the surfactant has been termed the hydrophile/lipophile balance (HLB) and is a valuable tool in categorizing and selecting surfactants in the preparation of formulations. Surfactants may be classified into different classes based on the nature of the hydrophilic group: nonionic, anionic, cationic and amphoteric (Rieger, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 285).

Naturally occurring emulsifiers used in emulsion formulations include lanolin, beeswax, phosphatides, lecithin and acacia. Absorption bases possess hydrophilic properties such that they can soak up water to form w/o emulsions yet retain their semisolid consistencies, such as anhydrous lanolin and hydrophilic petrolatum. Finely divided solids have also been used as good emulsifiers especially in combination with surfactants and in viscous preparations. These include polar inorganic solids, such as heavy metal hydroxides, nonswelling clays such as bentonite, attapulgite, hectorite, kaolin, montmorillonite, colloidal aluminum silicate and colloidal magnesium aluminum silicate, pigments and nonpolar solids such as carbon or glyceryl tristearate.

A large variety of non-emulsifying materials are also included in emulsion formulations and contribute to the properties of emulsions. These include fats, oils, waxes, fatty acids, fatty alcohols, fatty esters, humectants, hydrophilic colloids, preservatives and antioxidants (Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199).

Hydrophilic colloids or hydrocolloids include naturally occurring gums and synthetic polymers such as polysaccharides (for example, acacia, agar, alginic acid, carrageenan, guar gum, karaya gum, and tragacanth), cellulose derivatives (for example, carboxymethylcellulose and carboxypropylcellulose), and synthetic polymers (for example, carbomers, cellulose ethers, and carboxyvinyl polymers). These disperse or swell in water to form colloidal solutions that stabilize emulsions by forming strong interfacial films around the dispersed-phase droplets and by increasing the viscosity of the external phase.

Since emulsions often contain a number of ingredients such as carbohydrates, proteins, sterols and phosphatides that may readily support the growth of microbes, these formulations often incorporate preservatives. Commonly used preservatives included in emulsion formulations include methyl paraben, propyl paraben, quaternary ammonium salts, benzalkonium chloride, esters of p-hydroxybenzoic acid, and boric acid. Antioxidants are also commonly added to emulsion formulations to prevent deterioration of the formulation. Antioxidants used may be free radical scavengers such as tocopherols, alkyl gallates, butylated hydroxyanisole, butylated hydroxytoluene, or reducing agents such as ascorbic acid and sodium metabisulfite, and antioxidant synergists such as citric acid, tartaric acid, and lecithin.

The application of emulsion formulations via dermatological, oral and parenteral routes and methods for their manufacture have been reviewed in the literature (Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Emulsion formulations for oral delivery have been very widely used because of ease of formulation, as well as efficacy from an absorption and bioavailability standpoint (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Idson, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 199). Mineral-oil base laxatives, oil-soluble vitamins and high fat nutritive preparations are among the materials that have commonly been administered orally as o/w emulsions.

In one embodiment of the present invention, the compositions of dsRNAs and nucleic acids are formulated as microemulsions. A microemulsion may be defined as a system of water, oil and amphiphile which is a single optically isotropic and thermodynamically stable liquid solution (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Typically microemulsions are systems that are prepared by first dispersing an oil in an aqueous surfactant solution and then adding a sufficient amount of a fourth component, generally an intermediate chain-length alcohol to form a transparent system. Therefore, microemulsions have also been described as thermodynamically stable, isotropically clear dispersions of two immiscible liquids that are stabilized by interfacial films of surface-active molecules (Leung and Shah, in: Controlled Release of Drugs: Polymers and Aggregate Systems, Rosoff, M., Ed., 1989, VCH Publishers, New York, pages 185-215). Microemulsions commonly are prepared via a combination of three to five components that include oil, water, surfactant, cosurfactant and electrolyte. Whether the microemulsion is of the water-in-oil (w/o) or an oil-in-water (o/w) type is dependent on the properties of the oil and surfactant used and on the structure and geometric packing of the polar heads and hydrocarbon tails of the surfactant molecules (Schott, in Remington's Pharmaceutical Sciences, Mack Publishing Co., Easton, Pa., 1985, p. 271).

The phenomenological approach utilizing phase diagrams has been extensively studied and has yielded a comprehensive knowledge, to one skilled in the art, of how to formulate microemulsions (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245; Block, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 335). Compared to conventional emulsions, microemulsions offer the advantage of solubilizing water-insoluble drugs in a formulation of thermodynamically stable droplets that are formed spontaneously.

Surfactants used in the preparation of microemulsions include, but are not limited to, ionic surfactants, non-ionic surfactants, Brij 96, polyoxyethylene oleyl ethers, polyglycerol fatty acid esters, tetraglycerol monolaurate (ML310), tetraglycerol monooleate (MO310), hexaglycerol monooleate (PO310), hexaglycerol pentaoleate (PO500), decaglycerol monocaprate (MCA750), decaglycerol monooleate (MO750), decaglycerol sequioleate (SO750), decaglycerol decaoleate (DAO750), alone or in combination with cosurfactants. The cosurfactant, usually a short-chain alcohol such as ethanol, 1-propanol, and 1-butanol, serves to increase the interfacial fluidity by penetrating into the surfactant film and consequently creating a disordered film because of the void space generated among surfactant molecules. Microemulsions may, however, be prepared without the use of cosurfactants and alcohol-free self-emulsifying microemulsion systems are known in the art. The aqueous phase may typically be, but is not limited to, water, an aqueous solution of the drug, glycerol, PEG300, PEG400, polyglycerols, propylene glycols, and derivatives of ethylene glycol. The oil phase may include, but is not limited to, materials such as Captex 300, Captex 355, Capmul MCM, fatty acid esters, medium chain (C8-C12) mono, di, and tri-glycerides, polyoxyethylated glyceryl fatty acid esters, fatty alcohols, polyglycolized glycerides, saturated polyglycolized C8-C10 glycerides, vegetable oils and silicone oil.

Microemulsions are particularly of interest from the standpoint of drug solubilization and the enhanced absorption of drugs. Lipid based microemulsions (both o/w and w/o) have been proposed to enhance the oral bioavailability of drugs, including peptides (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385-1390; Ritschel, Meth. Find. Exp. Clin. Pharmacol., 1993, 13, 205). Microemulsions afford advantages of improved drug solubilization, protection of drug from enzymatic hydrolysis, possible enhancement of drug absorption due to surfactant-induced alterations in membrane fluidity and permeability, ease of preparation, ease of oral administration over solid dosage forms, improved clinical potency, and decreased toxicity (Constantinides et al., Pharmaceutical Research, 1994, 11, 1385; Ho et al., J. Pharm. Sci., 1996, 85, 138-143). Often microemulsions may form spontaneously when their components are brought together at ambient temperature. This may be particularly advantageous when formulating thermolabile drugs, peptides or dsRNAs. Microemulsions have also been effective in the transdermal delivery of active components in both cosmetic and pharmaceutical applications. It is expected that the microemulsion compositions and formulations of the present invention will facilitate the increased systemic absorption of dsRNAs and nucleic acids from the gastrointestinal tract, as well as improve the local cellular uptake of dsRNAs and nucleic acids.

Microemulsions of the present invention may also contain additional components and additives such as sorbitan monostearate (Grill 3), Labrasol, and penetration enhancers to improve the properties of the formulation and to enhance the absorption of the dsRNAs and nucleic acids of the present invention. Penetration enhancers used in the microemulsions of the present invention may be classified as belonging to one of five broad categories—surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of these classes has been discussed above.

Liposomal Formulations

There are many organized surfactant structures besides microemulsions that have been studied and used for the formulation of drugs. These include monolayers, micelles, bilayers and vesicles. Vesicles, such as liposomes, have attracted great interest because of their specificity and the duration of action they offer from the standpoint of drug delivery. As used in the present invention, the term “liposome” means a vesicle composed of amphiphilic lipids arranged in a spherical bilayer or bilayers.

Liposomes are unilamellar or multilamellar vesicles which have a membrane formed from a lipophilic material and an aqueous interior. The aqueous portion contains the composition to be delivered. Cationic liposomes possess the advantage of being able to fuse to the cell wall. Non-cationic liposomes, although not able to fuse as efficiently with the cell wall, are taken up by macrophages in vivo.

In order to cross intact mammalian skin, lipid vesicles must pass through a series of fine pores, each with a diameter less than 50 nm, under the influence of a suitable transdermal gradient. Therefore, it is desirable to use a liposome which is highly deformable and able to pass through such fine pores.

Further advantages of liposomes include; liposomes obtained from natural phospholipids are biocompatible and biodegradable; liposomes can incorporate a wide range of water and lipid soluble drugs; liposomes can protect encapsulated drugs in their internal compartments from metabolism and degradation (Rosoff, in Pharmaceutical Dosage Forms, Lieberman, Rieger and Banker (Eds.), 1988, Marcel Dekker, Inc., New York, N.Y., volume 1, p. 245). Important considerations in the preparation of liposome formulations are the lipid surface charge, vesicle size and the aqueous volume of the liposomes.

Liposomes are useful for the transfer and delivery of active ingredients to the site of action. Because the liposomal membrane is structurally similar to biological membranes, when liposomes are applied to a tissue, the liposomes start to merge with the cellular membranes and as the merging of the liposome and cell progresses, the liposomal contents are emptied into the cell where the active agent may act.

Liposomal formulations have been the focus of extensive investigation as the mode of delivery for many drugs. There is growing evidence that for topical administration, liposomes present several advantages over other formulations. Such advantages include reduced side-effects related to high systemic absorption of the administered drug, increased accumulation of the administered drug at the desired target, and the ability to administer a wide variety of drugs, both hydrophilic and hydrophobic, into the skin.

Several reports have detailed the ability of liposomes to deliver agents including high-molecular weight DNA into the skin. Compounds including analgesics, antibodies, hormones and high-molecular weight DNAs have been administered to the skin. The majority of applications resulted in the targeting of the upper epidermis

Liposomes fall into two broad classes. Cationic liposomes are positively charged liposomes which interact with the negatively charged DNA molecules to form a stable complex. The positively charged DNA/liposome complex binds to the negatively charged cell surface and is internalized in an endosome. Due to the acidic pH within the endosome, the liposomes are ruptured, releasing their contents into the cell cytoplasm (Wang et al., Biochem. Biophys. Res. Commun., 1987, 147, 980-985).

Liposomes which are pH-sensitive or negatively-charged, entrap DNA rather than complex with it. Since both the DNA and the lipid are similarly charged, repulsion rather than complex formation occurs. Nevertheless, some DNA is entrapped within the aqueous interior of these liposomes. pH-sensitive liposomes have been used to deliver DNA encoding the thymidine kinase gene to cell monolayers in culture. Expression of the exogenous gene was detected in the target cells (Zhou et al., Journal of Controlled Release, 1992, 19, 269-274).

One major type of liposomal composition includes phospholipids other than naturally-derived phosphatidylcholine. Neutral liposome compositions, for example, can be formed from dimyristoyl phosphatidylcholine (DMPC) or dipalmitoyl phosphatidylcholine (DPPC). Anionic liposome compositions generally are formed from dimyristoyl phosphatidylglycerol, while anionic fusogenic liposomes are formed primarily from dioleoyl phosphatidylethanolamine (DOPE). Another type of liposomal composition is formed from phosphatidylcholine (PC) such as, for example, soybean PC, and egg PC. Another type is formed from mixtures of phospholipid and/or phosphatidylcholine and/or cholesterol.

Several studies have assessed the topical delivery of liposomal drug formulations to the skin. Application of liposomes containing interferon to guinea pig skin resulted in a reduction of skin herpes sores while delivery of interferon via other means (e.g., as a solution or as an emulsion) were ineffective (Weiner et al., Journal of Drug Targeting, 1992, 2, 405-410). Further, an additional study tested the efficacy of interferon administered as part of a liposomal formulation to the administration of interferon using an aqueous system, and concluded that the liposomal formulation was superior to aqueous administration (du Plessis et al., Antiviral Research, 1992, 18, 259-265).

Non-ionic liposomal systems have also been examined to determine their utility in the delivery of drugs to the skin, in particular systems comprising non-ionic surfactant and cholesterol. Non-ionic liposomal formulations comprising Novasome™ I (glyceryl dilaurate/cholesterol/po-lyoxyethylene-10-stearyl ether) and Novasome™ II (glyceryl distearate/cholesterol/polyoxyethylene-10-stearyl ether) were used to deliver cyclosporin-A into the dermis of mouse skin. Results indicated that such non-ionic liposomal systems were effective in facilitating the deposition of cyclosporin-A into different layers of the skin (Hu et al. S. T. P. Pharma. Sci., 1994, 4, 6, 466).

Liposomes also include “sterically stabilized” liposomes, a term which, as used herein, refers to liposomes comprising one or more specialized lipids that, when incorporated into liposomes, result in enhanced circulation lifetimes relative to liposomes lacking such specialized lipids. Examples of sterically stabilized liposomes are those in which part of the vesicle-forming lipid portion of the liposome (A) comprises one or more glycolipids, such as monosialoganglioside G_(M1), or (B) is derivatized with one or more hydrophilic polymers, such as a polyethylene glycol (PEG) moiety. While not wishing to be bound by any particular theory, it is thought in the art that, at least for sterically stabilized liposomes containing gangliosides, sphingomyelin, or PEG-derivatized lipids, the enhanced circulation half-life of these sterically stabilized liposomes derives from a reduced uptake into cells of the reticuloendothelial system (RES) (Allen et al., FEBS Letters, 1987, 223, 42; Wu et al., Cancer Research, 1993, 53, 3765).

Various liposomes comprising one or more glycolipids are known in the art. Papahadjopoulos et al. (Ann. N.Y. Acad. Sci., 1987, 507, 64) reported the ability of monosialoganglioside G_(M1), galactocerebroside sulfate and phosphatidylinositol to improve blood half-lives of liposomes. These findings were expounded upon by Gabizon et al. (Proc. Natl. Acad. Sci. U.S.A., 1988, 85, 6949). U.S. Pat. No. 4,837,028 and WO 88/04924, both to Allen et al., disclose liposomes comprising (1) sphingomyelin and (2) the ganglioside G_(M1) or a galactocerebroside sulfate ester. U.S. Pat. No. 5,543,152 (Webb et al.) discloses liposomes comprising sphingomyelin. Liposomes comprising 1,2-sn-dimyristoylphosphat-idylcholine are disclosed in WO 97/13499 (Lim et al).

Many liposomes comprising lipids derivatized with one or more hydrophilic polymers, and methods of preparation thereof, are known in the art. Sunamoto et al. (Bull. Chem. Soc. Jpn., 1980, 53, 2778) described liposomes comprising a nonionic detergent, 2C_(1215G), that contains a PEG moiety. Illum et al. (FEBS Lett., 1984, 167, 79) noted that hydrophilic coating of polystyrene particles with polymeric glycols results in significantly enhanced blood half-lives. Synthetic phospholipids modified by the attachment of carboxylic groups of polyalkylene glycols (e.g., PEG) are described by Sears (U.S. Pat. Nos. 4,426,330 and 4,534,899). Klibanov et al. (FEBS Lett., 1990, 268, 235) described experiments demonstrating that liposomes comprising phosphatidylethanolamine (PE) derivatized with PEG or PEG stearate have significant increases in blood circulation half-lives. Blume et al. (Biochimica et Biophysica Acta, 1990, 1029, 91) extended such observations to other PEG-derivatized phospholipids, e.g., DSPE-PEG, formed from the combination of distearoylphosphatidylethanolamine (DSPE) and PEG. Liposomes having covalently bound PEG moieties on their external surface are described in European Patent No. EP 0 445 131 B1 and WO 90/04384 to Fisher. Liposome compositions containing 1-20 mole percent of PE derivatized with PEG, and methods of use thereof, are described by Woodle et al. (U.S. Pat. Nos. 5,013,556 and 5,356,633) and Martin et al. (U.S. Pat. No. 5,213,804 and European Patent No. EP 0 496 813 B1). Liposomes comprising a number of other lipid-polymer conjugates are disclosed in WO 91/05545 and U.S. Pat. No. 5,225,212 (both to Martin et al.) and in WO 94/20073 (Zalipsky et al.) Liposomes comprising PEG-modified ceramide lipids are described in WO 96/10391 (Choi et al). U.S. Pat. No. 5,540,935 (Miyazaki et al.) and U.S. Pat. No. 5,556,948 (Tagawa et al.) describe PEG-containing liposomes that can be further derivatized with functional moieties on their surfaces.

A number of liposomes comprising nucleic acids are known in the art. WO 96/40062 to Thierry et al. discloses methods for encapsulating high molecular weight nucleic acids in liposomes. U.S. Pat. No. 5,264,221 to Tagawa et al. discloses protein-bonded liposomes and asserts that the contents of such liposomes may include a dsRNA. U.S. Pat. No. 5,665,710 to Rahman et al. describes certain methods of encapsulating oligodeoxynucleotides in liposomes. WO 97/04787 to Love et al. discloses liposomes comprising dsRNAs targeted to the raf gene.

Transfersomes are yet another type of liposomes, and are highly deformable lipid aggregates which are attractive candidates for drug delivery vehicles. Transfersomes may be described as lipid droplets which are so highly deformable that they are easily able to penetrate through pores which are smaller than the droplet. Transfersomes are adaptable to the environment in which they are used, e.g., they are self-optimizing (adaptive to the shape of pores in the skin), self-repairing, frequently reach their targets without fragmenting, and often self-loading. To make transfersomes it is possible to add surface edge-activators, usually surfactants, to a standard liposomal composition. Transfersomes have been used to deliver serum albumin to the skin. The transfersome-mediated delivery of serum albumin has been shown to be as effective as subcutaneous injection of a solution containing serum albumin.

Surfactants find wide application in formulations such as emulsions (including microemulsions) and liposomes. The most common way of classifying and ranking the properties of the many different types of surfactants, both natural and synthetic, is by the use of the hydrophile/lipophile balance (HLB). The nature of the hydrophilic group (also known as the “head”) provides the most useful means for categorizing the different surfactants used in formulations (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N. Y., 1988, p. 285).

If the surfactant molecule is not ionized, it is classified as a nonionic surfactant. Nonionic surfactants find wide application in pharmaceutical and cosmetic products and are usable over a wide range of pH values. In general their HLB values range from 2 to about 18 depending on their structure. Nonionic surfactants include nonionic esters such as ethylene glycol esters, propylene glycol esters, glyceryl esters, polyglyceryl esters, sorbitan esters, sucrose esters, and ethoxylated esters. Nonionic alkanolamides and ethers such as fatty alcohol ethoxylates, propoxylated alcohols, and ethoxylated/propoxylated block polymers are also included in this class. The polyoxyethylene surfactants are the most popular members of the nonionic surfactant class.

If the surfactant molecule carries a negative charge when it is dissolved or dispersed in water, the surfactant is classified as anionic. Anionic surfactants include carboxylates such as soaps, acyl lactylates, acyl amides of amino acids, esters of sulfuric acid such as alkyl sulfates and ethoxylated alkyl sulfates, sulfonates such as alkyl benzene sulfonates, acyl isethionates, acyl taurates and sulfosuccinates, and phosphates. The most important members of the anionic surfactant class are the alkyl sulfates and the soaps.

If the surfactant molecule carries a positive charge when it is dissolved or dispersed in water, the surfactant is classified as cationic. Cationic surfactants include quaternary ammonium salts and ethoxylated amines. The quaternary ammonium salts are the most used members of this class.

If the surfactant molecule has the ability to carry either a positive or negative charge, the surfactant is classified as amphoteric. Amphoteric surfactants include acrylic acid derivatives, substituted alkylamides, N-alkylbetaines and phosphatides.

The use of surfactants in drug products, formulations and in emulsions has been reviewed (Rieger, in Pharmaceutical Dosage Forms, Marcel Dekker, Inc., New York, N. Y., 1988, p. 285).

Nucleic Acid Lipid Particles

In one embodiment, a dsRNA featured in the invention is fully encapsulated in the lipid formulation to form a SPLP, pSPLP, SNALP, or other nucleic acid-lipid particle. As used herein, the term “SNALP” refers to a stable nucleic acid-lipid particle, including SPLP. As used herein, the term “SPLP” refers to a nucleic acid-lipid particle comprising plasmid DNA encapsulated within a lipid vesicle. SNALPs and SPLPs typically contain a cationic lipid, a non-cationic lipid, and a lipid that prevents aggregation of the particle (e.g., a PEG-lipid conjugate). SNALPs and SPLPs are extremely useful for systemic applications, as they exhibit extended circulation lifetimes following intravenous (i.v.) injection and accumulate at distal sites (e.g., sites physically separated from the administration site). SPLPs include “pSPLP,” which include an encapsulated condensing agent-nucleic acid complex as set forth in PCT Publication No. WO 00/03683. The particles of the present invention typically have a mean diameter of about 50 nm to about 150 nm, more typically about 60 nm to about 130 nm, more typically about 70 nm to about 110 nm, most typically about 70 to about 90 nm, and are substantially nontoxic. In addition, the nucleic acids when present in the nucleic acid-lipid particles of the present invention are resistant in aqueous solution to degradation with a nuclease. Nucleic acid-lipid particles and their method of preparation are disclosed in, e.g., U.S. Pat. Nos. 5,976,567; 5,981,501; 6,534,484; 6,586,410; 6,815,432; and PCT Publication No. WO 96/40964.

In one embodiment, the lipid to drug ratio (mass/mass ratio) (e.g., lipid to dsRNA ratio) will be in the range of from about 1:1 to about 50:1, from about 1:1 to about 25:1, from about 3:1 to about 15:1, from about 4:1 to about 10:1, from about 5:1 to about 9:1, or about 6:1 to about 9:1.

The cationic lipid may be, for example, N,N-dioleyl-N,N-dimethylammonium chloride (DODAC), N,N-distearyl-N,N-dimethylammonium bromide (DDAB), N—(I-(2,3-dioleoyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTAP), N—(I-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium chloride (DOTMA), N,N-dimethyl-2,3-dioleyloxy)propylamine (DODMA), 1,2-DiLinoleyloxy-N,N-dimethylaminopropane (DLinDMA), 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLenDMA), 1,2-Dilinoleylcarbamoyloxy-3-dimethylaminopropane (DLin-C-DAP), 1,2-Dilinoleyoxy-3-(dimethylamino)acetoxypropane (DLin-DAC), 1,2-Dilinoleyoxy-3-morpholinopropane (DLin-MA), 1,2-Dilinoleoyl-3-dimethylaminopropane (DLinDAP), 1,2-Dilinoleylthio-3-dimethylaminopropane (DLin-S-DMA), 1-Linoleoyl-2-linoleyloxy-3-dimethylaminopropane (DLin-2-DMAP), 1,2-Dilinoleyloxy-3-trimethylaminopropane chloride salt (DLin-TMA.Cl), 1,2-Dilinoleoyl-3-trimethylaminopropane chloride salt (DLin-TAP.Cl), 1,2-Dilinoleyloxy-3-(N-methylpiperazino)propane (DLin-MPZ), or 3-(N,N-Dilinoleylamino)-1,2-propanediol (DLinAP), 3-(N,N-Dioleylamino)-1,2-propanedio (DOAP), 1,2-Dilinoleyloxo-3-(2-N,N-dimethylamino)ethoxypropane (DLin-EG-DMA), 2,2-Dilinoleyl-4-dimethylaminomethyl-[1,3]-dioxolane (DLin-K-DMA) or analogs thereof, or a mixture thereof. The cationic lipid may comprise from about 20 mol % to about 50 mol % or about 40 mol % of the total lipid present in the particle.

In another embodiment, the compound 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane can be used to prepare lipid-siRNA nanoparticles. Synthesis of 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane is described in U.S. provisional patent application No. 61/107,998 filed on Oct. 23, 2008, which is herein incorporated by reference.

In one embodiment, the lipid-siRNA particle includes 40% 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane: 10% DSPC: 40% Cholesterol: 10% PEG-C-DOMG (mole percent) with a particle size of 63.0±20 nm and a 0.027 siRNA/Lipid Ratio.

The non-cationic lipid may be an anionic lipid or a neutral lipid including, but not limited to, distearoylphosphatidylcholine (DSPC), dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylglycerol (DOPG), dipalmitoylphosphatidylglycerol (DPPG), dioleoyl-phosphatidylethanolamine (DOPE), palmitoyloleoylphosphatidylcholine (POPC), palmitoyloleoyl-phosphatidylethanolamine (POPE), dioleoyl-phosphatidylethanolamine 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (DOPE-mal), dipalmitoyl phosphatidyl ethanolamine (DPPE), dimyristoylphosphoethanolamine (DMPE), distearoyl-phosphatidyl-ethanolamine (DSPE), 16-O-monomethyl PE, 16-O-dimethyl PE, 18-1-trans PE, 1-stearoyl-2-oleoyl-phosphatidyethanolamine (SOPE), cholesterol, or a mixture thereof. The non-cationic lipid may be from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle.

The conjugated lipid that inhibits aggregation of particles may be, for example, a polyethyleneglycol (PEG)-lipid including, without limitation, a PEG-diacylglycerol (DAG), a PEG-dialkyloxypropyl (DAA), a PEG-phospholipid, a PEG-ceramide (Cer), or a mixture thereof. The PEG-DAA conjugate may be, for example, a PEG-dilauryloxypropyl (Ci₂), a PEG-dimyristyloxypropyl (Ci₄), a PEG-dipalmityloxypropyl (Ci₆), or a PEG-distearyloxypropyl (C]₈). The conjugated lipid that prevents aggregation of particles may be from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.

In some embodiments, the nucleic acid-lipid particle further includes cholesterol at, e.g., about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle.

LNP01

In one embodiment, the lipidoid ND98.4HCl (MW 1487) (Formula 1), Cholesterol (Sigma-Aldrich), and PEG-Ceramide C16 (Avanti Polar Lipids) can be used to prepare lipid-siRNA nanoparticles (i.e., LNP01 particles). Stock solutions of each in ethanol can be prepared as follows: ND98, 133 mg/ml; Cholesterol, 25 mg/ml, PEG-Ceramide C16, 100 mg/ml. The ND98, Cholesterol, and PEG-Ceramide C16 stock solutions can then be combined in a, e.g., 42:48:10 molar ratio. The combined lipid solution can be mixed with aqueous siRNA (e.g., in sodium acetate pH 5) such that the final ethanol concentration is about 35-45% and the final sodium acetate concentration is about 100-300 mM. Lipid-siRNA nanoparticles typically form spontaneously upon mixing. Depending on the desired particle size distribution, the resultant nanoparticle mixture can be extruded through a polycarbonate membrane (e.g., 100 nm cut-off) using, for example, a thermobarrel extruder, such as Lipex Extruder (Northern Lipids, Inc). In some cases, the extrusion step can be omitted. Ethanol removal and simultaneous buffer exchange can be accomplished by, for example, dialysis or tangential flow filtration. Buffer can be exchanged with, for example, phosphate buffered saline (PBS) at about pH 7, e.g., about pH 6.9, about pH 7.0, about pH 7.1, about pH 7.2, about pH 7.3, or about pH 7.4.

LNP01 formulations are described, e.g., in International Application Publication No. WO 2008/042973, which is hereby incorporated by reference.

As mentioned above, the lipid-dsRNA particle can comprise a cationic lipid, a neutral lipid, a steroid, and optionally a lipid that prevents aggregation of the particle. The relative percentages of these constituents can vary depending on the type of lipids used. However, in general, the cationic lipid comprises from about 20 mol % to about 70 mol % or about 40 mol % to about 60 mol % of the total lipid present in the particle; neutral lipids comprise from about 5 mol % to about 90 mol %, about 10 mol %, or about 58 mol % if cholesterol is included, of the total lipid present in the particle; the steroid (typically cholesterol) can comprise from about 10 mol % to about 60 mol % or about 48 mol % of the total lipid present in the particle; finally, the lipid that prevents aggregation of the particle, typically a conjugated lipid (e.g., a PEG-conjugated lipid) can comprise from 0 mol % to about 20 mol % or about 2 mol % of the total lipid present in the particle.

In one embodiment, the lipid-dsRNA particle includes 40 mol % 2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane, 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 40 mol % Cholesterol, 10 mol % PEG-C-DOMG with a particle size of 63.0±20 nm and a 0.027 dsRNA/Lipid Ratio.

In another embodiment, the lipid-dsRNA particle includes 40 mol % 1,2-dilinoleyloxy-N,N-dimethyl-3-aminopropane (DLinDMA), 10 mol % 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), 2 mol % 3-N-[(qmethoxypoly(ethylene glycol)2000)carbamoyl]-1,2-dimyristyloxy-propylamine (PEG-C-DMA), and 48 mol % cholesterol.

In another embodiment, the lipid-dsRNA particle includes 57.1 mol % 1,2-Dilinolenyloxy-N,N-dimethylaminopropane (DLinDMA), 7.1 mol % DPPC, 34.4 mol % Cholesterol, 1.4 mol % PEG-cDMA.

In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid DLinDMA (1,2-dilinoleyloxy-3-(N,N-dimethyl)aminopropane).

In another embodiment, the lipid-dsRNA particle includes 48 mol % cholesterol, 20 mol % of the neutral lipid 1,2-distearoyl-sn-glycero-3-phosphocholine, 2 mol % of PEG-cDMA (3-N-[(methoxy poly(ethylene glycol)2000)carbamoyl]-1,2-dimyrestyloxypropylamine), and 30 mol % of the cationic lipid 2,2-Dilinoleyl-4-dimethylaminoethyl-[1,3]-dioxolane.

Additional exemplary lipid-siRNA formulations are as follows:

cationic lipid/non-cationic lipid// choleseterol/PEG-lipid conjugate Cationic Lipid Lipid:siRNA ratio Process LNP05 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG Extrusion dimethylaminoethyl- 57.5/7.5/31.5/3.5 [1,3]-dioxolane (XTC) lipid:siRNA ~6:1 LNP06 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG Extrusion dimethylaminoethyl- 57.5/7.5/31.5/3.5 [1,3]-dioxolane (XTC) lipid:siRNA ~11:1 LNP07 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG In-line dimethylaminoethyl- 60/7.5/31/1.5, mixing [1,3]-dioxolane (XTC) lipid:siRNA ~6:1 LNP08 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG In-line dimethylaminoethyl- 60/7.5/31/1.5, mixing [1,3]-dioxolane (XTC) lipid:siRNA ~11:1 LNP09 2,2-Dilinoleyl-4- XTC/DSPC/Cholesterol/PEG-DMG In-line dimethylaminoethyl- 50/10/38.5/1.5 mixing [1,3]-dioxolane (XTC) Lipid:siRNA 10:1 SNALP 1,2-Dilinolenyloxy- DLinDMA/DPPC/Cholesterol/PEG-cDMA N,N- (57.1/7.1/34.4/1.4) dimethylaminopropane lipid:siRNA ~7:1 (DLinDMA) SNALP- 2,2-Dilinoleyl-4- XTC/DPPC/Cholesterol/PEG-cDMA XTC dimethylaminoethyl- 57.1/7.1/34.4/1.4 [1,3]-dioxolane (XTC) lipid:siRNA ~7:1

Characterization of Lipid Formulated dsRNAs

Formulations prepared by either the in-line mixing or extrusion-free method can be characterized in similar manners. For example, formulations are typically characterized by visual inspection. They should be whitish translucent solutions free from aggregates or sediment. Particle size and particle size distribution of lipid-nanoparticles can be measured by light scattering using, for example, a Malvern Zetasizer Nano ZS (Malvern, USA). Particles should be about 20-300 nm, such as 40-100 nm in size. The particle size distribution should be unimodal. The total siRNA concentration in the formulation, as well as the entrapped fraction, is estimated using a dye exclusion assay. A sample of the formulated siRNA can be incubated with an RNA-binding dye, such as Ribogreen (Molecular Probes) in the presence or absence of a formulation disrupting surfactant, e.g., 0.5% Triton-X100. The total siRNA in the formulation can be determined by the signal from the sample containing the surfactant, relative to a standard curve. The entrapped fraction is determined by subtracting the “free” siRNA content (as measured by the signal in the absence of surfactant) from the total siRNA content. Percent entrapped siRNA is typically >85%. For SNALP formulation, the particle size is at least 30 nm, at least 40 nm, at least 50 nm, at least 60 nm, at least 70 nm, at least 80 nm, at least 90 nm, at least 100 nm, at least 110 nm, and at least 120 nm. The suitable range is typically about at least 50 nm to about at least 110 nm, about at least 60 nm to about at least 100 nm, or about at least 80 nm to about at least 90 nm.

Penetration Enhancers

In one embodiment, the present invention employs various penetration enhancers to effect the efficient delivery of nucleic acids, particularly dsRNAs, to the skin of animals. Most drugs are present in solution in both ionized and nonionized forms. However, usually only lipid soluble or lipophilic drugs readily cross cell membranes. It has been discovered that even non-lipophilic drugs may cross cell membranes if the membrane to be crossed is treated with a penetration enhancer. In addition to aiding the diffusion of non-lipophilic drugs across cell membranes, penetration enhancers also enhance the permeability of lipophilic drugs.

Penetration enhancers may be classified as belonging to one of five broad categories, i.e., surfactants, fatty acids, bile salts, chelating agents, and non-chelating non-surfactants (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92). Each of the above mentioned classes of penetration enhancers are described below in greater detail.

Surfactants: In connection with the present invention, surfactants (or “surface-active agents”) are chemical entities which, when dissolved in an aqueous solution, reduce the surface tension of the solution or the interfacial tension between the aqueous solution and another liquid, with the result that absorption of dsRNAs through the mucosa is enhanced. In addition to bile salts and fatty acids, these penetration enhancers include, for example, sodium lauryl sulfate, polyoxyethylene-9-lauryl ether and polyoxyethylene-20-cetyl ether) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, p. 92); and perfluorochemical emulsions, such as FC-43. Takahashi et al., J. Pharm. Pharmacol., 1988, 40, 252).

Fatty acids: Various fatty acids and their derivatives which act as penetration enhancers include, for example, oleic acid, lauric acid, capric acid (n-decanoic acid), myristic acid, palmitic acid, stearic acid, linoleic acid, linolenic acid, dicaprate, tricaprate, monoolein (1-monooleoyl-rac-glycerol), dilaurin, caprylic acid, arachidonic acid, glycerol 1-monocaprate, 1-dodecylazacycloheptan-2-one, acylcarnitines, acylcholines, C.sub.1-10 alkyl esters thereof (e.g., methyl, isopropyl and t-butyl), and mono- and di-glycerides thereof (i.e., oleate, laurate, caprate, myristate, palmitate, stearate, linoleate, etc.) (Lee et al., Critical Reviews in Therapeutic Drug Carryier Systems, 1991, p. 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; El Hariri et al., J. Pharm. Pharmacol., 1992, 44, 651-654).

Bile salts: The physiological role of bile includes the facilitation of dispersion and absorption of lipids and fat-soluble vitamins (Brunton, Chapter 38 in: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 9th Ed., Hardman et al. Eds., McGraw-Hill, New York, 1996, pp. 934-935). Various natural bile salts, and their synthetic derivatives, act as penetration enhancers. Thus the term “bile salts” includes any of the naturally occurring components of bile as well as any of their synthetic derivatives. The bile salts of the invention include, for example, cholic acid (or its pharmaceutically acceptable sodium salt, sodium cholate), dehydrocholic acid (sodium dehydrocholate), deoxycholic acid (sodium deoxycholate), glucholic acid (sodium glucholate), glycholic acid (sodium glycocholate), glycodeoxycholic acid (sodium glycodeoxycholate), taurocholic acid (sodium taurocholate), taurodeoxycholic acid (sodium taurodeoxycholate), chenodeoxycholic acid (sodium chenodeoxycholate), ursodeoxycholic acid (UDCA), sodium tauro-24,25-dihydro-fusidate (STDHF), sodium glycodihydrofusidate and polyoxyethylene-9-lauryl ether (POE) (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Swinyard, Chapter 39 In: Remington's Pharmaceutical Sciences, 18th Ed., Gennaro, ed., Mack Publishing Co., Easton, Pa., 1990, pages 782-783; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Yamamoto et al., J. Pharm. Exp. Ther., 1992, 263, 25; Yamashita et al., J. Pharm. Sci., 1990, 79, 579-583).

Chelating Agents: Chelating agents, as used in connection with the present invention, can be defined as compounds that remove metallic ions from solution by forming complexes therewith, with the result that absorption of dsRNAs through the mucosa is enhanced. With regards to their use as penetration enhancers in the present invention, chelating agents have the added advantage of also serving as DNase inhibitors, as most characterized DNA nucleases require a divalent metal ion for catalysis and are thus inhibited by chelating agents (Jarrett, J. Chromatogr., 1993, 618, 315-339). Chelating agents of the invention include but are not limited to disodium ethylenediaminetetraacetate (EDTA), citric acid, salicylates (e.g., sodium salicylate, 5-methoxysalicylate and homovanilate), N-acyl derivatives of collagen, laureth-9 and N-amino acyl derivatives of beta-diketones (enamines)(Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92; Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33; Buur et al., J. Control Rel., 1990, 14, 43-51).

Non-chelating non-surfactants: As used herein, non-chelating non-surfactant penetration enhancing compounds can be defined as compounds that demonstrate insignificant activity as chelating agents or as surfactants but that nonetheless enhance absorption of dsRNAs through the alimentary mucosa (Muranishi, Critical Reviews in Therapeutic Drug Carrier Systems, 1990, 7, 1-33). This class of penetration enhancers include, for example, unsaturated cyclic ureas, 1-alkyl- and 1-alkenylazacyclo-alkanone derivatives (Lee et al., Critical Reviews in Therapeutic Drug Carrier Systems, 1991, page 92); and non-steroidal anti-inflammatory agents such as diclofenac sodium, indomethacin and phenylbutazone (Yamashita et al., J. Pharm. Pharmacol., 1987, 39, 621-626).

Agents that enhance uptake of dsRNAs at the cellular level may also be added to the pharmaceutical and other compositions of the present invention. For example, cationic lipids, such as lipofectin (Junichi et al, U.S. Pat. No. 5,705,188), cationic glycerol derivatives, and polycationic molecules, such as polylysine (Lollo et al., PCT Application WO 97/30731), are also known to enhance the cellular uptake of dsRNAs.

Other agents may be utilized to enhance the penetration of the administered nucleic acids, including glycols such as ethylene glycol and propylene glycol, pyrrols such as 2-pyrrol, azones, and terpenes such as limonene and menthone.

Carriers

Certain compositions of the present invention also incorporate carrier compounds in the formulation. As used herein, “carrier compound” or “carrier” can refer to a nucleic acid, or analog thereof, which is inert (i.e., does not possess biological activity per se) but is recognized as a nucleic acid by in vivo processes that reduce the bioavailability of a nucleic acid having biological activity by, for example, degrading the biologically active nucleic acid or promoting its removal from circulation. The coadministration of a nucleic acid and a carrier compound, typically with an excess of the latter substance, can result in a substantial reduction of the amount of nucleic acid recovered in the liver, kidney or other extracirculatory reservoirs, presumably due to competition between the carrier compound and the nucleic acid for a common receptor. For example, the recovery of a partially phosphorothioate dsRNA in hepatic tissue can be reduced when it is coadministered with polyinosinic acid, dextran sulfate, polycytidic acid or 4-acetamido-4′isothiocyano-stilbene-2,2′-disulfonic acid (Miyao et al., DsRNA Res. Dev., 1995, 5, 115-121; Takakura et al., DsRNA & Nucl. Acid Drug Dev., 1996, 6, 177-183.

Excipients

In contrast to a carrier compound, a “pharmaceutical carrier” or “excipient” is a pharmaceutically acceptable solvent, suspending agent or any other pharmacologically inert vehicle for delivering one or more nucleic acids to an animal. The excipient may be liquid or solid and is selected, with the planned manner of administration in mind, so as to provide for the desired bulk, consistency, etc., when combined with a nucleic acid and the other components of a given pharmaceutical composition. Typical pharmaceutical carriers include, but are not limited to, binding agents (e.g., pregelatinized maize starch, polyvinylpyrrolidone or hydroxypropyl methylcellulose, etc.); fillers (e.g., lactose and other sugars, microcrystalline cellulose, pectin, gelatin, calcium sulfate, ethyl cellulose, polyacrylates or calcium hydrogen phosphate, etc.); lubricants (e.g., magnesium stearate, talc, silica, colloidal silicon dioxide, stearic acid, metallic stearates, hydrogenated vegetable oils, corn starch, polyethylene glycols, sodium benzoate, sodium acetate, etc.); disintegrants (e.g., starch, sodium starch glycolate, etc.); and wetting agents (e.g., sodium lauryl sulphate, etc).

Pharmaceutically acceptable organic or inorganic excipient suitable for non-parenteral administration which do not deleteriously react with nucleic acids can also be used to formulate the compositions of the present invention. Suitable pharmaceutically acceptable carriers include, but are not limited to, water, salt solutions, alcohols, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.

Formulations for topical administration of nucleic acids may include sterile and non-sterile aqueous solutions, non-aqueous solutions in common solvents such as alcohols, or solutions of the nucleic acids in liquid or solid oil bases. The solutions may also contain buffers, diluents and other suitable additives. Pharmaceutically acceptable organic or inorganic excipients suitable for non-parenteral administration which do not deleteriously react with nucleic acids can be used.

Suitable pharmaceutically acceptable excipients include, but are not limited to, water, salt solutions, alcohol, polyethylene glycols, gelatin, lactose, amylose, magnesium stearate, talc, silicic acid, viscous paraffin, hydroxymethylcellulose, polyvinylpyrrolidone and the like.

Other Components

The compositions of the present invention may additionally contain other adjunct components conventionally found in pharmaceutical compositions, at their art-established usage levels. Thus, for example, the compositions may contain additional, compatible, pharmaceutically-active materials such as, for example, antipruritics, astringents, local anesthetics or anti-inflammatory agents, or may contain additional materials useful in physically formulating various dosage forms of the compositions of the present invention, such as dyes, flavoring agents, preservatives, antioxidants, opacifiers, thickening agents and stabilizers. However, such materials, when added, should not unduly interfere with the biological activities of the components of the compositions of the present invention. The formulations can be sterilized and, if desired, mixed with auxiliary agents, e.g., lubricants, preservatives, stabilizers, wetting agents, emulsifiers, salts for influencing osmotic pressure, buffers, colorings, flavorings and/or aromatic substances and the like which do not deleteriously interact with the nucleic acid(s) of the formulation.

Aqueous suspensions may contain substances which increase the viscosity of the suspension including, for example, sodium carboxymethylcellulose, sorbitol and/or dextran. The suspension may also contain stabilizers.

Certain embodiments of the invention provide pharmaceutical compositions containing (a) one or more antisense compounds and (b) one or more other chemotherapeutic agents which function by a non-antisense mechanism. Examples of such chemotherapeutic agents include but are not limited to daunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphor-amide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the compounds of the invention, such chemotherapeutic agents may be used individually (e.g., 5-FU and oligonucleotide), sequentially (e.g., 5-FU and oligonucleotide for a period of time followed by MTX and oligonucleotide), or in combination with one or more other such chemotherapeutic agents (e.g., 5-FU, MTX and oligonucleotide, or 5-FU, radiotherapy and oligonucleotide). Anti-inflammatory drugs, including but not limited to nonsteroidal anti-inflammatory drugs and corticosteroids, and antiviral drugs, including but not limited to ribivirin, vidarabine, acyclovir and ganciclovir, may also be combined in compositions of the invention. See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed., Berkow et al., eds., 1987, Rahway, N.J., pages 2499-2506 and 46-49, respectively). Other non-antisense chemotherapeutic agents are also within the scope of this invention. Two or more combined compounds may be used together or sequentially.

Toxicity and therapeutic efficacy of such compounds can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population). The dose ratio between toxic and therapeutic effects is the therapeutic index and it can be expressed as the ratio LD50/ED50. Compounds which exhibit high therapeutic indices are preferred.

The data obtained from cell culture assays and animal studies can be used in formulation a range of dosage for use in humans. The dosage of compositions of the invention lies generally within a range of circulating concentrations that include the ED50 with little or no toxicity. The dosage may vary within this range depending upon the dosage form employed and the route of administration utilized. For any compound used in the method of the invention, the therapeutically effective dose can be estimated initially from cell culture assays. A dose may be formulated in animal models to achieve a circulating plasma concentration range of the compound or, when appropriate, of the polypeptide product of a target sequence (e.g., achieving a decreased concentration of the polypeptide) that includes the IC50 (i.e., the concentration of the test compound which achieves a half-maximal inhibition of symptoms) as determined in cell culture. Such information can be used to more accurately determine useful doses in humans. Levels in plasma may be measured, for example, by high performance liquid chromatography.

In addition to their administration, as discussed above, the dsRNAs featured in the invention can be administered in combination with other known agents effective in treatment of pathological processes mediated by GSK-3 expression. In any event, the administering physician can adjust the amount and timing of dsRNA administration on the basis of results observed using standard measures of efficacy known in the art or described herein.

Methods for Treating Diseases Caused by Expression of a GSK-3 Gene

The invention relates in particular to the use of a dsRNA targeting GSK-3 and compositions containing at least one such dsRNA, for the treatment of a GSK-3-mediated disorder or disease. For example, a dsRNA targeting a GSK-3 gene can be useful for the treatment of manic depression.

Other disorders which can be treated with the compounds, compositions and methods described herein include a metabolic disease, such as metabolic disorders (e.g., Type I or Type II diabetes or metabolic syndrome) and nervous system disorders, (e.g., CNS or nuerogenerative disorders (e.g., Alzheimer's disease, Parkinson's disease, Huntington's Disease, prion diseases (e.g., transmissible spongiform encephalopathies), stroke and schizophrenia). Compositions and methods for treating pathological conditions and diseases such as protozoan diseases (e.g., Plasmodium falciparum), cancer (e.g., colorectal cancer), and circadian rhythm diseases (e.g., sleep disorders, jet lag, and shift work), and are also provided. The dsRNAs described here can also be used to regulate skeletal muscle growth, inflammatory responses, platelet function, apoptosis, and cellular responses to DNA damage.

“Metabolic syndrome” is characterized by a group of metabolic risk factors including: abdominal obesity (excessive fat tissue in and around the abdomen), atherogenic dyslipidemia (blood fat disorders (including high triglycerides, low HDL cholesterol and high LDL cholesterol) that foster plaque build-up in artery walls), elevated blood pressure, insulin resistance or glucose intolerance (due to the body's inability to properly use insulin or blood sugar), a prothrombotic state (e.g., high fibrinogen or plasminogen activator inhibitor-1 in the blood), and a proinflammatory state (e.g., elevated C-reactive protein in the blood). People with metabolic syndrome are at increased risk of coronary heart disease and other diseases related to plaque buildups in artery walls (e.g., stroke and peripheral vascular disease), and Type II diabetes. Other metabolic diseases suitable for treatment with a dsRNA targeting GSK-3 include obesity and insulin resistance.

A dsRNA targeting GSK-3 can be also be useful for the treatment of cancer, such as a colorectal cancer.

A composition containing a dsRNA targeting GSK-3 may also be used to treat other tumors and cancers, such as breast cancer, lung cancer, head and neck cancer, brain cancer, abdominal cancer, colon cancer, colorectal cancer, esophagus cancer, gastrointestinal cancer, glioma, tongue cancer, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, retinoblastoma, Wilm's tumor, multiple myeloma and for the treatment of skin cancer, like melanoma, for the treatment of lymphomas and blood cancer.

Owing to the inhibitory effects on GSK-3 expression, a composition according to the invention or a pharmaceutical composition prepared therefrom can enhance the quality of life.

The invention further relates to the use of a dsRNA or a pharmaceutical composition thereof, e.g., for treating manic depression or another disorder described herein, in combination with other pharmaceuticals and/or other therapeutic methods, e.g., with known pharmaceuticals and/or known therapeutic methods, such as, for example, those which are currently employed for treating these disorders.

For example, in the treatment of manic depression, the patient can also be treated with one or more other therapeutic modalities, e.g., lithium salts, anticonvulsant mood stabilizers, antipsychotics, and other adjunctive treatments described herein. In an embodiment the patient is also treated with lithium salts. Lithium salts have been used as a first-line treatment for bipolar disorder. Common lithium salts are lithium carbonate and (probably less commonly) lithium citrate. Lithium orotate is used as an alternative treatment to lithium carbonate by some individuals with bipolar disorder. In an embodiment the patient is also treated with an anticonvulsant mood stabilizer. Anticonvulsant medications, particularly valproate and carbamazepine, have been used as alternatives or adjuncts to lithium in many cases. Valproate (Depakote, Epival) was FDA approved for the treatment of acute mania in 1995, and is now considered by some doctors to be the first line of therapy for bipolar disorder. A similar medication, valproic acid (Depakene) is also used. Anticonvulsants are also used in combination with antipsychotics. Newer anticonvulsant medications, including lamotrigine and oxcarbazepine, are also effective as mood stabilizers in bipolar disorder. Lamotrigine is particularly promising, as it alleviates bipolar depression and prevents recurrence at higher rates. Zonisamide (trade name Zonegran), another anticonvulsant, also may show promise in treating bipolar depression. Topiramate maybe useful for some patients. It appears to be useful in some treatment resistant cases and for anxiety issues when clonazepam cannot be prescribed. Other anticonvulsants effective in some cases and under study include phenytoin, levetiracetam, pregabalin and valnoctamide. In an embodiment the patient is also treated with an “atypical antipsychotic drug.” The newer atypical antipsychotic drugs such as risperidone, quetiapine, and olanzapine are often used in acutely manic patients. In light of recent evidence, olanzapine (Zyprexa) has been FDA approved as an effective monotherapy for the maintenance of bipolar disorder. Eli Lilly and Company also offers Symbyax, a combination of olanzapine and fluoxetine. Ziprasidone (Geodon) and aripriprazole (Abilify) also show promise. Other newer treatments include Modafinil (Provigil) and Pramipexole (Mirapex), which show promise in treating the cognitive deterioration related to bipolar depression. In addition Riluzole, an ALS treatment, has been shown to be effective treatment. The breast cancer medicine tamoxifen has shown quick response to manic phases. In an embodiment the patient is also treated with electroconvulsive therapy. Electroconvulsive therapy (ECT) is sometimes used to treat severe bipolar depression in cases where other treatments have failed and is 60 to 70 percent effective.

In an embodiment the patient is also treated with psychotherapy. Other treatments include omega-3 fatty acids, particularly as a supplement to other medication. There are also reports that medical marijuana can help control the mood swings in some forms of bipolar disorder.

In an embodiment a dsRNA described herein is administered to a patient who has previously been treated with another therapeutic or counseling modality but which has provided less than optimal results.

In the example of a metabolic disorder, e.g., diabetes, the patient can also be provided administration of a dsRNA targeting GSK-3 can be accompanied by a exercise regimen or by dietary restrictions. A dsRNA featured in the invention can also be administered with a drug or combination of drugs for managing Type II diabetes, e.g., a sulfonylurea, a biguanide, an alpha-glucosidase inhibitor, a thiazolidinedione, a meglitinide, a D-phenylalanine derivative, an amylin synthetic derivatives, an incretin mimetic, or an insulin. Exemplary insulins include regular insulins (Humulin®, Novolin®), insulin lispro (Humalog®), insulin aspart (Novolog®), insulin glulisine (Apidra®), prompt insulin zinc (Semilente®, slightly slower acting), inhaled insulin (Exubera®), intermediate-acting insulins, isophane insulin, neutral protamine Hagedorn (NPH), insulin zinc (Lente®), extended insulin zinc insulin (Ultralente®), insulin glargine (Lantus®), and insulin detemir (Levemir®).

In the example of cancer the patient can also be provided with a chemotherapy agent, such as deoxycoformycin, cisplatin, cyclophosphamide, 5-fluorouracil, adriamycin, daunorubicin, tamoxifen aunorubicin, daunomycin, dactinomycin, doxorubicin, epirubicin, idarubicin, esorubicin, bleomycin, mafosfamide, ifosfamide, cytosine arabinoside, bis-chloroethylnitrosurea, busulfan, mitomycin C, actinomycin D, mithramycin, prednisone, hydroxyprogesterone, testosterone, tamoxifen, dacarbazine, procarbazine, hexamethylmelamine, pentamethylmelamine, mitoxantrone, amsacrine, chlorambucil, methylcyclohexylnitrosurea, nitrogen mustards, melphalan, cyclophosphamide, 6-mercaptopurine, 6-thioguanine, cytarabine, 5-azacytidine, hydroxyurea, deoxycoformycin, 4-hydroxyperoxycyclophosphoramide, 5-fluorouracil (5-FU), 5-fluorodeoxyuridine (5-FUdR), methotrexate (MTX), colchicine, taxol, vincristine, vinblastine, etoposide (VP-16), trimetrexate, irinotecan, topotecan, gemcitabine, teniposide, cisplatin and diethylstilbestrol (DES). See, generally, The Merck Manual of Diagnosis and Therapy, 15th Ed. 1987, pp. 1206-1228, Berkow et al., eds., Rahway, N.J. When used with the dsRNAs featured in the invention, such chemotherapeutic agents may be used individually (e.g., deoxycoformycin and dsRNA), sequentially (e.g., antiviral and dsRNA for a period of time, followed by deoxycoformycin and dsRNA), or in combination with one or more other such agents (e.g., deoxycoformycin, antiviral and dsRNA, or deoxycoformycin, radiotherapy and dsRNA). Two or more combined compounds may be used together or sequentially.

Generally, the dsRNAs described here can be used in combination with other GSK-3 inhibitors. Examples of such inhibitors described in Meijer et al., Trends in Pharmacological Sciences, 25: 471 (September 2004), incorporated herein by reference include pyrroloazepines, (e.g., hymenialdisine), flavones (e.g., flavopiridol), benzazepinones (e.g., kenpaullone, alsterpaulione, and azakenpaullone), bis-indole indirubin-3′-oximes (e.g., indirubin-3′-oxime, 6-bromoindirubin-3′-oxime (BIO), and 6-bromoindirubin-3′-acetoxime), pyrrolopyrazines (e.g., aloisine A and aloisine B), thiadiazolidinones (e.g., TDZD8), pyridyloxadiazoles (e.g., Compound 12), pyrazolopyridines (e.g., pyrazolopyridine 18 and pyrazolopyridine 34), pyrazolopyridazines (e.g., pyrazolopyridine 9), aminopyrimidines (e.g., CHIR98014 and CHIR99021 (CT99021)), pyrazoloquinoxalines (Compound 1), oxindoles (indolinones) (e.g., SU9516), thiazoles (e.g., ARA014418), bisindolylmaleimides (e.g., staurosporine and Compound 5a), azaindolylmaleimides (e.g., Compound 29 and Compound 46), bisindolylmaleimides (e.g., GF109203x (bisindolylmaleimide I) and Ro318220 (bisindolylmaleimide IX)), arylindolemaleimides (e.g., SB216763), anilinomaleimides (e.g., SB415286), anilinoarylmaleimides (e.g., IS), phenylaminopyrimidines (e.g., CGP60474), triazoles (e.g., Compound 8b), pyrrolopyrimidines (e.g., TWS119), pyrazolopyrimidines (e.g., Compound 1A), chloromethyl thienyl ketone (e.g., Compound 17), atoms in competition with Mg²⁺ (e.g., lithium), atoms in competition with Mg²⁺ and ATP (e.g., beryllium), and uncompetitive atoms (e.g., zinc). Structures for some of the inhibitors can be found in FIG. 2 of Meijer et al. and are shown below.

Methods for Inhibiting Expression of the GSK-3 Gene

In yet another aspect, the invention provides a method for inhibiting the expression of an GSK-3 gene in a mammal. The method includes administering a composition featured in the invention to the mammal such that expression of the target GSK-3 gene is silenced.

When the organism to be treated is a mammal such as a human, the composition may be administered by any means known in the art including, but not limited to oral or parenteral routes, including intravenous, intramuscular, subcutaneous, transdermal, airway (aerosol), nasal, rectal, and topical (including buccal and sublingual) administration. In preferred embodiments, the compositions are administered by intravenous infusion or injection.

Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the invention, suitable methods and materials are described below. All publications, patent applications, patents, and other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting.

EXAMPLE Example 1 Design and Synthesis of siRNA Targeting GSK3

siRNA Design for Mouse Glycogen Synthase Kinase 3 Alpha (GSK3α)

All possible perfect match sense 19mer oligomers were extracted from mouse GSKalpha sequence NM_(—)001031667.1, the sole NCBI reference sequence for the mouse GSK3α gene, and identified as candidate target regions. The sequences are shown in Table 1 below.

In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.

To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8.).

The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

-   -   1. Number of mismatches in seed region, defined as positions 2-9         of the oligomer     -   2. Number of mismatches in cleavage site region, defined as         positions 10 and 11     -   3. Number of mismatches in non-seed region, non-cleavage region,         defined as positions 12-19     -   4. Mismatches in position 1 were ignored

The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:

Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)

The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse GSK3α transcript measured. The sequences are shown in Table 4.

Sense and antisense oligomers complementary to the human GSK3α gene (NM_(—)002093) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 6.

siRNA Design for Mouse Glycogen Synthase Kinase 3 Beta (GSK3β)

All possible perfect match sense 19mer oligomers were extracted from NM_(—)019827.4 the sole NCBI reference sequence for the mouse Gsk3β gene, and identified as candidate target regions. The sequences are shown in Table 2.

In order to rank candidate target sequences and their corresponding siRNAs and select appropriate ones, their predicted potential for interacting with irrelevant targets (off-target potential) was taken as the primary ranking parameter. siRNAs with low off-target potential were defined as preferable and assumed to be more specific in vivo.

To identify potential off-target genes, 19mer candidate sequences as well as their 19mer reverse complements were subjected to a homology search against the entire NCBI mouse reference mRNA sequence collection using the FASTA search algorithm (Pearson, W R, Lipman, D J. Improved Tools for Biological Sequence Comparison. PNAS (1988) 85: 2444-8).

The following off-target properties for every 19mer were extracted for each oligo-mouse transcript alignment to calculate the off-target score:

-   -   1. Number of mismatches in seed region, defined as positions 2-9         of the oligomer     -   2. Number of mismatches in cleavage site region, defined as         positions 10 and 11     -   3. Number of mismatches in non-seed region, non-cleavage region,         defined as positions 12-19     -   4. Mismatches in position 1 were ignored

The off-target score for each oligo-transcript pair was calculated for considering assumptions 1 to 3 as follows:

Off-target score=(number of seed mismatches*2.8)+(number of cleavage site mismatches*1.2)+(number of non-seed mismatches*1)

The most relevant off-target gene for each siRNA corresponding to the input 19mer sequence was defined as the gene with the lowest off-target score. The candidate oligomers were ranked first by the lowest off-target score for the antisense sequence, and secondarily by the lowest off-target score by its sense counterpart. The top 11 oligo sense and antisense pairs from the list were synthesized and their capacity for knockdown of the mouse Gsk3β transcript measured. The sequences are shown in Table 5.

Sense and antisense oligomers complementary to the human GSK3β gene (NM_(—)019884.2) were designed by first aligning the orthologous transcripts, and then identifying the human counterpart region of the mouse candidate target regions. The sequences are shown in Table 7.

Table 3 provides a description of the abbreviations used herein.

TABLE 3 Abbreviations of nucleotide monomers used in nucleic acid sequence representation. It will be understood that these monomers, when present in an oligonucleotide, are mutually linked by 5′-3′-phosphodiester bonds. Abbreviation^(a) Nucleotide(s) A adenosine-5′-phosphate C cytidine-5′-phosphate G guanosine-5′-phosphate T, dT 2′-deoxy-thymidine-5′-phosphate U uridine-5′-phosphate N any nucleotide (G, A, C, or T) a 2′-O-methyladenosine-5′-phosphate c 2′-O-methylcytidine-5′-phosphate g 2′-O-methylguanosine-5′-phosphate u 2′-O-methyluridine-5′-phosphate sT, sdT 2′-deoxy-thymidine-5′phosphate-phosphorothioate

Source of Reagents

Where the source of a reagent is not specifically given herein, such reagent may be obtained from any supplier of reagents for molecular biology at a quality/purity standard for application in molecular biology.

siRNA Synthesis

Single-stranded RNAs can be produced by solid phase synthesis on a scale of 1 μmole using an Expedite 8909 synthesizer (Applied Biosystems, Applera Deutschland GmbH, Darmstadt, Germany) and controlled pore glass (CPG, 500 Å, Proligo Biochemie GmbH, Hamburg, Germany) as solid support. RNA and RNA containing 2′-O-methyl nucleotides can be generated by solid phase synthesis employing the corresponding phosphoramidites and 2′-O-methyl phosphoramidites, respectively (Proligo Biochemie GmbH, Hamburg, Germany). These building blocks can be incorporated at selected sites within the sequence of the oligoribonucleotide chain using standard nucleoside phosphoramidite chemistry such as described in Current protocols in nucleic acid chemistry, Beaucage, S. L. et al. (Edrs.), John Wiley & Sons, Inc., New York, N.Y., USA. Phosphorothioate linkages can be introduced by replacement of the iodine oxidizer solution with a solution of the Beaucage reagent (Chruachem Ltd, Glasgow, UK) in acetonitrile (1%). Further ancillary reagents can be obtained from Mallinckrodt Baker (Griesheim, Germany).

Deprotection and purification of the crude oligoribonucleotides by anion exchange HPLC can be carried out according to established procedures. Yields and concentrations can be determined by UV absorption of a solution of the respective RNA at a wavelength of 260 nm using a spectral photometer (DU 640B, Beckman Coulter GmbH, Unterschleiβheim, Germany). Double stranded RNA can be generated by mixing an equimolar solution of complementary strands in annealing buffer (20 mM sodium phosphate, pH 6.8; 100 mM sodium chloride), heated in a water bath at 85-90° C. for 3 minutes and cooled to room temperature over a period of 3-4 hours. The annealed RNA solution can be stored at −20° C. until use.

For the synthesis of 3′-cholesterol-conjugated siRNAs (herein referred to as -Chol-3′), an appropriately modified solid support can be used for RNA synthesis. The modified solid support was prepared as follows:

Diethyl-2-azabutane-1,4-dicarboxylate AA

A 4.7 M aqueous solution of sodium hydroxide (50 mL) can be added into a stirred, ice-cooled solution of ethyl glycinate hydrochloride (32.19 g, 0.23 mole) in water (50 mL). Then, ethyl acrylate (23.1 g, 0.23 mole) can be added and the mixture can be stirred at room temperature until completion of the reaction can be ascertained by TLC. After 19 h the solution can be partitioned with dichloromethane (3×100 mL). The organic layer can be dried with anhydrous sodium sulfate, filtered and evaporated. The residue can be distilled to afford AA (28.8 g, 61%).

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonyl-amino)-hexanoyl]-amino}-propionic acid ethyl ester AB

Fmoc-6-amino-hexanoic acid (9.12 g, 25.83 mmol) can be dissolved in dichloromethane (50 mL) and cooled with ice. Diisopropylcarbodiimde (3.25 g, 3.99 mL, 25.83 mmol) can be added to the solution at 0° C. It can then be followed by the addition of Diethyl-azabutane-1,4-dicarboxylate (5 g, 24.6 mmol) and dimethylamino pyridine (0.305 g, 2.5 mmol). The solution can be brought to room temperature and stirred further for 6 h. Completion of the reaction was ascertained by TLC. The reaction mixture can be concentrated under vacuum and ethyl acetate can be added to precipitate diisopropyl urea. The suspension can be filtered. The filtrate can be washed with 5% aqueous hydrochloric acid, 5% sodium bicarbonate and water. The combined organic layer can be dried over sodium sulfate and concentrated to give the crude product which can be purified by column chromatography (50% EtOAC/Hexanes) to yield 11.87 g (88%) of AB.

3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) can be dissolved in 20% piperidine in dimethylformamide at 0° C. The solution can be stirred continuously for 1 h. The reaction mixture can be concentrated under vacuum, water can be added to the residue, and the product can be extracted with ethyl acetate. The crude product can be purified by conversion into its hydrochloride salt.

3-({6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoyl}ethoxycarbonylmethyl-amino)-propionic acid ethyl ester AD

The hydrochloride salt of 3-[(6-Amino-hexanoyl)-ethoxycarbonylmethyl-amino]-propionic acid ethyl ester AC (4.7 g, 14.8 mmol) can be taken up in dichloromethane. The suspension was cooled to 0° C. on ice. To the suspension diisopropylethylamine (3.87 g, 5.2 mL, 30 mmol) can be added. To the resulting solution cholesteryl chloroformate (6.675 g, 14.8 mmol) can be added. The reaction mixture can be stirred overnight. The reaction mixture can be diluted with dichloromethane and washed with 10% hydrochloric acid. The product can be purified by flash chromatography (10.3 g, 92%).

1-{6-[17-(1,5-Dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoy}-4-oxo-pyrrolidine-3-carboxylic acid ethyl ester AE

Potassium t-butoxide (1.1 g, 9.8 mmol) can be slurried in 30 mL of dry toluene. The mixture can be cooled to 0° C. on ice and 5 g (6.6 mmol) of diester AD can be added slowly with stirring within 20 mins. The temperature can be kept below 5° C. during the addition. The stirring can be continued for 30 mins at 0° C. and 1 mL of glacial acetic acid can be added, immediately followed by 4 g of NaH₂PO₄.H₂O in 40 mL of water. The resultant mixture can be extracted twice with 100 mL of dichloromethane each and the combined organic extracts can be washed twice with 10 mL of phosphate buffer each, dried, and evaporated to dryness. The residue can be dissolved in 60 mL of toluene, cooled to 0° C. and extracted with three 50 mL portions of cold pH 9.5 carbonate buffer. The aqueous extracts can be adjusted to pH 3 with phosphoric acid, and extracted with five 40 mL portions of chloroform which can be combined, dried and evaporated to dryness. The residue can be purified by column chromatography using 25% ethylacetate/hexane to afford 1.9 g of b-ketoester (39%).

[6-(3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-yl)-6-oxo-hexyl]-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AF

Methanol (2 mL) can be added dropwise over a period of 1 h to a refluxing mixture of b-ketoester AE (1.5 g, 2.2 mmol) and sodium borohydride (0.226 g, 6 mmol) in tetrahydrofuran (10 mL). Stirring can be continued at reflux temperature for 1 h. After cooling to room temperature, 1 N HCl (12.5 mL) can be added, the mixture was extracted with ethylacetate (3×40 mL). The combined ethylacetate layer can be dried over anhydrous sodium sulfate and concentrated under vacuum to yield the product which can be purified by column chromatography (10% MeOH/CHCl₃) (89%).

(6-{3-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-6-oxo-hexyl)-carbamic acid 17-(1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester AG

Diol AF (1.25 gm 1.994 mmol) can be dried by evaporating with pyridine (2×5 mL) in vacuo. Anhydrous pyridine (10 mL) and 4,4′-dimethoxytritylchloride (0.724 g, 2.13 mmol) can be added with stirring. The reaction can be carried out at room temperature overnight. The reaction can be quenched by the addition of methanol. The reaction mixture can be concentrated under vacuum and to the residue dichloromethane (50 mL) was added. The organic layer can be washed with 1M aqueous sodium bicarbonate. The organic layer can be dried over anhydrous sodium sulfate, filtered and concentrated. The residual pyridine can be removed by evaporating with toluene. The crude product can be purified by column chromatography (2% MeOH/Chloroform, Rf=0.5 in 5% MeOH/CHCl₃) (1.75 g, 95%).

Succinic acid mono-(4-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-1-{6-[17-(1,5-dimethyl-hexyl)-10,13-dimethyl 2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H cyclopenta[a]phenanthren-3-yloxycarbonylamino]-hexanoy}1-pyrrolidin-3-yl) ester AH

Compound AG (1.0 g, 1.05 mmol) can be mixed with succinic anhydride (0.150 g, 1.5 mmol) and DMAP (0.073 g, 0.6 mmol) and dried in a vacuum at 40° C. overnight. The mixture can be dissolved in anhydrous dichloroethane (3 mL), triethylamine (0.318 g, 0.440 mL, 3.15 mmol) can be added and the solution can be stirred at room temperature under argon atmosphere for 16 h. It can then be diluted with dichloromethane (40 mL) and washed with ice cold aqueous citric acid (5 wt %, 30 mL) and water (2×20 mL). The organic phase can be dried over anhydrous sodium sulfate and concentrated to dryness. The residue can be used as such for the next step.

Cholesterol Derivatised CPG AI

Succinate AH (0.254 g, 0.242 mmol) can be dissolved in a mixture of dichloromethane/acetonitrile (3:2, 3 mL). To that solution DMAP (0.0296 g, 0.242 mmol) in acetonitrile (1.25 mL), 2,2′-Dithio-bis(5-nitropyridine) (0.075 g, 0.242 mmol) in acetonitrile/dichloroethane (3:1, 1.25 mL) can be added successively. To the resulting solution triphenylphosphine (0.064 g, 0.242 mmol) in acetonitrile (0.6 ml) was added. The reaction mixture can turn bright orange in color. The solution can be agitated briefly using a wrist-action shaker (5 mins). Long chain alkyl amine-CPG (LCAA-CPG) (1.5 g, 61 mM) can be added. The suspension can be agitated for 2 h. The CPG was filtered through a sintered funnel and washed with acetonitrile, dichloromethane and ether successively. Unreacted amino groups can be masked using acetic anhydride/pyridine. The achieved loading of the CPG can be measured by taking UV measurement (37 mM/g).

The synthesis of siRNAs bearing a 5′-12-dodecanoic acid bisdecylamide group (herein referred to as “5′-C32-”) or a 5′-cholesteryl derivative group (herein referred to as “5′-Chol-”) can be performed as described in WO 2004/065601, except that, for the cholesteryl derivative, the oxidation step can be performed using the Beaucage reagent in order to introduce a phosphorothioate linkage at the 5′-end of the nucleic acid oligomer.

Example 2 In Vitro Screen of GSK3α and GSK3β siRNAs Against Endogenous GSK3α and GSK3β mRNA Expression in Mouse HT22 Cells

Mouse HT22 cells were a gift from Dr. Marcy MacDonald and cultured in Dulbecco's modified Eagle's medium supplied with 10% fetal bovine serum and differentiated in modified serum-free medium (Dulbecco's modified Eagle's medium, N2 supplement, 50 ng/ml nerve growth factor-β, 100 μM phorbol 12,13-dibutyrate, 100 μM dibutyryl cAMP) for 24-48 h before treatment. All treatments were performed in differentiation medium with reduced nerve growth factor-13 content (5 ng/ml) at 37° C. in a humidified incubator with 5% CO₂.

Cells were transfected with the modified siRNAtargeting mouse GSK3α or GSK3β described in Table 4 and Table 5. For transfection with siRNA, HT22 cells were seeded at a density of 1.0×10⁵ cells/well in 6-well tissue culture plates and transfected directly. Transfection of siRNA (37.5 nM for single dose screen) was carried out with Lipofectamine2000 (Invitrogen, Carlsbad, Calif.) as described by the manufacturer. For dose-response curves, siRNA concentrations ranged from 10 nM to 0.1 nM in 10-fold dilutions.

24 hours after transfection, HT22 cells were lysed and cDNA was generated for GSK3α or GSK3β and GAPDH mRNA quantitation. GSK3α or GSK3β mRNA levels were normalized to GAPDH mRNA levels. For each siRNA, 2 individual data points were collected. An siRNA duplex unrelated to the GSK3α or GSK3β gene was used as a control. The activity of a given GSK3α- or GSK3β-specific siRNA duplex was expressed as the fraction of the GSK3α or GSK3β mRNA level in treated cells relative to the GSK3α or GSK3β mRNA level in cells treated with the control siRNA duplex.

Duplex Identifier Used in the Figures and in Examples 2-5 Refer to the Modified Version of the Duplex, e.g., AD-18821 as Used in the Figures and Examples 2-5 Refers to the Modified Version of AD-18821, e.g., AD-18821-B1.

FIG. 1 and FIG. 2 provide the results from the in vitro HT22 screen where the siRNAs were tested at a single dose of 37.5 nM. The fraction of GSK3α and GSK3β mRNA remaining in treated cells compared to controls, ±standard deviation, is shown. A number of GSK3α siRNAs (AD-18821, AD-18825 or AD-18832) at 37.5 nM were effective at reducing GSK3α mRNA levels by more than 40%, without affecting GSK3β mRNA levels, in HT22 cells. A number of GSK3β siRNAs (AD-18833, AD-18834, AD-18836, AD-18837, AD-18838, AD-18841, AD-18842, AD-18843 or AD-18844) at 37.5 nM were effective at reducing GSK3 β mRNA levels by more than 40%, without affecting GSK3α mRNA levels, in HT22 cells.

FIG. 3 and FIG. 4 show the dose-dependence of selected siRNAs on mRNA reduction in HT22 cells. Several siRNAs targeting GSK3α (AD-18821, AD-18825 or AD-18826) exhibited IC50 values of less than or equal to 1-10 nM in suppressing GSK3α mRNA after transfection into HT22 cells (FIG. 3). Several siRNAs targeting GSK3β (AD-18838 or AD-18843) exhibited IC50 values of less than 1 nM in suppressing GSK3β mRNA (FIG. 4).

Example 3 GSK3β dsRNAs Reduce Endogenous GSK3β Protein in HT22 Cells

HT22 cells were cultured and transfected as previously described with 75 nM of 11 siRNAs against GSK3β (AD-18833, AD-18834, AD-18835, AD-18836, AD-18837, AD-18838, AD-18839, AD-18841, AD-18842, AD-18843 or AD-18844); one control unrelated siRNA (AD-1955) or Lipofectamine2000 alone (Control). 48 hours post-transfection, the cells were harvested and lysed. Proteins in the lysates were separated on a denaturing polyacrylamide gel. GSK3β and β-actin were detected by standard western blot protocols using antibodies that bind to the proteins. For GSK3β detection, the membrane was probed with a monoclonal GSK3β antibody produced in rabbit (Cell Signaling, Danvers, Mass.) followed by a secondary antibody donkey anti-rabbit IgG horseradish peroxidase (GE Healthcare, Piscataway, N.J.). β-actin was detected by mouse anti-actin antibody (Sigma, St. Louis, Mo.) followed by a Sheep anti-mouse IgG horseradish peroxidase secondary antibody (GE Healthcare, Piscataway, N.J.).

FIG. 5 provides the results. AD-18838, AD-18843 and AD-18844, all at 75 nM, decreased the level of GSK3β protein relative to the control protein β-actin, whereas the control unrelated siRNA had no effect on the level of GSK3β protein. These results demonstrate that dsRNAs targeting GSK3β effectively reduce not only GSK3β mRNA levels, but also GSK3β protein levels.

Example 4 In Vivo Down-Modulation of Endogenous GSK3α or GSK3β mRNA Levels by CNS Administration of GSK3α or GSK3β dsRNAs in Mice

To assess the biological activity of GSK3 dsRNAs in vivo, dsRNAs targeting GSK3α (AD-18821, AD-18825, and AD-18826) or GSK3β (AD-18838, AD-18843, and AD-18844) were evaluated.

In mice, 1.26 mg AD-18821, AD-18825, AD-18826, AD-18838, AD-18843, AD-18844, or phosphate-buffered saline (PBS, vehicle control) was administered by continuous infusion into the nucleus accumbens over 14 days. Ten week old male C57BL6 mice (Charles River Laboratory) received stereotaxic implantations of 30-gauge infusion cannulae (Plastics One, Roanok, Va.) such that unilateral infusions were targeted to the nucleus accumbens (anteroposterior+1.1 mm, mediolateral+1.3 mm, relative to bregma; dorsoventral 4.5 mm, relative to skull surface). Mini-osmotic pumps (model 1002) were primed overnight according to the manufacturer's specifications, implanted subcutaneously, and connected via catheters, to deliver (6 mice per treatment group) PBS, 1.1 mM (15 mg/mL) of GSK3α siRNAs (AD-18821, AD-18825, or AD-18826) or 1.1 mM (15 mg/mL) of GSK3β siRNAs (AD-18838, AD-18843, or AD-18844) at 0.25 μL/hr over 14 days. At the end of the 14 day infusion period, animals were sacrificed, brains were removed, and 1.2 mm punches from the ipsilateral nucleus accumbens encompassing the infusion site, from 1 mm thick coronal brain slabs, were flash frozen and stored at −80° C. Individual brain punches from each mouse were quantified for GSK3α and GSK3β mRNA. Each brain punch was run in triplicate for RT-qPCR. Approximately 60 ng of total RNA in a 20 μl total reaction volume was used for RT-qPCR. GSK3α and GSK3β primers were custom designed and obtained from IDT (Integrated DNA Technologies, Inc., Coralville, Iowa). RT-qPCR was run with SBYR. GAPDH was used as the internal control for normalization. Relative expression of GSK3α and GSK3β mRNA was quantified by 2^(ΔCt) (where ΔCt=Ct_(gene)−Ct_(GAPDH)).

The GSK3β siRNAs, AD-18844, AD-18838 or AD-18843, showed 53% (ANOVA; p=0.012) (FIG. 6), 28% or 25% GSK3β mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3β siRNA, AD-18844, had no effect on GSK3α mRNA levels. The GSK3α siRNAs, AD-18826, AD-18825 or AD-18821, showed 51% (p=0.052; Tukey Post-hoc ANOVA) (FIG. 7), 42% (t-test; p=0.004) or 15% GSK3α mRNA reduction in the ipsilateral nucleus accumbens, respectively, compared to PBS control. The GSK3α siRNA, AD-18826, had no effect on GSK3β mRNA levels.

These results demonstrate that infusion into the nucleus accumbens of AD-18844 and AD-18826 are efficacious in vivo in specifically down-modulating GSK3β and GSK3α mRNA levels, respectively, in the nucleus accumbens.

Example 5 Inhibition of GSK-3 Expression in Human Cells

A set of siRNA targeting human GSK3α and GSK3β (Table 6 and Table 7) are evaluated for inhibition of GSK-3 expression in human cell lines. Human cell lines expressing endogenouseGSK3 are transfected with at least one of the duplexes in Table 6 or Table 7, e.g., huGSKA-3 (orthologous to AD-18826-b1) and/or huGSKB-11 (orthologous to AD-18826-b1). The human duplexes can be modified in a similar manner to the mouse duplexes. The transfected cells are assayed for effects on mRNA and protein levels using techniques described herein and known to one of skill in the art.

Example 6 Inhibition of GSK-3 Expression in Humans

A human subject is treated with a pharmaceutical composition comprising a pharmaceutical formulation of an siRNA targeting a human GSK-3 gene.

A subject in need of treatment is selected or identified. The subject can be in need of treatment for manic depression, a metabolic disease, a nervous system disorders, or cancer.

At time zero, a suitable first dose of the composition is subcutaneously administered to the subject. The composition is formulated as described herein. After a period of time, the subject's condition is evaluated, e.g., by measurement episodes of mania, episodes of depression, and the like. This measurement can be accompanied by a measurement of GSK-3 expression in said subject, and/or the products of the successful siRNA-targeting of GSK-3. Other relevant criteria can also be measured. The number and strength of doses are adjusted according to the subject's needs.

After treatment, the subject's condition is compared to the condition existing prior to the treatment, or relative to the condition of a similarly afflicted but untreated subject.

TABLE 1 Sequences of duplexes targeting Mouse GSK3-alpha Sequences of possible duplexes targeting mouse GSK3-alpha. Target sequence location identifies target sequence in mouse GSK3-alpha mRNA NM_001031667.1. Unmodified sense strand is identical to target sequence. Unmodified a antisense strand is complementary to target sequence. Target SEQ Unmodified SEQ sequence ID sequence ID Modified sequence location NO: 5′ to 3′ NO: 5′ to 3′ Strand  670-689    1 AACUGCAGAUUAUGCGUAA    2 AAcuGcAGAuuAuGcGuAAdTsdT sense  670-689    3 UUACGCAUAAUCUGCAGUU    4 UuACGcAuAAUCUGcAGUUdTsdT antis 1074-1093    5 ACAGAUUACACCUCGUCCA    6 AcAGAuuAcAccucGuccAdTsdT sense 1074-1093    7 UGGACGAGGUGUAAUCUGU    8 UGGACGAGGUGuAAUCUGUdTsdT antis  330-349    9 GGCGGCGGGAAAGCGUCAG   10 GGcGGcGGGAAAGcGucAGdTsdT sense  330-349   11 CUGACGCUUUCCCGCCGCC   12 CUGACGCUUUCCCGCCGCCdTsdT antis  239-258   13 GGCGCGGACCAGCUCGUUC   14 GGcGcGGAccAGcucGuucdTsdT sense  239-258   15 GAACGAGCUGGUCCGCGCC   16 GAACGAGCUGGUCCGCGCCdTsdT antis 1340-1359   17 CCUACUGGAGUACACGCCA   18 ccuAcuGGAGuAcAcGccAdTsdT sense 1340-1359   19 UGGCGUGUACUCCAGUAGG   20 UGGCGUGuACUCcAGuAGGdTsdT antis 1342-1361   21 UACUGGAGUACACGCCAUC   22 uAcuGGAGuAcAcGccAucdTsdT sense 1342-1361   23 GAUGGCGUGUACUCCAGUA   24 GAUGGCGUGuACUCcAGuAdTsdT antis 1073-1092   25 CACAGAUUACACCUCGUCC   26 cAcAGAuuAcAccucGuccdTsdT sense 1073-1092   27 GGACGAGGUGUAAUCUGUG   28 GGACGAGGUGuAAUCUGUGdTsdT antis 1236-1255   29 CCUAACUAUACGGAGUUCA   30 ccuAAcuAuAcGGAGuucAdTsdT sense 1236-1255   31 UGAACUCCGUAUAGUUAGG   32 UGAACUCCGuAuAGUuAGGdTsdT antis  435-454   33 GCGGGCACUAGCUUCCCGC   34 GcGGGcAcuAGcuucccGcdTsdT sense  435-454   35 GCGGGAAGCUAGUGCCCGC   36 GCGGGAAGCuAGUGCCCGCdTsdT antis 1231-1250   37 UGAACCCUAACUAUACGGA   38 uGAAcccuAAcuAuAcGGAdTsdT sense 1231-1250   39 UCCGUAUAGUUAGGGUUCA   40 UCCGuAuAGUuAGGGUUcAdTsdT antis 1234-1253   41 ACCCUAACUAUACGGAGUU   42 AcccuAAcuAuAcGGAGuudTsdT sense 1234-1253   43 AACUCCGUAUAGUUAGGGU   44 AACUCCGuAuAGUuAGGGUdTsdT antis 1235-1254   45 CCCUAACUAUACGGAGUUC   46 cccuAAcuAuAcGGAGuucdTsdT sense 1235-1254   47 GAACUCCGUAUAGUUAGGG   48 GAACUCCGuAuAGUuAGGGdTsdT antis 1233-1252   49 AACCCUAACUAUACGGAGU   50 AAcccuAAcuAuAcGGAGudTsdT sense 1233-1252   51 ACUCCGUAUAGUUAGGGUU   52 ACUCCGuAuAGUuAGGGUUdTsdT antis 2027-2046   53 GCCCCCUGGGUGUAAAUAG   54 GcccccuGGGuGuAAAuAGdTsdT sense 2027-2046   55 CUAUUUACACCCAGGGGGC   56 CuAUUuAcACCcAGGGGGCdTsdT antis    5-24   57 UGACAACGAAGCCGACGGC   58 uGAcAAcGAAGccGAcGGcdTsdT sense    5-24   59 GCCGUCGGCUUCGUUGUCA   60 GCCGUCGGCUUCGUUGUcAdTsdT antis 1071-1090   61 GCCACAGAUUACACCUCGU   62 GccAcAGAuuAcAccucGudTsdT sense 1071-1090   63 ACGAGGUGUAAUCUGUGGC   64 ACGAGGUGuAAUCUGUGGCdTsdT antis 2000-2019   65 AGCCCAUCUCUCGUCUUCC   66 AGcccAucucucGucuuccdTsdT sense 2000-2019   67 GGAAGACGAGAGAUGGGCU   68 GGAAGACGAGAGAUGGGCUdTsdT antis    4-23   69 GUGACAACGAAGCCGACGG   70 GuGAcAAcGAAGccGAcGGdTsdT sense    4-23   71 CCGUCGGCUUCGUUGUCAC   72 CCGUCGGCUUCGUUGUcACdTsdT antis 1085-1104   73 CUCGUCCAUCGAUGUGUGG   74 cucGuccAucGAuGuGuGGdTsdT sense 1085-1104   75 CCACACAUCGAUGGACGAG   76 CcAcAcAUCGAUGGACGAGdTsdT antis 2070-2089   77 AAACGUCAAUUCACACCAU   78 AAAcGucAAuucAcAccAudTsdT sense 2070-2089   79 AUGGUGUGAAUUGACGUUU   80 AUGGUGUGAAUUGACGUUUdTsdT antis 2072-2091   81 ACGUCAAUUCACACCAUUC   82 AcGucAAuucAcAccAuucdTsdT sense 2072-2091   83 GAAUGGUGUGAAUUGACGU   84 GAAUGGUGUGAAUUGACGUdTsdT antis  251-270   85 CUCGUUCGCGGAGCCAGGA   86 cucGuucGcGGAGccAGGAdTsdT sense  251-270   87 UCCUGGCUCCGCGAACGAG   88 UCCUGGCUCCGCGAACGAGdTsdT antis  241-260   89 CGCGGACCAGCUCGUUCGC   90 cGcGGAccAGcucGuucGcdTsdT sense  241-260   91 GCGAACGAGCUGGUCCGCG   92 GCGAACGAGCUGGUCCGCGdTsdT antis  581-600   93 CGGAGUAGUAUACCAGGCA   94 cGGAGuAGuAuAccAGGcAdTsdT sense  581-600   95 UGCCUGGUAUACUACUCCG   96 UGCCUGGuAuACuACUCCGdTsdT antis 1076-1095   97 AGAUUACACCUCGUCCAUC   98 AGAuuAcAccucGuccAucdTsdT sense 1076-1095   99 GAUGGACGAGGUGUAAUCU  100 GAUGGACGAGGUGuAAUCUdTsdT antis 2069-2088  101 AAAACGUCAAUUCACACCA  102 AAAAcGucAAuucAcAccAdTsdT sense 2069-2088  103 UGGUGUGAAUUGACGUUUU  104 UGGUGUGAAUUGACGUUUUdTsdT antis    6-25  105 GACAACGAAGCCGACGGCA  106 GAcAAcGAAGccGAcGGcAdTsdT sense    6-25  107 UGCCGUCGGCUUCGUUGUC  108 UGCCGUCGGCUUCGUUGUCdTsdT antis   16-35  109 CCGACGGCAGAGGGACUUC  110 ccGAcGGcAGAGGGAcuucdTsdT sense   16-35  111 GAAGUCCCUCUGCCGUCGG  112 GAAGUCCCUCUGCCGUCGGdTsdT antis  243-262  113 CGGACCAGCUCGUUCGCGG  114 cGGAccAGcucGuucGcGGdTsdT sense  243-262  115 CCGCGAACGAGCUGGUCCG  116 CCGCGAACGAGCUGGUCCGdTsdT antis  244-263  117 GGACCAGCUCGUUCGCGGA  118 GGAccAGcucGuucGcGGAdTsdT sense  244-263  119 UCCGCGAACGAGCUGGUCC  120 UCCGCGAACGAGCUGGUCCdTsdT antis  328-347  121 CUGGCGGCGGGAAAGCGUC  122 cuGGcGGcGGGAAAGcGucdTsdT sense  328-347  123 GACGCUUUCCCGCCGCCAG  124 GACGCUUUCCCGCCGCcAGdTsdT antis  331-350  125 GCGGCGGGAAAGCGUCAGU  126 GcGGcGGGAAAGcGucAGudTsdT sense  331-350  127 ACUGACGCUUUCCCGCCGC  128 ACUGACGCUUUCCCGCCGCdTsdT antis  340-359  129 AAGCGUCAGUCGGGGCUAU  130 AAGcGucAGucGGGGcuAudTsdT sense  340-359  131 AUAGCCCCGACUGACGCUU  132 AuAGCCCCGACUGACGCUUdTsdT antis  432-451  133 GGCGCGGGCACUAGCUUCC  134 GGcGcGGGcAcuAGcuuccdTsdT sense  432-451  135 GGAAGCUAGUGCCCGCGCC  136 GGAAGCuAGUGCCCGCGCCdTsdT antis  655-674  137 GGUUCAAGAACCGAGAACU  138 GGuucAAGAAccGAGAAcudTsdT sense  655-674  139 AGUUCUCGGUUCUUGAACC  140 AGUUCUCGGUUCUUGAACCdTsdT antis 1024-1043  141 CCUACAUCUGCUCUCGGUA  142 ccuAcAucuGcucucGGuAdTsdT sense 1024-1043  143 UACCGAGAGCAGAUGUAGG  144 uACCGAGAGcAGAUGuAGGdTsdT antis 1075-1094  145 CAGAUUACACCUCGUCCAU  146 cAGAuuAcAccucGuccAudTsdT sense 1075-1094  147 AUGGACGAGGUGUAAUCUG  148 AUGGACGAGGUGuAAUCUGdTsdT antis 1089-1108  149 UCCAUCGAUGUGUGGUCGG  150 uccAucGAuGuGuGGucGGdTsdT sense 1089-1108  151 CCGACCACACAUCGAUGGA  152 CCGACcAcAcAUCGAUGGAdTsdT antis 1090-1109  153 CCAUCGAUGUGUGGUCGGC  154 ccAucGAuGuGuGGucGGcdTsdT sense 1090-1109  155 GCCGACCACACAUCGAUGG  156 GCCGACcAcAcAUCGAUGGdTsdT antis 1092-1111  157 AUCGAUGUGUGGUCGGCUG  158 AucGAuGuGuGGucGGcuGdTsdT sense 1092-1111  159 CAGCCGACCACACAUCGAU  160 cAGCCGACcAcAcAUCGAUdTsdT antis 1093-1112  161 UCGAUGUGUGGUCGGCUGG  162 ucGAuGuGuGGucGGcuGGdTsdT sense 1093-1112  163 CCAGCCGACCACACAUCGA  164 CcAGCCGACcAcAcAUCGAdTsdT antis 1230-1249  165 AUGAACCCUAACUAUACGG  166 AuGAAcccuAAcuAuAcGGdTsdT sense 1230-1249  167 CCGUAUAGUUAGGGUUCAU  168 CCGuAuAGUuAGGGUUcAUdTsdT antis 1348-1367  169 AGUACACGCCAUCCUCAAG  170 AGuAcAcGccAuccucAAGdTsdT sense 1348-1367  171 CUUGAGGAUGGCGUGUACU  172 CUUGAGGAUGGCGUGuACUdTsdT antis 1401-1420  173 UUCGAUGAACUGCGGAGAC  174 uucGAuGAAcuGcGGAGAcdTsdT sense 1401-1420  175 GUCUCCGCAGUUCAUCGAA  176 GUCUCCGcAGUUcAUCGAAdTsdT antis 1402-1421  177 UCGAUGAACUGCGGAGACU  178 ucGAuGAAcuGcGGAGAcudTsdT sense 1402-1421  179 AGUCUCCGCAGUUCAUCGA  180 AGUCUCCGcAGUUcAUCGAdTsdT antis 1489-1508  181 UCCAACCAUCUCUCAAUGC  182 uccAAccAucucucAAuGcdTsdT sense 1489-1508  183 GCAUUGAGAGAUGGUUGGA  184 GcAUUGAGAGAUGGUUGGAdTsdT antis 1999-2018  185 CAGCCCAUCUCUCGUCUUC  186 cAGcccAucucucGucuucdTsdT sense 1999-2018  187 GAAGACGAGAGAUGGGCUG  188 GAAGACGAGAGAUGGGCUGdTsdT antis 2028-2047  189 CCCCCUGGGUGUAAAUAGA  190 cccccuGGGuGuAAAuAGAdTsdT sense 2028-2047  191 UCUAUUUACACCCAGGGGG  192 UCuAUUuAcACCcAGGGGGdTsdT antis 2068-2087  193 GAAAACGUCAAUUCACACC  194 GAAAAcGucAAuucAcAccdTsdT sense 2068-2087  195 GGUGUGAAUUGACGUUUUC  196 GGUGUGAAUUGACGUUUUCdTsdT antis 2080-2099  197 UCACACCAUUCAACUUGCC  198 ucAcAccAuucAAcuuGccdTsdT sense 2080-2099  199 GGCAAGUUGAAUGGUGUGA  200 GGcAAGUUGAAUGGUGUGAdTsdT antis 2083-2102  201 CACCAUUCAACUUGCCCCC  202 cAccAuucAAcuuGcccccdTsdT sense 2083-2102  203 GGGGGCAAGUUGAAUGGUG  204 GGGGGcAAGUUGAAUGGUGdTsdT antis 2084-2103  205 ACCAUUCAACUUGCCCCCC  206 AccAuucAAcuuGccccccdTsdT sense 2084-2103  207 GGGGGGCAAGUUGAAUGGU  208 GGGGGGcAAGUUGAAUGGUdTsdT antis 2086-2105  209 CAUUCAACUUGCCCCCCCC  210 cAuucAAcuuGccccccccdTsdT sense 2086-2105  211 GGGGGGGGCAAGUUGAAUG  212 GGGGGGGGcAAGUUGAAUGdTsdT antis 2244-2263  213 UUGGCAUGAAACCCUUAAA  214 uuGGcAuGAAAcccuuAAAdTsdT sense 2244-2263  215 UUUAAGGGUUUCAUGCCAA  216 UUuAAGGGUUUcAUGCcAAdTsdT antis   71-90  217 AGCCGGAGCCCGAACGGCG  218 AGccGGAGcccGAAcGGcGdTsdT sense   71-90  219 CGCCGUUCGGGCUCCGGCU  220 CGCCGUUCGGGCUCCGGCUdTsdT antis  177-196  221 CCUGCGCUCGGCGCCAUGA  222 ccuGcGcucGGcGccAuGAdTsdT sense  177-196  223 UCAUGGCGCCGAGCGCAGG  224 UcAUGGCGCCGAGCGcAGGdTsdT antis  836-855  225 CACCCCUAUCAUCUACAUC  226 cAccccuAucAucuAcAucdTsdT sense  836-855  227 GAUGUAGAUGAUAGGGGUG  228 GAUGuAGAUGAuAGGGGUGdTsdT antis  929-948  229 GCCCCAGAAUUUGCUUGUG  230 GccccAGAAuuuGcuuGuGdTsdT sense  929-948  231 CACAAGCAAAUUCUGGGGC  232 cAcAAGcAAAUUCUGGGGCdTsdT antis 1001-1020  233 GGUUCGGGGGGAGCCCAAU  234 GGuucGGGGGGAGcccAAudTsdT sense 1001-1020  235 AUUGGGCUCCCCCCGAACC  236 AUUGGGCUCCCCCCGAACCdTsdT antis 1091-1110  237 CAUCGAUGUGUGGUCGGCU  238 cAucGAuGuGuGGucGGcudTsdT sense 1091-1110  239 AGCCGACCACACAUCGAUG  240 AGCCGACcAcAcAUCGAUGdTsdT antis 1328-1347  241 ACUCUGCUCUAGCCUACUG  242 AcucuGcucuAGccuAcuGdTsdT sense 1328-1347  243 CAGUAGGCUAGAGCAGAGU  244 cAGuAGGCuAGAGcAGAGUdTsdT antis 1338-1357  245 AGCCUACUGGAGUACACGC  246 AGccuAcuGGAGuAcAcGcdTsdT sense 1338-1357  247 GCGUGUACUCCAGUAGGCU  248 GCGUGuACUCcAGuAGGCUdTsdT antis 1339-1358  249 GCCUACUGGAGUACACGCC  250 GccuAcuGGAGuAcAcGccdTsdT sense 1339-1358  251 GGCGUGUACUCCAGUAGGC  252 GGCGUGuACUCcAGuAGGCdTsdT antis 2059-2078  253 UUUCUUAAAGAAAACGUCA  254 uuucuuAAAGAAAAcGucAdTsdT sense 2059-2078  255 UGACGUUUUCUUUAAGAAA  256 UGACGUUUUCUUuAAGAAAdTsdT antis 2067-2086  257 AGAAAACGUCAAUUCACAC  258 AGAAAAcGucAAuucAcAcdTsdT sense 2067-2086  259 GUGUGAAUUGACGUUUUCU  260 GUGUGAAUUGACGUUUUCUdTsdT antis 2076-2095  261 CAAUUCACACCAUUCAACU  262 cAAuucAcAccAuucAAcudTsdT sense 2076-2095  263 AGUUGAAUGGUGUGAAUUG  264 AGUUGAAUGGUGUGAAUUGdTsdT antis 2089-2108  265 UCAACUUGCCCCCCCCAGC  266 ucAAcuuGccccccccAGcdTsdT sense 2089-2108  267 GCUGGGGGGGGCAAGUUGA  268 GCUGGGGGGGGcAAGUUGAdTsdT antis 2231-2250  269 GUUCAAUAAAUUAUUGGCA  270 GuucAAuAAAuuAuuGGcAdTsdT sense 2231-2250  271 UGCCAAUAAUUUAUUGAAC  272 UGCcAAuAAUUuAUUGAACdTsdT antis  207-226  273 CCUUCGGGAGGCGGCCCUG  274 ccuucGGGAGGcGGcccuGdTsdT sense  207-226  275 CAGGGCCGCCUCCCGAAGG  276 cAGGGCCGCCUCCCGAAGGdTsdT antis  240-259  277 GCGCGGACCAGCUCGUUCG  278 GcGcGGAccAGcucGuucGdTsdT sense  240-259  279 CGAACGAGCUGGUCCGCGC  280 CGAACGAGCUGGUCCGCGCdTsdT antis  242-261  281 GCGGACCAGCUCGUUCGCG  282 GcGGAccAGcucGuucGcGdTsdT sense  242-261  283 CGCGAACGAGCUGGUCCGC  284 CGCGAACGAGCUGGUCCGCdTsdT antis  249-268  285 AGCUCGUUCGCGGAGCCAG  286 AGcucGuucGcGGAGccAGdTsdT sense  249-268  287 CUGGCUCCGCGAACGAGCU  288 CUGGCUCCGCGAACGAGCUdTsdT antis  252-271  289 UCGUUCGCGGAGCCAGGAG  290 ucGuucGcGGAGccAGGAGdTsdT sense  252-271  291 CUCCUGGCUCCGCGAACGA  292 CUCCUGGCUCCGCGAACGAdTsdT antis  324-343  293 GGCACUGGCGGCGGGAAAG  294 GGcAcuGGcGGcGGGAAAGdTsdT sense  324-343  295 CUUUCCCGCCGCCAGUGCC  296 CUUUCCCGCCGCcAGUGCCdTsdT antis  329-348  297 UGGCGGCGGGAAAGCGUCA  298 uGGcGGcGGGAAAGcGucAdTsdT sense  329-348  299 UGACGCUUUCCCGCCGCCA  300 UGACGCUUUCCCGCCGCcAdTsdT antis  427-446  301 GCCCCGGCGCGGGCACUAG  302 GccccGGcGcGGGcAcuAGdTsdT sense  427-446  303 CUAGUGCCCGCGCCGGGGC  304 CuAGUGCCCGCGCCGGGGCdTsdT antis  428-447  305 CCCCGGCGCGGGCACUAGC  306 ccccGGcGcGGGcAcuAGcdTsdT sense  428-447  307 GCUAGUGCCCGCGCCGGGG  308 GCuAGUGCCCGCGCCGGGGdTsdT antis  429-448  309 CCCGGCGCGGGCACUAGCU  310 cccGGcGcGGGcAcuAGcudTsdT sense  429-448  311 AGCUAGUGCCCGCGCCGGG  312 AGCuAGUGCCCGCGCCGGGdTsdT antis  430-449  313 CCGGCGCGGGCACUAGCUU  314 ccGGcGcGGGcAcuAGcuudTsdT sense  430-449  315 AAGCUAGUGCCCGCGCCGG  316 AAGCuAGUGCCCGCGCCGGdTsdT antis  438-457  317 GGCACUAGCUUCCCGCCGC  318 GGcAcuAGcuucccGccGcdTsdT sense  438-457  319 GCGGCGGGAAGCUAGUGCC  320 GCGGCGGGAAGCuAGUGCCdTsdT antis  583-602  321 GAGUAGUAUACCAGGCACG  322 GAGuAGuAuAccAGGcAcGdTsdT sense  583-602  323 CGUGCCUGGUAUACUACUC  324 CGUGCCUGGuAuACuACUCdTsdT antis  654-673  325 AGGUUCAAGAACCGAGAAC  326 AGGuucAAGAAccGAGAAcdTsdT sense  654-673  327 GUUCUCGGUUCUUGAACCU  328 GUUCUCGGUUCUUGAACCUdTsdT antis  667-686  329 GAGAACUGCAGAUUAUGCG  330 GAGAAcuGcAGAuuAuGcGdTsdT sense  667-686  331 CGCAUAAUCUGCAGUUCUC  332 CGcAuAAUCUGcAGUUCUCdTsdT antis  928-947  333 AGCCCCAGAAUUUGCUUGU  334 AGccccAGAAuuuGcuuGudTsdT sense  928-947  335 ACAAGCAAAUUCUGGGGCU  336 AcAAGcAAAUUCUGGGGCUdTsdT antis  994-1013  337 AGCAGCUGGUUCGGGGGGA  338 AGcAGcuGGuucGGGGGGAdTsdT sense  994-1013  339 UCCCCCCGAACCAGCUGCU  340 UCCCCCCGAACcAGCUGCUdTsdT antis 1005-1024  341 CGGGGGGAGCCCAAUGUGU  342 cGGGGGGAGcccAAuGuGudTsdT sense 1005-1024  343 ACACAUUGGGCUCCCCCCG  344 AcAcAUUGGGCUCCCCCCGdTsdT antis 1008-1027  345 GGGGAGCCCAAUGUGUCCU  346 GGGGAGcccAAuGuGuccudTsdT sense 1008-1027  347 AGGACACAUUGGGCUCCCC  348 AGGAcAcAUUGGGCUCCCCdTsdT antis 1124-1143  349 UGAGCUACUUCUCGGCCAG  350 uGAGcuAcuucucGGccAGdTsdT sense 1124-1143  351 CUGGCCGAGAAGUAGCUCA  352 CUGGCCGAGAAGuAGCUcAdTsdT antis 1303-1322  353 CAAAGACACCACCUGAGGC  354 cAAAGAcAccAccuGAGGcdTsdT sense 1303-1322  355 GCCUCAGGUGGUGUCUUUG  356 GCCUcAGGUGGUGUCUUUGdTsdT antis 1311-1330  357 CCACCUGAGGCCAUUGCAC  358 ccAccuGAGGccAuuGcAcdTsdT sense 1311-1330  359 GUGCAAUGGCCUCAGGUGG  360 GUGcAAUGGCCUcAGGUGGdTsdT antis 1444-1463  361 GCCCGCUUCCCCCCCUGUU  362 GcccGcuucccccccuGuudTsdT sense 1444-1463  363 AACAGGGGGGGAAGCGGGC  364 AAcAGGGGGGGAAGCGGGCdTsdT antis 1488-1507  365 AUCCAACCAUCUCUCAAUG  366 AuccAAccAucucucAAuGdTsdT sense 1488-1507  367 CAUUGAGAGAUGGUUGGAU  368 cAUUGAGAGAUGGUUGGAUdTsdT antis 1851-1870  369 AUUUUAACUGUUUGUAGGG  370 AuuuuAAcuGuuuGuAGGGdTsdT sense 1851-1870  371 CCCUACAAACAGUUAAAAU  372 CCCuAcAAAcAGUuAAAAUdTsdT antis 1852-1871  373 UUUUAACUGUUUGUAGGGG  374 uuuuAAcuGuuuGuAGGGGdTsdT sense 1852-1871  375 CCCCUACAAACAGUUAAAA  376 CCCCuAcAAAcAGUuAAAAdTsdT antis 1935-1954  377 CUCCCCCAGGCUACCACUC  378 cucccccAGGcuAccAcucdTsdT sense 1935-1954  379 GAGUGGUAGCCUGGGGGAG  380 GAGUGGuAGCCUGGGGGAGdTsdT antis 1975-1994  381 GGUCCCUUGUAAAUAGAAC  382 GGucccuuGuAAAuAGAAcdTsdT sense 1975-1994  383 GUUCUAUUUACAAGGGACC  384 GUUCuAUUuAcAAGGGACCdTsdT antis 2029-2048  385 CCCCUGGGUGUAAAUAGAU  386 ccccuGGGuGuAAAuAGAudTsdT sense 2029-2048  387 AUCUAUUUACACCCAGGGG  388 AUCuAUUuAcACCcAGGGGdTsdT antis 2033-2052  389 UGGGUGUAAAUAGAUUGUU  390 uGGGuGuAAAuAGAuuGuudTsdT sense 2033-2052  391 AACAAUCUAUUUACACCCA  392 AAcAAUCuAUUuAcACCcAdTsdT antis 2062-2081  393 CUUAAAGAAAACGUCAAUU  394 cuuAAAGAAAAcGucAAuudTsdT sense 2062-2081  395 AAUUGACGUUUUCUUUAAG  396 AAUUGACGUUUUCUUuAAGdTsdT antis 2063-2082  397 UUAAAGAAAACGUCAAUUC  398 uuAAAGAAAAcGucAAuucdTsdT sense 2063-2082  399 GAAUUGACGUUUUCUUUAA  400 GAAUUGACGUUUUCUUuAAdTsdT antis 2078-2097  401 AUUCACACCAUUCAACUUG  402 AuucAcAccAuucAAcuuGdTsdT sense 2078-2097  403 CAAGUUGAAUGGUGUGAAU  404 cAAGUUGAAUGGUGUGAAUdTsdT antis 2082-2101  405 ACACCAUUCAACUUGCCCC  406 AcAccAuucAAcuuGccccdTsdT sense 2082-2101  407 GGGGCAAGUUGAAUGGUGU  408 GGGGcAAGUUGAAUGGUGUdTsdT antis 2181-2200  409 UCCCUGGUGUCUUAGUUUC  410 ucccuGGuGucuuAGuuucdTsdT sense 2181-2200  411 GAAACUAAGACACCAGGGA  412 GAAACuAAGAcACcAGGGAdTsdT antis 2197-2216  413 UUCCACAGUAAGGUUUGCC  414 uuccAcAGuAAGGuuuGccdTsdT sense 2197-2216  415 GGCAAACCUUACUGUGGAA  416 GGcAAACCUuACUGUGGAAdTsdT antis 2209-2228  417 GUUUGCCUGUGUACAGACC  418 GuuuGccuGuGuAcAGAccdTsdT sense 2209-2228  419 GGUCUGUACACAGGCAAAC  420 GGUCUGuAcAcAGGcAAACdTsdT antis 2232-2251  421 UUCAAUAAAUUAUUGGCAU  422 uucAAuAAAuuAuuGGcAudTsdT sense 2232-2251  423 AUGCCAAUAAUUUAUUGAA  424 AUGCcAAuAAUUuAUUGAAdTsdT antis 2235-2254  425 AAUAAAUUAUUGGCAUGAA  426 AAuAAAuuAuuGGcAuGAAdTsdT sense 2235-2254  427 UUCAUGCCAAUAAUUUAUU  428 UUcAUGCcAAuAAUUuAUUdTsdT antis 2243-2262  429 AUUGGCAUGAAACCCUUAA  430 AuuGGcAuGAAAcccuuAAdTsdT sense 2243-2262  431 UUAAGGGUUUCAUGCCAAU  432 UuAAGGGUUUcAUGCcAAUdTsdT antis  336-355  433 GGGAAAGCGUCAGUCGGGG  434 GGGAAAGcGucAGucGGGGdTsdT sense  336-355  435 CCCCGACUGACGCUUUCCC  436 CCCCGACUGACGCUUUCCCdTsdT antis  894-913  437 AUCCACUCCCAAGGUGUGU  438 AuccAcucccAAGGuGuGudTsdT sense  894-913  439 ACACACCUUGGGAGUGGAU  440 AcAcACCUUGGGAGUGGAUdTsdT antis 1070-1089  441 AGCCACAGAUUACACCUCG  442 AGccAcAGAuuAcAccucGdTsdT sense 1070-1089  443 CGAGGUGUAAUCUGUGGCU  444 CGAGGUGuAAUCUGUGGCUdTsdT antis 1346-1365  445 GGAGUACACGCCAUCCUCA  446 GGAGuAcAcGccAuccucAdTsdT sense 1346-1365  447 UGAGGAUGGCGUGUACUCC  448 UGAGGAUGGCGUGuACUCCdTsdT antis 1976-1995  449 GUCCCUUGUAAAUAGAACC  450 GucccuuGuAAAuAGAAccdTsdT sense 1976-1995  451 GGUUCUAUUUACAAGGGAC  452 GGUUCuAUUuAcAAGGGACdTsdT antis 1977-1996  453 UCCCUUGUAAAUAGAACCA  454 ucccuuGuAAAuAGAAccAdTsdT sense 1977-1996  455 UGGUUCUAUUUACAAGGGA  456 UGGUUCuAUUuAcAAGGGAdTsdT antis 2194-2213  457 AGUUUCCACAGUAAGGUUU  458 AGuuuccAcAGuAAGGuuudTsdT sense 2194-2213  459 AAACCUUACUGUGGAAACU  460 AAACCUuACUGUGGAAACUdTsdT antis 1229-1248  461 GAUGAACCCUAACUAUACG  462 GAuGAAcccuAAcuAuAcGdTsdT sense 1229-1248  463 CGUAUAGUUAGGGUUCAUC  464 CGuAuAGUuAGGGUUcAUCdTsdT antis  341-360  465 AGCGUCAGUCGGGGCUAUG  466 AGcGucAGucGGGGcuAuGdTsdT sense  341-360  467 CAUAGCCCCGACUGACGCU  468 cAuAGCCCCGACUGACGCUdTsdT antis  574-593  469 GCUCAUUCGGAGUAGUAUA  470 GcucAuucGGAGuAGuAuAdTsdT sense  574-593  471 UAUACUACUCCGAAUGAGC  472 uAuACuACUCCGAAUGAGCdTsdT antis  578-597  473 AUUCGGAGUAGUAUACCAG  474 AuucGGAGuAGuAuAccAGdTsdT sense  578-597  475 CUGGUAUACUACUCCGAAU  476 CUGGuAuACuACUCCGAAUdTsdT antis  672-691  477 CUGCAGAUUAUGCGUAAGC  478 cuGcAGAuuAuGcGuAAGcdTsdT sense  672-691  479 GCUUACGCAUAAUCUGCAG  480 GCUuACGcAuAAUCUGcAGdTsdT antis  673-692  481 UGCAGAUUAUGCGUAAGCU  482 uGcAGAuuAuGcGuAAGcudTsdT sense  673-692  483 AGCUUACGCAUAAUCUGCA  484 AGCUuACGcAuAAUCUGcAdTsdT antis  674-693  485 GCAGAUUAUGCGUAAGCUG  486 GcAGAuuAuGcGuAAGcuGdTsdT sense  674-693  487 CAGCUUACGCAUAAUCUGC  488 cAGCUuACGcAuAAUCUGCdTsdT antis 1433-1452  489 CCCCAACGACCGCCCGCUU  490 ccccAAcGAccGcccGcuudTsdT sense 1433-1452  491 AAGCGGGCGGUCGUUGGGG  492 AAGCGGGCGGUCGUUGGGGdTsdT antis 1434-1453  493 CCCAACGACCGCCCGCUUC  494 cccAAcGAccGcccGcuucdTsdT sense 1434-1453  495 GAAGCGGGCGGUCGUUGGG  496 GAAGCGGGCGGUCGUUGGGdTsdT antis 1640-1659  497 UGCUACCCUCGCUAGCUCU  498 uGcuAcccucGcuAGcucudTsdT sense 1640-1659  499 AGAGCUAGCGAGGGUAGCA  500 AGAGCuAGCGAGGGuAGcAdTsdT antis  458-477  501 GGGAGUGAAGCUGGGCCGU  502 GGGAGuGAAGcuGGGccGudTsdT sense  458-477  503 ACGGCCCAGCUUCACUCCC  504 ACGGCCcAGCUUcACUCCCdTsdT antis  459-478  505 GGAGUGAAGCUGGGCCGUG  506 GGAGuGAAGcuGGGccGuGdTsdT sense  459-478  507 CACGGCCCAGCUUCACUCC  508 cACGGCCcAGCUUcACUCCdTsdT antis  573-592  509 GGCUCAUUCGGAGUAGUAU  510 GGcucAuucGGAGuAGuAudTsdT sense  573-592  511 AUACUACUCCGAAUGAGCC  512 AuACuACUCCGAAUGAGCCdTsdT antis  575-594  513 CUCAUUCGGAGUAGUAUAC  514 cucAuucGGAGuAGuAuAcdTsdT sense  575-594  515 GUAUACUACUCCGAAUGAG  516 GuAuACuACUCCGAAUGAGdTsdT antis  576-595  517 UCAUUCGGAGUAGUAUACC  518 ucAuucGGAGuAGuAuAccdTsdT sense  576-595  519 GGUAUACUACUCCGAAUGA  520 GGuAuACuACUCCGAAUGAdTsdT antis  577-596  521 CAUUCGGAGUAGUAUACCA  522 cAuucGGAGuAGuAuAccAdTsdT sense  577-596  523 UGGUAUACUACUCCGAAUG  524 UGGuAuACuACUCCGAAUGdTsdT antis  579-598  525 UUCGGAGUAGUAUACCAGG  526 uucGGAGuAGuAuAccAGGdTsdT sense  579-598  527 CCUGGUAUACUACUCCGAA  528 CCUGGuAuACuACUCCGAAdTsdT antis  671-690  529 ACUGCAGAUUAUGCGUAAG  530 AcuGcAGAuuAuGcGuAAGdTsdT sense  671-690  531 CUUACGCAUAAUCUGCAGU  532 CUuACGcAuAAUCUGcAGUdTsdT antis  786-805  533 CCCGAGACGGUGUACCGAG  534 cccGAGAcGGuGuAccGAGdTsdT sense  786-805  535 CUCGGUACACCGUCUCGGG  536 CUCGGuAcACCGUCUCGGGdTsdT antis  787-806  537 CCGAGACGGUGUACCGAGU  538 ccGAGAcGGuGuAccGAGudTsdT sense  787-806  539 ACUCGGUACACCGUCUCGG  540 ACUCGGuAcACCGUCUCGGdTsdT antis  789-808  541 GAGACGGUGUACCGAGUGG  542 GAGAcGGuGuAccGAGuGGdTsdT sense  789-808  543 CCACUCGGUACACCGUCUC  544 CcACUCGGuAcACCGUCUCdTsdT antis 1065-1084  545 UUUGGAGCCACAGAUUACA  546 uuuGGAGccAcAGAuuAcAdTsdT sense 1065-1084  547 UGUAAUCUGUGGCUCCAAA  548 UGuAAUCUGUGGCUCcAAAdTsdT antis 1226-1245  549 AGAGAUGAACCCUAACUAU  550 AGAGAuGAAcccuAAcuAudTsdT sense 1226-1245  551 AUAGUUAGGGUUCAUCUCU  552 AuAGUuAGGGUUcAUCUCUdTsdT antis 1228-1247  553 AGAUGAACCCUAACUAUAC  554 AGAuGAAcccuAAcuAuAcdTsdT sense 1228-1247  555 GUAUAGUUAGGGUUCAUCU  556 GuAuAGUuAGGGUUcAUCUdTsdT antis 1636-1655  557 CAACUGCUACCCUCGCUAG  558 cAAcuGcuAcccucGcuAGdTsdT sense 1636-1655  559 CUAGCGAGGGUAGCAGUUG  560 CuAGCGAGGGuAGcAGUUGdTsdT antis 1639-1658  561 CUGCUACCCUCGCUAGCUC  562 cuGcuAcccucGcuAGcucdTsdT sense 1639-1658  563 GAGCUAGCGAGGGUAGCAG  564 GAGCuAGCGAGGGuAGcAGdTsdT antis 2036-2055  565 GUGUAAAUAGAUUGUUAUA  566 GuGuAAAuAGAuuGuuAuAdTsdT sense 2036-2055  567 UAUAACAAUCUAUUUACAC  568 uAuAAcAAUCuAUUuAcACdTsdT antis  426-445  569 GGCCCCGGCGCGGGCACUA  570 GGccccGGcGcGGGcAcuAdTsdT sense  426-445  571 UAGUGCCCGCGCCGGGGCC  572 uAGUGCCCGCGCCGGGGCCdTsdT antis  883-902  573 GCUUGGCCUACAUCCACUC  574 GcuuGGccuAcAuccAcucdTsdT sense  883-902  575 GAGUGGAUGUAGGCCAAGC  576 GAGUGGAUGuAGGCcAAGCdTsdT antis 1227-1246  577 GAGAUGAACCCUAACUAUA  578 GAGAuGAAcccuAAcuAuAdTsdT sense 1227-1246  579 UAUAGUUAGGGUUCAUCUC  580 uAuAGUuAGGGUUcAUCUCdTsdT antis 1369-1388  581 UCUCCCCACUCGAGGCUUG  582 ucuccccAcucGAGGcuuGdTsdT sense 1369-1388  583 CAAGCCUCGAGUGGGGAGA  584 cAAGCCUCGAGUGGGGAGAdTsdT antis 1393-1412  585 ACAGCUUCUUCGAUGAACU  586 AcAGcuucuucGAuGAAcudTsdT sense 1393-1412  587 AGUUCAUCGAAGAAGCUGU  588 AGUUcAUCGAAGAAGCUGUdTsdT antis 1431-1450  589 CUCCCCAACGACCGCCCGC  590 cuccccAAcGAccGcccGcdTsdT sense 1431-1450  591 GCGGGCGGUCGUUGGGGAG  592 GCGGGCGGUCGUUGGGGAGdTsdT antis 1436-1455  593 CAACGACCGCCCGCUUCCC  594 cAAcGAccGcccGcuucccdTsdT sense 1436-1455  595 GGGAAGCGGGCGGUCGUUG  596 GGGAAGCGGGCGGUCGUUGdTsdT antis 1437-1456  597 AACGACCGCCCGCUUCCCC  598 AAcGAccGcccGcuuccccdTsdT sense 1437-1456  599 GGGGAAGCGGGCGGUCGUU  600 GGGGAAGCGGGCGGUCGUUdTsdT antis 2176-2195  601 GAGAGUCCCUGGUGUCUUA  602 GAGAGucccuGGuGucuuAdTsdT sense 2176-2195  603 UAAGACACCAGGGACUCUC  604 uAAGAcACcAGGGACUCUCdTsdT antis  599-618  605 ACGGCUGGCAGAGACGAGG  606 AcGGcuGGcAGAGAcGAGGdTsdT sense  599-618  607 CCUCGUCUCUGCCAGCCGU  608 CCUCGUCUCUGCcAGCCGUdTsdT antis  706-725  609 UUGUGAGGCUGCGGUACUU  610 uuGuGAGGcuGcGGuAcuudTsdT sense  706-725  611 AAGUACCGCAGCCUCACAA  612 AAGuACCGcAGCCUcAcAAdTsdT antis  707-726  613 UGUGAGGCUGCGGUACUUU  614 uGuGAGGcuGcGGuAcuuudTsdT sense  707-726  615 AAAGUACCGCAGCCUCACA  616 AAAGuACCGcAGCCUcAcAdTsdT antis  791-810  617 GACGGUGUACCGAGUGGCC  618 GAcGGuGuAccGAGuGGccdTsdT sense  791-810  619 GGCCACUCGGUACACCGUC  620 GGCcACUCGGuAcACCGUCdTsdT antis  899-918  621 CUCCCAAGGUGUGUGUCAC  622 cucccAAGGuGuGuGucAcdTsdT sense  899-918  623 GUGACACACACCUUGGGAG  624 GUGAcAcAcACCUUGGGAGdTsdT antis  989-1008  625 UGCAAAGCAGCUGGUUCGG  626 uGcAAAGcAGcuGGuucGGdTsdT sense  989-1008  627 CCGAACCAGCUGCUUUGCA  628 CCGAACcAGCUGCUUUGcAdTsdT antis 1064-1083  629 CUUUGGAGCCACAGAUUAC  630 cuuuGGAGccAcAGAuuAcdTsdT sense 1064-1083  631 GUAAUCUGUGGCUCCAAAG  632 GuAAUCUGUGGCUCcAAAGdTsdT antis 1066-1085  633 UUGGAGCCACAGAUUACAC  634 uuGGAGccAcAGAuuAcAcdTsdT sense 1066-1085  635 GUGUAAUCUGUGGCUCCAA  636 GUGuAAUCUGUGGCUCcAAdTsdT antis 1125-1144  637 GAGCUACUUCUCGGCCAGC  638 GAGcuAcuucucGGccAGcdTsdT sense 1125-1144  639 GCUGGCCGAGAAGUAGCUC  640 GCUGGCCGAGAAGuAGCUCdTsdT antis 1225-1244  641 GAGAGAUGAACCCUAACUA  642 GAGAGAuGAAcccuAAcuAdTsdT sense 1225-1244  643 UAGUUAGGGUUCAUCUCUC  644 uAGUuAGGGUUcAUCUCUCdTsdT antis 1265-1284  645 GAUCAAAGCUCACCCUUGG  646 GAucAAAGcucAcccuuGGdTsdT sense 1265-1284  647 CCAAGGGUGAGCUUUGAUC  648 CcAAGGGUGAGCUUUGAUCdTsdT antis 1269-1288  649 AAAGCUCACCCUUGGACAA  650 AAAGcucAcccuuGGAcAAdTsdT sense 1269-1288  651 UUGUCCAAGGGUGAGCUUU  652 UUGUCcAAGGGUGAGCUUUdTsdT antis 1365-1384  653 AGGCUCUCCCCACUCGAGG  654 AGGcucuccccAcucGAGGdTsdT sense 1365-1384  655 CCUCGAGUGGGGAGAGCCU  656 CCUCGAGUGGGGAGAGCCUdTsdT antis 1481-1500  657 ACUGUCCAUCCAACCAUCU  658 AcuGuccAuccAAccAucudTsdT sense 1481-1500  659 AGAUGGUUGGAUGGACAGU  660 AGAUGGUUGGAUGGAcAGUdTsdT antis 1637-1656  661 AACUGCUACCCUCGCUAGC  662 AAcuGcuAcccucGcuAGcdTsdT sense 1637-1656  663 GCUAGCGAGGGUAGCAGUU  664 GCuAGCGAGGGuAGcAGUUdTsdT antis 1979-1998  665 CCUUGUAAAUAGAACCAGC  666 ccuuGuAAAuAGAAccAGcdTsdT sense 1979-1998  667 GCUGGUUCUAUUUACAAGG  668 GCUGGUUCuAUUuAcAAGGdTsdT antis 2196-2215  669 UUUCCACAGUAAGGUUUGC  670 uuuccAcAGuAAGGuuuGcdTsdT sense 2196-2215  671 GCAAACCUUACUGUGGAAA  672 GcAAACCUuACUGUGGAAAdTsdT antis 1978-1997  673 CCCUUGUAAAUAGAACCAG  674 cccuuGuAAAuAGAAccAGdTsdT sense 1978-1997  675 CUGGUUCUAUUUACAAGGG  676 CUGGUUCuAUUuAcAAGGGdTsdT antis  651-670  677 AAAAGGUUCAAGAACCGAG  678 AAAAGGuucAAGAAccGAGdTsdT sense  651-670  679 CUCGGUUCUUGAACCUUUU  680 CUCGGUUCUUGAACCUUUUdTsdT antis  702-721  681 AAUAUUGUGAGGCUGCGGU  682 AAuAuuGuGAGGcuGcGGudTsdT sense  702-721  683 ACCGCAGCCUCACAAUAUU  684 ACCGcAGCCUcAcAAuAUUdTsdT antis 1363-1382  685 CAAGGCUCUCCCCACUCGA  686 cAAGGcucuccccAcucGAdTsdT sense 1363-1382  687 UCGAGUGGGGAGAGCCUUG  688 UCGAGUGGGGAGAGCCUUGdTsdT antis  701-720  689 CAAUAUUGUGAGGCUGCGG  690 cAAuAuuGuGAGGcuGcGGdTsdT sense  701-720  691 CCGCAGCCUCACAAUAUUG  692 CCGcAGCCUcAcAAuAUUGdTsdT antis 1237-1256  693 CUAACUAUACGGAGUUCAA  694 cuAAcuAuAcGGAGuucAAdTsdT sense 1237-1256  695 UUGAACUCCGUAUAGUUAG  696 UUGAACUCCGuAuAGUuAGdTsdT antis 2064-2083  697 UAAAGAAAACGUCAAUUCA  698 uAAAGAAAAcGucAAuucAdTsdT sense 2064-2083  699 UGAAUUGACGUUUUCUUUA  700 UGAAUUGACGUUUUCUUuAdTsdT antis  828-847  701 AAGCUGAUCACCCCUAUCA  702 AAGcuGAucAccccuAucAdTsdT sense  828-847  703 UGAUAGGGGUGAUCAGCUU  704 UGAuAGGGGUGAUcAGCUUdTsdT antis  930-949  705 CCCCAGAAUUUGCUUGUGG  706 ccccAGAAuuuGcuuGuGGdTsdT sense  930-949  707 CCACAAGCAAAUUCUGGGG  708 CcAcAAGcAAAUUCUGGGGdTsdT antis  995-1014  709 GCAGCUGGUUCGGGGGGAG  710 GcAGcuGGuucGGGGGGAGdTsdT sense  995-1014  711 CUCCCCCCGAACCAGCUGC  712 CUCCCCCCGAACcAGCUGCdTsdT antis 1478-1497  713 UGAACUGUCCAUCCAACCA  714 uGAAcuGuccAuccAAccAdTsdT sense 1478-1497  715 UGGUUGGAUGGACAGUUCA  716 UGGUUGGAUGGAcAGUUcAdTsdT antis 1604-1623  717 GACUGGCCAAGAUUGGCAG  718 GAcuGGccAAGAuuGGcAGdTsdT sense 1604-1623  719 CUGCCAAUCUUGGCCAGUC  720 CUGCcAAUCUUGGCcAGUCdTsdT antis 1808-1827  721 CUCCCUCAGCAGCCUAACC  722 cucccucAGcAGccuAAccdTsdT sense 1808-1827  723 GGUUAGGCUGCUGAGGGAG  724 GGUuAGGCUGCUGAGGGAGdTsdT antis 2177-2196  725 AGAGUCCCUGGUGUCUUAG  726 AGAGucccuGGuGucuuAGdTsdT sense 2177-2196  727 CUAAGACACCAGGGACUCU  728 CuAAGAcACcAGGGACUCUdTsdT antis   82-101  729 GAACGGCGCGGCCUGGAAG  730 GAAcGGcGcGGccuGGAAGdTsdT sense   82-101  731 CUUCCAGGCCGCGCCGUUC  732 CUUCcAGGCCGCGCCGUUCdTsdT antis 1077-1096  733 GAUUACACCUCGUCCAUCG  734 GAuuAcAccucGuccAucGdTsdT sense 1077-1096  735 CGAUGGACGAGGUGUAAUC  736 CGAUGGACGAGGUGuAAUCdTsdT antis 1238-1257  737 UAACUAUACGGAGUUCAAG  738 uAAcuAuAcGGAGuucAAGdTsdT sense 1238-1257  739 CUUGAACUCCGUAUAGUUA  740 CUUGAACUCCGuAuAGUuAdTsdT antis  248-267  741 CAGCUCGUUCGCGGAGCCA  742 cAGcucGuucGcGGAGccAdTsdT sense  248-267  743 UGGCUCCGCGAACGAGCUG  744 UGGCUCCGCGAACGAGCUGdTsdT antis  250-269  745 GCUCGUUCGCGGAGCCAGG  746 GcucGuucGcGGAGccAGGdTsdT sense  250-269  747 CCUGGCUCCGCGAACGAGC  748 CCUGGCUCCGCGAACGAGCdTsdT antis  327-346  749 ACUGGCGGCGGGAAAGCGU  750 AcuGGcGGcGGGAAAGcGudTsdT sense  327-346  751 ACGCUUUCCCGCCGCCAGU  752 ACGCUUUCCCGCCGCcAGUdTsdT antis  332-351  753 CGGCGGGAAAGCGUCAGUC  754 cGGcGGGAAAGcGucAGucdTsdT sense  332-351  755 GACUGACGCUUUCCCGCCG  756 GACUGACGCUUUCCCGCCGdTsdT antis  376-395  757 CCUCGAGCUCCGGGGGUGG  758 ccucGAGcuccGGGGGuGGdTsdT sense  376-395  759 CCACCCCCGGAGCUCGAGG  760 CcACCCCCGGAGCUCGAGGdTsdT antis  468-487  761 CUGGGCCGUGACAGCGGGA  762 cuGGGccGuGAcAGcGGGAdTsdT sense  468-487  763 UCCCGCUGUCACGGCCCAG  764 UCCCGCUGUcACGGCCcAGdTsdT antis  584-603  765 AGUAGUAUACCAGGCACGG  766 AGuAGuAuAccAGGcAcGGdTsdT sense  584-603  767 CCGUGCCUGGUAUACUACU  768 CCGUGCCUGGuAuACuACUdTsdT antis  785-804  769 GCCCGAGACGGUGUACCGA  770 GcccGAGAcGGuGuAccGAdTsdT sense  785-804  771 UCGGUACACCGUCUCGGGC  772 UCGGuAcACCGUCUCGGGCdTsdT antis 1010-1029  773 GGAGCCCAAUGUGUCCUAC  774 GGAGcccAAuGuGuccuAcdTsdT sense 1010-1029  775 GUAGGACACAUUGGGCUCC  776 GuAGGAcAcAUUGGGCUCCdTsdT antis 1011-1030  777 GAGCCCAAUGUGUCCUACA  778 GAGcccAAuGuGuccuAcAdTsdT sense 1011-1030  779 UGUAGGACACAUUGGGCUC  780 UGuAGGAcAcAUUGGGCUCdTsdT antis 1021-1040  781 UGUCCUACAUCUGCUCUCG  782 uGuccuAcAucuGcucucGdTsdT sense 1021-1040  783 CGAGAGCAGAUGUAGGACA  784 CGAGAGcAGAUGuAGGAcAdTsdT antis 1022-1041  785 GUCCUACAUCUGCUCUCGG  786 GuccuAcAucuGcucucGGdTsdT sense 1022-1041  787 CCGAGAGCAGAUGUAGGAC  788 CCGAGAGcAGAUGuAGGACdTsdT antis 1023-1042  789 UCCUACAUCUGCUCUCGGU  790 uccuAcAucuGcucucGGudTsdT sense 1023-1042  791 ACCGAGAGCAGAUGUAGGA  792 ACCGAGAGcAGAUGuAGGAdTsdT antis 1072-1091  793 CCACAGAUUACACCUCGUC  794 ccAcAGAuuAcAccucGucdTsdT sense 1072-1091  795 GACGAGGUGUAAUCUGUGG  796 GACGAGGUGuAAUCUGUGGdTsdT antis 1127-1146  797 GCUACUUCUCGGCCAGCCC  798 GcuAcuucucGGccAGcccdTsdT sense 1127-1146  799 GGGCUGGCCGAGAAGUAGC  800 GGGCUGGCCGAGAAGuAGCdTsdT antis 1408-1427  801 AACUGCGGAGACUCGGAGC  802 AAcuGcGGAGAcucGGAGcdTsdT sense 1408-1427  803 GCUCCGAGUCUCCGCAGUU  804 GCUCCGAGUCUCCGcAGUUdTsdT antis 1432-1451  805 UCCCCAACGACCGCCCGCU  806 uccccAAcGAccGcccGcudTsdT sense 1432-1451  807 AGCGGGCGGUCGUUGGGGA  808 AGCGGGCGGUCGUUGGGGAdTsdT antis 1982-2001  809 UGUAAAUAGAACCAGCCCA  810 uGuAAAuAGAAccAGcccAdTsdT sense 1982-2001  811 UGGGCUGGUUCUAUUUACA  812 UGGGCUGGUUCuAUUuAcAdTsdT antis 2030-2049  813 CCCUGGGUGUAAAUAGAUU  814 cccuGGGuGuAAAuAGAuudTsdT sense 2030-2049  815 AAUCUAUUUACACCCAGGG  816 AAUCuAUUuAcACCcAGGGdTsdT antis 2073-2092  817 CGUCAAUUCACACCAUUCA  818 cGucAAuucAcAccAuucAdTsdT sense 2073-2092  819 UGAAUGGUGUGAAUUGACG  820 UGAAUGGUGUGAAUUGACGdTsdT antis 2218-2237  821 UGUACAGACCUCUGUUCAA  822 uGuAcAGAccucuGuucAAdTsdT sense 2218-2237  823 UUGAACAGAGGUCUGUACA  824 UUGAAcAGAGGUCUGuAcAdTsdT antis 2229-2248  825 CUGUUCAAUAAAUUAUUGG  826 cuGuucAAuAAAuuAuuGGdTsdT sense 2229-2248  827 CCAAUAAUUUAUUGAACAG  828 CcAAuAAUUuAUUGAAcAGdTsdT antis    7-26  829 ACAACGAAGCCGACGGCAG  830 AcAAcGAAGccGAcGGcAGdTsdT sense    7-26  831 CUGCCGUCGGCUUCGUUGU  832 CUGCCGUCGGCUUCGUUGUdTsdT antis    8-27  833 CAACGAAGCCGACGGCAGA  834 cAAcGAAGccGAcGGcAGAdTsdT sense    8-27  835 UCUGCCGUCGGCUUCGUUG  836 UCUGCCGUCGGCUUCGUUGdTsdT antis   76-95  837 GAGCCCGAACGGCGCGGCC  838 GAGcccGAAcGGcGcGGccdTsdT sense   76-95  839 GGCCGCGCCGUUCGGGCUC  840 GGCCGCGCCGUUCGGGCUCdTsdT antis  176-195  841 GCCUGCGCUCGGCGCCAUG  842 GccuGcGcucGGcGccAuGdTsdT sense  176-195  843 CAUGGCGCCGAGCGCAGGC  844 cAUGGCGCCGAGCGcAGGCdTsdT antis  434-453  845 CGCGGGCACUAGCUUCCCG  846 cGcGGGcAcuAGcuucccGdTsdT sense  434-453  847 CGGGAAGCUAGUGCCCGCG  848 CGGGAAGCuAGUGCCCGCGdTsdT antis  472-491  849 GCCGUGACAGCGGGAAGGU  850 GccGuGAcAGcGGGAAGGudTsdT sense  472-491  851 ACCUUCCCGCUGUCACGGC  852 ACCUUCCCGCUGUcACGGCdTsdT antis  537-556  853 GAAGUGGCUUACACUGACA  854 GAAGuGGcuuAcAcuGAcAdTsdT sense  537-556  855 UGUCAGUGUAAGCCACUUC  856 UGUcAGUGuAAGCcACUUCdTsdT antis  656-675  857 GUUCAAGAACCGAGAACUG  858 GuucAAGAAccGAGAAcuGdTsdT sense  656-675  859 CAGUUCUCGGUUCUUGAAC  860 cAGUUCUCGGUUCUUGAACdTsdT antis  657-676  861 UUCAAGAACCGAGAACUGC  862 uucAAGAAccGAGAAcuGcdTsdT sense  657-676  863 GCAGUUCUCGGUUCUUGAA  864 GcAGUUCUCGGUUCUUGAAdTsdT antis  784-803  865 UGCCCGAGACGGUGUACCG  866 uGcccGAGAcGGuGuAccGdTsdT sense  784-803  867 CGGUACACCGUCUCGGGCA  868 CGGuAcACCGUCUCGGGcAdTsdT antis 1404-1423  869 GAUGAACUGCGGAGACUCG  870 GAuGAAcuGcGGAGAcucGdTsdT sense 1404-1423  871 CGAGUCUCCGCAGUUCAUC  872 CGAGUCUCCGcAGUUcAUCdTsdT antis 1405-1424  873 AUGAACUGCGGAGACUCGG  874 AuGAAcuGcGGAGAcucGGdTsdT sense 1405-1424  875 CCGAGUCUCCGCAGUUCAU  876 CCGAGUCUCCGcAGUUcAUdTsdT antis 1445-1464  877 CCCGCUUCCCCCCCUGUUC  878 cccGcuucccccccuGuucdTsdT sense 1445-1464  879 GAACAGGGGGGGAAGCGGG  880 GAAcAGGGGGGGAAGCGGGdTsdT antis 1446-1465  881 CCGCUUCCCCCCCUGUUCA  882 ccGcuucccccccuGuucAdTsdT sense 1446-1465  883 UGAACAGGGGGGGAAGCGG  884 UGAAcAGGGGGGGAAGCGGdTsdT antis 1470-1489  885 AGUCCUGGUGAACUGUCCA  886 AGuccuGGuGAAcuGuccAdTsdT sense 1470-1489  887 UGGACAGUUCACCAGGACU  888 UGGAcAGUUcACcAGGACUdTsdT antis 1897-1916  889 GGGGGUGUGAGGACCUUCU  890 GGGGGuGuGAGGAccuucudTsdT sense 1897-1916  891 AGAAGGUCCUCACACCCCC  892 AGAAGGUCCUcAcACCCCCdTsdT antis 1937-1956  893 CCCCCAGGCUACCACUCCU  894 cccccAGGcuAccAcuccudTsdT sense 1937-1956  895 AGGAGUGGUAGCCUGGGGG  896 AGGAGUGGuAGCCUGGGGGdTsdT antis 1981-2000  897 UUGUAAAUAGAACCAGCCC  898 uuGuAAAuAGAAccAGcccdTsdT sense 1981-2000  899 GGGCUGGUUCUAUUUACAA  900 GGGCUGGUUCuAUUuAcAAdTsdT antis 1985-2004  901 AAAUAGAACCAGCCCAGCC  902 AAAuAGAAccAGcccAGccdTsdT sense 1985-2004  903 GGCUGGGCUGGUUCUAUUU  904 GGCUGGGCUGGUUCuAUUUdTsdT antis 2061-2080  905 UCUUAAAGAAAACGUCAAU  906 ucuuAAAGAAAAcGucAAudTsdT sense 2061-2080  907 AUUGACGUUUUCUUUAAGA  908 AUUGACGUUUUCUUuAAGAdTsdT antis 2065-2084  909 AAAGAAAACGUCAAUUCAC  910 AAAGAAAAcGucAAuucAcdTsdT sense 2065-2084  911 GUGAAUUGACGUUUUCUUU  912 GUGAAUUGACGUUUUCUUUdTsdT antis    1-20  913 GUGGUGACAACGAAGCCGA  914 GuGGuGAcAAcGAAGccGAdTsdT sense    1-20  915 UCGGCUUCGUUGUCACCAC  916 UCGGCUUCGUUGUcACcACdTsdT antis   11-30  917 CGAAGCCGACGGCAGAGGG  918 cGAAGccGAcGGcAGAGGGdTsdT sense   11-30  919 CCCUCUGCCGUCGGCUUCG  920 CCCUCUGCCGUCGGCUUCGdTsdT antis   70-89  921 GAGCCGGAGCCCGAACGGC  922 GAGccGGAGcccGAAcGGcdTsdT sense   70-89  923 GCCGUUCGGGCUCCGGCUC  924 GCCGUUCGGGCUCCGGCUCdTsdT antis   73-92  925 CCGGAGCCCGAACGGCGCG  926 ccGGAGcccGAAcGGcGcGdTsdT sense   73-92  927 CGCGCCGUUCGGGCUCCGG  928 CGCGCCGUUCGGGCUCCGGdTsdT antis  150-169  929 CAGGCAGCCCGAGCCCCGC  930 cAGGcAGcccGAGccccGcdTsdT sense  150-169  931 GCGGGGCUCGGGCUGCCUG  932 GCGGGGCUCGGGCUGCCUGdTsdT antis  178-197  933 CUGCGCUCGGCGCCAUGAG  934 cuGcGcucGGcGccAuGAGdTsdT sense  178-197  935 CUCAUGGCGCCGAGCGCAG  936 CUcAUGGCGCCGAGCGcAGdTsdT antis  180-199  937 GCGCUCGGCGCCAUGAGCG  938 GcGcucGGcGccAuGAGcGdTsdT sense  180-199  939 CGCUCAUGGCGCCGAGCGC  940 CGCUcAUGGCGCCGAGCGCdTsdT antis  196-215  941 GCGGCGGCGGGCCUUCGGG  942 GcGGcGGcGGGccuucGGGdTsdT sense  196-215  943 CCCGAAGGCCCGCCGCCGC  944 CCCGAAGGCCCGCCGCCGCdTsdT antis  202-221  945 GCGGGCCUUCGGGAGGCGG  946 GcGGGccuucGGGAGGcGGdTsdT sense  202-221  947 CCGCCUCCCGAAGGCCCGC  948 CCGCCUCCCGAAGGCCCGCdTsdT antis  223-242  949 CUGGGGGCUCGGGCCGGGC  950 cuGGGGGcucGGGccGGGcdTsdT sense  223-242  951 GCCCGGCCCGAGCCCCCAG  952 GCCCGGCCCGAGCCCCcAGdTsdT antis  238-257  953 GGGCGCGGACCAGCUCGUU  954 GGGcGcGGAccAGcucGuudTsdT sense  238-257  955 AACGAGCUGGUCCGCGCCC  956 AACGAGCUGGUCCGCGCCCdTsdT antis  317-336  957 CCCAGGAGGCACUGGCGGC  958 cccAGGAGGcAcuGGcGGcdTsdT sense  317-336  959 GCCGCCAGUGCCUCCUGGG  960 GCCGCcAGUGCCUCCUGGGdTsdT antis  337-356  961 GGAAAGCGUCAGUCGGGGC  962 GGAAAGcGucAGucGGGGcdTsdT sense  337-356  963 GCCCCGACUGACGCUUUCC  964 GCCCCGACUGACGCUUUCCdTsdT antis  436-455  965 CGGGCACUAGCUUCCCGCC  966 cGGGcAcuAGcuucccGccdTsdT sense  436-455  967 GGCGGGAAGCUAGUGCCCG  968 GGCGGGAAGCuAGUGCCCGdTsdT antis  449-468  969 CCCGCCGCCGGGAGUGAAG  970 cccGccGccGGGAGuGAAGdTsdT sense  449-468  971 CUUCACUCCCGGCGGCGGG  972 CUUcACUCCCGGCGGCGGGdTsdT antis  464-483  973 GAAGCUGGGCCGUGACAGC  974 GAAGcuGGGccGuGAcAGcdTsdT sense  464-483  975 GCUGUCACGGCCCAGCUUC  976 GCUGUcACGGCCcAGCUUCdTsdT antis  534-553  977 CAAGAAGUGGCUUACACUG  978 cAAGAAGuGGcuuAcAcuGdTsdT sense  534-553  979 CAGUGUAAGCCACUUCUUG  980 cAGUGuAAGCcACUUCUUGdTsdT antis  535-554  981 AAGAAGUGGCUUACACUGA  982 AAGAAGuGGcuuAcAcuGAdTsdT sense  535-554  983 UCAGUGUAAGCCACUUCUU  984 UcAGUGuAAGCcACUUCUUdTsdT antis  536-555  985 AGAAGUGGCUUACACUGAC  986 AGAAGuGGcuuAcAcuGAcdTsdT sense  536-555  987 GUCAGUGUAAGCCACUUCU  988 GUcAGUGuAAGCcACUUCUdTsdT antis  821-840  989 CAAGGCCAAGCUGAUCACC  990 cAAGGccAAGcuGAucAccdTsdT sense  821-840  991 GGUGAUCAGCUUGGCCUUG  992 GGUGAUcAGCUUGGCCUUGdTsdT antis  826-845  993 CCAAGCUGAUCACCCCUAU  994 ccAAGcuGAucAccccuAudTsdT sense  826-845  995 AUAGGGGUGAUCAGCUUGG  996 AuAGGGGUGAUcAGCUUGGdTsdT antis  897-916  997 CACUCCCAAGGUGUGUGUC  998 cAcucccAAGGuGuGuGucdTsdT sense  897-916  999 GACACACACCUUGGGAGUG 1000 GAcAcAcACCUUGGGAGUGdTsdT antis  898-917 1001 ACUCCCAAGGUGUGUGUCA 1002 AcucccAAGGuGuGuGucAdTsdT sense  898-917 1003 UGACACACACCUUGGGAGU 1004 UGAcAcAcACCUUGGGAGUdTsdT antis  990-1009 1005 GCAAAGCAGCUGGUUCGGG 1006 GcAAAGcAGcuGGuucGGGdTsdT sense  990-1009 1007 CCCGAACCAGCUGCUUUGC 1008 CCCGAACcAGCUGCUUUGCdTsdT antis  992-1011 1009 AAAGCAGCUGGUUCGGGGG 1010 AAAGcAGcuGGuucGGGGGdTsdT sense  992-1011 1011 CCCCCGAACCAGCUGCUUU 1012 CCCCCGAACcAGCUGCUUUdTsdT antis  996-1015 1013 CAGCUGGUUCGGGGGGAGC 1014 cAGcuGGuucGGGGGGAGcdTsdT sense  996-1015 1015 GCUCCCCCCGAACCAGCUG 1016 GCUCCCCCCGAACcAGCUGdTsdT antis 1007-1026 1017 GGGGGAGCCCAAUGUGUCC 1018 GGGGGAGcccAAuGuGuccdTsdT sense 1007-1026 1019 GGACACAUUGGGCUCCCCC 1020 GGAcAcAUUGGGCUCCCCCdTsdT antis 1013-1032 1021 GCCCAAUGUGUCCUACAUC 1022 GcccAAuGuGuccuAcAucdTsdT sense 1013-1032 1023 GAUGUAGGACACAUUGGGC 1024 GAUGuAGGAcAcAUUGGGCdTsdT antis 1030-1049 1025 UCUGCUCUCGGUACUACCG 1026 ucuGcucucGGuAcuAccGdTsdT sense 1030-1049 1027 CGGUAGUACCGAGAGCAGA 1028 CGGuAGuACCGAGAGcAGAdTsdT antis 1104-1123 1029 UCGGCUGGCUGUGUACUUG 1030 ucGGcuGGcuGuGuAcuuGdTsdT sense 1104-1123 1031 CAAGUACACAGCCAGCCGA 1032 cAAGuAcAcAGCcAGCCGAdTsdT antis 1109-1128 1033 UGGCUGUGUACUUGCUGAG 1034 uGGcuGuGuAcuuGcuGAGdTsdT sense 1109-1128 1035 CUCAGCAAGUACACAGCCA 1036 CUcAGcAAGuAcAcAGCcAdTsdT antis 1120-1139 1037 UUGCUGAGCUACUUCUCGG 1038 uuGcuGAGcuAcuucucGGdTsdT sense 1120-1139 1039 CCGAGAAGUAGCUCAGCAA 1040 CCGAGAAGuAGCUcAGcAAdTsdT antis 1122-1141 1041 GCUGAGCUACUUCUCGGCC 1042 GcuGAGcuAcuucucGGccdTsdT sense 1122-1141 1043 GGCCGAGAAGUAGCUCAGC 1044 GGCCGAGAAGuAGCUcAGCdTsdT antis 1266-1285 1045 AUCAAAGCUCACCCUUGGA 1046 AucAAAGcucAcccuuGGAdTsdT sense 1266-1285 1047 UCCAAGGGUGAGCUUUGAU 1048 UCcAAGGGUGAGCUUUGAUdTsdT antis 1329-1348 1049 CUCUGCUCUAGCCUACUGG 1050 cucuGcucuAGccuAcuGGdTsdT sense 1329-1348 1051 CCAGUAGGCUAGAGCAGAG 1052 CcAGuAGGCuAGAGcAGAGdTsdT antis 1343-1362 1053 ACUGGAGUACACGCCAUCC 1054 AcuGGAGuAcAcGccAuccdTsdT sense 1343-1362 1055 GGAUGGCGUGUACUCCAGU 1056 GGAUGGCGUGuACUCcAGUdTsdT antis 1364-1383 1057 AAGGCUCUCCCCACUCGAG 1058 AAGGcucuccccAcucGAGdTsdT sense 1364-1383 1059 CUCGAGUGGGGAGAGCCUU 1060 CUCGAGUGGGGAGAGCCUUdTsdT antis 1411-1430 1061 UGCGGAGACUCGGAGCCCA 1062 uGcGGAGAcucGGAGcccAdTsdT sense 1411-1430 1063 UGGGCUCCGAGUCUCCGCA 1064 UGGGCUCCGAGUCUCCGcAdTsdT antis 1570-1589 1065 ACAACCCAUCCUCACAAGC 1066 AcAAcccAuccucAcAAGcdTsdT sense 1570-1589 1067 GCUUGUGAGGAUGGGUUGU 1068 GCUUGUGAGGAUGGGUUGUdTsdT antis 1589-1608 1069 UUUAACUGAAGCUCAGACU 1070 uuuAAcuGAAGcucAGAcudTsdT sense 1589-1608 1071 AGUCUGAGCUUCAGUUAAA 1072 AGUCUGAGCUUcAGUuAAAdTsdT antis 1609-1628 1073 GCCAAGAUUGGCAGCCAUC 1074 GccAAGAuuGGcAGccAucdTsdT sense 1609-1628 1075 GAUGGCUGCCAAUCUUGGC 1076 GAUGGCUGCcAAUCUUGGCdTsdT antis 1613-1632 1077 AGAUUGGCAGCCAUCUGAU 1078 AGAuuGGcAGccAucuGAudTsdT sense 1613-1632 1079 AUCAGAUGGCUGCCAAUCU 1080 AUcAGAUGGCUGCcAAUCUdTsdT antis 1615-1634 1081 AUUGGCAGCCAUCUGAUGC 1082 AuuGGcAGccAucuGAuGcdTsdT sense 1615-1634 1083 GCAUCAGAUGGCUGCCAAU 1084 GcAUcAGAUGGCUGCcAAUdTsdT antis 1809-1828 1085 UCCCUCAGCAGCCUAACCU 1086 ucccucAGcAGccuAAccudTsdT sense 1809-1828 1087 AGGUUAGGCUGCUGAGGGA 1088 AGGUuAGGCUGCUGAGGGAdTsdT antis 1844-1863 1089 AAAGAGGAUUUUAACUGUU 1090 AAAGAGGAuuuuAAcuGuudTsdT sense 1844-1863 1091 AACAGUUAAAAUCCUCUUU 1092 AAcAGUuAAAAUCCUCUUUdTsdT antis 1847-1866 1093 GAGGAUUUUAACUGUUUGU 1094 GAGGAuuuuAAcuGuuuGudTsdT sense 1847-1866 1095 ACAAACAGUUAAAAUCCUC 1096 AcAAAcAGUuAAAAUCCUCdTsdT antis 1853-1872 1097 UUUAACUGUUUGUAGGGGA 1098 uuuAAcuGuuuGuAGGGGAdTsdT sense 1853-1872 1099 UCCCCUACAAACAGUUAAA 1100 UCCCCuAcAAAcAGUuAAAdTsdT antis 1857-1876 1101 ACUGUUUGUAGGGGAGGGG 1102 AcuGuuuGuAGGGGAGGGGdTsdT sense 1857-1876 1103 CCCCUCCCCUACAAACAGU 1104 CCCCUCCCCuAcAAAcAGUdTsdT antis 1896-1915 1105 UGGGGGUGUGAGGACCUUC 1106 uGGGGGuGuGAGGAccuucdTsdT sense 1896-1915 1107 GAAGGUCCUCACACCCCCA 1108 GAAGGUCCUcAcACCCCcAdTsdT antis 1936-1955 1109 UCCCCCAGGCUACCACUCC 1110 ucccccAGGcuAccAcuccdTsdT sense 1936-1955 1111 GGAGUGGUAGCCUGGGGGA 1112 GGAGUGGuAGCCUGGGGGAdTsdT antis 1967-1986 1113 CUCUCCCAGGUCCCUUGUA 1114 cucucccAGGucccuuGuAdTsdT sense 1967-1986 1115 UACAAGGGACCUGGGAGAG 1116 uAcAAGGGACCUGGGAGAGdTsdT antis 1997-2016 1117 CCCAGCCCAUCUCUCGUCU 1118 cccAGcccAucucucGucudTsdT sense 1997-2016 1119 AGACGAGAGAUGGGCUGGG 1120 AGACGAGAGAUGGGCUGGGdTsdT antis 2001-2020 1121 GCCCAUCUCUCGUCUUCCC 1122 GcccAucucucGucuucccdTsdT sense 2001-2020 1123 GGGAAGACGAGAGAUGGGC 1124 GGGAAGACGAGAGAUGGGCdTsdT antis 2074-2093 1125 GUCAAUUCACACCAUUCAA 1126 GucAAuucAcAccAuucAAdTsdT sense 2074-2093 1127 UUGAAUGGUGUGAAUUGAC 1128 UUGAAUGGUGUGAAUUGACdTsdT antis 2093-2112 1129 CUUGCCCCCCCCAGCUGUA 1130 cuuGccccccccAGcuGuAdTsdT sense 2093-2112 1131 UACAGCUGGGGGGGGCAAG 1132 uAcAGCUGGGGGGGGcAAGdTsdT antis 2164-2183 1133 GAGGGGAGUAGAGAGAGUC 1134 GAGGGGAGuAGAGAGAGucdTsdT sense 2164-2183 1135 GACUCUCUCUACUCCCCUC 1136 GACUCUCUCuACUCCCCUCdTsdT antis 2168-2187 1137 GGAGUAGAGAGAGUCCCUG 1138 GGAGuAGAGAGAGucccuGdTsdT sense 2168-2187 1139 CAGGGACUCUCUCUACUCC 1140 cAGGGACUCUCUCuACUCCdTsdT antis 2185-2204 1141 UGGUGUCUUAGUUUCCACA 1142 uGGuGucuuAGuuuccAcAdTsdT sense 2185-2204 1143 UGUGGAAACUAAGACACCA 1144 UGUGGAAACuAAGAcACcAdTsdT antis 2191-2210 1145 CUUAGUUUCCACAGUAAGG 1146 cuuAGuuuccAcAGuAAGGdTsdT sense 2191-2210 1147 CCUUACUGUGGAAACUAAG 1148 CCUuACUGUGGAAACuAAGdTsdT antis 2202-2221 1149 CAGUAAGGUUUGCCUGUGU 1150 cAGuAAGGuuuGccuGuGudTsdT sense 2202-2221 1151 ACACAGGCAAACCUUACUG 1152 AcAcAGGcAAACCUuACUGdTsdT antis 2242-2261 1153 UAUUGGCAUGAAACCCUUA 1154 uAuuGGcAuGAAAcccuuAdTsdT sense 2242-2261 1155 UAAGGGUUUCAUGCCAAUA 1156 uAAGGGUUUcAUGCcAAuAdTsdT antis  388-407 1157 GGGGUGGCCCCAGCGGCAG 1158 GGGGuGGccccAGcGGcAGdTsdT sense  388-407 1159 CUGCCGCUGGGGCCACCCC 1160 CUGCCGCUGGGGCcACCCCdTsdT antis  425-444 1161 UGGCCCCGGCGCGGGCACU 1162 uGGccccGGcGcGGGcAcudTsdT sense  425-444 1163 AGUGCCCGCGCCGGGGCCA 1164 AGUGCCCGCGCCGGGGCcAdTsdT antis 2163-2182 1165 GGAGGGGAGUAGAGAGAGU 1166 GGAGGGGAGuAGAGAGAGudTsdT sense 2163-2182 1167 ACUCUCUCUACUCCCCUCC 1168 ACUCUCUCuACUCCCCUCCdTsdT antis    3-22 1169 GGUGACAACGAAGCCGACG 1170 GGuGAcAAcGAAGccGAcGdTsdT sense    3-22 1171 CGUCGGCUUCGUUGUCACC 1172 CGUCGGCUUCGUUGUcACCdTsdT antis   12-31 1173 GAAGCCGACGGCAGAGGGA 1174 GAAGccGAcGGcAGAGGGAdTsdT sense   12-31 1175 UCCCUCUGCCGUCGGCUUC 1176 UCCCUCUGCCGUCGGCUUCdTsdT antis   72-91 1177 GCCGGAGCCCGAACGGCGC 1178 GccGGAGcccGAAcGGcGcdTsdT sense   72-91 1179 GCGCCGUUCGGGCUCCGGC 1180 GCGCCGUUCGGGCUCCGGCdTsdT antis   90-109 1181 CGGCCUGGAAGAGGCCGGA 1182 cGGccuGGAAGAGGccGGAdTsdT sense   90-109 1183 UCCGGCCUCUUCCAGGCCG 1184 UCCGGCCUCUUCcAGGCCGdTsdT antis  316-335 1185 GCCCAGGAGGCACUGGCGG 1186 GcccAGGAGGcAcuGGcGGdTsdT sense  316-335 1187 CCGCCAGUGCCUCCUGGGC 1188 CCGCcAGUGCCUCCUGGGCdTsdT antis  335-354 1189 CGGGAAAGCGUCAGUCGGG 1190 cGGGAAAGcGucAGucGGGdTsdT sense  335-354 1191 CCCGACUGACGCUUUCCCG 1192 CCCGACUGACGCUUUCCCGdTsdT antis  466-485 1193 AGCUGGGCCGUGACAGCGG 1194 AGcuGGGccGuGAcAGcGGdTsdT sense  466-485 1195 CCGCUGUCACGGCCCAGCU 1196 CCGCUGUcACGGCCcAGCUdTsdT antis  489-508 1197 GUGACCACAGUGGUAGCCA 1198 GuGAccAcAGuGGuAGccAdTsdT sense  489-508 1199 UGGCUACCACUGUGGUCAC 1200 UGGCuACcACUGUGGUcACdTsdT antis  708-727 1201 GUGAGGCUGCGGUACUUUU 1202 GuGAGGcuGcGGuAcuuuudTsdT sense  708-727 1203 AAAAGUACCGCAGCCUCAC 1204 AAAAGuACCGcAGCCUcACdTsdT antis 1098-1117 1205 GUGUGGUCGGCUGGCUGUG 1206 GuGuGGucGGcuGGcuGuGdTsdT sense 1098-1117 1207 CACAGCCAGCCGACCACAC 1208 cAcAGCcAGCCGACcAcACdTsdT antis 1117-1136 1209 UACUUGCUGAGCUACUUCU 1210 uAcuuGcuGAGcuAcuucudTsdT sense 1117-1136 1211 AGAAGUAGCUCAGCAAGUA 1212 AGAAGuAGCUcAGcAAGuAdTsdT antis 1305-1324 1213 AAGACACCACCUGAGGCCA 1214 AAGAcAccAccuGAGGccAdTsdT sense 1305-1324 1215 UGGCCUCAGGUGGUGUCUU 1216 UGGCCUcAGGUGGUGUCUUdTsdT antis 1341-1360 1217 CUACUGGAGUACACGCCAU 1218 cuAcuGGAGuAcAcGccAudTsdT sense 1341-1360 1219 AUGGCGUGUACUCCAGUAG 1220 AUGGCGUGuACUCcAGuAGdTsdT antis 1345-1364 1221 UGGAGUACACGCCAUCCUC 1222 uGGAGuAcAcGccAuccucdTsdT sense 1345-1364 1223 GAGGAUGGCGUGUACUCCA 1224 GAGGAUGGCGUGuACUCcAdTsdT antis 1811-1830 1225 CCUCAGCAGCCUAACCUCU 1226 ccucAGcAGccuAAccucudTsdT sense 1811-1830 1227 AGAGGUUAGGCUGCUGAGG 1228 AGAGGUuAGGCUGCUGAGGdTsdT antis 1850-1869 1229 GAUUUUAACUGUUUGUAGG 1230 GAuuuuAAcuGuuuGuAGGdTsdT sense 1850-1869 1231 CCUACAAACAGUUAAAAUC 1232 CCuAcAAAcAGUuAAAAUCdTsdT antis 1969-1988 1233 CUCCCAGGUCCCUUGUAAA 1234 cucccAGGucccuuGuAAAdTsdT sense 1969-1988 1235 UUUACAAGGGACCUGGGAG 1236 UUuAcAAGGGACCUGGGAGdTsdT antis 2162-2181 1237 AGGAGGGGAGUAGAGAGAG 1238 AGGAGGGGAGuAGAGAGAGdTsdT sense 2162-2181 1239 CUCUCUCUACUCCCCUCCU 1240 CUCUCUCuACUCCCCUCCUdTsdT antis 2195-2214 1241 GUUUCCACAGUAAGGUUUG 1242 GuuuccAcAGuAAGGuuuGdTsdT sense 2195-2214 1243 CAAACCUUACUGUGGAAAC 1244 cAAACCUuACUGUGGAAACdTsdT antis 1239-1258 1245 AACUAUACGGAGUUCAAGU 1246 AAcuAuAcGGAGuucAAGudTsdT sense 1239-1258 1247 ACUUGAACUCCGUAUAGUU 1248 ACUUGAACUCCGuAuAGUUdTsdT antis 1240-1259 1249 ACUAUACGGAGUUCAAGUU 1250 AcuAuAcGGAGuucAAGuudTsdT sense 1240-1259 1251 AACUUGAACUCCGUAUAGU 1252 AACUUGAACUCCGuAuAGUdTsdT antis   80-99 1253 CCGAACGGCGCGGCCUGGA 1254 ccGAAcGGcGcGGccuGGAdTsdT sense   80-99 1255 UCCAGGCCGCGCCGUUCGG 1256 UCcAGGCCGCGCCGUUCGGdTsdT antis  745-764 1257 AGAAGGACGAGCUGUAUUU 1258 AGAAGGAcGAGcuGuAuuudTsdT sense  745-764 1259 AAAUACAGCUCGUCCUUCU 1260 AAAuAcAGCUCGUCCUUCUdTsdT antis 1078-1097 1261 AUUACACCUCGUCCAUCGA 1262 AuuAcAccucGuccAucGAdTsdT sense 1078-1097 1263 UCGAUGGACGAGGUGUAAU 1264 UCGAUGGACGAGGUGuAAUdTsdT antis 2071-2090 1265 AACGUCAAUUCACACCAUU 1266 AAcGucAAuucAcAccAuudTsdT sense 2071-2090 1267 AAUGGUGUGAAUUGACGUU 1268 AAUGGUGUGAAUUGACGUUdTsdT antis   15-34 1269 GCCGACGGCAGAGGGACUU 1270 GccGAcGGcAGAGGGAcuudTsdT sense   15-34 1271 AAGUCCCUCUGCCGUCGGC 1272 AAGUCCCUCUGCCGUCGGCdTsdT antis   77-96 1273 AGCCCGAACGGCGCGGCCU 1274 AGcccGAAcGGcGcGGccudTsdT sense   77-96 1275 AGGCCGCGCCGUUCGGGCU 1276 AGGCCGCGCCGUUCGGGCUdTsdT antis  182-201 1277 GCUCGGCGCCAUGAGCGGC 1278 GcucGGcGccAuGAGcGGcdTsdT sense  182-201 1279 GCCGCUCAUGGCGCCGAGC 1280 GCCGCUcAUGGCGCCGAGCdTsdT antis  659-678 1281 CAAGAACCGAGAACUGCAG 1282 cAAGAAccGAGAAcuGcAGdTsdT sense  659-678 1283 CUGCAGUUCUCGGUUCUUG 1284 CUGcAGUUCUCGGUUCUUGdTsdT antis  788-807 1285 CGAGACGGUGUACCGAGUG 1286 cGAGAcGGuGuAccGAGuGdTsdT sense  788-807 1287 CACUCGGUACACCGUCUCG 1288 cACUCGGuAcACCGUCUCGdTsdT antis 1002-1021 1289 GUUCGGGGGGAGCCCAAUG 1290 GuucGGGGGGAGcccAAuGdTsdT sense 1002-1021 1291 CAUUGGGCUCCCCCCGAAC 1292 cAUUGGGCUCCCCCCGAACdTsdT antis 1333-1352 1293 GCUCUAGCCUACUGGAGUA 1294 GcucuAGccuAcuGGAGuAdTsdT sense 1333-1352 1295 UACUCCAGUAGGCUAGAGC 1296 uACUCcAGuAGGCuAGAGCdTsdT antis 1435-1454 1297 CCAACGACCGCCCGCUUCC 1298 ccAAcGAccGcccGcuuccdTsdT sense 1435-1454 1299 GGAAGCGGGCGGUCGUUGG 1300 GGAAGCGGGCGGUCGUUGGdTsdT antis 2246-2265 1301 GGCAUGAAACCCUUAAAAA 1302 GGcAuGAAAcccuuAAAAAdTsdT sense 2246-2265 1303 UUUUUAAGGGUUUCAUGCC 1304 UUUUuAAGGGUUUcAUGCCdTsdT antis   14-33 1305 AGCCGACGGCAGAGGGACU 1306 AGccGAcGGcAGAGGGAcudTsdT sense   14-33 1307 AGUCCCUCUGCCGUCGGCU 1308 AGUCCCUCUGCCGUCGGCUdTsdT antis   17-36 1309 CGACGGCAGAGGGACUUCA 1310 cGAcGGcAGAGGGAcuucAdTsdT sense   17-36 1311 UGAAGUCCCUCUGCCGUCG 1312 UGAAGUCCCUCUGCCGUCGdTsdT antis   18-37 1313 GACGGCAGAGGGACUUCAU 1314 GAcGGcAGAGGGAcuucAudTsdT sense   18-37 1315 AUGAAGUCCCUCUGCCGUC 1316 AUGAAGUCCCUCUGCCGUCdTsdT antis   78-97 1317 GCCCGAACGGCGCGGCCUG 1318 GcccGAAcGGcGcGGccuGdTsdT sense   78-97 1319 CAGGCCGCGCCGUUCGGGC 1320 cAGGCCGCGCCGUUCGGGCdTsdT antis   81-100 1321 CGAACGGCGCGGCCUGGAA 1322 cGAAcGGcGcGGccuGGAAdTsdT sense   81-100 1323 UUCCAGGCCGCGCCGUUCG 1324 UUCcAGGCCGCGCCGUUCGdTsdT antis   83-102 1325 AACGGCGCGGCCUGGAAGA 1326 AAcGGcGcGGccuGGAAGAdTsdT sense   83-102 1327 UCUUCCAGGCCGCGCCGUU 1328 UCUUCcAGGCCGCGCCGUUdTsdT antis   87-106 1329 GCGCGGCCUGGAAGAGGCC 1330 GcGcGGccuGGAAGAGGccdTsdT sense   87-106 1331 GGCCUCUUCCAGGCCGCGC 1332 GGCCUCUUCcAGGCCGCGCdTsdT antis  181-200 1333 CGCUCGGCGCCAUGAGCGG 1334 cGcucGGcGccAuGAGcGGdTsdT sense  181-200 1335 CCGCUCAUGGCGCCGAGCG 1336 CCGCUcAUGGCGCCGAGCGdTsdT antis  183-202 1337 CUCGGCGCCAUGAGCGGCG 1338 cucGGcGccAuGAGcGGcGdTsdT sense  183-202 1339 CGCCGCUCAUGGCGCCGAG 1340 CGCCGCUcAUGGCGCCGAGdTsdT antis  189-208 1341 GCCAUGAGCGGCGGCGGGC 1342 GccAuGAGcGGcGGcGGGcdTsdT sense  189-208 1343 GCCCGCCGCCGCUCAUGGC 1344 GCCCGCCGCCGCUcAUGGCdTsdT antis  191-210 1345 CAUGAGCGGCGGCGGGCCU 1346 cAuGAGcGGcGGcGGGccudTsdT sense  191-210 1347 AGGCCCGCCGCCGCUCAUG 1348 AGGCCCGCCGCCGCUcAUGdTsdT antis  254-273 1349 GUUCGCGGAGCCAGGAGGC 1350 GuucGcGGAGccAGGAGGcdTsdT sense  254-273 1351 GCCUCCUGGCUCCGCGAAC 1352 GCCUCCUGGCUCCGCGAACdTsdT antis  255-274 1353 UUCGCGGAGCCAGGAGGCG 1354 uucGcGGAGccAGGAGGcGdTsdT sense  255-274 1355 CGCCUCCUGGCUCCGCGAA 1356 CGCCUCCUGGCUCCGCGAAdTsdT antis  431-450 1357 CGGCGCGGGCACUAGCUUC 1358 cGGcGcGGGcAcuAGcuucdTsdT sense  431-450 1359 GAAGCUAGUGCCCGCGCCG 1360 GAAGCuAGUGCCCGCGCCGdTsdT antis  433-452 1361 GCGCGGGCACUAGCUUCCC 1362 GcGcGGGcAcuAGcuucccdTsdT sense  433-452 1363 GGGAAGCUAGUGCCCGCGC 1364 GGGAAGCuAGUGCCCGCGCdTsdT antis  441-460 1365 ACUAGCUUCCCGCCGCCGG 1366 AcuAGcuucccGccGccGGdTsdT sense  441-460 1367 CCGGCGGCGGGAAGCUAGU 1368 CCGGCGGCGGGAAGCuAGUdTsdT antis  442-461 1369 CUAGCUUCCCGCCGCCGGG 1370 cuAGcuucccGccGccGGGdTsdT sense  442-461 1371 CCCGGCGGCGGGAAGCUAG 1372 CCCGGCGGCGGGAAGCuAGdTsdT antis  446-465 1373 CUUCCCGCCGCCGGGAGUG 1374 cuucccGccGccGGGAGuGdTsdT sense  446-465 1375 CACUCCCGGCGGCGGGAAG 1376 cACUCCCGGCGGCGGGAAGdTsdT antis  473-492 1377 CCGUGACAGCGGGAAGGUG 1378 ccGuGAcAGcGGGAAGGuGdTsdT sense  473-492 1379 CACCUUCCCGCUGUCACGG 1380 cACCUUCCCGCUGUcACGGdTsdT antis  532-551 1381 CCCAAGAAGUGGCUUACAC 1382 cccAAGAAGuGGcuuAcAcdTsdT sense  532-551 1383 GUGUAAGCCACUUCUUGGG 1384 GUGuAAGCcACUUCUUGGGdTsdT antis  580-599 1385 UCGGAGUAGUAUACCAGGC 1386 ucGGAGuAGuAuAccAGGcdTsdT sense  580-599 1387 GCCUGGUAUACUACUCCGA 1388 GCCUGGuAuACuACUCCGAdTsdT antis  589-608 1389 UAUACCAGGCACGGCUGGC 1390 uAuAccAGGcAcGGcuGGcdTsdT sense  589-608 1391 GCCAGCCGUGCCUGGUAUA 1392 GCcAGCCGUGCCUGGuAuAdTsdT antis  598-617 1393 CACGGCUGGCAGAGACGAG 1394 cAcGGcuGGcAGAGAcGAGdTsdT sense  598-617 1395 CUCGUCUCUGCCAGCCGUG 1396 CUCGUCUCUGCcAGCCGUGdTsdT antis  837-856 1397 ACCCCUAUCAUCUACAUCA 1398 AccccuAucAucuAcAucAdTsdT sense  837-856 1399 UGAUGUAGAUGAUAGGGGU 1400 UGAUGuAGAUGAuAGGGGUdTsdT antis  838-857 1401 CCCCUAUCAUCUACAUCAA 1402 ccccuAucAucuAcAucAAdTsdT sense  838-857 1403 UUGAUGUAGAUGAUAGGGG 1404 UUGAUGuAGAUGAuAGGGGdTsdT antis  839-858 1405 CCCUAUCAUCUACAUCAAG 1406 cccuAucAucuAcAucAAGdTsdT sense  839-858 1407 CUUGAUGUAGAUGAUAGGG 1408 CUUGAUGuAGAUGAuAGGGdTsdT antis  922-941 1409 ACAUCAAGCCCCAGAAUUU 1410 AcAucAAGccccAGAAuuudTsdT sense  922-941 1411 AAAUUCUGGGGCUUGAUGU 1412 AAAUUCUGGGGCUUGAUGUdTsdT antis  923-942 1413 CAUCAAGCCCCAGAAUUUG 1414 cAucAAGccccAGAAuuuGdTsdT sense  923-942 1415 CAAAUUCUGGGGCUUGAUG 1416 cAAAUUCUGGGGCUUGAUGdTsdT antis 1012-1031 1417 AGCCCAAUGUGUCCUACAU 1418 AGcccAAuGuGuccuAcAudTsdT sense 1012-1031 1419 AUGUAGGACACAUUGGGCU 1420 AUGuAGGAcAcAUUGGGCUdTsdT antis 1014-1033 1421 CCCAAUGUGUCCUACAUCU 1422 cccAAuGuGuccuAcAucudTsdT sense 1014-1033 1423 AGAUGUAGGACACAUUGGG 1424 AGAUGuAGGAcAcAUUGGGdTsdT antis 1046-1065 1425 CCGUGCUCCAGAACUCAUC 1426 ccGuGcuccAGAAcucAucdTsdT sense 1046-1065 1427 GAUGAGUUCUGGAGCACGG 1428 GAUGAGUUCUGGAGcACGGdTsdT antis 1056-1075 1429 GAACUCAUCUUUGGAGCCA 1430 GAAcucAucuuuGGAGccAdTsdT sense 1056-1075 1431 UGGCUCCAAAGAUGAGUUC 1432 UGGCUCcAAAGAUGAGUUCdTsdT antis 1088-1107 1433 GUCCAUCGAUGUGUGGUCG 1434 GuccAucGAuGuGuGGucGdTsdT sense 1088-1107 1435 CGACCACACAUCGAUGGAC 1436 CGACcAcAcAUCGAUGGACdTsdT antis 1123-1142 1437 CUGAGCUACUUCUCGGCCA 1438 cuGAGcuAcuucucGGccAdTsdT sense 1123-1142 1439 UGGCCGAGAAGUAGCUCAG 1440 UGGCCGAGAAGuAGCUcAGdTsdT antis 1232-1251 1441 GAACCCUAACUAUACGGAG 1442 GAAcccuAAcuAuAcGGAGdTsdT sense 1232-1251 1443 CUCCGUAUAGUUAGGGUUC 1444 CUCCGuAuAGUuAGGGUUCdTsdT antis 1287-1306 1445 AAGGUGUUCAAAUCUUCAA 1446 AAGGuGuucAAAucuucAAdTsdT sense 1287-1306 1447 UUGAAGAUUUGAACACCUU 1448 UUGAAGAUUUGAAcACCUUdTsdT antis 1319-1338 1449 GGCCAUUGCACUCUGCUCU 1450 GGccAuuGcAcucuGcucudTsdT sense 1319-1338 1451 AGAGCAGAGUGCAAUGGCC 1452 AGAGcAGAGUGcAAUGGCCdTsdT antis 1349-1368 1453 GUACACGCCAUCCUCAAGG 1454 GuAcAcGccAuccucAAGGdTsdT sense 1349-1368 1455 CCUUGAGGAUGGCGUGUAC 1456 CCUUGAGGAUGGCGUGuACdTsdT antis 1409-1428 1457 ACUGCGGAGACUCGGAGCC 1458 AcuGcGGAGAcucGGAGccdTsdT sense 1409-1428 1459 GGCUCCGAGUCUCCGCAGU 1460 GGCUCCGAGUCUCCGcAGUdTsdT antis 1410-1429 1461 CUGCGGAGACUCGGAGCCC 1462 cuGcGGAGAcucGGAGcccdTsdT sense 1410-1429 1463 GGGCUCCGAGUCUCCGCAG 1464 GGGCUCCGAGUCUCCGcAGdTsdT antis 1448-1467 1465 GCUUCCCCCCCUGUUCAAC 1466 GcuucccccccuGuucAAcdTsdT sense 1448-1467 1467 GUUGAACAGGGGGGGAAGC 1468 GUUGAAcAGGGGGGGAAGCdTsdT antis 1449-1468 1469 CUUCCCCCCCUGUUCAACU 1470 cuucccccccuGuucAAcudTsdT sense 1449-1468 1471 AGUUGAACAGGGGGGGAAG 1472 AGUUGAAcAGGGGGGGAAGdTsdT antis 1450-1469 1473 UUCCCCCCCUGUUCAACUU 1474 uucccccccuGuucAAcuudTsdT sense 1450-1469 1475 AAGUUGAACAGGGGGGGAA 1476 AAGUUGAAcAGGGGGGGAAdTsdT antis 1567-1586 1477 CCUACAACCCAUCCUCACA 1478 ccuAcAAcccAuccucAcAdTsdT sense 1567-1586 1479 UGUGAGGAUGGGUUGUAGG 1480 UGUGAGGAUGGGUUGuAGGdTsdT antis 1583-1602 1481 ACAAGCUUUAACUGAAGCU 1482 AcAAGcuuuAAcuGAAGcudTsdT sense 1583-1602 1483 AGCUUCAGUUAAAGCUUGU 1484 AGCUUcAGUuAAAGCUUGUdTsdT antis 1596-1615 1485 GAAGCUCAGACUGGCCAAG 1486 GAAGcucAGAcuGGccAAGdTsdT sense 1596-1615 1487 CUUGGCCAGUCUGAGCUUC 1488 CUUGGCcAGUCUGAGCUUCdTsdT antis 1608-1627 1489 GGCCAAGAUUGGCAGCCAU 1490 GGccAAGAuuGGcAGccAudTsdT sense 1608-1627 1491 AUGGCUGCCAAUCUUGGCC 1492 AUGGCUGCcAAUCUUGGCCdTsdT antis 1638-1657 1493 ACUGCUACCCUCGCUAGCU 1494 AcuGcuAcccucGcuAGcudTsdT sense 1638-1657 1495 AGCUAGCGAGGGUAGCAGU 1496 AGCuAGCGAGGGuAGcAGUdTsdT antis 1854-1873 1497 UUAACUGUUUGUAGGGGAG 1498 uuAAcuGuuuGuAGGGGAGdTsdT sense 1854-1873 1499 CUCCCCUACAAACAGUUAA 1500 CUCCCCuAcAAAcAGUuAAdTsdT antis 1980-1999 1501 CUUGUAAAUAGAACCAGCC 1502 cuuGuAAAuAGAAccAGccdTsdT sense 1980-1999 1503 GGCUGGUUCUAUUUACAAG 1504 GGCUGGUUCuAUUuAcAAGdTsdT antis 2034-2053 1505 GGGUGUAAAUAGAUUGUUA 1506 GGGuGuAAAuAGAuuGuuAdTsdT sense 2034-2053 1507 UAACAAUCUAUUUACACCC 1508 uAAcAAUCuAUUuAcACCCdTsdT antis 2037-2056 1509 UGUAAAUAGAUUGUUAUAA 1510 uGuAAAuAGAuuGuuAuAAdTsdT sense 2037-2056 1511 UUAUAACAAUCUAUUUACA 1512 UuAuAAcAAUCuAUUuAcAdTsdT antis 2087-2106 1513 AUUCAACUUGCCCCCCCCA 1514 AuucAAcuuGccccccccAdTsdT sense 2087-2106 1515 UGGGGGGGGCAAGUUGAAU 1516 UGGGGGGGGcAAGUUGAAUdTsdT antis 2088-2107 1517 UUCAACUUGCCCCCCCCAG 1518 uucAAcuuGccccccccAGdTsdT sense 2088-2107 1519 CUGGGGGGGGCAAGUUGAA 1520 CUGGGGGGGGcAAGUUGAAdTsdT antis 2171-2190 1521 GUAGAGAGAGUCCCUGGUG 1522 GuAGAGAGAGucccuGGuGdTsdT sense 2171-2190 1523 CACCAGGGACUCUCUCUAC 1524 cACcAGGGACUCUCUCuACdTsdT antis 2212-2231 1525 UGCCUGUGUACAGACCUCU 1526 uGccuGuGuAcAGAccucudTsdT sense 2212-2231 1527 AGAGGUCUGUACACAGGCA 1528 AGAGGUCUGuAcAcAGGcAdTsdT antis 2221-2240 1529 ACAGACCUCUGUUCAAUAA 1530 AcAGAccucuGuucAAuAAdTsdT sense 2221-2240 1531 UUAUUGAACAGAGGUCUGU 1532 UuAUUGAAcAGAGGUCUGUdTsdT antis  190-209 1533 CCAUGAGCGGCGGCGGGCC 1534 ccAuGAGcGGcGGcGGGccdTsdT sense  190-209 1535 GGCCCGCCGCCGCUCAUGG 1536 GGCCCGCCGCCGCUcAUGGdTsdT antis  377-396 1537 CUCGAGCUCCGGGGGUGGC 1538 cucGAGcuccGGGGGuGGcdTsdT sense  377-396 1539 GCCACCCCCGGAGCUCGAG 1540 GCcACCCCCGGAGCUCGAGdTsdT antis  469-488 1541 UGGGCCGUGACAGCGGGAA 1542 uGGGccGuGAcAGcGGGAAdTsdT sense  469-488 1543 UUCCCGCUGUCACGGCCCA 1544 UUCCCGCUGUcACGGCCcAdTsdT antis  590-609 1545 AUACCAGGCACGGCUGGCA 1546 AuAccAGGcAcGGcuGGcAdTsdT sense  590-609 1547 UGCCAGCCGUGCCUGGUAU 1548 UGCcAGCCGUGCCUGGuAUdTsdT antis  658-677 1549 UCAAGAACCGAGAACUGCA 1550 ucAAGAAccGAGAAcuGcAdTsdT sense  658-677 1551 UGCAGUUCUCGGUUCUUGA 1552 UGcAGUUCUCGGUUCUUGAdTsdT antis  998-1017 1553 GCUGGUUCGGGGGGAGCCC 1554 GcuGGuucGGGGGGAGcccdTsdT sense  998-1017 1555 GGGCUCCCCCCGAACCAGC 1556 GGGCUCCCCCCGAACcAGCdTsdT antis  999-1018 1557 CUGGUUCGGGGGGAGCCCA 1558 cuGGuucGGGGGGAGcccAdTsdT sense  999-1018 1559 UGGGCUCCCCCCGAACCAG 1560 UGGGCUCCCCCCGAACcAGdTsdT antis 1025-1044 1561 CUACAUCUGCUCUCGGUAC 1562 cuAcAucuGcucucGGuAcdTsdT sense 1025-1044 1563 GUACCGAGAGCAGAUGUAG 1564 GuACCGAGAGcAGAUGuAGdTsdT antis 1327-1346 1565 CACUCUGCUCUAGCCUACU 1566 cAcucuGcucuAGccuAcudTsdT sense 1327-1346 1567 AGUAGGCUAGAGCAGAGUG 1568 AGuAGGCuAGAGcAGAGUGdTsdT antis 1417-1436 1569 GACUCGGAGCCCAGCUCCC 1570 GAcucGGAGcccAGcucccdTsdT sense 1417-1436 1571 GGGAGCUGGGCUCCGAGUC 1572 GGGAGCUGGGCUCCGAGUCdTsdT antis 1594-1613 1573 CUGAAGCUCAGACUGGCCA 1574 cuGAAGcucAGAcuGGccAdTsdT sense 1594-1613 1575 UGGCCAGUCUGAGCUUCAG 1576 UGGCcAGUCUGAGCUUcAGdTsdT antis 2213-2232 1577 GCCUGUGUACAGACCUCUG 1578 GccuGuGuAcAGAccucuGdTsdT sense 2213-2232 1579 CAGAGGUCUGUACACAGGC 1580 cAGAGGUCUGuAcAcAGGCdTsdT antis 1451-1470 1581 UCCCCCCCUGUUCAACUUC 1582 ucccccccuGuucAAcuucdTsdT sense 1451-1470 1583 GAAGUUGAACAGGGGGGGA 1584 GAAGUUGAAcAGGGGGGGAdTsdT antis 1563-1582 1585 ACUUCCUACAACCCAUCCU 1586 AcuuccuAcAAcccAuccudTsdT sense 1563-1582 1587 AGGAUGGGUUGUAGGAAGU 1588 AGGAUGGGUUGuAGGAAGUdTsdT antis 1607-1626 1589 UGGCCAAGAUUGGCAGCCA 1590 uGGccAAGAuuGGcAGccAdTsdT sense 1607-1626 1591 UGGCUGCCAAUCUUGGCCA 1592 UGGCUGCcAAUCUUGGCcAdTsdT antis 1939-1958 1593 CCCAGGCUACCACUCCUUC 1594 cccAGGcuAccAcuccuucdTsdT sense 1939-1958 1595 GAAGGAGUGGUAGCCUGGG 1596 GAAGGAGUGGuAGCCUGGGdTsdT antis   74-93 1597 CGGAGCCCGAACGGCGCGG 1598 cGGAGcccGAAcGGcGcGGdTsdT sense   74-93 1599 CCGCGCCGUUCGGGCUCCG 1600 CCGCGCCGUUCGGGCUCCGdTsdT antis   75-94 1601 GGAGCCCGAACGGCGCGGC 1602 GGAGcccGAAcGGcGcGGcdTsdT sense   75-94 1603 GCCGCGCCGUUCGGGCUCC 1604 GCCGCGCCGUUCGGGCUCCdTsdT antis   85-104 1605 CGGCGCGGCCUGGAAGAGG 1606 cGGcGcGGccuGGAAGAGGdTsdT sense   85-104 1607 CCUCUUCCAGGCCGCGCCG 1608 CCUCUUCcAGGCCGCGCCGdTsdT antis   86-105 1609 GGCGCGGCCUGGAAGAGGC 1610 GGcGcGGccuGGAAGAGGcdTsdT sense   86-105 1611 GCCUCUUCCAGGCCGCGCC 1612 GCCUCUUCcAGGCCGCGCCdTsdT antis  203-222 1613 CGGGCCUUCGGGAGGCGGC 1614 cGGGccuucGGGAGGcGGcdTsdT sense  203-222 1615 GCCGCCUCCCGAAGGCCCG 1616 GCCGCCUCCCGAAGGCCCGdTsdT antis  206-225 1617 GCCUUCGGGAGGCGGCCCU 1618 GccuucGGGAGGcGGcccudTsdT sense  206-225 1619 AGGGCCGCCUCCCGAAGGC 1620 AGGGCCGCCUCCCGAAGGCdTsdT antis  208-227 1621 CUUCGGGAGGCGGCCCUGG 1622 cuucGGGAGGcGGcccuGGdTsdT sense  208-227 1623 CCAGGGCCGCCUCCCGAAG 1624 CcAGGGCCGCCUCCCGAAGdTsdT antis  245-264 1625 GACCAGCUCGUUCGCGGAG 1626 GAccAGcucGuucGcGGAGdTsdT sense  245-264 1627 CUCCGCGAACGAGCUGGUC 1628 CUCCGCGAACGAGCUGGUCdTsdT antis  448-467 1629 UCCCGCCGCCGGGAGUGAA 1630 ucccGccGccGGGAGuGAAdTsdT sense  448-467 1631 UUCACUCCCGGCGGCGGGA 1632 UUcACUCCCGGCGGCGGGAdTsdT antis  452-471 1633 GCCGCCGGGAGUGAAGCUG 1634 GccGccGGGAGuGAAGcuGdTsdT sense  452-471 1635 CAGCUUCACUCCCGGCGGC 1636 cAGCUUcACUCCCGGCGGCdTsdT antis  453-472 1637 CCGCCGGGAGUGAAGCUGG 1638 ccGccGGGAGuGAAGcuGGdTsdT sense  453-472 1639 CCAGCUUCACUCCCGGCGG 1640 CcAGCUUcACUCCCGGCGGdTsdT antis  470-489 1641 GGGCCGUGACAGCGGGAAG 1642 GGGccGuGAcAGcGGGAAGdTsdT sense  470-489 1643 CUUCCCGCUGUCACGGCCC 1644 CUUCCCGCUGUcACGGCCCdTsdT antis  588-607 1645 GUAUACCAGGCACGGCUGG 1646 GuAuAccAGGcAcGGcuGGdTsdT sense  588-607 1647 CCAGCCGUGCCUGGUAUAC 1648 CcAGCCGUGCCUGGuAuACdTsdT antis  609-628 1649 GAGACGAGGGAACUGGUGG 1650 GAGAcGAGGGAAcuGGuGGdTsdT sense  609-628 1651 CCACCAGUUCCCUCGUCUC 1652 CcACcAGUUCCCUCGUCUCdTsdT antis  611-630 1653 GACGAGGGAACUGGUGGCC 1654 GAcGAGGGAAcuGGuGGccdTsdT sense  611-630 1655 GGCCACCAGUUCCCUCGUC 1656 GGCcACcAGUUCCCUCGUCdTsdT antis  649-668 1657 ACAAAAGGUUCAAGAACCG 1658 AcAAAAGGuucAAGAAccGdTsdT sense  649-668 1659 CGGUUCUUGAACCUUUUGU 1660 CGGUUCUUGAACCUUUUGUdTsdT antis  652-671 1661 AAAGGUUCAAGAACCGAGA 1662 AAAGGuucAAGAAccGAGAdTsdT sense  652-671 1663 UCUCGGUUCUUGAACCUUU 1664 UCUCGGUUCUUGAACCUUUdTsdT antis  653-672 1665 AAGGUUCAAGAACCGAGAA 1666 AAGGuucAAGAAccGAGAAdTsdT sense  653-672 1667 UUCUCGGUUCUUGAACCUU 1668 UUCUCGGUUCUUGAACCUUdTsdT antis  742-761 1669 AGAAGAAGGACGAGCUGUA 1670 AGAAGAAGGAcGAGcuGuAdTsdT sense  742-761 1671 UACAGCUCGUCCUUCUUCU 1672 uAcAGCUCGUCCUUCUUCUdTsdT antis  744-763 1673 AAGAAGGACGAGCUGUAUU 1674 AAGAAGGAcGAGcuGuAuudTsdT sense  744-763 1675 AAUACAGCUCGUCCUUCUU 1676 AAuAcAGCUCGUCCUUCUUdTsdT antis  790-809 1677 AGACGGUGUACCGAGUGGC 1678 AGAcGGuGuAccGAGuGGcdTsdT sense  790-809 1679 GCCACUCGGUACACCGUCU 1680 GCcACUCGGuAcACCGUCUdTsdT antis  840-859 1681 CCUAUCAUCUACAUCAAGG 1682 ccuAucAucuAcAucAAGGdTsdT sense  840-859 1683 CCUUGAUGUAGAUGAUAGG 1684 CCUUGAUGuAGAUGAuAGGdTsdT antis  882-901 1685 AGCUUGGCCUACAUCCACU 1686 AGcuuGGccuAcAuccAcudTsdT sense  882-901 1687 AGUGGAUGUAGGCCAAGCU 1688 AGUGGAUGuAGGCcAAGCUdTsdT antis  912-931 1689 UGUCACCGUGACAUCAAGC 1690 uGucAccGuGAcAucAAGcdTsdT sense  912-931 1691 GCUUGAUGUCACGGUGACA 1692 GCUUGAUGUcACGGUGAcAdTsdT antis  947-966 1693 GGACCCUGACACUGCUGUC 1694 GGAcccuGAcAcuGcuGucdTsdT sense  947-966 1695 GACAGCAGUGUCAGGGUCC 1696 GAcAGcAGUGUcAGGGUCCdTsdT antis 1009-1028 1697 GGGAGCCCAAUGUGUCCUA 1698 GGGAGcccAAuGuGuccuAdTsdT sense 1009-1028 1699 UAGGACACAUUGGGCUCCC 1700 uAGGAcAcAUUGGGCUCCCdTsdT antis 1017-1036 1701 AAUGUGUCCUACAUCUGCU 1702 AAuGuGuccuAcAucuGcudTsdT sense 1017-1036 1703 AGCAGAUGUAGGACACAUU 1704 AGcAGAUGuAGGAcAcAUUdTsdT antis 1113-1132 1705 UGUGUACUUGCUGAGCUAC 1706 uGuGuAcuuGcuGAGcuAcdTsdT sense 1113-1132 1707 GUAGCUCAGCAAGUACACA 1708 GuAGCUcAGcAAGuAcAcAdTsdT antis 1121-1140 1709 UGCUGAGCUACUUCUCGGC 1710 uGcuGAGcuAcuucucGGcdTsdT sense 1121-1140 1711 GCCGAGAAGUAGCUCAGCA 1712 GCCGAGAAGuAGCUcAGcAdTsdT antis 1268-1287 1713 CAAAGCUCACCCUUGGACA 1714 cAAAGcucAcccuuGGAcAdTsdT sense 1268-1287 1715 UGUCCAAGGGUGAGCUUUG 1716 UGUCcAAGGGUGAGCUUUGdTsdT antis 1290-1309 1717 GUGUUCAAAUCUUCAAAGA 1718 GuGuucAAAucuucAAAGAdTsdT sense 1290-1309 1719 UCUUUGAAGAUUUGAACAC 1720 UCUUUGAAGAUUUGAAcACdTsdT antis 1308-1327 1721 ACACCACCUGAGGCCAUUG 1722 AcAccAccuGAGGccAuuGdTsdT sense 1308-1327 1723 CAAUGGCCUCAGGUGGUGU 1724 cAAUGGCCUcAGGUGGUGUdTsdT antis 1312-1331 1725 CACCUGAGGCCAUUGCACU 1726 cAccuGAGGccAuuGcAcudTsdT sense 1312-1331 1727 AGUGCAAUGGCCUCAGGUG 1728 AGUGcAAUGGCCUcAGGUGdTsdT antis 1326-1345 1729 GCACUCUGCUCUAGCCUAC 1730 GcAcucuGcucuAGccuAcdTsdT sense 1326-1345 1731 GUAGGCUAGAGCAGAGUGC 1732 GuAGGCuAGAGcAGAGUGCdTsdT antis 1332-1351 1733 UGCUCUAGCCUACUGGAGU 1734 uGcucuAGccuAcuGGAGudTsdT sense 1332-1351 1735 ACUCCAGUAGGCUAGAGCA 1736 ACUCcAGuAGGCuAGAGcAdTsdT antis 1406-1425 1737 UGAACUGCGGAGACUCGGA 1738 uGAAcuGcGGAGAcucGGAdTsdT sense 1406-1425 1739 UCCGAGUCUCCGCAGUUCA 1740 UCCGAGUCUCCGcAGUUcAdTsdT antis 1407-1426 1741 GAACUGCGGAGACUCGGAG 1742 GAAcuGcGGAGAcucGGAGdTsdT sense 1407-1426 1743 CUCCGAGUCUCCGCAGUUC 1744 CUCCGAGUCUCCGcAGUUCdTsdT antis 1415-1434 1745 GAGACUCGGAGCCCAGCUC 1746 GAGAcucGGAGcccAGcucdTsdT sense 1415-1434 1747 GAGCUGGGCUCCGAGUCUC 1748 GAGCUGGGCUCCGAGUCUCdTsdT antis 1464-1483 1749 AACUUCAGUCCUGGUGAAC 1750 AAcuucAGuccuGGuGAAcdTsdT sense 1464-1483 1751 GUUCACCAGGACUGAAGUU 1752 GUUcACcAGGACUGAAGUUdTsdT antis 1465-1484 1753 ACUUCAGUCCUGGUGAACU 1754 AcuucAGuccuGGuGAAcudTsdT sense 1465-1484 1755 AGUUCACCAGGACUGAAGU 1756 AGUUcACcAGGACUGAAGUdTsdT antis 1479-1498 1757 GAACUGUCCAUCCAACCAU 1758 GAAcuGuccAuccAAccAudTsdT sense 1479-1498 1759 AUGGUUGGAUGGACAGUUC 1760 AUGGUUGGAUGGAcAGUUCdTsdT antis 1566-1585 1761 UCCUACAACCCAUCCUCAC 1762 uccuAcAAcccAuccucAcdTsdT sense 1566-1585 1763 GUGAGGAUGGGUUGUAGGA 1764 GUGAGGAUGGGUUGuAGGAdTsdT antis 1571-1590 1765 CAACCCAUCCUCACAAGCU 1766 cAAcccAuccucAcAAGcudTsdT sense 1571-1590 1767 AGCUUGUGAGGAUGGGUUG 1768 AGCUUGUGAGGAUGGGUUGdTsdT antis 1584-1603 1769 CAAGCUUUAACUGAAGCUC 1770 cAAGcuuuAAcuGAAGcucdTsdT sense 1584-1603 1771 GAGCUUCAGUUAAAGCUUG 1772 GAGCUUcAGUuAAAGCUUGdTsdT antis 1802-1821 1773 CUAGGCCUCCCUCAGCAGC 1774 cuAGGccucccucAGcAGcdTsdT sense 1802-1821 1775 GCUGCUGAGGGAGGCCUAG 1776 GCUGCUGAGGGAGGCCuAGdTsdT antis 1938-1957 1777 CCCCAGGCUACCACUCCUU 1778 ccccAGGcuAccAcuccuudTsdT sense 1938-1957 1779 AAGGAGUGGUAGCCUGGGG 1780 AAGGAGUGGuAGCCUGGGGdTsdT antis 1986-2005 1781 AAUAGAACCAGCCCAGCCC 1782 AAuAGAAccAGcccAGcccdTsdT sense 1986-2005 1783 GGGCUGGGCUGGUUCUAUU 1784 GGGCUGGGCUGGUUCuAUUdTsdT antis 1987-2006 1785 AUAGAACCAGCCCAGCCCA 1786 AuAGAAccAGcccAGcccAdTsdT sense 1987-2006 1787 UGGGCUGGGCUGGUUCUAU 1788 UGGGCUGGGCUGGUUCuAUdTsdT antis 2032-2051 1789 CUGGGUGUAAAUAGAUUGU 1790 cuGGGuGuAAAuAGAuuGudTsdT sense 2032-2051 1791 ACAAUCUAUUUACACCCAG 1792 AcAAUCuAUUuAcACCcAGdTsdT antis 2085-2104 1793 CCAUUCAACUUGCCCCCCC 1794 ccAuucAAcuuGcccccccdTsdT sense 2085-2104 1795 GGGGGGGCAAGUUGAAUGG 1796 GGGGGGGcAAGUUGAAUGGdTsdT antis 2090-2109 1797 CAACUUGCCCCCCCCAGCU 1798 cAAcuuGccccccccAGcudTsdT sense 2090-2109 1799 AGCUGGGGGGGGCAAGUUG 1800 AGCUGGGGGGGGcAAGUUGdTsdT antis 2094-2113 1801 UUGCCCCCCCCAGCUGUAC 1802 uuGccccccccAGcuGuAcdTsdT sense 2094-2113 1803 GUACAGCUGGGGGGGGCAA 1804 GuAcAGCUGGGGGGGGcAAdTsdT antis 2101-2120 1805 CCCCAGCUGUACCCCUUCU 1806 ccccAGcuGuAccccuucudTsdT sense 2101-2120 1807 AGAAGGGGUACAGCUGGGG 1808 AGAAGGGGuAcAGCUGGGGdTsdT antis 2104-2123 1809 CAGCUGUACCCCUUCUUGU 1810 cAGcuGuAccccuucuuGudTsdT sense 2104-2123 1811 ACAAGAAGGGGUACAGCUG 1812 AcAAGAAGGGGuAcAGCUGdTsdT antis 2105-2124 1813 AGCUGUACCCCUUCUUGUC 1814 AGcuGuAccccuucuuGucdTsdT sense 2105-2124 1815 GACAAGAAGGGGUACAGCU 1816 GAcAAGAAGGGGuAcAGCUdTsdT antis 2155-2174 1817 UCCUGGAAGGAGGGGAGUA 1818 uccuGGAAGGAGGGGAGuAdTsdT sense 2155-2174 1819 UACUCCCCUCCUUCCAGGA 1820 uACUCCCCUCCUUCcAGGAdTsdT antis 2167-2186 1821 GGGAGUAGAGAGAGUCCCU 1822 GGGAGuAGAGAGAGucccudTsdT sense 2167-2186 1823 AGGGACUCUCUCUACUCCC 1824 AGGGACUCUCUCuACUCCCdTsdT antis 2174-2193 1825 GAGAGAGUCCCUGGUGUCU 1826 GAGAGAGucccuGGuGucudTsdT sense 2174-2193 1827 AGACACCAGGGACUCUCUC 1828 AGAcACcAGGGACUCUCUCdTsdT antis 2216-2235 1829 UGUGUACAGACCUCUGUUC 1830 uGuGuAcAGAccucuGuucdTsdT sense 2216-2235 1831 GAACAGAGGUCUGUACACA 1832 GAAcAGAGGUCUGuAcAcAdTsdT antis 2217-2236 1833 GUGUACAGACCUCUGUUCA 1834 GuGuAcAGAccucuGuucAdTsdT sense 2217-2236 1835 UGAACAGAGGUCUGUACAC 1836 UGAAcAGAGGUCUGuAcACdTsdT antis 2236-2255 1837 AUAAAUUAUUGGCAUGAAA 1838 AuAAAuuAuuGGcAuGAAAdTsdT sense 2236-2255 1839 UUUCAUGCCAAUAAUUUAU 1840 UUUcAUGCcAAuAAUUuAUdTsdT antis 2237-2256 1841 UAAAUUAUUGGCAUGAAAC 1842 uAAAuuAuuGGcAuGAAAcdTsdT sense 2237-2256 1843 GUUUCAUGCCAAUAAUUUA 1844 GUUUcAUGCcAAuAAUUuAdTsdT antis 2245-2264 1845 UGGCAUGAAACCCUUAAAA 1846 uGGcAuGAAAcccuuAAAAdTsdT sense 2245-2264 1847 UUUUAAGGGUUUCAUGCCA 1848 UUUuAAGGGUUUcAUGCcAdTsdT antis   13-32 1849 AAGCCGACGGCAGAGGGAC 1850 AAGccGAcGGcAGAGGGAcdTsdT sense   13-32 1851 GUCCCUCUGCCGUCGGCUU 1852 GUCCCUCUGCCGUCGGCUUdTsdT antis   21-40 1853 GGCAGAGGGACUUCAUCUC 1854 GGcAGAGGGAcuucAucucdTsdT sense   21-40 1855 GAGAUGAAGUCCCUCUGCC 1856 GAGAUGAAGUCCCUCUGCCdTsdT antis   22-41 1857 GCAGAGGGACUUCAUCUCC 1858 GcAGAGGGAcuucAucuccdTsdT sense   22-41 1859 GGAGAUGAAGUCCCUCUGC 1860 GGAGAUGAAGUCCCUCUGCdTsdT antis   23-42 1861 CAGAGGGACUUCAUCUCCC 1862 cAGAGGGAcuucAucucccdTsdT sense   23-42 1863 GGGAGAUGAAGUCCCUCUG 1864 GGGAGAUGAAGUCCCUCUGdTsdT antis   25-44 1865 GAGGGACUUCAUCUCCCGG 1866 GAGGGAcuucAucucccGGdTsdT sense   25-44 1867 CCGGGAGAUGAAGUCCCUC 1868 CCGGGAGAUGAAGUCCCUCdTsdT antis   30-49 1869 ACUUCAUCUCCCGGCGUGC 1870 AcuucAucucccGGcGuGcdTsdT sense   30-49 1871 GCACGCCGGGAGAUGAAGU 1872 GcACGCCGGGAGAUGAAGUdTsdT antis   31-50 1873 CUUCAUCUCCCGGCGUGCC 1874 cuucAucucccGGcGuGccdTsdT sense   31-50 1875 GGCACGCCGGGAGAUGAAG 1876 GGcACGCCGGGAGAUGAAGdTsdT antis   32-51 1877 UUCAUCUCCCGGCGUGCCC 1878 uucAucucccGGcGuGcccdTsdT sense   32-51 1879 GGGCACGCCGGGAGAUGAA 1880 GGGcACGCCGGGAGAUGAAdTsdT antis   36-55 1881 UCUCCCGGCGUGCCCCGCG 1882 ucucccGGcGuGccccGcGdTsdT sense   36-55 1883 CGCGGGGCACGCCGGGAGA 1884 CGCGGGGcACGCCGGGAGAdTsdT antis   41-60 1885 CGGCGUGCCCCGCGGCGGG 1886 cGGcGuGccccGcGGcGGGdTsdT sense   41-60 1887 CCCGCCGCGGGGCACGCCG 1888 CCCGCCGCGGGGcACGCCGdTsdT antis   44-63 1889 CGUGCCCCGCGGCGGGCGC 1890 cGuGccccGcGGcGGGcGcdTsdT sense   44-63 1891 GCGCCCGCCGCGGGGCACG 1892 GCGCCCGCCGCGGGGcACGdTsdT antis   45-64 1893 GUGCCCCGCGGCGGGCGCU 1894 GuGccccGcGGcGGGcGcudTsdT sense   45-64 1895 AGCGCCCGCCGCGGGGCAC 1896 AGCGCCCGCCGCGGGGcACdTsdT antis   52-71 1897 GCGGCGGGCGCUGGGCCGG 1898 GcGGcGGGcGcuGGGccGGdTsdT sense   52-71 1899 CCGGCCCAGCGCCCGCCGC 1900 CCGGCCcAGCGCCCGCCGCdTsdT antis   58-77 1901 GGCGCUGGGCCGGAGCCGG 1902 GGcGcuGGGccGGAGccGGdTsdT sense   58-77 1903 CCGGCUCCGGCCCAGCGCC 1904 CCGGCUCCGGCCcAGCGCCdTsdT antis   84-103 1905 ACGGCGCGGCCUGGAAGAG 1906 AcGGcGcGGccuGGAAGAGdTsdT sense   84-103 1907 CUCUUCCAGGCCGCGCCGU 1908 CUCUUCcAGGCCGCGCCGUdTsdT antis   88-107 1909 CGCGGCCUGGAAGAGGCCG 1910 cGcGGccuGGAAGAGGccGdTsdT sense   88-107 1911 CGGCCUCUUCCAGGCCGCG 1912 CGGCCUCUUCcAGGCCGCGdTsdT antis   94-113 1913 CUGGAAGAGGCCGGAGCCC 1914 cuGGAAGAGGccGGAGcccdTsdT sense   94-113 1915 GGGCUCCGGCCUCUUCCAG 1916 GGGCUCCGGCCUCUUCcAGdTsdT antis   98-117 1917 AAGAGGCCGGAGCCCAGGG 1918 AAGAGGccGGAGcccAGGGdTsdT sense   98-117 1919 CCCUGGGCUCCGGCCUCUU 1920 CCCUGGGCUCCGGCCUCUUdTsdT antis  100-119 1921 GAGGCCGGAGCCCAGGGGA 1922 GAGGccGGAGcccAGGGGAdTsdT sense  100-119 1923 UCCCCUGGGCUCCGGCCUC 1924 UCCCCUGGGCUCCGGCCUCdTsdT antis  144-163 1925 GCAGCCCAGGCAGCCCGAG 1926 GcAGcccAGGcAGcccGAGdTsdT sense  144-163 1927 CUCGGGCUGCCUGGGCUGC 1928 CUCGGGCUGCCUGGGCUGCdTsdT antis  145-164 1929 CAGCCCAGGCAGCCCGAGC 1930 cAGcccAGGcAGcccGAGcdTsdT sense  145-164 1931 GCUCGGGCUGCCUGGGCUG 1932 GCUCGGGCUGCCUGGGCUGdTsdT antis  148-167 1933 CCCAGGCAGCCCGAGCCCC 1934 cccAGGcAGcccGAGccccdTsdT sense  148-167 1935 GGGGCUCGGGCUGCCUGGG 1936 GGGGCUCGGGCUGCCUGGGdTsdT antis  149-168 1937 CCAGGCAGCCCGAGCCCCG 1938 ccAGGcAGcccGAGccccGdTsdT sense  149-168 1939 CGGGGCUCGGGCUGCCUGG 1940 CGGGGCUCGGGCUGCCUGGdTsdT antis  157-176 1941 CCCGAGCCCCGCGGCCUGG 1942 cccGAGccccGcGGccuGGdTsdT sense  157-176 1943 CCAGGCCGCGGGGCUCGGG 1944 CcAGGCCGCGGGGCUCGGGdTsdT antis  168-187 1945 CGGCCUGGGCCUGCGCUCG 1946 cGGccuGGGccuGcGcucGdTsdT sense  168-187 1947 CGAGCGCAGGCCCAGGCCG 1948 CGAGCGcAGGCCcAGGCCGdTsdT antis  169-188 1949 GGCCUGGGCCUGCGCUCGG 1950 GGccuGGGccuGcGcucGGdTsdT sense  169-188 1951 CCGAGCGCAGGCCCAGGCC 1952 CCGAGCGcAGGCCcAGGCCdTsdT antis  175-194 1953 GGCCUGCGCUCGGCGCCAU 1954 GGccuGcGcucGGcGccAudTsdT sense  175-194 1955 AUGGCGCCGAGCGCAGGCC 1956 AUGGCGCCGAGCGcAGGCCdTsdT antis  179-198 1957 UGCGCUCGGCGCCAUGAGC 1958 uGcGcucGGcGccAuGAGcdTsdT sense  179-198 1959 GCUCAUGGCGCCGAGCGCA 1960 GCUcAUGGCGCCGAGCGcAdTsdT antis  192-211 1961 AUGAGCGGCGGCGGGCCUU 1962 AuGAGcGGcGGcGGGccuudTsdT sense  192-211 1963 AAGGCCCGCCGCCGCUCAU 1964 AAGGCCCGCCGCCGCUcAUdTsdT antis  193-212 1965 UGAGCGGCGGCGGGCCUUC 1966 uGAGcGGcGGcGGGccuucdTsdT sense  193-212 1967 GAAGGCCCGCCGCCGCUCA 1968 GAAGGCCCGCCGCCGCUcAdTsdT antis  194-213 1969 GAGCGGCGGCGGGCCUUCG 1970 GAGcGGcGGcGGGccuucGdTsdT sense  194-213 1971 CGAAGGCCCGCCGCCGCUC 1972 CGAAGGCCCGCCGCCGCUCdTsdT antis  195-214 1973 AGCGGCGGCGGGCCUUCGG 1974 AGcGGcGGcGGGccuucGGdTsdT sense  195-214 1975 CCGAAGGCCCGCCGCCGCU 1976 CCGAAGGCCCGCCGCCGCUdTsdT antis  197-216 1977 CGGCGGCGGGCCUUCGGGA 1978 cGGcGGcGGGccuucGGGAdTsdT sense  197-216 1979 UCCCGAAGGCCCGCCGCCG 1980 UCCCGAAGGCCCGCCGCCGdTsdT antis  200-219 1981 CGGCGGGCCUUCGGGAGGC 1982 cGGcGGGccuucGGGAGGcdTsdT sense  200-219 1983 GCCUCCCGAAGGCCCGCCG 1984 GCCUCCCGAAGGCCCGCCGdTsdT antis  246-265 1985 ACCAGCUCGUUCGCGGAGC 1986 AccAGcucGuucGcGGAGcdTsdT sense  246-265 1987 GCUCCGCGAACGAGCUGGU 1988 GCUCCGCGAACGAGCUGGUdTsdT antis  253-272 1989 CGUUCGCGGAGCCAGGAGG 1990 cGuucGcGGAGccAGGAGGdTsdT sense  253-272 1991 CCUCCUGGCUCCGCGAACG 1992 CCUCCUGGCUCCGCGAACGdTsdT antis  257-276 1993 CGCGGAGCCAGGAGGCGGA 1994 cGcGGAGccAGGAGGcGGAdTsdT sense  257-276 1995 UCCGCCUCCUGGCUCCGCG 1996 UCCGCCUCCUGGCUCCGCGdTsdT antis  258-277 1997 GCGGAGCCAGGAGGCGGAG 1998 GcGGAGccAGGAGGcGGAGdTsdT sense  258-277 1999 CUCCGCCUCCUGGCUCCGC 2000 CUCCGCCUCCUGGCUCCGCdTsdT antis  297-316 2001 CCCGGGGGCUCGGCCUCUG 2002 cccGGGGGcucGGccucuGdTsdT sense  297-316 2003 CAGAGGCCGAGCCCCCGGG 2004 cAGAGGCCGAGCCCCCGGGdTsdT antis  298-317 2005 CCGGGGGCUCGGCCUCUGG 2006 ccGGGGGcucGGccucuGGdTsdT sense  298-317 2007 CCAGAGGCCGAGCCCCCGG 2008 CcAGAGGCCGAGCCCCCGGdTsdT antis  321-340 2009 GGAGGCACUGGCGGCGGGA 2010 GGAGGcAcuGGcGGcGGGAdTsdT sense  321-340 2011 UCCCGCCGCCAGUGCCUCC 2012 UCCCGCCGCcAGUGCCUCCdTsdT antis  323-342 2013 AGGCACUGGCGGCGGGAAA 2014 AGGcAcuGGcGGcGGGAAAdTsdT sense  323-342 2015 UUUCCCGCCGCCAGUGCCU 2016 UUUCCCGCCGCcAGUGCCUdTsdT antis  325-344 2017 GCACUGGCGGCGGGAAAGC 2018 GcAcuGGcGGcGGGAAAGcdTsdT sense  325-344 2019 GCUUUCCCGCCGCCAGUGC 2020 GCUUUCCCGCCGCcAGUGCdTsdT antis  326-345 2021 CACUGGCGGCGGGAAAGCG 2022 cAcuGGcGGcGGGAAAGcGdTsdT sense  326-345 2023 CGCUUUCCCGCCGCCAGUG 2024 CGCUUUCCCGCCGCcAGUGdTsdT antis  338-357 2025 GAAAGCGUCAGUCGGGGCU 2026 GAAAGcGucAGucGGGGcudTsdT sense  338-357 2027 AGCCCCGACUGACGCUUUC 2028 AGCCCCGACUGACGCUUUCdTsdT antis  370-389 2029 UGGGAGCCUCGAGCUCCGG 2030 uGGGAGccucGAGcuccGGdTsdT sense  370-389 2031 CCGGAGCUCGAGGCUCCCA 2032 CCGGAGCUCGAGGCUCCcAdTsdT antis  371-390 2033 GGGAGCCUCGAGCUCCGGG 2034 GGGAGccucGAGcuccGGGdTsdT sense  371-390 2035 CCCGGAGCUCGAGGCUCCC 2036 CCCGGAGCUCGAGGCUCCCdTsdT antis  372-391 2037 GGAGCCUCGAGCUCCGGGG 2038 GGAGccucGAGcuccGGGGdTsdT sense  372-391 2039 CCCCGGAGCUCGAGGCUCC 2040 CCCCGGAGCUCGAGGCUCCdTsdT antis  373-392 2041 GAGCCUCGAGCUCCGGGGG 2042 GAGccucGAGcuccGGGGGdTsdT sense  373-392 2043 CCCCCGGAGCUCGAGGCUC 2044 CCCCCGGAGCUCGAGGCUCdTsdT antis  375-394 2045 GCCUCGAGCUCCGGGGGUG 2046 GccucGAGcuccGGGGGuGdTsdT sense  375-394 2047 CACCCCCGGAGCUCGAGGC 2048 cACCCCCGGAGCUCGAGGCdTsdT antis  380-399 2049 GAGCUCCGGGGGUGGCCCC 2050 GAGcuccGGGGGuGGccccdTsdT sense  380-399 2051 GGGGCCACCCCCGGAGCUC 2052 GGGGCcACCCCCGGAGCUCdTsdT antis  385-404 2053 CCGGGGGUGGCCCCAGCGG 2054 ccGGGGGuGGccccAGcGGdTsdT sense  385-404 2055 CCGCUGGGGCCACCCCCGG 2056 CCGCUGGGGCcACCCCCGGdTsdT antis  389-408 2057 GGGUGGCCCCAGCGGCAGC 2058 GGGuGGccccAGcGGcAGcdTsdT sense  389-408 2059 GCUGCCGCUGGGGCCACCC 2060 GCUGCCGCUGGGGCcACCCdTsdT antis  439-458 2061 GCACUAGCUUCCCGCCGCC 2062 GcAcuAGcuucccGccGccdTsdT sense  439-458 2063 GGCGGCGGGAAGCUAGUGC 2064 GGCGGCGGGAAGCuAGUGCdTsdT antis  440-459 2065 CACUAGCUUCCCGCCGCCG 2066 cAcuAGcuucccGccGccGdTsdT sense  440-459 2067 CGGCGGCGGGAAGCUAGUG 2068 CGGCGGCGGGAAGCuAGUGdTsdT antis  445-464 2069 GCUUCCCGCCGCCGGGAGU 2070 GcuucccGccGccGGGAGudTsdT sense  445-464 2071 ACUCCCGGCGGCGGGAAGC 2072 ACUCCCGGCGGCGGGAAGCdTsdT antis  447-466 2073 UUCCCGCCGCCGGGAGUGA 2074 uucccGccGccGGGAGuGAdTsdT sense  447-466 2075 UCACUCCCGGCGGCGGGAA 2076 UcACUCCCGGCGGCGGGAAdTsdT antis  463-482 2077 UGAAGCUGGGCCGUGACAG 2078 uGAAGcuGGGccGuGAcAGdTsdT sense  463-482 2079 CUGUCACGGCCCAGCUUCA 2080 CUGUcACGGCCcAGCUUcAdTsdT antis  471-490 2081 GGCCGUGACAGCGGGAAGG 2082 GGccGuGAcAGcGGGAAGGdTsdT sense  471-490 2083 CCUUCCCGCUGUCACGGCC 2084 CCUUCCCGCUGUcACGGCCdTsdT antis  474-493 2085 CGUGACAGCGGGAAGGUGA 2086 cGuGAcAGcGGGAAGGuGAdTsdT sense  474-493 2087 UCACCUUCCCGCUGUCACG 2088 UcACCUUCCCGCUGUcACGdTsdT antis  492-511 2089 ACCACAGUGGUAGCCACUG 2090 AccAcAGuGGuAGccAcuGdTsdT sense  492-511 2091 CAGUGGCUACCACUGUGGU 2092 cAGUGGCuACcACUGUGGUdTsdT antis  495-514 2093 ACAGUGGUAGCCACUGUAG 2094 AcAGuGGuAGccAcuGuAGdTsdT sense  495-514 2095 CUACAGUGGCUACCACUGU 2096 CuAcAGUGGCuACcACUGUdTsdT antis  496-515 2097 CAGUGGUAGCCACUGUAGG 2098 cAGuGGuAGccAcuGuAGGdTsdT sense  496-515 2099 CCUACAGUGGCUACCACUG 2100 CCuAcAGUGGCuACcACUGdTsdT antis  506-525 2101 CACUGUAGGCCAAGGCCCA 2102 cAcuGuAGGccAAGGcccAdTsdT sense  506-525 2103 UGGGCCUUGGCCUACAGUG 2104 UGGGCCUUGGCCuAcAGUGdTsdT antis  507-526 2105 ACUGUAGGCCAAGGCCCAG 2106 AcuGuAGGccAAGGcccAGdTsdT sense  507-526 2107 CUGGGCCUUGGCCUACAGU 2108 CUGGGCCUUGGCCuAcAGUdTsdT antis  509-528 2109 UGUAGGCCAAGGCCCAGAG 2110 uGuAGGccAAGGcccAGAGdTsdT sense  509-528 2111 CUCUGGGCCUUGGCCUACA 2112 CUCUGGGCCUUGGCCuAcAdTsdT antis  510-529 2113 GUAGGCCAAGGCCCAGAGC 2114 GuAGGccAAGGcccAGAGcdTsdT sense  510-529 2115 GCUCUGGGCCUUGGCCUAC 2116 GCUCUGGGCCUUGGCCuACdTsdT antis  582-601 2117 GGAGUAGUAUACCAGGCAC 2118 GGAGuAGuAuAccAGGcAcdTsdT sense  582-601 2119 GUGCCUGGUAUACUACUCC 2120 GUGCCUGGuAuACuACUCCdTsdT antis  585-604 2121 GUAGUAUACCAGGCACGGC 2122 GuAGuAuAccAGGcAcGGcdTsdT sense  585-604 2123 GCCGUGCCUGGUAUACUAC 2124 GCCGUGCCUGGuAuACuACdTsdT antis  595-614 2125 AGGCACGGCUGGCAGAGAC 2126 AGGcAcGGcuGGcAGAGAcdTsdT sense  595-614 2127 GUCUCUGCCAGCCGUGCCU 2128 GUCUCUGCcAGCCGUGCCUdTsdT antis  596-615 2129 GGCACGGCUGGCAGAGACG 2130 GGcAcGGcuGGcAGAGAcGdTsdT sense  596-615 2131 CGUCUCUGCCAGCCGUGCC 2132 CGUCUCUGCcAGCCGUGCCdTsdT antis  597-616 2133 GCACGGCUGGCAGAGACGA 2134 GcAcGGcuGGcAGAGAcGAdTsdT sense  597-616 2135 UCGUCUCUGCCAGCCGUGC 2136 UCGUCUCUGCcAGCCGUGCdTsdT antis  610-629 2137 AGACGAGGGAACUGGUGGC 2138 AGAcGAGGGAAcuGGuGGcdTsdT sense  610-629 2139 GCCACCAGUUCCCUCGUCU 2140 GCcACcAGUUCCCUCGUCUdTsdT antis  612-631 2141 ACGAGGGAACUGGUGGCCA 2142 AcGAGGGAAcuGGuGGccAdTsdT sense  612-631 2143 UGGCCACCAGUUCCCUCGU 2144 UGGCcACcAGUUCCCUCGUdTsdT antis  614-633 2145 GAGGGAACUGGUGGCCAUC 2146 GAGGGAAcuGGuGGccAucdTsdT sense  614-633 2147 GAUGGCCACCAGUUCCCUC 2148 GAUGGCcACcAGUUCCCUCdTsdT antis  646-665 2149 AGGACAAAAGGUUCAAGAA 2150 AGGAcAAAAGGuucAAGAAdTsdT sense  646-665 2151 UUCUUGAACCUUUUGUCCU 2152 UUCUUGAACCUUUUGUCCUdTsdT antis  661-680 2153 AGAACCGAGAACUGCAGAU 2154 AGAAccGAGAAcuGcAGAudTsdT sense  661-680 2155 AUCUGCAGUUCUCGGUUCU 2156 AUCUGcAGUUCUCGGUUCUdTsdT antis  668-687 2157 AGAACUGCAGAUUAUGCGU 2158 AGAAcuGcAGAuuAuGcGudTsdT sense  668-687 2159 ACGCAUAAUCUGCAGUUCU 2160 ACGcAuAAUCUGcAGUUCUdTsdT antis  669-688 2161 GAACUGCAGAUUAUGCGUA 2162 GAAcuGcAGAuuAuGcGuAdTsdT sense  669-688 2163 UACGCAUAAUCUGCAGUUC 2164 uACGcAuAAUCUGcAGUUCdTsdT antis  703-722 2165 AUAUUGUGAGGCUGCGGUA 2166 AuAuuGuGAGGcuGcGGuAdTsdT sense  703-722 2167 UACCGCAGCCUCACAAUAU 2168 uACCGcAGCCUcAcAAuAUdTsdT antis  704-723 2169 UAUUGUGAGGCUGCGGUAC 2170 uAuuGuGAGGcuGcGGuAcdTsdT sense  704-723 2171 GUACCGCAGCCUCACAAUA 2172 GuACCGcAGCCUcAcAAuAdTsdT antis  705-724 2173 AUUGUGAGGCUGCGGUACU 2174 AuuGuGAGGcuGcGGuAcudTsdT sense  705-724 2175 AGUACCGCAGCCUCACAAU 2176 AGuACCGcAGCCUcAcAAUdTsdT antis  738-757 2177 GGGGAGAAGAAGGACGAGC 2178 GGGGAGAAGAAGGAcGAGcdTsdT sense  738-757 2179 GCUCGUCCUUCUUCUCCCC 2180 GCUCGUCCUUCUUCUCCCCdTsdT antis  824-843 2181 GGCCAAGCUGAUCACCCCU 2182 GGccAAGcuGAucAccccudTsdT sense  824-843 2183 AGGGGUGAUCAGCUUGGCC 2184 AGGGGUGAUcAGCUUGGCCdTsdT antis  827-846 2185 CAAGCUGAUCACCCCUAUC 2186 cAAGcuGAucAccccuAucdTsdT sense  827-846 2187 GAUAGGGGUGAUCAGCUUG 2188 GAuAGGGGUGAUcAGCUUGdTsdT antis  879-898 2189 CGGAGCUUGGCCUACAUCC 2190 cGGAGcuuGGccuAcAuccdTsdT sense  879-898 2191 GGAUGUAGGCCAAGCUCCG 2192 GGAUGuAGGCcAAGCUCCGdTsdT antis  880-899 2193 GGAGCUUGGCCUACAUCCA 2194 GGAGcuuGGccuAcAuccAdTsdT sense  880-899 2195 UGGAUGUAGGCCAAGCUCC 2196 UGGAUGuAGGCcAAGCUCCdTsdT antis  881-900 2197 GAGCUUGGCCUACAUCCAC 2198 GAGcuuGGccuAcAuccAcdTsdT sense  881-900 2199 GUGGAUGUAGGCCAAGCUC 2200 GUGGAUGuAGGCcAAGCUCdTsdT antis  884-903 2201 CUUGGCCUACAUCCACUCC 2202 cuuGGccuAcAuccAcuccdTsdT sense  884-903 2203 GGAGUGGAUGUAGGCCAAG 2204 GGAGUGGAUGuAGGCcAAGdTsdT antis  886-905 2205 UGGCCUACAUCCACUCCCA 2206 uGGccuAcAuccAcucccAdTsdT sense  886-905 2207 UGGGAGUGGAUGUAGGCCA 2208 UGGGAGUGGAUGuAGGCcAdTsdT antis  896-915 2209 CCACUCCCAAGGUGUGUGU 2210 ccAcucccAAGGuGuGuGudTsdT sense  896-915 2211 ACACACACCUUGGGAGUGG 2212 AcAcAcACCUUGGGAGUGGdTsdT antis  916-935 2213 ACCGUGACAUCAAGCCCCA 2214 AccGuGAcAucAAGccccAdTsdT sense  916-935 2215 UGGGGCUUGAUGUCACGGU 2216 UGGGGCUUGAUGUcACGGUdTsdT antis  917-936 2217 CCGUGACAUCAAGCCCCAG 2218 ccGuGAcAucAAGccccAGdTsdT sense  917-936 2219 CUGGGGCUUGAUGUCACGG 2220 CUGGGGCUUGAUGUcACGGdTsdT antis  931-950 2221 CCCAGAAUUUGCUUGUGGA 2222 cccAGAAuuuGcuuGuGGAdTsdT sense  931-950 2223 UCCACAAGCAAAUUCUGGG 2224 UCcAcAAGcAAAUUCUGGGdTsdT antis  933-952 2225 CAGAAUUUGCUUGUGGACC 2226 cAGAAuuuGcuuGuGGAccdTsdT sense  933-952 2227 GGUCCACAAGCAAAUUCUG 2228 GGUCcAcAAGcAAAUUCUGdTsdT antis  991-1010 2229 CAAAGCAGCUGGUUCGGGG 2230 cAAAGcAGcuGGuucGGGGdTsdT sense  991-1010 2231 CCCCGAACCAGCUGCUUUG 2232 CCCCGAACcAGCUGCUUUGdTsdT antis  993-1012 2233 AAGCAGCUGGUUCGGGGGG 2234 AAGcAGcuGGuucGGGGGGdTsdT sense  993-1012 2235 CCCCCCGAACCAGCUGCUU 2236 CCCCCCGAACcAGCUGCUUdTsdT antis 1000-1019 2237 UGGUUCGGGGGGAGCCCAA 2238 uGGuucGGGGGGAGcccAAdTsdT sense 1000-1019 2239 UUGGGCUCCCCCCGAACCA 2240 UUGGGCUCCCCCCGAACcAdTsdT antis 1003-1022 2241 UUCGGGGGGAGCCCAAUGU 2242 uucGGGGGGAGcccAAuGudTsdT sense 1003-1022 2243 ACAUUGGGCUCCCCCCGAA 2244 AcAUUGGGCUCCCCCCGAAdTsdT antis 1004-1023 2245 UCGGGGGGAGCCCAAUGUG 2246 ucGGGGGGAGcccAAuGuGdTsdT sense 1004-1023 2247 CACAUUGGGCUCCCCCCGA 2248 cAcAUUGGGCUCCCCCCGAdTsdT antis 1006-1025 2249 GGGGGGAGCCCAAUGUGUC 2250 GGGGGGAGcccAAuGuGucdTsdT sense 1006-1025 2251 GACACAUUGGGCUCCCCCC 2252 GAcAcAUUGGGCUCCCCCCdTsdT antis 1015-1034 2253 CCAAUGUGUCCUACAUCUG 2254 ccAAuGuGuccuAcAucuGdTsdT sense 1015-1034 2255 CAGAUGUAGGACACAUUGG 2256 cAGAUGuAGGAcAcAUUGGdTsdT antis 1016-1035 2257 CAAUGUGUCCUACAUCUGC 2258 cAAuGuGuccuAcAucuGcdTsdT sense 1016-1035 2259 GCAGAUGUAGGACACAUUG 2260 GcAGAUGuAGGAcAcAUUGdTsdT antis 1031-1050 2261 CUGCUCUCGGUACUACCGU 2262 cuGcucucGGuAcuAccGudTsdT sense 1031-1050 2263 ACGGUAGUACCGAGAGCAG 2264 ACGGuAGuACCGAGAGcAGdTsdT antis 1045-1064 2265 ACCGUGCUCCAGAACUCAU 2266 AccGuGcuccAGAAcucAudTsdT sense 1045-1064 2267 AUGAGUUCUGGAGCACGGU 2268 AUGAGUUCUGGAGcACGGUdTsdT antis 1047-1066 2269 CGUGCUCCAGAACUCAUCU 2270 cGuGcuccAGAAcucAucudTsdT sense 1047-1066 2271 AGAUGAGUUCUGGAGCACG 2272 AGAUGAGUUCUGGAGcACGdTsdT antis 1051-1070 2273 CUCCAGAACUCAUCUUUGG 2274 cuccAGAAcucAucuuuGGdTsdT sense 1051-1070 2275 CCAAAGAUGAGUUCUGGAG 2276 CcAAAGAUGAGUUCUGGAGdTsdT antis 1055-1074 2277 AGAACUCAUCUUUGGAGCC 2278 AGAAcucAucuuuGGAGccdTsdT sense 1055-1074 2279 GGCUCCAAAGAUGAGUUCU 2280 GGCUCcAAAGAUGAGUUCUdTsdT antis 1058-1077 2281 ACUCAUCUUUGGAGCCACA 2282 AcucAucuuuGGAGccAcAdTsdT sense 1058-1077 2283 UGUGGCUCCAAAGAUGAGU 2284 UGUGGCUCcAAAGAUGAGUdTsdT antis 1061-1080 2285 CAUCUUUGGAGCCACAGAU 2286 cAucuuuGGAGccAcAGAudTsdT sense 1061-1080 2287 AUCUGUGGCUCCAAAGAUG 2288 AUCUGUGGCUCcAAAGAUGdTsdT antis 1062-1081 2289 AUCUUUGGAGCCACAGAUU 2290 AucuuuGGAGccAcAGAuudTsdT sense 1062-1081 2291 AAUCUGUGGCUCCAAAGAU 2292 AAUCUGUGGCUCcAAAGAUdTsdT antis 1086-1105 2293 UCGUCCAUCGAUGUGUGGU 2294 ucGuccAucGAuGuGuGGudTsdT sense 1086-1105 2295 ACCACACAUCGAUGGACGA 2296 ACcAcAcAUCGAUGGACGAdTsdT antis 1099-1118 2297 UGUGGUCGGCUGGCUGUGU 2298 uGuGGucGGcuGGcuGuGudTsdT sense 1099-1118 2299 ACACAGCCAGCCGACCACA 2300 AcAcAGCcAGCCGACcAcAdTsdT antis 1100-1119 2301 GUGGUCGGCUGGCUGUGUA 2302 GuGGucGGcuGGcuGuGuAdTsdT sense 1100-1119 2303 UACACAGCCAGCCGACCAC 2304 uAcAcAGCcAGCCGACcACdTsdT antis 1101-1120 2305 UGGUCGGCUGGCUGUGUAC 2306 uGGucGGcuGGcuGuGuAcdTsdT sense 1101-1120 2307 GUACACAGCCAGCCGACCA 2308 GuAcAcAGCcAGCCGACcAdTsdT antis 1112-1131 2309 CUGUGUACUUGCUGAGCUA 2310 cuGuGuAcuuGcuGAGcuAdTsdT sense 1112-1131 2311 UAGCUCAGCAAGUACACAG 2312 uAGCUcAGcAAGuAcAcAGdTsdT antis 1114-1133 2313 GUGUACUUGCUGAGCUACU 2314 GuGuAcuuGcuGAGcuAcudTsdT sense 1114-1133 2315 AGUAGCUCAGCAAGUACAC 2316 AGuAGCUcAGcAAGuAcACdTsdT antis 1115-1134 2317 UGUACUUGCUGAGCUACUU 2318 uGuAcuuGcuGAGcuAcuudTsdT sense 1115-1134 2319 AAGUAGCUCAGCAAGUACA 2320 AAGuAGCUcAGcAAGuAcAdTsdT antis 1119-1138 2321 CUUGCUGAGCUACUUCUCG 2322 cuuGcuGAGcuAcuucucGdTsdT sense 1119-1138 2323 CGAGAAGUAGCUCAGCAAG 2324 CGAGAAGuAGCUcAGcAAGdTsdT antis 1126-1145 2325 AGCUACUUCUCGGCCAGCC 2326 AGcuAcuucucGGccAGccdTsdT sense 1126-1145 2327 GGCUGGCCGAGAAGUAGCU 2328 GGCUGGCCGAGAAGuAGCUdTsdT antis 1139-1158 2329 CCAGCCCAUCUUCCCUGGG 2330 ccAGcccAucuucccuGGGdTsdT sense 1139-1158 2331 CCCAGGGAAGAUGGGCUGG 2332 CCcAGGGAAGAUGGGCUGGdTsdT antis 1146-1165 2333 AUCUUCCCUGGGGACAGUG 2334 AucuucccuGGGGAcAGuGdTsdT sense 1146-1165 2335 CACUGUCCCCAGGGAAGAU 2336 cACUGUCCCcAGGGAAGAUdTsdT antis 1224-1243 2337 CGAGAGAUGAACCCUAACU 2338 cGAGAGAuGAAcccuAAcudTsdT sense 1224-1243 2339 AGUUAGGGUUCAUCUCUCG 2340 AGUuAGGGUUcAUCUCUCGdTsdT antis 1263-1282 2341 CAGAUCAAAGCUCACCCUU 2342 cAGAucAAAGcucAcccuudTsdT sense 1263-1282 2343 AAGGGUGAGCUUUGAUCUG 2344 AAGGGUGAGCUUUGAUCUGdTsdT antis 1264-1283 2345 AGAUCAAAGCUCACCCUUG 2346 AGAucAAAGcucAcccuuGdTsdT sense 1264-1283 2347 CAAGGGUGAGCUUUGAUCU 2348 cAAGGGUGAGCUUUGAUCUdTsdT antis 1267-1286 2349 UCAAAGCUCACCCUUGGAC 2350 ucAAAGcucAcccuuGGAcdTsdT sense 1267-1286 2351 GUCCAAGGGUGAGCUUUGA 2352 GUCcAAGGGUGAGCUUUGAdTsdT antis 1285-1304 2353 CAAAGGUGUUCAAAUCUUC 2354 cAAAGGuGuucAAAucuucdTsdT sense 1285-1304 2355 GAAGAUUUGAACACCUUUG 2356 GAAGAUUUGAAcACCUUUGdTsdT antis 1286-1305 2357 AAAGGUGUUCAAAUCUUCA 2358 AAAGGuGuucAAAucuucAdTsdT sense 1286-1305 2359 UGAAGAUUUGAACACCUUU 2360 UGAAGAUUUGAAcACCUUUdTsdT antis 1295-1314 2361 CAAAUCUUCAAAGACACCA 2362 cAAAucuucAAAGAcAccAdTsdT sense 1295-1314 2363 UGGUGUCUUUGAAGAUUUG 2364 UGGUGUCUUUGAAGAUUUGdTsdT antis 1304-1323 2365 AAAGACACCACCUGAGGCC 2366 AAAGAcAccAccuGAGGccdTsdT sense 1304-1323 2367 GGCCUCAGGUGGUGUCUUU 2368 GGCCUcAGGUGGUGUCUUUdTsdT antis 1306-1325 2369 AGACACCACCUGAGGCCAU 2370 AGAcAccAccuGAGGccAudTsdT sense 1306-1325 2371 AUGGCCUCAGGUGGUGUCU 2372 AUGGCCUcAGGUGGUGUCUdTsdT antis 1307-1326 2373 GACACCACCUGAGGCCAUU 2374 GAcAccAccuGAGGccAuudTsdT sense 1307-1326 2375 AAUGGCCUCAGGUGGUGUC 2376 AAUGGCCUcAGGUGGUGUCdTsdT antis 1310-1329 2377 ACCACCUGAGGCCAUUGCA 2378 AccAccuGAGGccAuuGcAdTsdT sense 1310-1329 2379 UGCAAUGGCCUCAGGUGGU 2380 UGcAAUGGCCUcAGGUGGUdTsdT antis 1313-1332 2381 ACCUGAGGCCAUUGCACUC 2382 AccuGAGGccAuuGcAcucdTsdT sense 1313-1332 2383 GAGUGCAAUGGCCUCAGGU 2384 GAGUGcAAUGGCCUcAGGUdTsdT antis 1315-1334 2385 CUGAGGCCAUUGCACUCUG 2386 cuGAGGccAuuGcAcucuGdTsdT sense 1315-1334 2387 CAGAGUGCAAUGGCCUCAG 2388 cAGAGUGcAAUGGCCUcAGdTsdT antis 1322-1341 2389 CAUUGCACUCUGCUCUAGC 2390 cAuuGcAcucuGcucuAGcdTsdT sense 1322-1341 2391 GCUAGAGCAGAGUGCAAUG 2392 GCuAGAGcAGAGUGcAAUGdTsdT antis 1330-1349 2393 UCUGCUCUAGCCUACUGGA 2394 ucuGcucuAGccuAcuGGAdTsdT sense 1330-1349 2395 UCCAGUAGGCUAGAGCAGA 2396 UCcAGuAGGCuAGAGcAGAdTsdT antis 1344-1363 2397 CUGGAGUACACGCCAUCCU 2398 cuGGAGuAcAcGccAuccudTsdT sense 1344-1363 2399 AGGAUGGCGUGUACUCCAG 2400 AGGAUGGCGUGuACUCcAGdTsdT antis 1347-1366 2401 GAGUACACGCCAUCCUCAA 2402 GAGuAcAcGccAuccucAAdTsdT sense 1347-1366 2403 UUGAGGAUGGCGUGUACUC 2404 UUGAGGAUGGCGUGuACUCdTsdT antis 1350-1369 2405 UACACGCCAUCCUCAAGGC 2406 uAcAcGccAuccucAAGGcdTsdT sense 1350-1369 2407 GCCUUGAGGAUGGCGUGUA 2408 GCCUUGAGGAUGGCGUGuAdTsdT antis 1366-1385 2409 GGCUCUCCCCACUCGAGGC 2410 GGcucuccccAcucGAGGcdTsdT sense 1366-1385 2411 GCCUCGAGUGGGGAGAGCC 2412 GCCUCGAGUGGGGAGAGCCdTsdT antis 1367-1386 2413 GCUCUCCCCACUCGAGGCU 2414 GcucuccccAcucGAGGcudTsdT sense 1367-1386 2415 AGCCUCGAGUGGGGAGAGC 2416 AGCCUCGAGUGGGGAGAGCdTsdT antis 1368-1387 2417 CUCUCCCCACUCGAGGCUU 2418 cucuccccAcucGAGGcuudTsdT sense 1368-1387 2419 AAGCCUCGAGUGGGGAGAG 2420 AAGCCUCGAGUGGGGAGAGdTsdT antis 1403-1422 2421 CGAUGAACUGCGGAGACUC 2422 cGAuGAAcuGcGGAGAcucdTsdT sense 1403-1422 2423 GAGUCUCCGCAGUUCAUCG 2424 GAGUCUCCGcAGUUcAUCGdTsdT antis 1412-1431 2425 GCGGAGACUCGGAGCCCAG 2426 GcGGAGAcucGGAGcccAGdTsdT sense 1412-1431 2427 CUGGGCUCCGAGUCUCCGC 2428 CUGGGCUCCGAGUCUCCGCdTsdT antis 1413-1432 2429 CGGAGACUCGGAGCCCAGC 2430 cGGAGAcucGGAGcccAGcdTsdT sense 1413-1432 2431 GCUGGGCUCCGAGUCUCCG 2432 GCUGGGCUCCGAGUCUCCGdTsdT antis 1414-1433 2433 GGAGACUCGGAGCCCAGCU 2434 GGAGAcucGGAGcccAGcudTsdT sense 1414-1433 2435 AGCUGGGCUCCGAGUCUCC 2436 AGCUGGGCUCCGAGUCUCCdTsdT antis 1416-1435 2437 AGACUCGGAGCCCAGCUCC 2438 AGAcucGGAGcccAGcuccdTsdT sense 1416-1435 2439 GGAGCUGGGCUCCGAGUCU 2440 GGAGCUGGGCUCCGAGUCUdTsdT antis 1418-1437 2441 ACUCGGAGCCCAGCUCCCC 2442 AcucGGAGcccAGcuccccdTsdT sense 1418-1437 2443 GGGGAGCUGGGCUCCGAGU 2444 GGGGAGCUGGGCUCCGAGUdTsdT antis 1420-1439 2445 UCGGAGCCCAGCUCCCCAA 2446 ucGGAGcccAGcuccccAAdTsdT sense 1420-1439 2447 UUGGGGAGCUGGGCUCCGA 2448 UUGGGGAGCUGGGCUCCGAdTsdT antis 1438-1457 2449 ACGACCGCCCGCUUCCCCC 2450 AcGAccGcccGcuucccccdTsdT sense 1438-1457 2451 GGGGGAAGCGGGCGGUCGU 2452 GGGGGAAGCGGGCGGUCGUdTsdT antis 1447-1466 2453 CGCUUCCCCCCCUGUUCAA 2454 cGcuucccccccuGuucAAdTsdT sense 1447-1466 2455 UUGAACAGGGGGGGAAGCG 2456 UUGAAcAGGGGGGGAAGCGdTsdT antis 1471-1490 2457 GUCCUGGUGAACUGUCCAU 2458 GuccuGGuGAAcuGuccAudTsdT sense 1471-1490 2459 AUGGACAGUUCACCAGGAC 2460 AUGGAcAGUUcACcAGGACdTsdT antis 1476-1495 2461 GGUGAACUGUCCAUCCAAC 2462 GGuGAAcuGuccAuccAAcdTsdT sense 1476-1495 2463 GUUGGAUGGACAGUUCACC 2464 GUUGGAUGGAcAGUUcACCdTsdT antis 1477-1496 2465 GUGAACUGUCCAUCCAACC 2466 GuGAAcuGuccAuccAAccdTsdT sense 1477-1496 2467 GGUUGGAUGGACAGUUCAC 2468 GGUUGGAUGGAcAGUUcACdTsdT antis 1486-1505 2469 CCAUCCAACCAUCUCUCAA 2470 ccAuccAAccAucucucAAdTsdT sense 1486-1505 2471 UUGAGAGAUGGUUGGAUGG 2472 UUGAGAGAUGGUUGGAUGGdTsdT antis 1487-1506 2473 CAUCCAACCAUCUCUCAAU 2474 cAuccAAccAucucucAAudTsdT sense 1487-1506 2475 AUUGAGAGAUGGUUGGAUG 2476 AUUGAGAGAUGGUUGGAUGdTsdT antis 1491-1510 2477 CAACCAUCUCUCAAUGCCA 2478 cAAccAucucucAAuGccAdTsdT sense 1491-1510 2479 UGGCAUUGAGAGAUGGUUG 2480 UGGcAUUGAGAGAUGGUUGdTsdT antis 1492-1511 2481 AACCAUCUCUCAAUGCCAU 2482 AAccAucucucAAuGccAudTsdT sense 1492-1511 2483 AUGGCAUUGAGAGAUGGUU 2484 AUGGcAUUGAGAGAUGGUUdTsdT antis 1493-1512 2485 ACCAUCUCUCAAUGCCAUU 2486 AccAucucucAAuGccAuudTsdT sense 1493-1512 2487 AAUGGCAUUGAGAGAUGGU 2488 AAUGGcAUUGAGAGAUGGUdTsdT antis 1551-1570 2489 UCUCCCCUCACCACUUCCU 2490 ucuccccucAccAcuuccudTsdT sense 1551-1570 2491 AGGAAGUGGUGAGGGGAGA 2492 AGGAAGUGGUGAGGGGAGAdTsdT antis 1553-1572 2493 UCCCCUCACCACUUCCUAC 2494 uccccucAccAcuuccuAcdTsdT sense 1553-1572 2495 GUAGGAAGUGGUGAGGGGA 2496 GuAGGAAGUGGUGAGGGGAdTsdT antis 1556-1575 2497 CCUCACCACUUCCUACAAC 2498 ccucAccAcuuccuAcAAcdTsdT sense 1556-1575 2499 GUUGUAGGAAGUGGUGAGG 2500 GUUGuAGGAAGUGGUGAGGdTsdT antis 1560-1579 2501 ACCACUUCCUACAACCCAU 2502 AccAcuuccuAcAAcccAudTsdT sense 1560-1579 2503 AUGGGUUGUAGGAAGUGGU 2504 AUGGGUUGuAGGAAGUGGUdTsdT antis 1561-1580 2505 CCACUUCCUACAACCCAUC 2506 ccAcuuccuAcAAcccAucdTsdT sense 1561-1580 2507 GAUGGGUUGUAGGAAGUGG 2508 GAUGGGUUGuAGGAAGUGGdTsdT antis 1562-1581 2509 CACUUCCUACAACCCAUCC 2510 cAcuuccuAcAAcccAuccdTsdT sense 1562-1581 2511 GGAUGGGUUGUAGGAAGUG 2512 GGAUGGGUUGuAGGAAGUGdTsdT antis 1564-1583 2513 CUUCCUACAACCCAUCCUC 2514 cuuccuAcAAcccAuccucdTsdT sense 1564-1583 2515 GAGGAUGGGUUGUAGGAAG 2516 GAGGAUGGGUUGuAGGAAGdTsdT antis 1565-1584 2517 UUCCUACAACCCAUCCUCA 2518 uuccuAcAAcccAuccucAdTsdT sense 1565-1584 2519 UGAGGAUGGGUUGUAGGAA 2520 UGAGGAUGGGUUGuAGGAAdTsdT antis 1568-1587 2521 CUACAACCCAUCCUCACAA 2522 cuAcAAcccAuccucAcAAdTsdT sense 1568-1587 2523 UUGUGAGGAUGGGUUGUAG 2524 UUGUGAGGAUGGGUUGuAGdTsdT antis 1569-1588 2525 UACAACCCAUCCUCACAAG 2526 uAcAAcccAuccucAcAAGdTsdT sense 1569-1588 2527 CUUGUGAGGAUGGGUUGUA 2528 CUUGUGAGGAUGGGUUGuAdTsdT antis 1572-1591 2529 AACCCAUCCUCACAAGCUU 2530 AAcccAuccucAcAAGcuudTsdT sense 1572-1591 2531 AAGCUUGUGAGGAUGGGUU 2532 AAGCUUGUGAGGAUGGGUUdTsdT antis 1573-1592 2533 ACCCAUCCUCACAAGCUUU 2534 AcccAuccucAcAAGcuuudTsdT sense 1573-1592 2535 AAAGCUUGUGAGGAUGGGU 2536 AAAGCUUGUGAGGAUGGGUdTsdT antis 1590-1609 2537 UUAACUGAAGCUCAGACUG 2538 uuAAcuGAAGcucAGAcuGdTsdT sense 1590-1609 2539 CAGUCUGAGCUUCAGUUAA 2540 cAGUCUGAGCUUcAGUuAAdTsdT antis 1591-1610 2541 UAACUGAAGCUCAGACUGG 2542 uAAcuGAAGcucAGAcuGGdTsdT sense 1591-1610 2543 CCAGUCUGAGCUUCAGUUA 2544 CcAGUCUGAGCUUcAGUuAdTsdT antis 1592-1611 2545 AACUGAAGCUCAGACUGGC 2546 AAcuGAAGcucAGAcuGGcdTsdT sense 1592-1611 2547 GCCAGUCUGAGCUUCAGUU 2548 GCcAGUCUGAGCUUcAGUUdTsdT antis 1593-1612 2549 ACUGAAGCUCAGACUGGCC 2550 AcuGAAGcucAGAcuGGccdTsdT sense 1593-1612 2551 GGCCAGUCUGAGCUUCAGU 2552 GGCcAGUCUGAGCUUcAGUdTsdT antis 1595-1614 2553 UGAAGCUCAGACUGGCCAA 2554 uGAAGcucAGAcuGGccAAdTsdT sense 1595-1614 2555 UUGGCCAGUCUGAGCUUCA 2556 UUGGCcAGUCUGAGCUUcAdTsdT antis 1601-1620 2557 UCAGACUGGCCAAGAUUGG 2558 ucAGAcuGGccAAGAuuGGdTsdT sense 1601-1620 2559 CCAAUCUUGGCCAGUCUGA 2560 CcAAUCUUGGCcAGUCUGAdTsdT antis 1606-1625 2561 CUGGCCAAGAUUGGCAGCC 2562 cuGGccAAGAuuGGcAGccdTsdT sense 1606-1625 2563 GGCUGCCAAUCUUGGCCAG 2564 GGCUGCcAAUCUUGGCcAGdTsdT antis 1610-1629 2565 CCAAGAUUGGCAGCCAUCU 2566 ccAAGAuuGGcAGccAucudTsdT sense 1610-1629 2567 AGAUGGCUGCCAAUCUUGG 2568 AGAUGGCUGCcAAUCUUGGdTsdT antis 1614-1633 2569 GAUUGGCAGCCAUCUGAUG 2570 GAuuGGcAGccAucuGAuGdTsdT sense 1614-1633 2571 CAUCAGAUGGCUGCCAAUC 2572 cAUcAGAUGGCUGCcAAUCdTsdT antis 1650-1669 2573 GCUAGCUCUUCCUGAGGGC 2574 GcuAGcucuuccuGAGGGcdTsdT sense 1650-1669 2575 GCCCUCAGGAAGAGCUAGC 2576 GCCCUcAGGAAGAGCuAGCdTsdT antis 1654-1673 2577 GCUCUUCCUGAGGGCCCCA 2578 GcucuuccuGAGGGccccAdTsdT sense 1654-1673 2579 UGGGGCCCUCAGGAAGAGC 2580 UGGGGCCCUcAGGAAGAGCdTsdT antis 1657-1676 2581 CUUCCUGAGGGCCCCACCG 2582 cuuccuGAGGGccccAccGdTsdT sense 1657-1676 2583 CGGUGGGGCCCUCAGGAAG 2584 CGGUGGGGCCCUcAGGAAGdTsdT antis 1799-1818 2585 CAUCUAGGCCUCCCUCAGC 2586 cAucuAGGccucccucAGcdTsdT sense 1799-1818 2587 GCUGAGGGAGGCCUAGAUG 2588 GCUGAGGGAGGCCuAGAUGdTsdT antis 1801-1820 2589 UCUAGGCCUCCCUCAGCAG 2590 ucuAGGccucccucAGcAGdTsdT sense 1801-1820 2591 CUGCUGAGGGAGGCCUAGA 2592 CUGCUGAGGGAGGCCuAGAdTsdT antis 1839-1858 2593 UUUUUAAAGAGGAUUUUAA 2594 uuuuuAAAGAGGAuuuuAAdTsdT sense 1839-1858 2595 UUAAAAUCCUCUUUAAAAA 2596 UuAAAAUCCUCUUuAAAAAdTsdT antis 1840-1859 2597 UUUUAAAGAGGAUUUUAAC 2598 uuuuAAAGAGGAuuuuAAcdTsdT sense 1840-1859 2599 GUUAAAAUCCUCUUUAAAA 2600 GUuAAAAUCCUCUUuAAAAdTsdT antis 1841-1860 2601 UUUAAAGAGGAUUUUAACU 2602 uuuAAAGAGGAuuuuAAcudTsdT sense 1841-1860 2603 AGUUAAAAUCCUCUUUAAA 2604 AGUuAAAAUCCUCUUuAAAdTsdT antis 1842-1861 2605 UUAAAGAGGAUUUUAACUG 2606 uuAAAGAGGAuuuuAAcuGdTsdT sense 1842-1861 2607 CAGUUAAAAUCCUCUUUAA 2608 cAGUuAAAAUCCUCUUuAAdTsdT antis 1843-1862 2609 UAAAGAGGAUUUUAACUGU 2610 uAAAGAGGAuuuuAAcuGudTsdT sense 1843-1862 2611 ACAGUUAAAAUCCUCUUUA 2612 AcAGUuAAAAUCCUCUUuAdTsdT antis 1845-1864 2613 AAGAGGAUUUUAACUGUUU 2614 AAGAGGAuuuuAAcuGuuudTsdT sense 1845-1864 2615 AAACAGUUAAAAUCCUCUU 2616 AAAcAGUuAAAAUCCUCUUdTsdT antis 1849-1868 2617 GGAUUUUAACUGUUUGUAG 2618 GGAuuuuAAcuGuuuGuAGdTsdT sense 1849-1868 2619 CUACAAACAGUUAAAAUCC 2620 CuAcAAAcAGUuAAAAUCCdTsdT antis 1858-1877 2621 CUGUUUGUAGGGGAGGGGA 2622 cuGuuuGuAGGGGAGGGGAdTsdT sense 1858-1877 2623 UCCCCUCCCCUACAAACAG 2624 UCCCCUCCCCuAcAAAcAGdTsdT antis 1859-1878 2625 UGUUUGUAGGGGAGGGGAG 2626 uGuuuGuAGGGGAGGGGAGdTsdT sense 1859-1878 2627 CUCCCCUCCCCUACAAACA 2628 CUCCCCUCCCCuAcAAAcAdTsdT antis 1862-1881 2629 UUGUAGGGGAGGGGAGAAA 2630 uuGuAGGGGAGGGGAGAAAdTsdT sense 1862-1881 2631 UUUCUCCCCUCCCCUACAA 2632 UUUCUCCCCUCCCCuAcAAdTsdT antis 1863-1882 2633 UGUAGGGGAGGGGAGAAAA 2634 uGuAGGGGAGGGGAGAAAAdTsdT sense 1863-1882 2635 UUUUCUCCCCUCCCCUACA 2636 UUUUCUCCCCUCCCCuAcAdTsdT antis 1874-1893 2637 GGAGAAAAGGAAGGACGGG 2638 GGAGAAAAGGAAGGAcGGGdTsdT sense 1874-1893 2639 CCCGUCCUUCCUUUUCUCC 2640 CCCGUCCUUCCUUUUCUCCdTsdT antis 1875-1894 2641 GAGAAAAGGAAGGACGGGG 2642 GAGAAAAGGAAGGAcGGGGdTsdT sense 1875-1894 2643 CCCCGUCCUUCCUUUUCUC 2644 CCCCGUCCUUCCUUUUCUCdTsdT antis 1876-1895 2645 AGAAAAGGAAGGACGGGGU 2646 AGAAAAGGAAGGAcGGGGudTsdT sense 1876-1895 2647 ACCCCGUCCUUCCUUUUCU 2648 ACCCCGUCCUUCCUUUUCUdTsdT antis 1878-1897 2649 AAAAGGAAGGACGGGGUUU 2650 AAAAGGAAGGAcGGGGuuudTsdT sense 1878-1897 2651 AAACCCCGUCCUUCCUUUU 2652 AAACCCCGUCCUUCCUUUUdTsdT antis 1898-1917 2653 GGGGUGUGAGGACCUUCUA 2654 GGGGuGuGAGGAccuucuAdTsdT sense 1898-1917 2655 UAGAAGGUCCUCACACCCC 2656 uAGAAGGUCCUcAcACCCCdTsdT antis 1899-1918 2657 GGGUGUGAGGACCUUCUAC 2658 GGGuGuGAGGAccuucuAcdTsdT sense 1899-1918 2659 GUAGAAGGUCCUCACACCC 2660 GuAGAAGGUCCUcAcACCCdTsdT antis 1900-1919 2661 GGUGUGAGGACCUUCUACC 2662 GGuGuGAGGAccuucuAccdTsdT sense 1900-1919 2663 GGUAGAAGGUCCUCACACC 2664 GGuAGAAGGUCCUcAcACCdTsdT antis 1902-1921 2665 UGUGAGGACCUUCUACCCC 2666 uGuGAGGAccuucuAccccdTsdT sense 1902-1921 2667 GGGGUAGAAGGUCCUCACA 2668 GGGGuAGAAGGUCCUcAcAdTsdT antis 1903-1922 2669 GUGAGGACCUUCUACCCCC 2670 GuGAGGAccuucuAcccccdTsdT sense 1903-1922 2671 GGGGGUAGAAGGUCCUCAC 2672 GGGGGuAGAAGGUCCUcACdTsdT antis 1959-1978 2673 CUCCCCCCCUCUCCCAGGU 2674 cucccccccucucccAGGudTsdT sense 1959-1978 2675 ACCUGGGAGAGGGGGGGAG 2676 ACCUGGGAGAGGGGGGGAGdTsdT antis 1964-1983 2677 CCCCUCUCCCAGGUCCCUU 2678 ccccucucccAGGucccuudTsdT sense 1964-1983 2679 AAGGGACCUGGGAGAGGGG 2680 AAGGGACCUGGGAGAGGGGdTsdT antis 1970-1989 2681 UCCCAGGUCCCUUGUAAAU 2682 ucccAGGucccuuGuAAAudTsdT sense 1970-1989 2683 AUUUACAAGGGACCUGGGA 2684 AUUuAcAAGGGACCUGGGAdTsdT antis 1974-1993 2685 AGGUCCCUUGUAAAUAGAA 2686 AGGucccuuGuAAAuAGAAdTsdT sense 1974-1993 2687 UUCUAUUUACAAGGGACCU 2688 UUCuAUUuAcAAGGGACCUdTsdT antis 1983-2002 2689 GUAAAUAGAACCAGCCCAG 2690 GuAAAuAGAAccAGcccAGdTsdT sense 1983-2002 2691 CUGGGCUGGUUCUAUUUAC 2692 CUGGGCUGGUUCuAUUuACdTsdT antis 1984-2003 2693 UAAAUAGAACCAGCCCAGC 2694 uAAAuAGAAccAGcccAGcdTsdT sense 1984-2003 2695 GCUGGGCUGGUUCUAUUUA 2696 GCUGGGCUGGUUCuAUUuAdTsdT antis 1994-2013 2697 CAGCCCAGCCCAUCUCUCG 2698 cAGcccAGcccAucucucGdTsdT sense 1994-2013 2699 CGAGAGAUGGGCUGGGCUG 2700 CGAGAGAUGGGCUGGGCUGdTsdT antis 1995-2014 2701 AGCCCAGCCCAUCUCUCGU 2702 AGcccAGcccAucucucGudTsdT sense 1995-2014 2703 ACGAGAGAUGGGCUGGGCU 2704 ACGAGAGAUGGGCUGGGCUdTsdT antis 1996-2015 2705 GCCCAGCCCAUCUCUCGUC 2706 GcccAGcccAucucucGucdTsdT sense 1996-2015 2707 GACGAGAGAUGGGCUGGGC 2708 GACGAGAGAUGGGCUGGGCdTsdT antis 1998-2017 2709 CCAGCCCAUCUCUCGUCUU 2710 ccAGcccAucucucGucuudTsdT sense 1998-2017 2711 AAGACGAGAGAUGGGCUGG 2712 AAGACGAGAGAUGGGCUGGdTsdT antis 2016-2035 2713 UCCCUUCCCUGGCCCCCUG 2714 ucccuucccuGGcccccuGdTsdT sense 2016-2035 2715 CAGGGGGCCAGGGAAGGGA 2716 cAGGGGGCcAGGGAAGGGAdTsdT antis 2022-2041 2717 CCCUGGCCCCCUGGGUGUA 2718 cccuGGcccccuGGGuGuAdTsdT sense 2022-2041 2719 UACACCCAGGGGGCCAGGG 2720 uAcACCcAGGGGGCcAGGGdTsdT antis 2025-2044 2721 UGGCCCCCUGGGUGUAAAU 2722 uGGcccccuGGGuGuAAAudTsdT sense 2025-2044 2723 AUUUACACCCAGGGGGCCA 2724 AUUuAcACCcAGGGGGCcAdTsdT antis 2026-2045 2725 GGCCCCCUGGGUGUAAAUA 2726 GGcccccuGGGuGuAAAuAdTsdT sense 2026-2045 2727 UAUUUACACCCAGGGGGCC 2728 uAUUuAcACCcAGGGGGCCdTsdT antis 2035-2054 2729 GGUGUAAAUAGAUUGUUAU 2730 GGuGuAAAuAGAuuGuuAudTsdT sense 2035-2054 2731 AUAACAAUCUAUUUACACC 2732 AuAAcAAUCuAUUuAcACCdTsdT antis 2041-2060 2733 AAUAGAUUGUUAUAAUUUU 2734 AAuAGAuuGuuAuAAuuuudTsdT sense 2041-2060 2735 AAAAUUAUAACAAUCUAUU 2736 AAAAUuAuAAcAAUCuAUUdTsdT antis 2047-2066 2737 UUGUUAUAAUUUUUUCUUA 2738 uuGuuAuAAuuuuuucuuAdTsdT sense 2047-2066 2739 UAAGAAAAAAUUAUAACAA 2740 uAAGAAAAAAUuAuAAcAAdTsdT antis 2057-2076 2741 UUUUUCUUAAAGAAAACGU 2742 uuuuucuuAAAGAAAAcGudTsdT sense 2057-2076 2743 ACGUUUUCUUUAAGAAAAA 2744 ACGUUUUCUUuAAGAAAAAdTsdT antis 2058-2077 2745 UUUUCUUAAAGAAAACGUC 2746 uuuucuuAAAGAAAAcGucdTsdT sense 2058-2077 2747 GACGUUUUCUUUAAGAAAA 2748 GACGUUUUCUUuAAGAAAAdTsdT antis 2060-2079 2749 UUCUUAAAGAAAACGUCAA 2750 uucuuAAAGAAAAcGucAAdTsdT sense 2060-2079 2751 UUGACGUUUUCUUUAAGAA 2752 UUGACGUUUUCUUuAAGAAdTsdT antis 2066-2085 2753 AAGAAAACGUCAAUUCACA 2754 AAGAAAAcGucAAuucAcAdTsdT sense 2066-2085 2755 UGUGAAUUGACGUUUUCUU 2756 UGUGAAUUGACGUUUUCUUdTsdT antis 2075-2094 2757 UCAAUUCACACCAUUCAAC 2758 ucAAuucAcAccAuucAAcdTsdT sense 2075-2094 2759 GUUGAAUGGUGUGAAUUGA 2760 GUUGAAUGGUGUGAAUUGAdTsdT antis 2077-2096 2761 AAUUCACACCAUUCAACUU 2762 AAuucAcAccAuucAAcuudTsdT sense 2077-2096 2763 AAGUUGAAUGGUGUGAAUU 2764 AAGUUGAAUGGUGUGAAUUdTsdT antis 2079-2098 2765 UUCACACCAUUCAACUUGC 2766 uucAcAccAuucAAcuuGcdTsdT sense 2079-2098 2767 GCAAGUUGAAUGGUGUGAA 2768 GcAAGUUGAAUGGUGUGAAdTsdT antis 2081-2100 2769 CACACCAUUCAACUUGCCC 2770 cAcAccAuucAAcuuGcccdTsdT sense 2081-2100 2771 GGGCAAGUUGAAUGGUGUG 2772 GGGcAAGUUGAAUGGUGUGdTsdT antis 2091-2110 2773 AACUUGCCCCCCCCAGCUG 2774 AAcuuGccccccccAGcuGdTsdT sense 2091-2110 2775 CAGCUGGGGGGGGCAAGUU 2776 cAGCUGGGGGGGGcAAGUUdTsdT antis 2092-2111 2777 ACUUGCCCCCCCCAGCUGU 2778 AcuuGccccccccAGcuGudTsdT sense 2092-2111 2779 ACAGCUGGGGGGGGCAAGU 2780 AcAGCUGGGGGGGGcAAGUdTsdT antis 2096-2115 2781 GCCCCCCCCAGCUGUACCC 2782 GccccccccAGcuGuAcccdTsdT sense 2096-2115 2783 GGGUACAGCUGGGGGGGGC 2784 GGGuAcAGCUGGGGGGGGCdTsdT antis 2097-2116 2785 CCCCCCCCAGCUGUACCCC 2786 ccccccccAGcuGuAccccdTsdT sense 2097-2116 2787 GGGGUACAGCUGGGGGGGG 2788 GGGGuAcAGCUGGGGGGGGdTsdT antis 2098-2117 2789 CCCCCCCAGCUGUACCCCU 2790 cccccccAGcuGuAccccudTsdT sense 2098-2117 2791 AGGGGUACAGCUGGGGGGG 2792 AGGGGuAcAGCUGGGGGGGdTsdT antis 2099-2118 2793 CCCCCCAGCUGUACCCCUU 2794 ccccccAGcuGuAccccuudTsdT sense 2099-2118 2795 AAGGGGUACAGCUGGGGGG 2796 AAGGGGuAcAGCUGGGGGGdTsdT antis 2100-2119 2797 CCCCCAGCUGUACCCCUUC 2798 cccccAGcuGuAccccuucdTsdT sense 2100-2119 2799 GAAGGGGUACAGCUGGGGG 2800 GAAGGGGuAcAGCUGGGGGdTsdT antis 2107-2126 2801 CUGUACCCCUUCUUGUCCU 2802 cuGuAccccuucuuGuccudTsdT sense 2107-2126 2803 AGGACAAGAAGGGGUACAG 2804 AGGAcAAGAAGGGGuAcAGdTsdT antis 2108-2127 2805 UGUACCCCUUCUUGUCCUC 2806 uGuAccccuucuuGuccucdTsdT sense 2108-2127 2807 GAGGACAAGAAGGGGUACA 2808 GAGGAcAAGAAGGGGuAcAdTsdT antis 2123-2142 2809 CCUCUGCUCCCAAGGCUUC 2810 ccucuGcucccAAGGcuucdTsdT sense 2123-2142 2811 GAAGCCUUGGGAGCAGAGG 2812 GAAGCCUUGGGAGcAGAGGdTsdT antis 2124-2143 2813 CUCUGCUCCCAAGGCUUCC 2814 cucuGcucccAAGGcuuccdTsdT sense 2124-2143 2815 GGAAGCCUUGGGAGCAGAG 2816 GGAAGCCUUGGGAGcAGAGdTsdT antis 2151-2170 2817 CCCAUCCUGGAAGGAGGGG 2818 cccAuccuGGAAGGAGGGGdTsdT sense 2151-2170 2819 CCCCUCCUUCCAGGAUGGG 2820 CCCCUCCUUCcAGGAUGGGdTsdT antis 2157-2176 2821 CUGGAAGGAGGGGAGUAGA 2822 cuGGAAGGAGGGGAGuAGAdTsdT sense 2157-2176 2823 UCUACUCCCCUCCUUCCAG 2824 UCuACUCCCCUCCUUCcAGdTsdT antis 2158-2177 2825 UGGAAGGAGGGGAGUAGAG 2826 uGGAAGGAGGGGAGuAGAGdTsdT sense 2158-2177 2827 CUCUACUCCCCUCCUUCCA 2828 CUCuACUCCCCUCCUUCcAdTsdT antis 2159-2178 2829 GGAAGGAGGGGAGUAGAGA 2830 GGAAGGAGGGGAGuAGAGAdTsdT sense 2159-2178 2831 UCUCUACUCCCCUCCUUCC 2832 UCUCuACUCCCCUCCUUCCdTsdT antis 2160-2179 2833 GAAGGAGGGGAGUAGAGAG 2834 GAAGGAGGGGAGuAGAGAGdTsdT sense 2160-2179 2835 CUCUCUACUCCCCUCCUUC 2836 CUCUCuACUCCCCUCCUUCdTsdT antis 2165-2184 2837 AGGGGAGUAGAGAGAGUCC 2838 AGGGGAGuAGAGAGAGuccdTsdT sense 2165-2184 2839 GGACUCUCUCUACUCCCCU 2840 GGACUCUCUCuACUCCCCUdTsdT antis 2166-2185 2841 GGGGAGUAGAGAGAGUCCC 2842 GGGGAGuAGAGAGAGucccdTsdT sense 2166-2185 2843 GGGACUCUCUCUACUCCCC 2844 GGGACUCUCUCuACUCCCCdTsdT antis 2169-2188 2845 GAGUAGAGAGAGUCCCUGG 2846 GAGuAGAGAGAGucccuGGdTsdT sense 2169-2188 2847 CCAGGGACUCUCUCUACUC 2848 CcAGGGACUCUCUCuACUCdTsdT antis 2173-2192 2849 AGAGAGAGUCCCUGGUGUC 2850 AGAGAGAGucccuGGuGucdTsdT sense 2173-2192 2851 GACACCAGGGACUCUCUCU 2852 GAcACcAGGGACUCUCUCUdTsdT antis 2178-2197 2853 GAGUCCCUGGUGUCUUAGU 2854 GAGucccuGGuGucuuAGudTsdT sense 2178-2197 2855 ACUAAGACACCAGGGACUC 2856 ACuAAGAcACcAGGGACUCdTsdT antis 2179-2198 2857 AGUCCCUGGUGUCUUAGUU 2858 AGucccuGGuGucuuAGuudTsdT sense 2179-2198 2859 AACUAAGACACCAGGGACU 2860 AACuAAGAcACcAGGGACUdTsdT antis 2182-2201  2861 CCCUGGUGUCUUAGUUUCC 2862 cccuGGuGucuuAGuuuccdTsdT sense 2182-2201  2863 GGAAACUAAGACACCAGGG 2864 GGAAACuAAGAcACcAGGGdTsdT antis 2183-2202  2865 CCUGGUGUCUUAGUUUCCA 2866 ccuGGuGucuuAGuuuccAdTsdT sense 2183-2202  2867 UGGAAACUAAGACACCAGG 2868 UGGAAACuAAGAcACcAGGdTsdT antis 2188-2207  2869 UGUCUUAGUUUCCACAGUA 2870 uGucuuAGuuuccAcAGuAdTsdT sense 2188-2207  2871 UACUGUGGAAACUAAGACA 2872 uACUGUGGAAACuAAGAcAdTsdT antis 2198-2217  2873 UCCACAGUAAGGUUUGCCU 2874 uccAcAGuAAGGuuuGccudTsdT sense 2198-2217  2875 AGGCAAACCUUACUGUGGA 2876 AGGcAAACCUuACUGUGGAdTsdT antis 2199-2218  2877 CCACAGUAAGGUUUGCCUG 2878 ccAcAGuAAGGuuuGccuGdTsdT sense 2199-2218  2879 CAGGCAAACCUUACUGUGG 2880 cAGGcAAACCUuACUGUGGdTsdT antis 2200-2219  2881 CACAGUAAGGUUUGCCUGU 2882 cAcAGuAAGGuuuGccuGudTsdT sense 2200-2219  2883 ACAGGCAAACCUUACUGUG 2884 AcAGGcAAACCUuACUGUGdTsdT antis 2201-2220  2885 ACAGUAAGGUUUGCCUGUG 2886 AcAGuAAGGuuuGccuGuGdTsdT sense 2201-2220  2887 CACAGGCAAACCUUACUGU 2888 cAcAGGcAAACCUuACUGUdTsdT antis 2203-2222  2889 AGUAAGGUUUGCCUGUGUA 2890 AGuAAGGuuuGccuGuGuAdTsdT sense 2203-2222  2891 UACACAGGCAAACCUUACU 2892 uAcAcAGGcAAACCUuACUdTsdT antis 2204-2223  2893 GUAAGGUUUGCCUGUGUAC 2894 GuAAGGuuuGccuGuGuAcdTsdT sense 2204-2223  2895 GUACACAGGCAAACCUUAC 2896 GuAcAcAGGcAAACCUuACdTsdT antis 2205-2224  2897 UAAGGUUUGCCUGUGUACA 2898 uAAGGuuuGccuGuGuAcAdTsdT sense 2205-2224  2899 UGUACACAGGCAAACCUUA 2900 UGuAcAcAGGcAAACCUuAdTsdT antis 2210-2229  2901 UUUGCCUGUGUACAGACCU 2902 uuuGccuGuGuAcAGAccudTsdT sense 2210-2229  2903 AGGUCUGUACACAGGCAAA 2904 AGGUCUGuAcAcAGGcAAAdTsdT antis 2211-2230  2905 UUGCCUGUGUACAGACCUC 2906 uuGccuGuGuAcAGAccucdTsdT sense 2211-2230  2907 GAGGUCUGUACACAGGCAA 2908 GAGGUCUGuAcAcAGGcAAdTsdT antis 2214-2233  2909 CCUGUGUACAGACCUCUGU 2910 ccuGuGuAcAGAccucuGudTsdT sense 2214-2233  2911 ACAGAGGUCUGUACACAGG 2912 AcAGAGGUCUGuAcAcAGGdTsdT antis 2215-2234  2913 CUGUGUACAGACCUCUGUU 2914 cuGuGuAcAGAccucuGuudTsdT sense 2215-2234  2915 AACAGAGGUCUGUACACAG 2916 AAcAGAGGUCUGuAcAcAGdTsdT antis 2220-2239  2917 UACAGACCUCUGUUCAAUA 2918 uAcAGAccucuGuucAAuAdTsdT sense 2220-2239  2919 UAUUGAACAGAGGUCUGUA 2920 uAUUGAAcAGAGGUCUGuAdTsdT antis 2224-2243  2921 GACCUCUGUUCAAUAAAUU 2922 GAccucuGuucAAuAAAuudTsdT sense 2224-2243  2923 AAUUUAUUGAACAGAGGUC 2924 AAUUuAUUGAAcAGAGGUCdTsdT antis 2234-2253  2925 CAAUAAAUUAUUGGCAUGA 2926 cAAuAAAuuAuuGGcAuGAdTsdT sense 2234-2253  2927 UCAUGCCAAUAAUUUAUUG 2928 UcAUGCcAAuAAUUuAUUGdTsdT antis   51-70 2929 CGCGGCGGGCGCUGGGCCG 2930 cGcGGcGGGcGcuGGGccGdTsdT sense   51-70 2931 CGGCCCAGCGCCCGCCGCG 2932 CGGCCcAGCGCCCGCCGCGdTsdT antis  173-192 2933 UGGGCCUGCGCUCGGCGCC 2934 uGGGccuGcGcucGGcGccdTsdT sense  173-192 2935 GGCGCCGAGCGCAGGCCCA 2936 GGCGCCGAGCGcAGGCCcAdTsdT antis  205-224 2937 GGCCUUCGGGAGGCGGCCC 2938 GGccuucGGGAGGcGGcccdTsdT sense  205-224 2939 GGGCCGCCUCCCGAAGGCC 2940 GGGCCGCCUCCCGAAGGCCdTsdT antis  221-240 2941 CCCUGGGGGCUCGGGCCGG 2942 cccuGGGGGcucGGGccGGdTsdT sense  221-240 2943 CCGGCCCGAGCCCCCAGGG 2944 CCGGCCCGAGCCCCcAGGGdTsdT antis  224-243 2945 UGGGGGCUCGGGCCGGGCG 2946 uGGGGGcucGGGccGGGcGdTsdT sense  224-243 2947 CGCCCGGCCCGAGCCCCCA 2948 CGCCCGGCCCGAGCCCCcAdTsdT antis  387-406 2949 GGGGGUGGCCCCAGCGGCA 2950 GGGGGuGGccccAGcGGcAdTsdT sense  387-406 2951 UGCCGCUGGGGCCACCCCC 2952 UGCCGCUGGGGCcACCCCCdTsdT antis  392-411 2953 UGGCCCCAGCGGCAGCGGC 2954 uGGccccAGcGGcAGcGGcdTsdT sense  392-411 2955 GCCGCUGCCGCUGGGGCCA 2956 GCCGCUGCCGCUGGGGCcAdTsdT antis  465-484 2957 AAGCUGGGCCGUGACAGCG 2958 AAGcuGGGccGuGAcAGcGdTsdT sense  465-484 2959 CGCUGUCACGGCCCAGCUU 2960 CGCUGUcACGGCCcAGCUUdTsdT antis  505-524 2961 CCACUGUAGGCCAAGGCCC 2962 ccAcuGuAGGccAAGGcccdTsdT sense  505-524 2963 GGGCCUUGGCCUACAGUGG 2964 GGGCCUUGGCCuAcAGUGGdTsdT antis  587-606 2965 AGUAUACCAGGCACGGCUG 2966 AGuAuAccAGGcAcGGcuGdTsdT sense  587-606 2967 CAGCCGUGCCUGGUAUACU 2968 cAGCCGUGCCUGGuAuACUdTsdT antis  601-620 2969 GGCUGGCAGAGACGAGGGA 2970 GGcuGGcAGAGAcGAGGGAdTsdT sense  601-620 2971 UCCCUCGUCUCUGCCAGCC 2972 UCCCUCGUCUCUGCcAGCCdTsdT antis  743-762 2973 GAAGAAGGACGAGCUGUAU 2974 GAAGAAGGAcGAGcuGuAudTsdT sense  743-762 2975 AUACAGCUCGUCCUUCUUC 2976 AuAcAGCUCGUCCUUCUUCdTsdT antis  927-946 2977 AAGCCCCAGAAUUUGCUUG 2978 AAGccccAGAAuuuGcuuGdTsdT sense  927-946 2979 CAAGCAAAUUCUGGGGCUU 2980 cAAGcAAAUUCUGGGGCUUdTsdT antis  932-951 2981 CCAGAAUUUGCUUGUGGAC 2982 ccAGAAuuuGcuuGuGGAcdTsdT sense  932-951 2983 GUCCACAAGCAAAUUCUGG 2984 GUCcAcAAGcAAAUUCUGGdTsdT antis 1054-1073 2985 CAGAACUCAUCUUUGGAGC 2986 cAGAAcucAucuuuGGAGcdTsdT sense 1054-1073 2987 GCUCCAAAGAUGAGUUCUG 2988 GCUCcAAAGAUGAGUUCUGdTsdT antis 1060-1079 2989 UCAUCUUUGGAGCCACAGA 2990 ucAucuuuGGAGccAcAGAdTsdT sense 1060-1079 2991 UCUGUGGCUCCAAAGAUGA 2992 UCUGUGGCUCcAAAGAUGAdTsdT antis 1068-1087 2993 GGAGCCACAGAUUACACCU 2994 GGAGccAcAGAuuAcAccudTsdT sense 1068-1087 2995 AGGUGUAAUCUGUGGCUCC 2996 AGGUGuAAUCUGUGGCUCCdTsdT antis 1094-1113 2997 CGAUGUGUGGUCGGCUGGC 2998 cGAuGuGuGGucGGcuGGcdTsdT sense 1094-1113 2999 GCCAGCCGACCACACAUCG 3000 GCcAGCCGACcAcAcAUCGdTsdT antis 1107-1126 3001 GCUGGCUGUGUACUUGCUG 3002 GcuGGcuGuGuAcuuGcuGdTsdT sense 1107-1126 3003 CAGCAAGUACACAGCCAGC 3004 cAGcAAGuAcAcAGCcAGCdTsdT antis 1108-1127 3005 CUGGCUGUGUACUUGCUGA 3006 cuGGcuGuGuAcuuGcuGAdTsdT sense 1108-1127 3007 UCAGCAAGUACACAGCCAG 3008 UcAGcAAGuAcAcAGCcAGdTsdT antis 1138-1157 3009 GCCAGCCCAUCUUCCCUGG 3010 GccAGcccAucuucccuGGdTsdT sense 1138-1157 3011 CCAGGGAAGAUGGGCUGGC 3012 CcAGGGAAGAUGGGCUGGCdTsdT antis 1149-1168 3013 UUCCCUGGGGACAGUGGGG 3014 uucccuGGGGAcAGuGGGGdTsdT sense 1149-1168 3015 CCCCACUGUCCCCAGGGAA 3016 CCCcACUGUCCCcAGGGAAdTsdT antis 1474-1493 3017 CUGGUGAACUGUCCAUCCA 3018 cuGGuGAAcuGuccAuccAdTsdT sense 1474-1493 3019 UGGAUGGACAGUUCACCAG 3020 UGGAUGGAcAGUUcACcAGdTsdT antis 1480-1499 3021 AACUGUCCAUCCAACCAUC 3022 AAcuGuccAuccAAccAucdTsdT sense 1480-1499 3023 GAUGGUUGGAUGGACAGUU 3024 GAUGGUUGGAUGGAcAGUUdTsdT antis 1555-1574 3025 CCCUCACCACUUCCUACAA 3026 cccucAccAcuuccuAcAAdTsdT sense 1555-1574 3027 UUGUAGGAAGUGGUGAGGG 3028 UUGuAGGAAGUGGUGAGGGdTsdT antis 1848-1867 3029 AGGAUUUUAACUGUUUGUA 3030 AGGAuuuuAAcuGuuuGuAdTsdT sense 1848-1867 3031 UACAAACAGUUAAAAUCCU 3032 uAcAAAcAGUuAAAAUCCUdTsdT antis 2031-2050 3033 CCUGGGUGUAAAUAGAUUG 3034 ccuGGGuGuAAAuAGAuuGdTsdT sense 2031-2050 3035 CAAUCUAUUUACACCCAGG 3036 cAAUCuAUUuAcACCcAGGdTsdT antis 2042-2061 3037 AUAGAUUGUUAUAAUUUUU 3038 AuAGAuuGuuAuAAuuuuudTsdT sense 2042-2061 3039 AAAAAUUAUAACAAUCUAU 3040 AAAAAUuAuAAcAAUCuAUdTsdT antis 2127-2146 3041 UGCUCCCAAGGCUUCCUCC 3042 uGcucccAAGGcuuccuccdTsdT sense 2127-2146 3043 GGAGGAAGCCUUGGGAGCA 3044 GGAGGAAGCCUUGGGAGcAdTsdT antis 2230-2249 3045 UGUUCAAUAAAUUAUUGGC 3046 uGuucAAuAAAuuAuuGGcdTsdT sense 2230-2249 3047 GCCAAUAAUUUAUUGAACA 3048 GCcAAuAAUUuAUUGAAcAdTsdT antis   48-67 3049 CCCCGCGGCGGGCGCUGGG 3050 ccccGcGGcGGGcGcuGGGdTsdT sense   48-67 3051 CCCAGCGCCCGCCGCGGGG 3052 CCcAGCGCCCGCCGCGGGGdTsdT antis   50-69 3053 CCGCGGCGGGCGCUGGGCC 3054 ccGcGGcGGGcGcuGGGccdTsdT sense   50-69 3055 GGCCCAGCGCCCGCCGCGG 3056 GGCCcAGCGCCCGCCGCGGdTsdT antis   56-75 3057 CGGGCGCUGGGCCGGAGCC 3058 cGGGcGcuGGGccGGAGccdTsdT sense   56-75 3059 GGCUCCGGCCCAGCGCCCG 3060 GGCUCCGGCCcAGCGCCCGdTsdT antis   89-108 3061 GCGGCCUGGAAGAGGCCGG 3062 GcGGccuGGAAGAGGccGGdTsdT sense   89-108 3063 CCGGCCUCUUCCAGGCCGC 3064 CCGGCCUCUUCcAGGCCGCdTsdT antis   91-110 3065 GGCCUGGAAGAGGCCGGAG 3066 GGccuGGAAGAGGccGGAGdTsdT sense   91-110 3067 CUCCGGCCUCUUCCAGGCC 3068 CUCCGGCCUCUUCcAGGCCdTsdT antis   95-114 3069 UGGAAGAGGCCGGAGCCCA 3070 uGGAAGAGGccGGAGcccAdTsdT sense   95-114 3071 UGGGCUCCGGCCUCUUCCA 3072 UGGGCUCCGGCCUCUUCcAdTsdT antis   96-115 3073 GGAAGAGGCCGGAGCCCAG 3074 GGAAGAGGccGGAGcccAGdTsdT sense   96-115 3075 CUGGGCUCCGGCCUCUUCC 3076 CUGGGCUCCGGCCUCUUCCdTsdT antis  103-122 3077 GCCGGAGCCCAGGGGAGGC 3078 GccGGAGcccAGGGGAGGcdTsdT sense  103-122 3079 GCCUCCCCUGGGCUCCGGC 3080 GCCUCCCCUGGGCUCCGGCdTsdT antis  104-123 3081 CCGGAGCCCAGGGGAGGCG 3082 ccGGAGcccAGGGGAGGcGdTsdT sense  104-123 3083 CGCCUCCCCUGGGCUCCGG 3084 CGCCUCCCCUGGGCUCCGGdTsdT antis  105-124 3085 CGGAGCCCAGGGGAGGCGG 3086 cGGAGcccAGGGGAGGcGGdTsdT sense  105-124 3087 CCGCCUCCCCUGGGCUCCG 3088 CCGCCUCCCCUGGGCUCCGdTsdT antis  134-153 3089 AGCGGCGGGGGCAGCCCAG 3090 AGcGGcGGGGGcAGcccAGdTsdT sense  134-153 3091 CUGGGCUGCCCCCGCCGCU 3092 CUGGGCUGCCCCCGCCGCUdTsdT antis  147-166 3093 GCCCAGGCAGCCCGAGCCC 3094 GcccAGGcAGcccGAGcccdTsdT sense  147-166 3095 GGGCUCGGGCUGCCUGGGC 3096 GGGCUCGGGCUGCCUGGGCdTsdT antis  158-177 3097 CCGAGCCCCGCGGCCUGGG 3098 ccGAGccccGcGGccuGGGdTsdT sense  158-177 3099 CCCAGGCCGCGGGGCUCGG 3100 CCcAGGCCGCGGGGCUCGGdTsdT antis  167-186 3101 GCGGCCUGGGCCUGCGCUC 3102 GcGGccuGGGccuGcGcucdTsdT sense  167-186 3103 GAGCGCAGGCCCAGGCCGC 3104 GAGCGcAGGCCcAGGCCGCdTsdT antis  172-191 3105 CUGGGCCUGCGCUCGGCGC 3106 cuGGGccuGcGcucGGcGcdTsdT sense  172-191 3107 GCGCCGAGCGCAGGCCCAG 3108 GCGCCGAGCGcAGGCCcAGdTsdT antis  204-223 3109 GGGCCUUCGGGAGGCGGCC 3110 GGGccuucGGGAGGcGGccdTsdT sense  204-223 3111 GGCCGCCUCCCGAAGGCCC 3112 GGCCGCCUCCCGAAGGCCCdTsdT antis  209-228 3113 UUCGGGAGGCGGCCCUGGG 3114 uucGGGAGGcGGcccuGGGdTsdT sense  209-228 3115 CCCAGGGCCGCCUCCCGAA 3116 CCcAGGGCCGCCUCCCGAAdTsdT antis  231-250 3117 UCGGGCCGGGCGCGGACCA 3118 ucGGGccGGGcGcGGAccAdTsdT sense  231-250 3119 UGGUCCGCGCCCGGCCCGA 3120 UGGUCCGCGCCCGGCCCGAdTsdT antis  256-275 3121 UCGCGGAGCCAGGAGGCGG 3122 ucGcGGAGccAGGAGGcGGdTsdT sense  256-275 3123 CCGCCUCCUGGCUCCGCGA 3124 CCGCCUCCUGGCUCCGCGAdTsdT antis  294-313 3125 GGCCCCGGGGGCUCGGCCU 3126 GGccccGGGGGcucGGccudTsdT sense  294-313 3127 AGGCCGAGCCCCCGGGGCC 3128 AGGCCGAGCCCCCGGGGCCdTsdT antis  295-314 3129 GCCCCGGGGGCUCGGCCUC 3130 GccccGGGGGcucGGccucdTsdT sense  295-314 3131 GAGGCCGAGCCCCCGGGGC 3132 GAGGCCGAGCCCCCGGGGCdTsdT antis  318-337 3133 CCAGGAGGCACUGGCGGCG 3134 ccAGGAGGcAcuGGcGGcGdTsdT sense  318-337 3135 CGCCGCCAGUGCCUCCUGG 3136 CGCCGCcAGUGCCUCCUGGdTsdT antis  369-388 3137 GUGGGAGCCUCGAGCUCCG 3138 GuGGGAGccucGAGcuccGdTsdT sense  369-388 3139 CGGAGCUCGAGGCUCCCAC 3140 CGGAGCUCGAGGCUCCcACdTsdT antis  386-405 3141 CGGGGGUGGCCCCAGCGGC 3142 cGGGGGuGGccccAGcGGcdTsdT sense  386-405 3143 GCCGCUGGGGCCACCCCCG 3144 GCCGCUGGGGCcACCCCCGdTsdT antis  390-409 3145 GGUGGCCCCAGCGGCAGCG 3146 GGuGGccccAGcGGcAGcGdTsdT sense  390-409 3147 CGCUGCCGCUGGGGCCACC 3148 CGCUGCCGCUGGGGCcACCdTsdT antis  391-410 3149 GUGGCCCCAGCGGCAGCGG 3150 GuGGccccAGcGGcAGcGGdTsdT sense  391-410 3151 CCGCUGCCGCUGGGGCCAC 3152 CCGCUGCCGCUGGGGCcACdTsdT antis  460-479 3153 GAGUGAAGCUGGGCCGUGA 3154 GAGuGAAGcuGGGccGuGAdTsdT sense  460-479 3155 UCACGGCCCAGCUUCACUC 3156 UcACGGCCcAGCUUcACUCdTsdT antis  491-510 3157 GACCACAGUGGUAGCCACU 3158 GAccAcAGuGGuAGccAcudTsdT sense  491-510 3159 AGUGGCUACCACUGUGGUC 3160 AGUGGCuACcACUGUGGUCdTsdT antis  494-513 3161 CACAGUGGUAGCCACUGUA 3162 cAcAGuGGuAGccAcuGuAdTsdT sense  494-513 3163 UACAGUGGCUACCACUGUG 3164 uAcAGUGGCuACcACUGUGdTsdT antis  504-523 3165 GCCACUGUAGGCCAAGGCC 3166 GccAcuGuAGGccAAGGccdTsdT sense  504-523 3167 GGCCUUGGCCUACAGUGGC 3168 GGCCUUGGCCuAcAGUGGCdTsdT antis  593-612 3169 CCAGGCACGGCUGGCAGAG 3170 ccAGGcAcGGcuGGcAGAGdTsdT sense  593-612 3171 CUCUGCCAGCCGUGCCUGG 3172 CUCUGCcAGCCGUGCCUGGdTsdT antis  600-619 3173 CGGCUGGCAGAGACGAGGG 3174 cGGcuGGcAGAGAcGAGGGdTsdT sense  600-619 3175 CCCUCGUCUCUGCCAGCCG 3176 CCCUCGUCUCUGCcAGCCGdTsdT antis  613-632 3177 CGAGGGAACUGGUGGCCAU 3178 cGAGGGAAcuGGuGGccAudTsdT sense  613-632 3179 AUGGCCACCAGUUCCCUCG 3180 AUGGCcACcAGUUCCCUCGdTsdT antis  650-669 3181 CAAAAGGUUCAAGAACCGA 3182 cAAAAGGuucAAGAAccGAdTsdT sense  650-669 3183 UCGGUUCUUGAACCUUUUG 3184 UCGGUUCUUGAACCUUUUGdTsdT antis  841-860 3185 CUAUCAUCUACAUCAAGGU 3186 cuAucAucuAcAucAAGGudTsdT sense  841-860 3187 ACCUUGAUGUAGAUGAUAG 3188 ACCUUGAUGuAGAUGAuAGdTsdT antis  842-861 3189 UAUCAUCUACAUCAAGGUG 3190 uAucAucuAcAucAAGGuGdTsdT sense  842-861 3191 CACCUUGAUGUAGAUGAUA 3192 cACCUUGAUGuAGAUGAuAdTsdT antis  895-914 3193 UCCACUCCCAAGGUGUGUG 3194 uccAcucccAAGGuGuGuGdTsdT sense  895-914 3195 CACACACCUUGGGAGUGGA 3196 cAcAcACCUUGGGAGUGGAdTsdT antis  900-919 3197 UCCCAAGGUGUGUGUCACC 3198 ucccAAGGuGuGuGucAccdTsdT sense  900-919 3199 GGUGACACACACCUUGGGA 3200 GGUGAcAcAcACCUUGGGAdTsdT antis  901-920 3201 CCCAAGGUGUGUGUCACCG 3202 cccAAGGuGuGuGucAccGdTsdT sense  901-920 3203 CGGUGACACACACCUUGGG 3204 CGGUGAcAcAcACCUUGGGdTsdT antis  924-943 3205 AUCAAGCCCCAGAAUUUGC 3206 AucAAGccccAGAAuuuGcdTsdT sense  924-943 3207 GCAAAUUCUGGGGCUUGAU 3208 GcAAAUUCUGGGGCUUGAUdTsdT antis  925-944 3209 UCAAGCCCCAGAAUUUGCU 3210 ucAAGccccAGAAuuuGcudTsdT sense  925-944 3211 AGCAAAUUCUGGGGCUUGA 3212 AGcAAAUUCUGGGGCUUGAdTsdT antis  926-945 3213 CAAGCCCCAGAAUUUGCUU 3214 cAAGccccAGAAuuuGcuudTsdT sense  926-945 3215 AAGCAAAUUCUGGGGCUUG 3216 AAGcAAAUUCUGGGGCUUGdTsdT antis  953-972 3217 UGACACUGCUGUCCUCAAG 3218 uGAcAcuGcuGuccucAAGdTsdT sense  953-972 3219 CUUGAGGACAGCAGUGUCA 3220 CUUGAGGAcAGcAGUGUcAdTsdT antis 1053-1072 3221 CCAGAACUCAUCUUUGGAG 3222 ccAGAAcucAucuuuGGAGdTsdT sense 1053-1072 3223 CUCCAAAGAUGAGUUCUGG 3224 CUCcAAAGAUGAGUUCUGGdTsdT antis 1057-1076 3225 AACUCAUCUUUGGAGCCAC 3226 AAcucAucuuuGGAGccAcdTsdT sense 1057-1076 3227 GUGGCUCCAAAGAUGAGUU 3228 GUGGCUCcAAAGAUGAGUUdTsdT antis 1063-1082 3229 UCUUUGGAGCCACAGAUUA 3230 ucuuuGGAGccAcAGAuuAdTsdT sense 1063-1082 3231 UAAUCUGUGGCUCCAAAGA 3232 uAAUCUGUGGCUCcAAAGAdTsdT antis 1069-1088 3233 GAGCCACAGAUUACACCUC 3234 GAGccAcAGAuuAcAccucdTsdT sense 1069-1088 3235 GAGGUGUAAUCUGUGGCUC 3236 GAGGUGuAAUCUGUGGCUCdTsdT antis 1106-1125 3237 GGCUGGCUGUGUACUUGCU 3238 GGcuGGcuGuGuAcuuGcudTsdT sense 1106-1125 3239 AGCAAGUACACAGCCAGCC 3240 AGcAAGuAcAcAGCcAGCCdTsdT antis 1118-1137 3241 ACUUGCUGAGCUACUUCUC 3242 AcuuGcuGAGcuAcuucucdTsdT sense 1118-1137 3243 GAGAAGUAGCUCAGCAAGU 3244 GAGAAGuAGCUcAGcAAGUdTsdT antis 1135-1154 3245 UCGGCCAGCCCAUCUUCCC 3246 ucGGccAGcccAucuucccdTsdT sense 1135-1154 3247 GGGAAGAUGGGCUGGCCGA 3248 GGGAAGAUGGGCUGGCCGAdTsdT antis 1137-1156 3249 GGCCAGCCCAUCUUCCCUG 3250 GGccAGcccAucuucccuGdTsdT sense 1137-1156 3251 CAGGGAAGAUGGGCUGGCC 3252 cAGGGAAGAUGGGCUGGCCdTsdT antis 1140-1159 3253 CAGCCCAUCUUCCCUGGGG 3254 cAGcccAucuucccuGGGGdTsdT sense 1140-1159 3255 CCCCAGGGAAGAUGGGCUG 3256 CCCcAGGGAAGAUGGGCUGdTsdT antis 1145-1164 3257 CAUCUUCCCUGGGGACAGU 3258 cAucuucccuGGGGAcAGudTsdT sense 1145-1164 3259 ACUGUCCCCAGGGAAGAUG 3260 ACUGUCCCcAGGGAAGAUGdTsdT antis 1150-1169 3261 UCCCUGGGGACAGUGGGGU 3262 ucccuGGGGAcAGuGGGGudTsdT sense 1150-1169 3263 ACCCCACUGUCCCCAGGGA 3264 ACCCcACUGUCCCcAGGGAdTsdT antis 1270-1289 3265 AAGCUCACCCUUGGACAAA 3266 AAGcucAcccuuGGAcAAAdTsdT sense 1270-1289 3267 UUUGUCCAAGGGUGAGCUU 3268 UUUGUCcAAGGGUGAGCUUdTsdT antis 1296-1315 3269 AAAUCUUCAAAGACACCAC 3270 AAAucuucAAAGAcAccAcdTsdT sense 1296-1315 3271 GUGGUGUCUUUGAAGAUUU 3272 GUGGUGUCUUUGAAGAUUUdTsdT antis 1297-1316 3273 AAUCUUCAAAGACACCACC 3274 AAucuucAAAGAcAccAccdTsdT sense 1297-1316 3275 GGUGGUGUCUUUGAAGAUU 3276 GGUGGUGUCUUUGAAGAUUdTsdT antis 1302-1321 3277 UCAAAGACACCACCUGAGG 3278 ucAAAGAcAccAccuGAGGdTsdT sense 1302-1321 3279 CCUCAGGUGGUGUCUUUGA 3280 CCUcAGGUGGUGUCUUUGAdTsdT antis 1309-1328 3281 CACCACCUGAGGCCAUUGC 3282 cAccAccuGAGGccAuuGcdTsdT sense 1309-1328 3283 GCAAUGGCCUCAGGUGGUG 3284 GcAAUGGCCUcAGGUGGUGdTsdT antis 1331-1350 3285 CUGCUCUAGCCUACUGGAG 3286 cuGcucuAGccuAcuGGAGdTsdT sense 1331-1350 3287 CUCCAGUAGGCUAGAGCAG 3288 CUCcAGuAGGCuAGAGcAGdTsdT antis 1422-1441 3289 GGAGCCCAGCUCCCCAACG 3290 GGAGcccAGcuccccAAcGdTsdT sense 1422-1441 3291 CGUUGGGGAGCUGGGCUCC 3292 CGUUGGGGAGCUGGGCUCCdTsdT antis 1441-1460 3293 ACCGCCCGCUUCCCCCCCU 3294 AccGcccGcuucccccccudTsdT sense 1441-1460 3295 AGGGGGGGAAGCGGGCGGU 3296 AGGGGGGGAAGCGGGCGGUdTsdT antis 1475-1494 3297 UGGUGAACUGUCCAUCCAA 3298 uGGuGAAcuGuccAuccAAdTsdT sense 1475-1494 3299 UUGGAUGGACAGUUCACCA 3300 UUGGAUGGAcAGUUcACcAdTsdT antis 1490-1509 3301 CCAACCAUCUCUCAAUGCC 3302 ccAAccAucucucAAuGccdTsdT sense 1490-1509 3303 GGCAUUGAGAGAUGGUUGG 3304 GGcAUUGAGAGAUGGUUGGdTsdT antis 1543-1562 3305 GCCCUGCUUCUCCCCUCAC 3306 GcccuGcuucuccccucAcdTsdT sense 1543-1562 3307 GUGAGGGGAGAAGCAGGGC 3308 GUGAGGGGAGAAGcAGGGCdTsdT antis 1544-1563 3309 CCCUGCUUCUCCCCUCACC 3310 cccuGcuucuccccucAccdTsdT sense 1544-1563 3311 GGUGAGGGGAGAAGCAGGG 3312 GGUGAGGGGAGAAGcAGGGdTsdT antis 1545-1564 3313 CCUGCUUCUCCCCUCACCA 3314 ccuGcuucuccccucAccAdTsdT sense 1545-1564 3315 UGGUGAGGGGAGAAGCAGG 3316 UGGUGAGGGGAGAAGcAGGdTsdT antis 1546-1565 3317 CUGCUUCUCCCCUCACCAC 3318 cuGcuucuccccucAccAcdTsdT sense 1546-1565 3319 GUGGUGAGGGGAGAAGCAG 3320 GUGGUGAGGGGAGAAGcAGdTsdT antis 1550-1569 3321 UUCUCCCCUCACCACUUCC 3322 uucuccccucAccAcuuccdTsdT sense 1550-1569 3323 GGAAGUGGUGAGGGGAGAA 3324 GGAAGUGGUGAGGGGAGAAdTsdT antis 1559-1578 3325 CACCACUUCCUACAACCCA 3326 cAccAcuuccuAcAAcccAdTsdT sense 1559-1578 3327 UGGGUUGUAGGAAGUGGUG 3328 UGGGUUGuAGGAAGUGGUGdTsdT antis 1574-1593 3329 CCCAUCCUCACAAGCUUUA 3330 cccAuccucAcAAGcuuuAdTsdT sense 1574-1593 3331 UAAAGCUUGUGAGGAUGGG 3332 uAAAGCUUGUGAGGAUGGGdTsdT antis 1585-1604 3333 AAGCUUUAACUGAAGCUCA 3334 AAGcuuuAAcuGAAGcucAdTsdT sense 1585-1604 3335 UGAGCUUCAGUUAAAGCUU 3336 UGAGCUUcAGUuAAAGCUUdTsdT antis 1598-1617 3337 AGCUCAGACUGGCCAAGAU 3338 AGcucAGAcuGGccAAGAudTsdT sense 1598-1617 3339 AUCUUGGCCAGUCUGAGCU 3340 AUCUUGGCcAGUCUGAGCUdTsdT antis 1599-1618 3341 GCUCAGACUGGCCAAGAUU 3342 GcucAGAcuGGccAAGAuudTsdT sense 1599-1618 3343 AAUCUUGGCCAGUCUGAGC 3344 AAUCUUGGCcAGUCUGAGCdTsdT antis 1605-1624 3345 ACUGGCCAAGAUUGGCAGC 3346 AcuGGccAAGAuuGGcAGcdTsdT sense 1605-1624 3347 GCUGCCAAUCUUGGCCAGU 3348 GCUGCcAAUCUUGGCcAGUdTsdT antis 1611-1630 3349 CAAGAUUGGCAGCCAUCUG 3350 cAAGAuuGGcAGccAucuGdTsdT sense 1611-1630 3351 CAGAUGGCUGCCAAUCUUG 3352 cAGAUGGCUGCcAAUCUUGdTsdT antis 1612-1631 3353 AAGAUUGGCAGCCAUCUGA 3354 AAGAuuGGcAGccAucuGAdTsdT sense 1612-1631 3355 UCAGAUGGCUGCCAAUCUU 3356 UcAGAUGGCUGCcAAUCUUdTsdT antis 1651-1670 3357 CUAGCUCUUCCUGAGGGCC 3358 cuAGcucuuccuGAGGGccdTsdT sense 1651-1670 3359 GGCCCUCAGGAAGAGCUAG 3360 GGCCCUcAGGAAGAGCuAGdTsdT antis 1655-1674 3361 CUCUUCCUGAGGGCCCCAC 3362 cucuuccuGAGGGccccAcdTsdT sense 1655-1674 3363 GUGGGGCCCUCAGGAAGAG 3364 GUGGGGCCCUcAGGAAGAGdTsdT antis 1656-1675 3365 UCUUCCUGAGGGCCCCACC 3366 ucuuccuGAGGGccccAccdTsdT sense 1656-1675 3367 GGUGGGGCCCUCAGGAAGA 3368 GGUGGGGCCCUcAGGAAGAdTsdT antis 1803-1822 3369 UAGGCCUCCCUCAGCAGCC 3370 uAGGccucccucAGcAGccdTsdT sense 1803-1822 3371 GGCUGCUGAGGGAGGCCUA 3372 GGCUGCUGAGGGAGGCCuAdTsdT antis 1804-1823 3373 AGGCCUCCCUCAGCAGCCU 3374 AGGccucccucAGcAGccudTsdT sense 1804-1823 3375 AGGCUGCUGAGGGAGGCCU 3376 AGGCUGCUGAGGGAGGCCUdTsdT antis 1805-1824 3377 GGCCUCCCUCAGCAGCCUA 3378 GGccucccucAGcAGccuAdTsdT sense 1805-1824 3379 UAGGCUGCUGAGGGAGGCC 3380 uAGGCUGCUGAGGGAGGCCdTsdT antis 1806-1825 3381 GCCUCCCUCAGCAGCCUAA 3382 GccucccucAGcAGccuAAdTsdT sense 1806-1825 3383 UUAGGCUGCUGAGGGAGGC 3384 UuAGGCUGCUGAGGGAGGCdTsdT antis 1810-1829 3385 CCCUCAGCAGCCUAACCUC 3386 cccucAGcAGccuAAccucdTsdT sense 1810-1829 3387 GAGGUUAGGCUGCUGAGGG 3388 GAGGUuAGGCUGCUGAGGGdTsdT antis 1846-1865 3389 AGAGGAUUUUAACUGUUUG 3390 AGAGGAuuuuAAcuGuuuGdTsdT sense 1846-1865 3391 CAAACAGUUAAAAUCCUCU 3392 cAAAcAGUuAAAAUCCUCUdTsdT antis 1871-1890 3393 AGGGGAGAAAAGGAAGGAC 3394 AGGGGAGAAAAGGAAGGAcdTsdT sense 1871-1890 3395 GUCCUUCCUUUUCUCCCCU 3396 GUCCUUCCUUUUCUCCCCUdTsdT antis 1873-1892 3397 GGGAGAAAAGGAAGGACGG 3398 GGGAGAAAAGGAAGGAcGGdTsdT sense 1873-1892 3399 CCGUCCUUCCUUUUCUCCC 3400 CCGUCCUUCCUUUUCUCCCdTsdT antis 1877-1896 3401 GAAAAGGAAGGACGGGGUU 3402 GAAAAGGAAGGAcGGGGuudTsdT sense 1877-1896 3403 AACCCCGUCCUUCCUUUUC 3404 AACCCCGUCCUUCCUUUUCdTsdT antis 1933-1952 3405 CCCUCCCCCAGGCUACCAC 3406 cccucccccAGGcuAccAcdTsdT sense 1933-1952 3407 GUGGUAGCCUGGGGGAGGG 3408 GUGGuAGCCUGGGGGAGGGdTsdT antis 1934-1953 3409 CCUCCCCCAGGCUACCACU 3410 ccucccccAGGcuAccAcudTsdT sense 1934-1953 3411 AGUGGUAGCCUGGGGGAGG 3412 AGUGGuAGCCUGGGGGAGGdTsdT antis 1940-1959 3413 CCAGGCUACCACUCCUUCC 3414 ccAGGcuAccAcuccuuccdTsdT sense 1940-1959 3415 GGAAGGAGUGGUAGCCUGG 3416 GGAAGGAGUGGuAGCCUGGdTsdT antis 1941-1960 3417 CAGGCUACCACUCCUUCCC 3418 cAGGcuAccAcuccuucccdTsdT sense 1941-1960 3419 GGGAAGGAGUGGUAGCCUG 3420 GGGAAGGAGUGGuAGCCUGdTsdT antis 1945-1964 3421 CUACCACUCCUUCCCUCCC 3422 cuAccAcuccuucccucccdTsdT sense 1945-1964 3423 GGGAGGGAAGGAGUGGUAG 3424 GGGAGGGAAGGAGUGGuAGdTsdT antis 1946-1965 3425 UACCACUCCUUCCCUCCCC 3426 uAccAcuccuucccuccccdTsdT sense 1946-1965 3427 GGGGAGGGAAGGAGUGGUA 3428 GGGGAGGGAAGGAGUGGuAdTsdT antis 1953-1972 3429 CCUUCCCUCCCCCCCUCUC 3430 ccuucccucccccccucucdTsdT sense 1953-1972 3431 GAGAGGGGGGGAGGGAAGG 3432 GAGAGGGGGGGAGGGAAGGdTsdT antis 2023-2042 3433 CCUGGCCCCCUGGGUGUAA 3434 ccuGGcccccuGGGuGuAAdTsdT sense 2023-2042 3435 UUACACCCAGGGGGCCAGG 3436 UuAcACCcAGGGGGCcAGGdTsdT antis 2024-2043 3437 CUGGCCCCCUGGGUGUAAA 3438 cuGGcccccuGGGuGuAAAdTsdT sense 2024-2043 3439 UUUACACCCAGGGGGCCAG 3440 UUuAcACCcAGGGGGCcAGdTsdT antis 2040-2059 3441 AAAUAGAUUGUUAUAAUUU 3442 AAAuAGAuuGuuAuAAuuudTsdT sense 2040-2059 3443 AAAUUAUAACAAUCUAUUU 3444 AAAUuAuAAcAAUCuAUUUdTsdT antis 2043-2062 3445 UAGAUUGUUAUAAUUUUUU 3446 uAGAuuGuuAuAAuuuuuudTsdT sense 2043-2062 3447 AAAAAAUUAUAACAAUCUA 3448 AAAAAAUuAuAAcAAUCuAdTsdT antis 2044-2063 3449 AGAUUGUUAUAAUUUUUUC 3450 AGAuuGuuAuAAuuuuuucdTsdT sense 2044-2063 3451 GAAAAAAUUAUAACAAUCU 3452 GAAAAAAUuAuAAcAAUCUdTsdT antis 2045-2064 3453 GAUUGUUAUAAUUUUUUCU 3454 GAuuGuuAuAAuuuuuucudTsdT sense 2045-2064 3455 AGAAAAAAUUAUAACAAUC 3456 AGAAAAAAUuAuAAcAAUCdTsdT antis 2046-2065 3457 AUUGUUAUAAUUUUUUCUU 3458 AuuGuuAuAAuuuuuucuudTsdT sense 2046-2065 3459 AAGAAAAAAUUAUAACAAU 3460 AAGAAAAAAUuAuAAcAAUdTsdT antis 2049-2068 3461 GUUAUAAUUUUUUCUUAAA 3462 GuuAuAAuuuuuucuuAAAdTsdT sense 2049-2068 3463 UUUAAGAAAAAAUUAUAAC 3464 UUuAAGAAAAAAUuAuAACdTsdT antis 2117-2136 3465 UCUUGUCCUCUGCUCCCAA 3466 ucuuGuccucuGcucccAAdTsdT sense 2117-2136 3467 UUGGGAGCAGAGGACAAGA 3468 UUGGGAGcAGAGGAcAAGAdTsdT antis 2118-2137 3469 CUUGUCCUCUGCUCCCAAG 3470 cuuGuccucuGcucccAAGdTsdT sense 2118-2137 3471 CUUGGGAGCAGAGGACAAG 3472 CUUGGGAGcAGAGGAcAAGdTsdT antis 2129-2148 3473 CUCCCAAGGCUUCCUCCCU 3474 cucccAAGGcuuccucccudTsdT sense 2129-2148 3475 AGGGAGGAAGCCUUGGGAG 3476 AGGGAGGAAGCCUUGGGAGdTsdT antis 2130-2149 3477 UCCCAAGGCUUCCUCCCUC 3478 ucccAAGGcuuccucccucdTsdT sense 2130-2149 3479 GAGGGAGGAAGCCUUGGGA 3480 GAGGGAGGAAGCCUUGGGAdTsdT antis 2133-2152 3481 CAAGGCUUCCUCCCUCUCC 3482 cAAGGcuuccucccucuccdTsdT sense 2133-2152 3483 GGAGAGGGAGGAAGCCUUG 3484 GGAGAGGGAGGAAGCCUUGdTsdT antis 2134-2153 3485 AAGGCUUCCUCCCUCUCCC 3486 AAGGcuuccucccucucccdTsdT sense 2134-2153 3487 GGGAGAGGGAGGAAGCCUU 3488 GGGAGAGGGAGGAAGCCUUdTsdT antis 2146-2165 3489 CUCUCCCCAUCCUGGAAGG 3490 cucuccccAuccuGGAAGGdTsdT sense 2146-2165 3491 CCUUCCAGGAUGGGGAGAG 3492 CCUUCcAGGAUGGGGAGAGdTsdT antis 2150-2169 3493 CCCCAUCCUGGAAGGAGGG 3494 ccccAuccuGGAAGGAGGGdTsdT sense 2150-2169 3495 CCCUCCUUCCAGGAUGGGG 3496 CCCUCCUUCcAGGAUGGGGdTsdT antis 2152-2171 3497 CCAUCCUGGAAGGAGGGGA 3498 ccAuccuGGAAGGAGGGGAdTsdT sense 2152-2171 3499 UCCCCUCCUUCCAGGAUGG 3500 UCCCCUCCUUCcAGGAUGGdTsdT antis 2156-2175 3501 CCUGGAAGGAGGGGAGUAG 3502 ccuGGAAGGAGGGGAGuAGdTsdT sense 2156-2175 3503 CUACUCCCCUCCUUCCAGG 3504 CuACUCCCCUCCUUCcAGGdTsdT antis 2161-2180 3505 AAGGAGGGGAGUAGAGAGA 3506 AAGGAGGGGAGuAGAGAGAdTsdT sense 2161-2180 3507 UCUCUCUACUCCCCUCCUU 3508 UCUCUCuACUCCCCUCCUUdTsdT antis 2208-2227 3509 GGUUUGCCUGUGUACAGAC 3510 GGuuuGccuGuGuAcAGAcdTsdT sense 2208-2227 3511 GUCUGUACACAGGCAAACC 3512 GUCUGuAcAcAGGcAAACCdTsdT antis 2219-2238 3513 GUACAGACCUCUGUUCAAU 3514 GuAcAGAccucuGuucAAudTsdT sense 2219-2238 3515 AUUGAACAGAGGUCUGUAC 3516 AUUGAAcAGAGGUCUGuACdTsdT antis 2233-2252 3517 UCAAUAAAUUAUUGGCAUG 3518 ucAAuAAAuuAuuGGcAuGdTsdT sense 2233-2252 3519 CAUGCCAAUAAUUUAUUGA 3520 cAUGCcAAuAAUUuAUUGAdTsdT antis   2-21 3521 UGGUGACAACGAAGCCGAC 3522 uGGuGAcAAcGAAGccGAcdTsdT sense   2-21 3523 GUCGGCUUCGUUGUCACCA 3524 GUCGGCUUCGUUGUcACcAdTsdT antis  138-157 3525 GCGGGGGCAGCCCAGGCAG 3526 GcGGGGGcAGcccAGGcAGdTsdT sense  138-157 3527 CUGCCUGGGCUGCCCCCGC 3528 CUGCCUGGGCUGCCCCCGCdTsdT antis  381-400 3529 AGCUCCGGGGGUGGCCCCA 3530 AGcuccGGGGGuGGccccAdTsdT sense  381-400 3531 UGGGGCCACCCCCGGAGCU 3532 UGGGGCcACCCCCGGAGCUdTsdT antis  592-611 3533 ACCAGGCACGGCUGGCAGA 3534 AccAGGcAcGGcuGGcAGAdTsdT sense  592-611 3535 UCUGCCAGCCGUGCCUGGU 3536 UCUGCcAGCCGUGCCUGGUdTsdT antis  615-634 3537 AGGGAACUGGUGGCCAUCA 3538 AGGGAAcuGGuGGccAucAdTsdT sense  615-634 3539 UGAUGGCCACCAGUUCCCU 3540 UGAUGGCcACcAGUUCCCUdTsdT antis 1026-1045 3541 UACAUCUGCUCUCGGUACU 3542 uAcAucuGcucucGGuAcudTsdT sense 1026-1045 3543 AGUACCGAGAGCAGAUGUA 3544 AGuACCGAGAGcAGAUGuAdTsdT antis 1027-1046 3545 ACAUCUGCUCUCGGUACUA 3546 AcAucuGcucucGGuAcuAdTsdT sense 1027-1046 3547 UAGUACCGAGAGCAGAUGU 3548 uAGuACCGAGAGcAGAUGUdTsdT antis 1105-1124 3549 CGGCUGGCUGUGUACUUGC 3550 cGGcuGGcuGuGuAcuuGcdTsdT sense 1105-1124 3551 GCAAGUACACAGCCAGCCG 3552 GcAAGuAcAcAGCcAGCCGdTsdT antis 1362-1381 3553 UCAAGGCUCUCCCCACUCG 3554 ucAAGGcucuccccAcucGdTsdT sense 1362-1381 3555 CGAGUGGGGAGAGCCUUGA 3556 CGAGUGGGGAGAGCCUUGAdTsdT antis 1440-1459 3557 GACCGCCCGCUUCCCCCCC 3558 GAccGcccGcuucccccccdTsdT sense 1440-1459 3559 GGGGGGGAAGCGGGCGGUC 3560 GGGGGGGAAGCGGGCGGUCdTsdT antis 2017-2036 3561 CCCUUCCCUGGCCCCCUGG 3562 cccuucccuGGcccccuGGdTsdT sense 2017-2036 3563 CCAGGGGGCCAGGGAAGGG 3564 CcAGGGGGCcAGGGAAGGGdTsdT antis 2018-2037 3565 CCUUCCCUGGCCCCCUGGG 3566 ccuucccuGGcccccuGGGdTsdT sense 2018-2037 3567 CCCAGGGGGCCAGGGAAGG 3568 CCcAGGGGGCcAGGGAAGGdTsdT antis 2019-2038 3569 CUUCCCUGGCCCCCUGGGU 3570 cuucccuGGcccccuGGGudTsdT sense 2019-2038 3571 ACCCAGGGGGCCAGGGAAG 3572 ACCcAGGGGGCcAGGGAAGdTsdT antis 2148-2167 3573 CUCCCCAUCCUGGAAGGAG 3574 cuccccAuccuGGAAGGAGdTsdT sense 2148-2167 3575 CUCCUUCCAGGAUGGGGAG 3576 CUCCUUCcAGGAUGGGGAGdTsdT antis 2149-2168 3577 UCCCCAUCCUGGAAGGAGG 3578 uccccAuccuGGAAGGAGGdTsdT sense 2149-2168 3579 CCUCCUUCCAGGAUGGGGA 3580 CCUCCUUCcAGGAUGGGGAdTsdT antis 1335-1354 3581 UCUAGCCUACUGGAGUACA 3582 ucuAGccuAcuGGAGuAcAdTsdT sense 1335-1354 3583 UGUACUCCAGUAGGCUAGA 3584 UGuACUCcAGuAGGCuAGAdTsdT antis  342-361 3585 GCGUCAGUCGGGGCUAUGG 3586 GcGucAGucGGGGcuAuGGdTsdT sense  342-361 3587 CCAUAGCCCCGACUGACGC 3588 CcAuAGCCCCGACUGACGCdTsdT antis  675-694 3589 CAGAUUAUGCGUAAGCUGG 3590 cAGAuuAuGcGuAAGcuGGdTsdT sense  675-694 3591 CCAGCUUACGCAUAAUCUG 3592 CcAGCUuACGcAuAAUCUGdTsdT antis 1080-1099 3593 UACACCUCGUCCAUCGAUG 3594 uAcAccucGuccAucGAuGdTsdT sense 1080-1099 3595 CAUCGAUGGACGAGGUGUA 3596 cAUCGAUGGACGAGGUGuAdTsdT antis  333-352 3597 GGCGGGAAAGCGUCAGUCG 3598 GGcGGGAAAGcGucAGucGdTsdT sense  333-352 3599 CGACUGACGCUUUCCCGCC 3600 CGACUGACGCUUUCCCGCCdTsdT antis  475-494 3601 GUGACAGCGGGAAGGUGAC 3602 GuGAcAGcGGGAAGGuGAcdTsdT sense  475-494 3603 GUCACCUUCCCGCUGUCAC 3604 GUcACCUUCCCGCUGUcACdTsdT antis  533-552 3605 CCAAGAAGUGGCUUACACU 3606 ccAAGAAGuGGcuuAcAcudTsdT sense  533-552 3607 AGUGUAAGCCACUUCUUGG 3608 AGUGuAAGCcACUUCUUGGdTsdT antis  746-765 3609 GAAGGACGAGCUGUAUUUG 3610 GAAGGAcGAGcuGuAuuuGdTsdT sense  746-765 3611 CAAAUACAGCUCGUCCUUC 3612 cAAAuAcAGCUCGUCCUUCdTsdT antis  747-766 3613 AAGGACGAGCUGUAUUUGA 3614 AAGGAcGAGcuGuAuuuGAdTsdT sense  747-766 3615 UCAAAUACAGCUCGUCCUU 3616 UcAAAuAcAGCUCGUCCUUdTsdT antis  830-849 3617 GCUGAUCACCCCUAUCAUC 3618 GcuGAucAccccuAucAucdTsdT sense  830-849 3619 GAUGAUAGGGGUGAUCAGC 3620 GAUGAuAGGGGUGAUcAGCdTsdT antis 1334-1353 3621 CUCUAGCCUACUGGAGUAC 3622 cucuAGccuAcuGGAGuAcdTsdT sense 1334-1353 3623 GUACUCCAGUAGGCUAGAG 3624 GuACUCcAGuAGGCuAGAGdTsdT antis  497-516 3625 AGUGGUAGCCACUGUAGGC 3626 AGuGGuAGccAcuGuAGGcdTsdT sense  497-516 3627 GCCUACAGUGGCUACCACU 3628 GCCuAcAGUGGCuACcACUdTsdT antis 1641-1660 3629 GCUACCCUCGCUAGCUCUU 3630 GcuAcccucGcuAGcucuudTsdT sense 1641-1660 3631 AAGAGCUAGCGAGGGUAGC 3632 AAGAGCuAGCGAGGGuAGCdTsdT antis 1642-1661 3633 CUACCCUCGCUAGCUCUUC 3634 cuAcccucGcuAGcucuucdTsdT sense 1642-1661 3635 GAAGAGCUAGCGAGGGUAG 3636 GAAGAGCuAGCGAGGGuAGdTsdT antis  676-695 3637 AGAUUAUGCGUAAGCUGGA 3638 AGAuuAuGcGuAAGcuGGAdTsdT sense  676-695 3639 UCCAGCUUACGCAUAAUCU 3640 UCcAGCUuACGcAuAAUCUdTsdT antis 1128-1147 3641 CUACUUCUCGGCCAGCCCA 3642 cuAcuucucGGccAGcccAdTsdT sense 1128-1147 3643 UGGGCUGGCCGAGAAGUAG 3644 UGGGCUGGCCGAGAAGuAGdTsdT antis   40-59 3645 CCGGCGUGCCCCGCGGCGG 3646 ccGGcGuGccccGcGGcGGdTsdT sense   40-59 3647 CCGCCGCGGGGCACGCCGG 3648 CCGCCGCGGGGcACGCCGGdTsdT antis  199-218 3649 GCGGCGGGCCUUCGGGAGG 3650 GcGGcGGGccuucGGGAGGdTsdT sense  199-218 3651 CCUCCCGAAGGCCCGCCGC 3652 CCUCCCGAAGGCCCGCCGCdTsdT antis  222-241 3653 CCUGGGGGCUCGGGCCGGG 3654 ccuGGGGGcucGGGccGGGdTsdT sense  222-241 3655 CCCGGCCCGAGCCCCCAGG 3656 CCCGGCCCGAGCCCCcAGGdTsdT antis  343-362 3657 CGUCAGUCGGGGCUAUGGG 3658 cGucAGucGGGGcuAuGGGdTsdT sense  343-362 3659 CCCAUAGCCCCGACUGACG 3660 CCcAuAGCCCCGACUGACGdTsdT antis  437-456 3661 GGGCACUAGCUUCCCGCCG 3662 GGGcAcuAGcuucccGccGdTsdT sense  437-456 3663 CGGCGGGAAGCUAGUGCCC 3664 CGGCGGGAAGCuAGUGCCCdTsdT antis  538-557 3665 AAGUGGCUUACACUGACAU 3666 AAGuGGcuuAcAcuGAcAudTsdT sense  538-557 3667 AUGUCAGUGUAAGCCACUU 3668 AUGUcAGUGuAAGCcACUUdTsdT antis  663-682 3669 AACCGAGAACUGCAGAUUA 3670 AAccGAGAAcuGcAGAuuAdTsdT sense  663-682 3671 UAAUCUGCAGUUCUCGGUU 3672 uAAUCUGcAGUUCUCGGUUdTsdT antis  887-906 3673 GGCCUACAUCCACUCCCAA 3674 GGccuAcAuccAcucccAAdTsdT sense  887-906 3675 UUGGGAGUGGAUGUAGGCC 3676 UUGGGAGUGGAUGuAGGCCdTsdT antis  997-1016 3677 AGCUGGUUCGGGGGGAGCC 3678 AGcuGGuucGGGGGGAGccdTsdT sense  997-1016 3679 GGCUCCCCCCGAACCAGCU 3680 GGCUCCCCCCGAACcAGCUdTsdT antis 1079-1098 3681 UUACACCUCGUCCAUCGAU 3682 uuAcAccucGuccAucGAudTsdT sense 1079-1098 3683 AUCGAUGGACGAGGUGUAA 3684 AUCGAUGGACGAGGUGuAAdTsdT antis 1323-1342 3685 AUUGCACUCUGCUCUAGCC 3686 AuuGcAcucuGcucuAGccdTsdT sense 1323-1342 3687 GGCUAGAGCAGAGUGCAAU 3688 GGCuAGAGcAGAGUGcAAUdTsdT antis 1370-1389 3689 CUCCCCACUCGAGGCUUGU 3690 cuccccAcucGAGGcuuGudTsdT sense 1370-1389 3691 ACAAGCCUCGAGUGGGGAG 3692 AcAAGCCUCGAGUGGGGAGdTsdT antis 1494-1513 3693 CCAUCUCUCAAUGCCAUUC 3694 ccAucucucAAuGccAuucdTsdT sense 1494-1513 3695 GAAUGGCAUUGAGAGAUGG 3696 GAAUGGcAUUGAGAGAUGGdTsdT antis   57-76 3697 GGGCGCUGGGCCGGAGCCG 3698 GGGcGcuGGGccGGAGccGdTsdT sense   57-76 3699 CGGCUCCGGCCCAGCGCCC 3700 CGGCUCCGGCCcAGCGCCCdTsdT antis  137-156 3701 GGCGGGGGCAGCCCAGGCA 3702 GGcGGGGGcAGcccAGGcAdTsdT sense  137-156 3703 UGCCUGGGCUGCCCCCGCC 3704 UGCCUGGGCUGCCCCCGCCdTsdT antis  141-160 3705 GGGGCAGCCCAGGCAGCCC 3706 GGGGcAGcccAGGcAGcccdTsdT sense  141-160 3707 GGGCUGCCUGGGCUGCCCC 3708 GGGCUGCCUGGGCUGCCCCdTsdT antis  198-217 3709 GGCGGCGGGCCUUCGGGAG 3710 GGcGGcGGGccuucGGGAGdTsdT sense  198-217 3711 CUCCCGAAGGCCCGCCGCC 3712 CUCCCGAAGGCCCGCCGCCdTsdT antis  319-338 3713 CAGGAGGCACUGGCGGCGG 3714 cAGGAGGcAcuGGcGGcGGdTsdT sense  319-338 3715 CCGCCGCCAGUGCCUCCUG 3716 CCGCCGCcAGUGCCUCCUGdTsdT antis  417-436 3717 GGCAGCGGUGGCCCCGGCG 3718 GGcAGcGGuGGccccGGcGdTsdT sense  417-436 3719 CGCCGGGGCCACCGCUGCC 3720 CGCCGGGGCcACCGCUGCCdTsdT antis  490-509 3721 UGACCACAGUGGUAGCCAC 3722 uGAccAcAGuGGuAGccAcdTsdT sense  490-509 3723 GUGGCUACCACUGUGGUCA 3724 GUGGCuACcACUGUGGUcAdTsdT antis  503-522 3725 AGCCACUGUAGGCCAAGGC 3726 AGccAcuGuAGGccAAGGcdTsdT sense  503-522 3727 GCCUUGGCCUACAGUGGCU 3728 GCCUUGGCCuAcAGUGGCUdTsdT antis  539-558 3729 AGUGGCUUACACUGACAUC 3730 AGuGGcuuAcAcuGAcAucdTsdT sense  539-558 3731 GAUGUCAGUGUAAGCCACU 3732 GAUGUcAGUGuAAGCcACUdTsdT antis  602-621 3733 GCUGGCAGAGACGAGGGAA 3734 GcuGGcAGAGAcGAGGGAAdTsdT sense  602-621 3735 UUCCCUCGUCUCUGCCAGC 3736 UUCCCUCGUCUCUGCcAGCdTsdT antis  793-812 3737 CGGUGUACCGAGUGGCCCG 3738 cGGuGuAccGAGuGGcccGdTsdT sense  793-812 3739 CGGGCCACUCGGUACACCG 3740 CGGGCcACUCGGuAcACCGdTsdT antis  825-844 3741 GCCAAGCUGAUCACCCCUA 3742 GccAAGcuGAucAccccuAdTsdT sense  825-844 3743 UAGGGGUGAUCAGCUUGGC 3744 uAGGGGUGAUcAGCUUGGCdTsdT antis  829-848 3745 AGCUGAUCACCCCUAUCAU 3746 AGcuGAucAccccuAucAudTsdT sense  829-848 3747 AUGAUAGGGGUGAUCAGCU 3748 AUGAuAGGGGUGAUcAGCUdTsdT antis  843-862 3749 AUCAUCUACAUCAAGGUGU 3750 AucAucuAcAucAAGGuGudTsdT sense  843-862 3751 ACACCUUGAUGUAGAUGAU 3752 AcACCUUGAUGuAGAUGAUdTsdT antis  844-863 3753 UCAUCUACAUCAAGGUGUA 3754 ucAucuAcAucAAGGuGuAdTsdT sense  844-863 3755 UACACCUUGAUGUAGAUGA 3756 uAcACCUUGAUGuAGAUGAdTsdT antis  888-907 3757 GCCUACAUCCACUCCCAAG 3758 GccuAcAuccAcucccAAGdTsdT sense  888-907 3759 CUUGGGAGUGGAUGUAGGC 3760 CUUGGGAGUGGAUGuAGGCdTsdT antis  902-921 3761 CCAAGGUGUGUGUCACCGU 3762 ccAAGGuGuGuGucAccGudTsdT sense  902-921 3763 ACGGUGACACACACCUUGG 3764 ACGGUGAcAcAcACCUUGGdTsdT antis 1067-1086 3765 UGGAGCCACAGAUUACACC 3766 uGGAGccAcAGAuuAcAccdTsdT sense 1067-1086 3767 GGUGUAAUCUGUGGCUCCA 3768 GGUGuAAUCUGUGGCUCcAdTsdT antis 1095-1114 3769 GAUGUGUGGUCGGCUGGCU 3770 GAuGuGuGGucGGcuGGcudTsdT sense 1095-1114 3771 AGCCAGCCGACCACACAUC 3772 AGCcAGCCGACcAcAcAUCdTsdT antis 1154-1173 3773 UGGGGACAGUGGGGUGGAC 3774 uGGGGAcAGuGGGGuGGAcdTsdT sense 1154-1173 3775 GUCCACCCCACUGUCCCCA 3776 GUCcACCCcACUGUCCCcAdTsdT antis 1271-1290 3777 AGCUCACCCUUGGACAAAG 3778 AGcucAcccuuGGAcAAAGdTsdT sense 1271-1290 3779 CUUUGUCCAAGGGUGAGCU 3780 CUUUGUCcAAGGGUGAGCUdTsdT antis 1272-1291 3781 GCUCACCCUUGGACAAAGG 3782 GcucAcccuuGGAcAAAGGdTsdT sense 1272-1291 3783 CCUUUGUCCAAGGGUGAGC 3784 CCUUUGUCcAAGGGUGAGCdTsdT antis 1289-1308 3785 GGUGUUCAAAUCUUCAAAG 3786 GGuGuucAAAucuucAAAGdTsdT sense 1289-1308 3787 CUUUGAAGAUUUGAACACC 3788 CUUUGAAGAUUUGAAcACCdTsdT antis 1324-1343 3789 UUGCACUCUGCUCUAGCCU 3790 uuGcAcucuGcucuAGccudTsdT sense 1324-1343 3791 AGGCUAGAGCAGAGUGCAA 3792 AGGCuAGAGcAGAGUGcAAdTsdT antis 1351-1370 3793 ACACGCCAUCCUCAAGGCU 3794 AcAcGccAuccucAAGGcudTsdT sense 1351-1370 3795 AGCCUUGAGGAUGGCGUGU 3796 AGCCUUGAGGAUGGCGUGUdTsdT antis 1371-1390 3797 UCCCCACUCGAGGCUUGUG 3798 uccccAcucGAGGcuuGuGdTsdT sense 1371-1390 3799 CACAAGCCUCGAGUGGGGA 3800 cAcAAGCCUCGAGUGGGGAdTsdT antis 1392-1411 3801 CACAGCUUCUUCGAUGAAC 3802 cAcAGcuucuucGAuGAAcdTsdT sense 1392-1411 3803 GUUCAUCGAAGAAGCUGUG 3804 GUUcAUCGAAGAAGCUGUGdTsdT antis 1395-1414 3805 AGCUUCUUCGAUGAACUGC 3806 AGcuucuucGAuGAAcuGcdTsdT sense 1395-1414 3807 GCAGUUCAUCGAAGAAGCU 3808 GcAGUUcAUCGAAGAAGCUdTsdT antis 1439-1458 3809 CGACCGCCCGCUUCCCCCC 3810 cGAccGcccGcuuccccccdTsdT sense 1439-1458 3811 GGGGGGAAGCGGGCGGUCG 3812 GGGGGGAAGCGGGCGGUCGdTsdT antis 1442-1461 3813 CCGCCCGCUUCCCCCCCUG 3814 ccGcccGcuucccccccuGdTsdT sense 1442-1461 3815 CAGGGGGGGAAGCGGGCGG 3816 cAGGGGGGGAAGCGGGCGGdTsdT antis 1467-1486 3817 UUCAGUCCUGGUGAACUGU 3818 uucAGuccuGGuGAAcuGudTsdT sense 1467-1486 3819 ACAGUUCACCAGGACUGAA 3820 AcAGUUcACcAGGACUGAAdTsdT antis 1468-1487 3821 UCAGUCCUGGUGAACUGUC 3822 ucAGuccuGGuGAAcuGucdTsdT sense 1468-1487 3823 GACAGUUCACCAGGACUGA 3824 GAcAGUUcACcAGGACUGAdTsdT antis 1482-1501 3825 CUGUCCAUCCAACCAUCUC 3826 cuGuccAuccAAccAucucdTsdT sense 1482-1501 3827 GAGAUGGUUGGAUGGACAG 3828 GAGAUGGUUGGAUGGAcAGdTsdT antis 1483-1502 3829 UGUCCAUCCAACCAUCUCU 3830 uGuccAuccAAccAucucudTsdT sense 1483-1502 3831 AGAGAUGGUUGGAUGGACA 3832 AGAGAUGGUUGGAUGGAcAdTsdT antis 1495-1514 3833 CAUCUCUCAAUGCCAUUCU 3834 cAucucucAAuGccAuucudTsdT sense 1495-1514 3835 AGAAUGGCAUUGAGAGAUG 3836 AGAAUGGcAUUGAGAGAUGdTsdT antis 1554-1573 3837 CCCCUCACCACUUCCUACA 3838 ccccucAccAcuuccuAcAdTsdT sense 1554-1573 3839 UGUAGGAAGUGGUGAGGGG 3840 UGuAGGAAGUGGUGAGGGGdTsdT antis 1597-1616 3841 AAGCUCAGACUGGCCAAGA 3842 AAGcucAGAcuGGccAAGAdTsdT sense 1597-1616 3843 UCUUGGCCAGUCUGAGCUU 3844 UCUUGGCcAGUCUGAGCUUdTsdT antis 1659-1678 3845 UCCUGAGGGCCCCACCGAC 3846 uccuGAGGGccccAccGAcdTsdT sense 1659-1678 3847 GUCGGUGGGGCCCUCAGGA 3848 GUCGGUGGGGCCCUcAGGAdTsdT antis 1814-1833 3849 CAGCAGCCUAACCUCUGUG 3850 cAGcAGccuAAccucuGuGdTsdT sense 1814-1833 3851 CACAGAGGUUAGGCUGCUG 3852 cAcAGAGGUuAGGCUGCUGdTsdT antis 1815-1834 3853 AGCAGCCUAACCUCUGUGG 3854 AGcAGccuAAccucuGuGGdTsdT sense 1815-1834 3855 CCACAGAGGUUAGGCUGCU 3856 CcAcAGAGGUuAGGCUGCUdTsdT antis 1904-1923 3857 UGAGGACCUUCUACCCCCU 3858 uGAGGAccuucuAcccccudTsdT sense 1904-1923 3859 AGGGGGUAGAAGGUCCUCA 3860 AGGGGGuAGAAGGUCCUcAdTsdT antis 1905-1924 3861 GAGGACCUUCUACCCCCUU 3862 GAGGAccuucuAcccccuudTsdT sense 1905-1924 3863 AAGGGGGUAGAAGGUCCUC 3864 AAGGGGGuAGAAGGUCCUCdTsdT antis 2012-2031 3865 GUCUUCCCUUCCCUGGCCC 3866 GucuucccuucccuGGcccdTsdT sense 2012-2031 3867 GGGCCAGGGAAGGGAAGAC 3868 GGGCcAGGGAAGGGAAGACdTsdT antis 2095-2114 3869 UGCCCCCCCCAGCUGUACC 3870 uGccccccccAGcuGuAccdTsdT sense 2095-2114 3871 GGUACAGCUGGGGGGGGCA 3872 GGuAcAGCUGGGGGGGGcAdTsdT antis 2102-2121 3873 CCCAGCUGUACCCCUUCUU 3874 cccAGcuGuAccccuucuudTsdT sense 2102-2121 3875 AAGAAGGGGUACAGCUGGG 3876 AAGAAGGGGuAcAGCUGGGdTsdT antis 2184-2203 3877 CUGGUGUCUUAGUUUCCAC 3878 cuGGuGucuuAGuuuccAcdTsdT sense 2184-2203 3879 GUGGAAACUAAGACACCAG 3880 GUGGAAACuAAGAcACcAGdTsdT antis 2192-2211 3881 UUAGUUUCCACAGUAAGGU 3882 uuAGuuuccAcAGuAAGGudTsdT sense 2192-2211 3883 ACCUUACUGUGGAAACUAA 3884 ACCUuACUGUGGAAACuAAdTsdT antis 2227-2246 3885 CUCUGUUCAAUAAAUUAUU 3886 cucuGuucAAuAAAuuAuudTsdT sense 2227-2246 3887 AAUAAUUUAUUGAACAGAG 3888 AAuAAUUuAUUGAAcAGAGdTsdT antis  151-170 3889 AGGCAGCCCGAGCCCCGCG 3890 AGGcAGcccGAGccccGcGdTsdT sense  151-170 3891 CGCGGGGCUCGGGCUGCCU 3892 CGCGGGGCUCGGGCUGCCUdTsdT antis  404-423 3893 CAGCGGCGGAGGAGGCAGC 3894 cAGcGGcGGAGGAGGcAGcdTsdT sense  404-423 3895 GCUGCCUCCUCCGCCGCUG 3896 GCUGCCUCCUCCGCCGCUGdTsdT antis  530-549 3897 UUCCCAAGAAGUGGCUUAC 3898 uucccAAGAAGuGGcuuAcdTsdT sense  530-549 3899 GUAAGCCACUUCUUGGGAA 3900 GuAAGCcACUUCUUGGGAAdTsdT antis  954-973 3901 GACACUGCUGUCCUCAAGC 3902 GAcAcuGcuGuccucAAGcdTsdT sense  954-973 3903 GCUUGAGGACAGCAGUGUC 3904 GCUUGAGGAcAGcAGUGUCdTsdT antis 1394-1413 3905 CAGCUUCUUCGAUGAACUG 3906 cAGcuucuucGAuGAAcuGdTsdT sense 1394-1413 3907 CAGUUCAUCGAAGAAGCUG 3908 cAGUUcAUCGAAGAAGCUGdTsdT antis 2002-2021 3909 CCCAUCUCUCGUCUUCCCU 3910 cccAucucucGucuucccudTsdT sense 2002-2021 3911 AGGGAAGACGAGAGAUGGG 3912 AGGGAAGACGAGAGAUGGGdTsdT antis 2003-2022 3913 CCAUCUCUCGUCUUCCCUU 3914 ccAucucucGucuucccuudTsdT sense 2003-2022 3915 AAGGGAAGACGAGAGAUGG 3916 AAGGGAAGACGAGAGAUGGdTsdT antis 2121-2140 3917 GUCCUCUGCUCCCAAGGCU 3918 GuccucuGcucccAAGGcudTsdT sense 2121-2140 3919 AGCCUUGGGAGCAGAGGAC 3920 AGCCUUGGGAGcAGAGGACdTsdT antis   24-43 3921 AGAGGGACUUCAUCUCCCG 3922 AGAGGGAcuucAucucccGdTsdT sense   24-43 3923 CGGGAGAUGAAGUCCCUCU 3924 CGGGAGAUGAAGUCCCUCUdTsdT antis   49-68 3925 CCCGCGGCGGGCGCUGGGC 3926 cccGcGGcGGGcGcuGGGcdTsdT sense   49-68 3927 GCCCAGCGCCCGCCGCGGG 3928 GCCcAGCGCCCGCCGCGGGdTsdT antis  107-126 3929 GAGCCCAGGGGAGGCGGCG 3930 GAGcccAGGGGAGGcGGcGdTsdT sense  107-126 3931 CGCCGCCUCCCCUGGGCUC 3932 CGCCGCCUCCCCUGGGCUCdTsdT antis  126-145 3933 GCAGAGGCAGCGGCGGGGG 3934 GcAGAGGcAGcGGcGGGGGdTsdT sense  126-145 3935 CCCCCGCCGCUGCCUCUGC 3936 CCCCCGCCGCUGCCUCUGCdTsdT antis  153-172 3937 GCAGCCCGAGCCCCGCGGC 3938 GcAGcccGAGccccGcGGcdTsdT sense  153-172 3939 GCCGCGGGGCUCGGGCUGC 3940 GCCGCGGGGCUCGGGCUGCdTsdT antis  259-278 3941 CGGAGCCAGGAGGCGGAGG 3942 cGGAGccAGGAGGcGGAGGdTsdT sense  259-278 3943 CCUCCGCCUCCUGGCUCCG 3944 CCUCCGCCUCCUGGCUCCGdTsdT antis  261-280 3945 GAGCCAGGAGGCGGAGGCG 3946 GAGccAGGAGGcGGAGGcGdTsdT sense  261-280 3947 CGCCUCCGCCUCCUGGCUC 3948 CGCCUCCGCCUCCUGGCUCdTsdT antis  512-531 3949 AGGCCAAGGCCCAGAGCGU 3950 AGGccAAGGcccAGAGcGudTsdT sense  512-531 3951 ACGCUCUGGGCCUUGGCCU 3952 ACGCUCUGGGCCUUGGCCUdTsdT antis  660-679 3953 AAGAACCGAGAACUGCAGA 3954 AAGAAccGAGAAcuGcAGAdTsdT sense  660-679 3955 UCUGCAGUUCUCGGUUCUU 3956 UCUGcAGUUCUCGGUUCUUdTsdT antis  709-728 3957 UGAGGCUGCGGUACUUUUU 3958 uGAGGcuGcGGuAcuuuuudTsdT sense  709-728 3959 AAAAAGUACCGCAGCCUCA 3960 AAAAAGuACCGcAGCCUcAdTsdT antis  710-729 3961 GAGGCUGCGGUACUUUUUC 3962 GAGGcuGcGGuAcuuuuucdTsdT sense  710-729 3963 GAAAAAGUACCGCAGCCUC 3964 GAAAAAGuACCGcAGCCUCdTsdT antis  792-811 3965 ACGGUGUACCGAGUGGCCC 3966 AcGGuGuAccGAGuGGcccdTsdT sense  792-811 3967 GGGCCACUCGGUACACCGU 3968 GGGCcACUCGGuAcACCGUdTsdT antis  903-922 3969 CAAGGUGUGUGUCACCGUG 3970 cAAGGuGuGuGucAccGuGdTsdT sense  903-922 3971 CACGGUGACACACACCUUG 3972 cACGGUGAcAcAcACCUUGdTsdT antis 1110-1129 3973 GGCUGUGUACUUGCUGAGC 3974 GGcuGuGuAcuuGcuGAGcdTsdT sense 1110-1129 3975 GCUCAGCAAGUACACAGCC 3976 GCUcAGcAAGuAcAcAGCCdTsdT antis 1129-1148 3977 UACUUCUCGGCCAGCCCAU 3978 uAcuucucGGccAGcccAudTsdT sense 1129-1148 3979 AUGGGCUGGCCGAGAAGUA 3980 AUGGGCUGGCCGAGAAGuAdTsdT antis 1142-1161 3981 GCCCAUCUUCCCUGGGGAC 3982 GcccAucuucccuGGGGAcdTsdT sense 1142-1161 3983 GUCCCCAGGGAAGAUGGGC 3984 GUCCCcAGGGAAGAUGGGCdTsdT antis 1153-1172 3985 CUGGGGACAGUGGGGUGGA 3986 cuGGGGAcAGuGGGGuGGAdTsdT sense 1153-1172 3987 UCCACCCCACUGUCCCCAG 3988 UCcACCCcACUGUCCCcAGdTsdT antis 1472-1491 3989 UCCUGGUGAACUGUCCAUC 3990 uccuGGuGAAcuGuccAucdTsdT sense 1472-1491 3991 GAUGGACAGUUCACCAGGA 3992 GAUGGAcAGUUcACcAGGAdTsdT antis 1473-1492 3993 CCUGGUGAACUGUCCAUCC 3994 ccuGGuGAAcuGuccAuccdTsdT sense 1473-1492 3995 GGAUGGACAGUUCACCAGG 3996 GGAUGGAcAGUUcACcAGGdTsdT antis 1652-1671 3997 UAGCUCUUCCUGAGGGCCC 3998 uAGcucuuccuGAGGGcccdTsdT sense 1652-1671 3999 GGGCCCUCAGGAAGAGCUA 4000 GGGCCCUcAGGAAGAGCuAdTsdT antis 1653-1672 4001 AGCUCUUCCUGAGGGCCCC 4002 AGcucuuccuGAGGGccccdTsdT sense 1653-1672 4003 GGGGCCCUCAGGAAGAGCU 4004 GGGGCCCUcAGGAAGAGCUdTsdT antis 1812-1831 4005 CUCAGCAGCCUAACCUCUG 4006 cucAGcAGccuAAccucuGdTsdT sense 1812-1831 4007 CAGAGGUUAGGCUGCUGAG 4008 cAGAGGUuAGGCUGCUGAGdTsdT antis 1952-1971 4009 UCCUUCCCUCCCCCCCUCU 4010 uccuucccucccccccucudTsdT sense 1952-1971 4011 AGAGGGGGGGAGGGAAGGA 4012 AGAGGGGGGGAGGGAAGGAdTsdT antis 1968-1987 4013 UCUCCCAGGUCCCUUGUAA 4014 ucucccAGGucccuuGuAAdTsdT sense 1968-1987 4015 UUACAAGGGACCUGGGAGA 4016 UuAcAAGGGACCUGGGAGAdTsdT antis 2051-2070 4017 UAUAAUUUUUUCUUAAAGA 4018 uAuAAuuuuuucuuAAAGAdTsdT sense 2051-2070 4019 UCUUUAAGAAAAAAUUAUA 4020 UCUUuAAGAAAAAAUuAuAdTsdT antis 2056-2075 4021 UUUUUUCUUAAAGAAAACG 4022 uuuuuucuuAAAGAAAAcGdTsdT sense 2056-2075 4023 CGUUUUCUUUAAGAAAAAA 4024 CGUUUUCUUuAAGAAAAAAdTsdT antis 2128-2147 4025 GCUCCCAAGGCUUCCUCCC 4026 GcucccAAGGcuuccucccdTsdT sense 2128-2147 4027 GGGAGGAAGCCUUGGGAGC 4028 GGGAGGAAGCCUUGGGAGCdTsdT antis 2135-2154 4029 AGGCUUCCUCCCUCUCCCC 4030 AGGcuuccucccucuccccdTsdT sense 2135-2154 4031 GGGGAGAGGGAGGAAGCCU 4032 GGGGAGAGGGAGGAAGCCUdTsdT antis 2136-2155 4033 GGCUUCCUCCCUCUCCCCA 4034 GGcuuccucccucuccccAdTsdT sense 2136-2155 4035 UGGGGAGAGGGAGGAAGCC 4036 UGGGGAGAGGGAGGAAGCCdTsdT antis 2147-2166 4037 UCUCCCCAUCCUGGAAGGA 4038 ucuccccAuccuGGAAGGAdTsdT sense 2147-2166 4039 UCCUUCCAGGAUGGGGAGA 4040 UCCUUCcAGGAUGGGGAGAdTsdT antis  511-530 4041 UAGGCCAAGGCCCAGAGCG 4042 uAGGccAAGGcccAGAGcGdTsdT sense  511-530 4043 CGCUCUGGGCCUUGGCCUA 4044 CGCUCUGGGCCUUGGCCuAdTsdT antis  677-696 4045 GAUUAUGCGUAAGCUGGAC 4046 GAuuAuGcGuAAGcuGGAcdTsdT sense  677-696 4047 GUCCAGCUUACGCAUAAUC 4048 GUCcAGCUuACGcAuAAUCdTsdT antis  682-701 4049 UGCGUAAGCUGGACCACUG 4050 uGcGuAAGcuGGAccAcuGdTsdT sense  682-701 4051 CAGUGGUCCAGCUUACGCA 4052 cAGUGGUCcAGCUuACGcAdTsdT antis  796-815 4053 UGUACCGAGUGGCCCGCCA 4054 uGuAccGAGuGGcccGccAdTsdT sense  796-815 4055 UGGCGGGCCACUCGGUACA 4056 UGGCGGGCcACUCGGuAcAdTsdT antis  750-769 4057 GACGAGCUGUAUUUGAAUC 4058 GAcGAGcuGuAuuuGAAucdTsdT sense  750-769 4059 GAUUCAAAUACAGCUCGUC 4060 GAUUcAAAuAcAGCUCGUCdTsdT antis 1646-1665 4061 CCUCGCUAGCUCUUCCUGA 4062 ccucGcuAGcucuuccuGAdTsdT sense 1646-1665 4063 UCAGGAAGAGCUAGCGAGG 4064 UcAGGAAGAGCuAGCGAGGdTsdT antis  664-683 4065 ACCGAGAACUGCAGAUUAU 4066 AccGAGAAcuGcAGAuuAudTsdT sense  664-683 4067 AUAAUCUGCAGUUCUCGGU 4068 AuAAUCUGcAGUUCUCGGUdTsdT antis  751-770 4069 ACGAGCUGUAUUUGAAUCU 4070 AcGAGcuGuAuuuGAAucudTsdT sense  751-770 4071 AGAUUCAAAUACAGCUCGU 4072 AGAUUcAAAuAcAGCUCGUdTsdT antis  835-854 4073 UCACCCCUAUCAUCUACAU 4074 ucAccccuAucAucuAcAudTsdT sense  835-854 4075 AUGUAGAUGAUAGGGGUGA 4076 AUGuAGAUGAuAGGGGUGAdTsdT antis 1399-1418 4077 UCUUCGAUGAACUGCGGAG 4078 ucuucGAuGAAcuGcGGAGdTsdT sense 1399-1418 4079 CUCCGCAGUUCAUCGAAGA 4080 CUCCGcAGUUcAUCGAAGAdTsdT antis 2175-2194 4081 AGAGAGUCCCUGGUGUCUU 4082 AGAGAGucccuGGuGucuudTsdT sense 2175-2194 4083 AAGACACCAGGGACUCUCU 4084 AAGAcACcAGGGACUCUCUdTsdT antis   19-38 4085 ACGGCAGAGGGACUUCAUC 4086 AcGGcAGAGGGAcuucAucdTsdT sense   19-38 4087 GAUGAAGUCCCUCUGCCGU 4088 GAUGAAGUCCCUCUGCCGUdTsdT antis   79-98 4089 CCCGAACGGCGCGGCCUGG 4090 cccGAAcGGcGcGGccuGGdTsdT sense   79-98 4091 CCAGGCCGCGCCGUUCGGG 4092 CcAGGCCGCGCCGUUCGGGdTsdT antis  186-205 4093 GGCGCCAUGAGCGGCGGCG 4094 GGcGccAuGAGcGGcGGcGdTsdT sense  186-205 4095 CGCCGCCGCUCAUGGCGCC 4096 CGCCGCCGCUcAUGGCGCCdTsdT antis  187-206 4097 GCGCCAUGAGCGGCGGCGG 4098 GcGccAuGAGcGGcGGcGGdTsdT sense  187-206 4099 CCGCCGCCGCUCAUGGCGC 4100 CCGCCGCCGCUcAUGGCGCdTsdT antis  334-353 4101 GCGGGAAAGCGUCAGUCGG 4102 GcGGGAAAGcGucAGucGGdTsdT sense  334-353 4103 CCGACUGACGCUUUCCCGC 4104 CCGACUGACGCUUUCCCGCdTsdT antis  349-368 4105 UCGGGGCUAUGGGUGGGGG 4106 ucGGGGcuAuGGGuGGGGGdTsdT sense  349-368 4107 CCCCCACCCAUAGCCCCGA 4108 CCCCcACCcAuAGCCCCGAdTsdT antis  451-470 4109 CGCCGCCGGGAGUGAAGCU 4110 cGccGccGGGAGuGAAGcudTsdT sense  451-470 4111 AGCUUCACUCCCGGCGGCG 4112 AGCUUcACUCCCGGCGGCGdTsdT antis  476-495 4113 UGACAGCGGGAAGGUGACC 4114 uGAcAGcGGGAAGGuGAccdTsdT sense  476-495 4115 GGUCACCUUCCCGCUGUCA 4116 GGUcACCUUCCCGCUGUcAdTsdT antis  480-499 4117 AGCGGGAAGGUGACCACAG 4118 AGcGGGAAGGuGAccAcAGdTsdT sense  480-499 4119 CUGUGGUCACCUUCCCGCU 4120 CUGUGGUcACCUUCCCGCUdTsdT antis  481-500 4121 GCGGGAAGGUGACCACAGU 4122 GcGGGAAGGuGAccAcAGudTsdT sense  481-500 4123 ACUGUGGUCACCUUCCCGC 4124 ACUGUGGUcACCUUCCCGCdTsdT antis  516-535 4125 CAAGGCCCAGAGCGUUCCC 4126 cAAGGcccAGAGcGuucccdTsdT sense  516-535 4127 GGGAACGCUCUGGGCCUUG 4128 GGGAACGCUCUGGGCCUUGdTsdT antis  586-605 4129 UAGUAUACCAGGCACGGCU 4130 uAGuAuAccAGGcAcGGcudTsdT sense  586-605 4131 AGCCGUGCCUGGUAUACUA 4132 AGCCGUGCCUGGuAuACuAdTsdT antis  608-627 4133 AGAGACGAGGGAACUGGUG 4134 AGAGAcGAGGGAAcuGGuGdTsdT sense  608-627 4135 CACCAGUUCCCUCGUCUCU 4136 cACcAGUUCCCUCGUCUCUdTsdT antis  662-681 4137 GAACCGAGAACUGCAGAUU 4138 GAAccGAGAAcuGcAGAuudTsdT sense  662-681 4139 AAUCUGCAGUUCUCGGUUC 4140 AAUCUGcAGUUCUCGGUUCdTsdT antis  678-697 4141 AUUAUGCGUAAGCUGGACC 4142 AuuAuGcGuAAGcuGGAccdTsdT sense  678-697 4143 GGUCCAGCUUACGCAUAAU 4144 GGUCcAGCUuACGcAuAAUdTsdT antis  679-698 4145 UUAUGCGUAAGCUGGACCA 4146 uuAuGcGuAAGcuGGAccAdTsdT sense  679-698 4147 UGGUCCAGCUUACGCAUAA 4148 UGGUCcAGCUuACGcAuAAdTsdT antis  680-699 4149 UAUGCGUAAGCUGGACCAC 4150 uAuGcGuAAGcuGGAccAcdTsdT sense  680-699 4151 GUGGUCCAGCUUACGCAUA 4152 GUGGUCcAGCUuACGcAuAdTsdT antis  683-702 4153 GCGUAAGCUGGACCACUGC 4154 GcGuAAGcuGGAccAcuGcdTsdT sense  683-702 4155 GCAGUGGUCCAGCUUACGC 4156 GcAGUGGUCcAGCUuACGCdTsdT antis  714-733 4157 CUGCGGUACUUUUUCUACU 4158 cuGcGGuAcuuuuucuAcudTsdT sense  714-733 4159 AGUAGAAAAAGUACCGCAG 4160 AGuAGAAAAAGuACCGcAGdTsdT antis  715-734 4161 UGCGGUACUUUUUCUACUC 4162 uGcGGuAcuuuuucuAcucdTsdT sense  715-734 4163 GAGUAGAAAAAGUACCGCA 4164 GAGuAGAAAAAGuACCGcAdTsdT antis  754-773 4165 AGCUGUAUUUGAAUCUGGU 4166 AGcuGuAuuuGAAucuGGudTsdT sense  754-773 4167 ACCAGAUUCAAAUACAGCU 4168 ACcAGAUUcAAAuAcAGCUdTsdT antis  795-814 4169 GUGUACCGAGUGGCCCGCC 4170 GuGuAccGAGuGGcccGccdTsdT sense  795-814 4171 GGCGGGCCACUCGGUACAC 4172 GGCGGGCcACUCGGuAcACdTsdT antis  797-816 4173 GUACCGAGUGGCCCGCCAC 4174 GuAccGAGuGGcccGccAcdTsdT sense  797-816 4175 GUGGCGGGCCACUCGGUAC 4176 GUGGCGGGCcACUCGGuACdTsdT antis  799-818 4177 ACCGAGUGGCCCGCCACUU 4178 AccGAGuGGcccGccAcuudTsdT sense  799-818 4179 AAGUGGCGGGCCACUCGGU 4180 AAGUGGCGGGCcACUCGGUdTsdT antis  800-819 4181 CCGAGUGGCCCGCCACUUC 4182 ccGAGuGGcccGccAcuucdTsdT sense  800-819 4183 GAAGUGGCGGGCCACUCGG 4184 GAAGUGGCGGGCcACUCGGdTsdT antis  834-853 4185 AUCACCCCUAUCAUCUACA 4186 AucAccccuAucAucuAcAdTsdT sense  834-853 4187 UGUAGAUGAUAGGGGUGAU 4188 UGuAGAUGAuAGGGGUGAUdTsdT antis  845-864 4189 CAUCUACAUCAAGGUGUAC 4190 cAucuAcAucAAGGuGuAcdTsdT sense  845-864 4191 GUACACCUUGAUGUAGAUG 4192 GuAcACCUUGAUGuAGAUGdTsdT antis  850-869 4193 ACAUCAAGGUGUACAUGUA 4194 AcAucAAGGuGuAcAuGuAdTsdT sense  850-869 4195 UACAUGUACACCUUGAUGU 4196 uAcAUGuAcACCUUGAUGUdTsdT antis  885-904 4197 UUGGCCUACAUCCACUCCC 4198 uuGGccuAcAuccAcucccdTsdT sense  885-904 4199 GGGAGUGGAUGUAGGCCAA 4200 GGGAGUGGAUGuAGGCcAAdTsdT antis  890-909 4201 CUACAUCCACUCCCAAGGU 4202 cuAcAuccAcucccAAGGudTsdT sense  890-909 4203 ACCUUGGGAGUGGAUGUAG 4204 ACCUUGGGAGUGGAUGuAGdTsdT antis  921-940 4205 GACAUCAAGCCCCAGAAUU 4206 GAcAucAAGccccAGAAuudTsdT sense  921-940 4207 AAUUCUGGGGCUUGAUGUC 4208 AAUUCUGGGGCUUGAUGUCdTsdT antis  934-953 4209 AGAAUUUGCUUGUGGACCC 4210 AGAAuuuGcuuGuGGAcccdTsdT sense  934-953 4211 GGGUCCACAAGCAAAUUCU 4212 GGGUCcAcAAGcAAAUUCUdTsdT antis 1032-1051 4213 UGCUCUCGGUACUACCGUG 4214 uGcucucGGuAcuAccGuGdTsdT sense 1032-1051 4215 CACGGUAGUACCGAGAGCA 4216 cACGGuAGuACCGAGAGcAdTsdT antis 1033-1052 4217 GCUCUCGGUACUACCGUGC 4218 GcucucGGuAcuAccGuGcdTsdT sense 1033-1052 4219 GCACGGUAGUACCGAGAGC 4220 GcACGGuAGuACCGAGAGCdTsdT antis 1081-1100 4221 ACACCUCGUCCAUCGAUGU 4222 AcAccucGuccAucGAuGudTsdT sense 1081-1100 4223 ACAUCGAUGGACGAGGUGU 4224 AcAUCGAUGGACGAGGUGUdTsdT antis 1082-1101 4225 CACCUCGUCCAUCGAUGUG 4226 cAccucGuccAucGAuGuGdTsdT sense 1082-1101 4227 CACAUCGAUGGACGAGGUG 4228 cAcAUCGAUGGACGAGGUGdTsdT antis 1083-1102 4229 ACCUCGUCCAUCGAUGUGU 4230 AccucGuccAucGAuGuGudTsdT sense 1083-1102 4231 ACACAUCGAUGGACGAGGU 4232 AcAcAUCGAUGGACGAGGUdTsdT antis 1241-1260 4233 CUAUACGGAGUUCAAGUUC 4234 cuAuAcGGAGuucAAGuucdTsdT sense 1241-1260 4235 GAACUUGAACUCCGUAUAG 4236 GAACUUGAACUCCGuAuAGdTsdT antis 1242-1261 4237 UAUACGGAGUUCAAGUUCC 4238 uAuAcGGAGuucAAGuuccdTsdT sense 1242-1261 4239 GGAACUUGAACUCCGUAUA 4240 GGAACUUGAACUCCGuAuAdTsdT antis 1243-1262 4241 AUACGGAGUUCAAGUUCCC 4242 AuAcGGAGuucAAGuucccdTsdT sense 1243-1262 4243 GGGAACUUGAACUCCGUAU 4244 GGGAACUUGAACUCCGuAUdTsdT antis 1396-1415 4245 GCUUCUUCGAUGAACUGCG 4246 GcuucuucGAuGAAcuGcGdTsdT sense 1396-1415 4247 CGCAGUUCAUCGAAGAAGC 4248 CGcAGUUcAUCGAAGAAGCdTsdT antis 1397-1416 4249 CUUCUUCGAUGAACUGCGG 4250 cuucuucGAuGAAcuGcGGdTsdT sense 1397-1416 4251 CCGCAGUUCAUCGAAGAAG 4252 CCGcAGUUcAUCGAAGAAGdTsdT antis 1398-1417 4253 UUCUUCGAUGAACUGCGGA 4254 uucuucGAuGAAcuGcGGAdTsdT sense 1398-1417 4255 UCCGCAGUUCAUCGAAGAA 4256 UCCGcAGUUcAUCGAAGAAdTsdT antis 1400-1419 4257 CUUCGAUGAACUGCGGAGA 4258 cuucGAuGAAcuGcGGAGAdTsdT sense 1400-1419 4259 UCUCCGCAGUUCAUCGAAG 4260 UCUCCGcAGUUcAUCGAAGdTsdT antis 1452-1471 4261 CCCCCCCUGUUCAACUUCA 4262 cccccccuGuucAAcuucAdTsdT sense 1452-1471 4263 UGAAGUUGAACAGGGGGGG 4264 UGAAGUUGAAcAGGGGGGGdTsdT antis 1576-1595 4265 CAUCCUCACAAGCUUUAAC 4266 cAuccucAcAAGcuuuAAcdTsdT sense 1576-1595 4267 GUUAAAGCUUGUGAGGAUG 4268 GUuAAAGCUUGUGAGGAUGdTsdT antis 1634-1653 4269 CACAACUGCUACCCUCGCU 4270 cAcAAcuGcuAcccucGcudTsdT sense 1634-1653 4271 AGCGAGGGUAGCAGUUGUG 4272 AGCGAGGGuAGcAGUUGUGdTsdT antis 1635-1654 4273 ACAACUGCUACCCUCGCUA 4274 AcAAcuGcuAcccucGcuAdTsdT sense 1635-1654 4275 UAGCGAGGGUAGCAGUUGU 4276 uAGCGAGGGuAGcAGUUGUdTsdT antis 1643-1662 4277 UACCCUCGCUAGCUCUUCC 4278 uAcccucGcuAGcucuuccdTsdT sense 1643-1662 4279 GGAAGAGCUAGCGAGGGUA 4280 GGAAGAGCuAGCGAGGGuAdTsdT antis 1645-1664 4281 CCCUCGCUAGCUCUUCCUG 4282 cccucGcuAGcucuuccuGdTsdT sense 1645-1664 4283 CAGGAAGAGCUAGCGAGGG 4284 cAGGAAGAGCuAGCGAGGGdTsdT antis 1660-1679 4285 CCUGAGGGCCCCACCGACU 4286 ccuGAGGGccccAccGAcudTsdT sense 1660-1679 4287 AGUCGGUGGGGCCCUCAGG 4288 AGUCGGUGGGGCCCUcAGGdTsdT antis 1664-1683 4289 AGGGCCCCACCGACUACCC 4290 AGGGccccAccGAcuAcccdTsdT sense 1664-1683 4291 GGGUAGUCGGUGGGGCCCU 4292 GGGuAGUCGGUGGGGCCCUdTsdT antis 1665-1684 4293 GGGCCCCACCGACUACCCC 4294 GGGccccAccGAcuAccccdTsdT sense 1665-1684 4295 GGGGUAGUCGGUGGGGCCC 4296 GGGGuAGUCGGUGGGGCCCdTsdT antis 1816-1835 4297 GCAGCCUAACCUCUGUGGU 4298 GcAGccuAAccucuGuGGudTsdT sense 1816-1835 4299 ACCACAGAGGUUAGGCUGC 4300 ACcAcAGAGGUuAGGCUGCdTsdT antis 1817-1836 4301 CAGCCUAACCUCUGUGGUG 4302 cAGccuAAccucuGuGGuGdTsdT sense 1817-1836 4303 CACCACAGAGGUUAGGCUG 4304 cACcAcAGAGGUuAGGCUGdTsdT antis 1973-1992 4305 CAGGUCCCUUGUAAAUAGA 4306 cAGGucccuuGuAAAuAGAdTsdT sense 1973-1992 4307 UCUAUUUACAAGGGACCUG 4308 UCuAUUuAcAAGGGACCUGdTsdT antis 2206-2225 4309 AAGGUUUGCCUGUGUACAG 4310 AAGGuuuGccuGuGuAcAGdTsdT sense 2206-2225 4311 CUGUACACAGGCAAACCUU 4312 CUGuAcAcAGGcAAACCUUdTsdT antis 2207-2226 4313 AGGUUUGCCUGUGUACAGA 4314 AGGuuuGccuGuGuAcAGAdTsdT sense 2207-2226 4315 UCUGUACACAGGCAAACCU 4316 UCUGuAcAcAGGcAAACCUdTsdT antis 2222-2241 4317 CAGACCUCUGUUCAAUAAA 4318 cAGAccucuGuucAAuAAAdTsdT sense 2222-2241 4319 UUUAUUGAACAGAGGUCUG 4320 UUuAUUGAAcAGAGGUCUGdTsdT antis  542-561 4321 GGCUUACACUGACAUCAAA 4322 GGcuuAcAcuGAcAucAAAdTsdT sense  542-561 4323 UUUGAUGUCAGUGUAAGCC 4324 UUUGAUGUcAGUGuAAGCCdTsdT antis  681-700 4325 AUGCGUAAGCUGGACCACU 4326 AuGcGuAAGcuGGAccAcudTsdT sense  681-700 4327 AGUGGUCCAGCUUACGCAU 4328 AGUGGUCcAGCUuACGcAUdTsdT antis  748-767 4329 AGGACGAGCUGUAUUUGAA 4330 AGGAcGAGcuGuAuuuGAAdTsdT sense  748-767 4331 UUCAAAUACAGCUCGUCCU 4332 UUcAAAuAcAGCUCGUCCUdTsdT antis  749-768 4333 GGACGAGCUGUAUUUGAAU 4334 GGAcGAGcuGuAuuuGAAudTsdT sense  749-768 4335 AUUCAAAUACAGCUCGUCC 4336 AUUcAAAuAcAGCUCGUCCdTsdT antis 1352-1371 4337 CACGCCAUCCUCAAGGCUC 4338 cAcGccAuccucAAGGcucdTsdT sense 1352-1371 4339 GAGCCUUGAGGAUGGCGUG 4340 GAGCCUUGAGGAUGGCGUGdTsdT antis 1944-1963 4341 GCUACCACUCCUUCCCUCC 4342 GcuAccAcuccuucccuccdTsdT sense 1944-1963 4343 GGAGGGAAGGAGUGGUAGC 4344 GGAGGGAAGGAGUGGuAGCdTsdT antis 2004-2023 4345 CAUCUCUCGUCUUCCCUUC 4346 cAucucucGucuucccuucdTsdT sense 2004-2023 4347 GAAGGGAAGACGAGAGAUG 4348 GAAGGGAAGACGAGAGAUGdTsdT antis  348-367 4349 GUCGGGGCUAUGGGUGGGG 4350 GucGGGGcuAuGGGuGGGGdTsdT sense  348-367 4351 CCCCACCCAUAGCCCCGAC 4352 CCCcACCcAuAGCCCCGACdTsdT antis   39-58 4353 CCCGGCGUGCCCCGCGGCG 4354 cccGGcGuGccccGcGGcGdTsdT sense   39-58 4355 CGCCGCGGGGCACGCCGGG 4356 CGCCGCGGGGcACGCCGGGdTsdT antis  184-203 4357 UCGGCGCCAUGAGCGGCGG 4358 ucGGcGccAuGAGcGGcGGdTsdT sense  184-203 4359 CCGCCGCUCAUGGCGCCGA 4360 CCGCCGCUcAUGGCGCCGAdTsdT antis  344-363 4361 GUCAGUCGGGGCUAUGGGU 4362 GucAGucGGGGcuAuGGGudTsdT sense  344-363 4363 ACCCAUAGCCCCGACUGAC 4364 ACCcAuAGCCCCGACUGACdTsdT antis  347-366 4365 AGUCGGGGCUAUGGGUGGG 4366 AGucGGGGcuAuGGGuGGGdTsdT sense  347-366 4367 CCCACCCAUAGCCCCGACU 4368 CCcACCcAuAGCCCCGACUdTsdT antis  454-473 4369 CGCCGGGAGUGAAGCUGGG 4370 cGccGGGAGuGAAGcuGGGdTsdT sense  454-473 4371 CCCAGCUUCACUCCCGGCG 4372 CCcAGCUUcACUCCCGGCGdTsdT antis  456-475 4373 CCGGGAGUGAAGCUGGGCC 4374 ccGGGAGuGAAGcuGGGccdTsdT sense  456-475 4375 GGCCCAGCUUCACUCCCGG 4376 GGCCcAGCUUcACUCCCGGdTsdT antis  477-496 4377 GACAGCGGGAAGGUGACCA 4378 GAcAGcGGGAAGGuGAccAdTsdT sense  477-496 4379 UGGUCACCUUCCCGCUGUC 4380 UGGUcACCUUCCCGCUGUCdTsdT antis  479-498 4381 CAGCGGGAAGGUGACCACA 4382 cAGcGGGAAGGuGAccAcAdTsdT sense  479-498 4383 UGUGGUCACCUUCCCGCUG 4384 UGUGGUcACCUUCCCGCUGdTsdT antis  517-536 4385 AAGGCCCAGAGCGUUCCCA 4386 AAGGcccAGAGcGuucccAdTsdT sense  517-536 4387 UGGGAACGCUCUGGGCCUU 4388 UGGGAACGCUCUGGGCCUUdTsdT antis  518-537 4389 AGGCCCAGAGCGUUCCCAA 4390 AGGcccAGAGcGuucccAAdTsdT sense  518-537 4391 UUGGGAACGCUCUGGGCCU 4392 UUGGGAACGCUCUGGGCCUdTsdT antis  519-538 4393 GGCCCAGAGCGUUCCCAAG 4394 GGcccAGAGcGuucccAAGdTsdT sense  519-538 4395 CUUGGGAACGCUCUGGGCC 4396 CUUGGGAACGCUCUGGGCCdTsdT antis  544-563 4397 CUUACACUGACAUCAAAGU 4398 cuuAcAcuGAcAucAAAGudTsdT sense  544-563 4399 ACUUUGAUGUCAGUGUAAG 4400 ACUUUGAUGUcAGUGuAAGdTsdT antis  545-564 4401 UUACACUGACAUCAAAGUG 4402 uuAcAcuGAcAucAAAGuGdTsdT sense  545-564 4403 CACUUUGAUGUCAGUGUAA 4404 cACUUUGAUGUcAGUGuAAdTsdT antis  603-622 4405 CUGGCAGAGACGAGGGAAC 4406 cuGGcAGAGAcGAGGGAAcdTsdT sense  603-622 4407 GUUCCCUCGUCUCUGCCAG 4408 GUUCCCUCGUCUCUGCcAGdTsdT antis  604-623 4409 UGGCAGAGACGAGGGAACU 4410 uGGcAGAGAcGAGGGAAcudTsdT sense  604-623 4411 AGUUCCCUCGUCUCUGCCA 4412 AGUUCCCUCGUCUCUGCcAdTsdT antis  741-760 4413 GAGAAGAAGGACGAGCUGU 4414 GAGAAGAAGGAcGAGcuGudTsdT sense  741-760 4415 ACAGCUCGUCCUUCUUCUC 4416 AcAGCUCGUCCUUCUUCUCdTsdT antis  752-771 4417 CGAGCUGUAUUUGAAUCUG 4418 cGAGcuGuAuuuGAAucuGdTsdT sense  752-771 4419 CAGAUUCAAAUACAGCUCG 4420 cAGAUUcAAAuAcAGCUCGdTsdT antis  753-772 4421 GAGCUGUAUUUGAAUCUGG 4422 GAGcuGuAuuuGAAucuGGdTsdT sense  753-772 4423 CCAGAUUCAAAUACAGCUC 4424 CcAGAUUcAAAuAcAGCUCdTsdT antis  831-850 4425 CUGAUCACCCCUAUCAUCU 4426 cuGAucAccccuAucAucudTsdT sense  831-850 4427 AGAUGAUAGGGGUGAUCAG 4428 AGAUGAuAGGGGUGAUcAGdTsdT antis  832-851 4429 UGAUCACCCCUAUCAUCUA 4430 uGAucAccccuAucAucuAdTsdT sense  832-851 4431 UAGAUGAUAGGGGUGAUCA 4432 uAGAUGAuAGGGGUGAUcAdTsdT antis  833-852 4433 GAUCACCCCUAUCAUCUAC 4434 GAucAccccuAucAucuAcdTsdT sense  833-852 4435 GUAGAUGAUAGGGGUGAUC 4436 GuAGAUGAuAGGGGUGAUCdTsdT antis  913-932 4437 GUCACCGUGACAUCAAGCC 4438 GucAccGuGAcAucAAGccdTsdT sense  913-932 4439 GGCUUGAUGUCACGGUGAC 4440 GGCUUGAUGUcACGGUGACdTsdT antis  918-937 4441 CGUGACAUCAAGCCCCAGA 4442 cGuGAcAucAAGccccAGAdTsdT sense  918-937 4443 UCUGGGGCUUGAUGUCACG 4444 UCUGGGGCUUGAUGUcACGdTsdT antis  920-939 4445 UGACAUCAAGCCCCAGAAU 4446 uGAcAucAAGccccAGAAudTsdT sense  920-939 4447 AUUCUGGGGCUUGAUGUCA 4448 AUUCUGGGGCUUGAUGUcAdTsdT antis 1018-1037 4449 AUGUGUCCUACAUCUGCUC 4450 AuGuGuccuAcAucuGcucdTsdT sense 1018-1037 4451 GAGCAGAUGUAGGACACAU 4452 GAGcAGAUGuAGGAcAcAUdTsdT antis 1019-1038 4453 UGUGUCCUACAUCUGCUCU 4454 uGuGuccuAcAucuGcucudTsdT sense 1019-1038 4455 AGAGCAGAUGUAGGACACA 4456 AGAGcAGAUGuAGGAcAcAdTsdT antis 1097-1116 4457 UGUGUGGUCGGCUGGCUGU 4458 uGuGuGGucGGcuGGcuGudTsdT sense 1097-1116 4459 ACAGCCAGCCGACCACACA 4460 AcAGCcAGCCGACcAcAcAdTsdT antis 1102-1121 4461 GGUCGGCUGGCUGUGUACU 4462 GGucGGcuGGcuGuGuAcudTsdT sense 1102-1121 4463 AGUACACAGCCAGCCGACC 4464 AGuAcAcAGCcAGCCGACCdTsdT antis 1155-1174 4465 GGGGACAGUGGGGUGGACC 4466 GGGGAcAGuGGGGuGGAccdTsdT sense 1155-1174 4467 GGUCCACCCCACUGUCCCC 4468 GGUCcACCCcACUGUCCCCdTsdT antis 1245-1264 4469 ACGGAGUUCAAGUUCCCCC 4470 AcGGAGuucAAGuucccccdTsdT sense 1245-1264 4471 GGGGGAACUUGAACUCCGU 4472 GGGGGAACUUGAACUCCGUdTsdT antis 1274-1293 4473 UCACCCUUGGACAAAGGUG 4474 ucAcccuuGGAcAAAGGuGdTsdT sense 1274-1293 4475 CACCUUUGUCCAAGGGUGA 4476 cACCUUUGUCcAAGGGUGAdTsdT antis 1276-1295 4477 ACCCUUGGACAAAGGUGUU 4478 AcccuuGGAcAAAGGuGuudTsdT sense 1276-1295 4479 AACACCUUUGUCCAAGGGU 4480 AAcACCUUUGUCcAAGGGUdTsdT antis 1316-1335 4481 UGAGGCCAUUGCACUCUGC 4482 uGAGGccAuuGcAcucuGcdTsdT sense 1316-1335 4483 GCAGAGUGCAAUGGCCUCA 4484 GcAGAGUGcAAUGGCCUcAdTsdT antis 1318-1337 4485 AGGCCAUUGCACUCUGCUC 4486 AGGccAuuGcAcucuGcucdTsdT sense 1318-1337 4487 GAGCAGAGUGCAAUGGCCU 4488 GAGcAGAGUGcAAUGGCCUdTsdT antis 1321-1340 4489 CCAUUGCACUCUGCUCUAG 4490 ccAuuGcAcucuGcucuAGdTsdT sense 1321-1340 4491 CUAGAGCAGAGUGCAAUGG 4492 CuAGAGcAGAGUGcAAUGGdTsdT antis 1325-1344 4493 UGCACUCUGCUCUAGCCUA 4494 uGcAcucuGcucuAGccuAdTsdT sense 1325-1344 4495 UAGGCUAGAGCAGAGUGCA 4496 uAGGCuAGAGcAGAGUGcAdTsdT antis 1337-1356 4497 UAGCCUACUGGAGUACACG 4498 uAGccuAcuGGAGuAcAcGdTsdT sense 1337-1356 4499 CGUGUACUCCAGUAGGCUA 4500 CGUGuACUCcAGuAGGCuAdTsdT antis 1375-1394 4501 CACUCGAGGCUUGUGCCCA 4502 cAcucGAGGcuuGuGcccAdTsdT sense 1375-1394 4503 UGGGCACAAGCCUCGAGUG 4504 UGGGcAcAAGCCUCGAGUGdTsdT antis 1443-1462 4505 CGCCCGCUUCCCCCCCUGU 4506 cGcccGcuucccccccuGudTsdT sense 1443-1462 4507 ACAGGGGGGGAAGCGGGCG 4508 AcAGGGGGGGAAGCGGGCGdTsdT antis 1466-1485 4509 CUUCAGUCCUGGUGAACUG 4510 cuucAGuccuGGuGAAcuGdTsdT sense 1466-1485 4511 CAGUUCACCAGGACUGAAG 4512 cAGUUcACcAGGACUGAAGdTsdT antis 1581-1600 4513 UCACAAGCUUUAACUGAAG 4514 ucAcAAGcuuuAAcuGAAGdTsdT sense 1581-1600 4515 CUUCAGUUAAAGCUUGUGA 4516 CUUcAGUuAAAGCUUGUGAdTsdT antis 1602-1621 4517 CAGACUGGCCAAGAUUGGC 4518 cAGAcuGGccAAGAuuGGcdTsdT sense 1602-1621 4519 GCCAAUCUUGGCCAGUCUG 4520 GCcAAUCUUGGCcAGUCUGdTsdT antis 1603-1622 4521 AGACUGGCCAAGAUUGGCA 4522 AGAcuGGccAAGAuuGGcAdTsdT sense 1603-1622 4523 UGCCAAUCUUGGCCAGUCU 4524 UGCcAAUCUUGGCcAGUCUdTsdT antis 1644-1663 4525 ACCCUCGCUAGCUCUUCCU 4526 AcccucGcuAGcucuuccudTsdT sense 1644-1663 4527 AGGAAGAGCUAGCGAGGGU 4528 AGGAAGAGCuAGCGAGGGUdTsdT antis 1666-1685 4529 GGCCCCACCGACUACCCCU 4530 GGccccAccGAcuAccccudTsdT sense 1666-1685 4531 AGGGGUAGUCGGUGGGGCC 4532 AGGGGuAGUCGGUGGGGCCdTsdT antis 1820-1839 4533 CCUAACCUCUGUGGUGGGC 4534 ccuAAccucuGuGGuGGGcdTsdT sense 1820-1839 4535 GCCCACCACAGAGGUUAGG 4536 GCCcACcAcAGAGGUuAGGdTsdT antis 1821-1840 4537 CUAACCUCUGUGGUGGGCU 4538 cuAAccucuGuGGuGGGcudTsdT sense 1821-1840 4539 AGCCCACCACAGAGGUUAG 4540 AGCCcACcAcAGAGGUuAGdTsdT antis 1855-1874 4541 UAACUGUUUGUAGGGGAGG 4542 uAAcuGuuuGuAGGGGAGGdTsdT sense 1855-1874 4543 CCUCCCCUACAAACAGUUA 4544 CCUCCCCuAcAAAcAGUuAdTsdT antis 1861-1880 4545 UUUGUAGGGGAGGGGAGAA 4546 uuuGuAGGGGAGGGGAGAAdTsdT sense 1861-1880 4547 UUCUCCCCUCCCCUACAAA 4548 UUCUCCCCUCCCCuAcAAAdTsdT antis 1912-1931 4549 UUCUACCCCCUUGGUCCCC 4550 uucuAcccccuuGGuccccdTsdT sense 1912-1931 4551 GGGGACCAAGGGGGUAGAA 4552 GGGGACcAAGGGGGuAGAAdTsdT antis 1960-1979 4553 UCCCCCCCUCUCCCAGGUC 4554 ucccccccucucccAGGucdTsdT sense 1960-1979 4555 GACCUGGGAGAGGGGGGGA 4556 GACCUGGGAGAGGGGGGGAdTsdT antis 2009-2028 4557 CUCGUCUUCCCUUCCCUGG 4558 cucGucuucccuucccuGGdTsdT sense 2009-2028 4559 CCAGGGAAGGGAAGACGAG 4560 CcAGGGAAGGGAAGACGAGdTsdT antis 2010-2029 4561 UCGUCUUCCCUUCCCUGGC 4562 ucGucuucccuucccuGGcdTsdT sense 2010-2029 4563 GCCAGGGAAGGGAAGACGA 4564 GCcAGGGAAGGGAAGACGAdTsdT antis 2011-2030 4565 CGUCUUCCCUUCCCUGGCC 4566 cGucuucccuucccuGGccdTsdT sense 2011-2030 4567 GGCCAGGGAAGGGAAGACG 4568 GGCcAGGGAAGGGAAGACGdTsdT antis 2223-2242 4569 AGACCUCUGUUCAAUAAAU 4570 AGAccucuGuucAAuAAAudTsdT sense 2223-2242 4571 AUUUAUUGAACAGAGGUCU 4572 AUUuAUUGAAcAGAGGUCUdTsdT antis 2226-2245 4573 CCUCUGUUCAAUAAAUUAU 4574 ccucuGuucAAuAAAuuAudTsdT sense 2226-2245 4575 AUAAUUUAUUGAACAGAGG 4576 AuAAUUuAUUGAAcAGAGGdTsdT antis 2228-2247 4577 UCUGUUCAAUAAAUUAUUG 4578 ucuGuucAAuAAAuuAuuGdTsdT sense 2228-2247 4579 CAAUAAUUUAUUGAACAGA 4580 cAAuAAUUuAUUGAAcAGAdTsdT antis    9-28 4581 AACGAAGCCGACGGCAGAG 4582 AAcGAAGccGAcGGcAGAGdTsdT sense    9-28 4583 CUCUGCCGUCGGCUUCGUU 4584 CUCUGCCGUCGGCUUCGUUdTsdT antis   10-29 4585 ACGAAGCCGACGGCAGAGG 4586 AcGAAGccGAcGGcAGAGGdTsdT sense   10-29 4587 CCUCUGCCGUCGGCUUCGU 4588 CCUCUGCCGUCGGCUUCGUdTsdT antis   20-39 4589 CGGCAGAGGGACUUCAUCU 4590 cGGcAGAGGGAcuucAucudTsdT sense   20-39 4591 AGAUGAAGUCCCUCUGCCG 4592 AGAUGAAGUCCCUCUGCCGdTsdT antis   26-45 4593 AGGGACUUCAUCUCCCGGC 4594 AGGGAcuucAucucccGGcdTsdT sense   26-45 4595 GCCGGGAGAUGAAGUCCCU 4596 GCCGGGAGAUGAAGUCCCUdTsdT antis   27-46 4597 GGGACUUCAUCUCCCGGCG 4598 GGGAcuucAucucccGGcGdTsdT sense   27-46 4599 CGCCGGGAGAUGAAGUCCC 4600 CGCCGGGAGAUGAAGUCCCdTsdT antis   28-47 4601 GGACUUCAUCUCCCGGCGU 4602 GGAcuucAucucccGGcGudTsdT sense   28-47 4603 ACGCCGGGAGAUGAAGUCC 4604 ACGCCGGGAGAUGAAGUCCdTsdT antis   29-48 4605 GACUUCAUCUCCCGGCGUG 4606 GAcuucAucucccGGcGuGdTsdT sense   29-48 4607 CACGCCGGGAGAUGAAGUC 4608 cACGCCGGGAGAUGAAGUCdTsdT antis   37-56 4609 CUCCCGGCGUGCCCCGCGG 4610 cucccGGcGuGccccGcGGdTsdT sense   37-56 4611 CCGCGGGGCACGCCGGGAG 4612 CCGCGGGGcACGCCGGGAGdTsdT antis   38-57 4613 UCCCGGCGUGCCCCGCGGC 4614 ucccGGcGuGccccGcGGcdTsdT sense   38-57 4615 GCCGCGGGGCACGCCGGGA 4616 GCCGCGGGGcACGCCGGGAdTsdT antis   42-61 4617 GGCGUGCCCCGCGGCGGGC 4618 GGcGuGccccGcGGcGGGcdTsdT sense   42-61 4619 GCCCGCCGCGGGGCACGCC 4620 GCCCGCCGCGGGGcACGCCdTsdT antis   43-62 4621 GCGUGCCCCGCGGCGGGCG 4622 GcGuGccccGcGGcGGGcGdTsdT sense   43-62 4623 CGCCCGCCGCGGGGCACGC 4624 CGCCCGCCGCGGGGcACGCdTsdT antis   59-78 4625 GCGCUGGGCCGGAGCCGGA 4626 GcGcuGGGccGGAGccGGAdTsdT sense   59-78 4627 UCCGGCUCCGGCCCAGCGC 4628 UCCGGCUCCGGCCcAGCGCdTsdT antis   60-79 4629 CGCUGGGCCGGAGCCGGAG 4630 cGcuGGGccGGAGccGGAGdTsdT sense   60-79 4631 CUCCGGCUCCGGCCCAGCG 4632 CUCCGGCUCCGGCCcAGCGdTsdT antis   99-118 4633 AGAGGCCGGAGCCCAGGGG 4634 AGAGGccGGAGcccAGGGGdTsdT sense   99-118 4635 CCCCUGGGCUCCGGCCUCU 4636 CCCCUGGGCUCCGGCCUCUdTsdT antis  108-127 4637 AGCCCAGGGGAGGCGGCGG 4638 AGcccAGGGGAGGcGGcGGdTsdT sense  108-127 4639 CCGCCGCCUCCCCUGGGCU 4640 CCGCCGCCUCCCCUGGGCUdTsdT antis  109-128 4641 GCCCAGGGGAGGCGGCGGC 4642 GcccAGGGGAGGcGGcGGcdTsdT sense  109-128 4643 GCCGCCGCCUCCCCUGGGC 4644 GCCGCCGCCUCCCCUGGGCdTsdT antis  133-152 4645 CAGCGGCGGGGGCAGCCCA 4646 cAGcGGcGGGGGcAGcccAdTsdT sense  133-152 4647 UGGGCUGCCCCCGCCGCUG 4648 UGGGCUGCCCCCGCCGCUGdTsdT antis  135-154 4649 GCGGCGGGGGCAGCCCAGG 4650 GcGGcGGGGGcAGcccAGGdTsdT sense  135-154 4651 CCUGGGCUGCCCCCGCCGC 4652 CCUGGGCUGCCCCCGCCGCdTsdT antis  136-155 4653 CGGCGGGGGCAGCCCAGGC 4654 cGGcGGGGGcAGcccAGGcdTsdT sense  136-155 4655 GCCUGGGCUGCCCCCGCCG 4656 GCCUGGGCUGCCCCCGCCGdTsdT antis  140-159 4657 GGGGGCAGCCCAGGCAGCC 4658 GGGGGcAGcccAGGcAGccdTsdT sense  140-159 4659 GGCUGCCUGGGCUGCCCCC 4660 GGCUGCCUGGGCUGCCCCCdTsdT antis  165-184 4661 CCGCGGCCUGGGCCUGCGC 4662 ccGcGGccuGGGccuGcGcdTsdT sense  165-184 4663 GCGCAGGCCCAGGCCGCGG 4664 GCGcAGGCCcAGGCCGCGGdTsdT antis  170-189 4665 GCCUGGGCCUGCGCUCGGC 4666 GccuGGGccuGcGcucGGcdTsdT sense  170-189 4667 GCCGAGCGCAGGCCCAGGC 4668 GCCGAGCGcAGGCCcAGGCdTsdT antis  171-190 4669 CCUGGGCCUGCGCUCGGCG 4670 ccuGGGccuGcGcucGGcGdTsdT sense  171-190 4671 CGCCGAGCGCAGGCCCAGG 4672 CGCCGAGCGcAGGCCcAGGdTsdT antis  185-204 4673 CGGCGCCAUGAGCGGCGGC 4674 cGGcGccAuGAGcGGcGGcdTsdT sense  185-204 4675 GCCGCCGCUCAUGGCGCCG 4676 GCCGCCGCUcAUGGCGCCGdTsdT antis  201-220 4677 GGCGGGCCUUCGGGAGGCG 4678 GGcGGGccuucGGGAGGcGdTsdT sense  201-220 4679 CGCCUCCCGAAGGCCCGCC 4680 CGCCUCCCGAAGGCCCGCCdTsdT antis  214-233 4681 GAGGCGGCCCUGGGGGCUC 4682 GAGGcGGcccuGGGGGcucdTsdT sense  214-233 4683 GAGCCCCCAGGGCCGCCUC 4684 GAGCCCCcAGGGCCGCCUCdTsdT antis  215-234 4685 AGGCGGCCCUGGGGGCUCG 4686 AGGcGGcccuGGGGGcucGdTsdT sense  215-234 4687 CGAGCCCCCAGGGCCGCCU 4688 CGAGCCCCcAGGGCCGCCUdTsdT antis  216-235 4689 GGCGGCCCUGGGGGCUCGG 4690 GGcGGcccuGGGGGcucGGdTsdT sense  216-235 4691 CCGAGCCCCCAGGGCCGCC 4692 CCGAGCCCCcAGGGCCGCCdTsdT antis  227-246 4693 GGGCUCGGGCCGGGCGCGG 4694 GGGcucGGGccGGGcGcGGdTsdT sense  227-246 4695 CCGCGCCCGGCCCGAGCCC 4696 CCGCGCCCGGCCCGAGCCCdTsdT antis  229-248 4697 GCUCGGGCCGGGCGCGGAC 4698 GcucGGGccGGGcGcGGAcdTsdT sense  229-248 4699 GUCCGCGCCCGGCCCGAGC 4700 GUCCGCGCCCGGCCCGAGCdTsdT antis  230-249 4701 CUCGGGCCGGGCGCGGACC 4702 cucGGGccGGGcGcGGAccdTsdT sense  230-249 4703 GGUCCGCGCCCGGCCCGAG 4704 GGUCCGCGCCCGGCCCGAGdTsdT antis  290-309 4705 CGGCGGCCCCGGGGGCUCG 4706 cGGcGGccccGGGGGcucGdTsdT sense  290-309 4707 CGAGCCCCCGGGGCCGCCG 4708 CGAGCCCCCGGGGCCGCCGdTsdT antis  292-311 4709 GCGGCCCCGGGGGCUCGGC 4710 GcGGccccGGGGGcucGGcdTsdT sense  292-311 4711 GCCGAGCCCCCGGGGCCGC 4712 GCCGAGCCCCCGGGGCCGCdTsdT antis  293-312 4713 CGGCCCCGGGGGCUCGGCC 4714 cGGccccGGGGGcucGGccdTsdT sense  293-312 4715 GGCCGAGCCCCCGGGGCCG 4716 GGCCGAGCCCCCGGGGCCGdTsdT antis  299-318 4717 CGGGGGCUCGGCCUCUGGC 4718 cGGGGGcucGGccucuGGcdTsdT sense  299-318 4719 GCCAGAGGCCGAGCCCCCG 4720 GCcAGAGGCCGAGCCCCCGdTsdT antis  300-319 4721 GGGGGCUCGGCCUCUGGCC 4722 GGGGGcucGGccucuGGccdTsdT sense  300-319 4723 GGCCAGAGGCCGAGCCCCC 4724 GGCcAGAGGCCGAGCCCCCdTsdT antis  302-321 4725 GGGCUCGGCCUCUGGCCCA 4726 GGGcucGGccucuGGcccAdTsdT sense  302-321 4727 UGGGCCAGAGGCCGAGCCC 4728 UGGGCcAGAGGCCGAGCCCdTsdT antis  304-323 4729 GCUCGGCCUCUGGCCCAGG 4730 GcucGGccucuGGcccAGGdTsdT sense  304-323 4731 CCUGGGCCAGAGGCCGAGC 4732 CCUGGGCcAGAGGCCGAGCdTsdT antis  305-324 4733 CUCGGCCUCUGGCCCAGGA 4734 cucGGccucuGGcccAGGAdTsdT sense  305-324 4735 UCCUGGGCCAGAGGCCGAG 4736 UCCUGGGCcAGAGGCCGAGdTsdT antis  306-325 4737 UCGGCCUCUGGCCCAGGAG 4738 ucGGccucuGGcccAGGAGdTsdT sense  306-325 4739 CUCCUGGGCCAGAGGCCGA 4740 CUCCUGGGCcAGAGGCCGAdTsdT antis  307-326 4741 CGGCCUCUGGCCCAGGAGG 4742 cGGccucuGGcccAGGAGGdTsdT sense  307-326 4743 CCUCCUGGGCCAGAGGCCG 4744 CCUCCUGGGCcAGAGGCCGdTsdT antis  322-341 4745 GAGGCACUGGCGGCGGGAA 4746 GAGGcAcuGGcGGcGGGAAdTsdT sense  322-341 4747 UUCCCGCCGCCAGUGCCUC 4748 UUCCCGCCGCcAGUGCCUCdTsdT antis  339-358 4749 AAAGCGUCAGUCGGGGCUA 4750 AAAGcGucAGucGGGGcuAdTsdT sense  339-358 4751 UAGCCCCGACUGACGCUUU 4752 uAGCCCCGACUGACGCUUUdTsdT antis  345-364 4753 UCAGUCGGGGCUAUGGGUG 4754 ucAGucGGGGcuAuGGGuGdTsdT sense  345-364 4755 CACCCAUAGCCCCGACUGA 4756 cACCcAuAGCCCCGACUGAdTsdT antis  346-365 4757 CAGUCGGGGCUAUGGGUGG 4758 cAGucGGGGcuAuGGGuGGdTsdT sense  346-365 4759 CCACCCAUAGCCCCGACUG 4760 CcACCcAuAGCCCCGACUGdTsdT antis  350-369 4761 CGGGGCUAUGGGUGGGGGC 4762 cGGGGcuAuGGGuGGGGGcdTsdT sense  350-369 4763 GCCCCCACCCAUAGCCCCG 4764 GCCCCcACCcAuAGCCCCGdTsdT antis  374-393 4765 AGCCUCGAGCUCCGGGGGU 4766 AGccucGAGcuccGGGGGudTsdT sense  374-393 4767 ACCCCCGGAGCUCGAGGCU 4768 ACCCCCGGAGCUCGAGGCUdTsdT antis  378-397 4769 UCGAGCUCCGGGGGUGGCC 4770 ucGAGcuccGGGGGuGGccdTsdT sense  378-397 4771 GGCCACCCCCGGAGCUCGA 4772 GGCcACCCCCGGAGCUCGAdTsdT antis  379-398 4773 CGAGCUCCGGGGGUGGCCC 4774 cGAGcuccGGGGGuGGcccdTsdT sense  379-398 4775 GGGCCACCCCCGGAGCUCG 4776 GGGCcACCCCCGGAGCUCGdTsdT antis  384-403 4777 UCCGGGGGUGGCCCCAGCG 4778 uccGGGGGuGGccccAGcGdTsdT sense  384-403 4779 CGCUGGGGCCACCCCCGGA 4780 CGCUGGGGCcACCCCCGGAdTsdT antis  394-413 4781 GCCCCAGCGGCAGCGGCGG 4782 GccccAGcGGcAGcGGcGGdTsdT sense  394-413 4783 CCGCCGCUGCCGCUGGGGC 4784 CCGCCGCUGCCGCUGGGGCdTsdT antis  418-437 4785 GCAGCGGUGGCCCCGGCGC 4786 GcAGcGGuGGccccGGcGcdTsdT sense  418-437 4787 GCGCCGGGGCCACCGCUGC 4788 GCGCCGGGGCcACCGCUGCdTsdT antis  419-438 4789 CAGCGGUGGCCCCGGCGCG 4790 cAGcGGuGGccccGGcGcGdTsdT sense  419-438 4791 CGCGCCGGGGCCACCGCUG 4792 CGCGCCGGGGCcACCGCUGdTsdT antis  421-440 4793 GCGGUGGCCCCGGCGCGGG 4794 GcGGuGGccccGGcGcGGGdTsdT sense  421-440 4795 CCCGCGCCGGGGCCACCGC 4796 CCCGCGCCGGGGCcACCGCdTsdT antis  422-441 4797 CGGUGGCCCCGGCGCGGGC 4798 cGGuGGccccGGcGcGGGcdTsdT sense  422-441 4799 GCCCGCGCCGGGGCCACCG 4800 GCCCGCGCCGGGGCcACCGdTsdT antis  423-442 4801 GGUGGCCCCGGCGCGGGCA 4802 GGuGGccccGGcGcGGGcAdTsdT sense  423-442 4803 UGCCCGCGCCGGGGCCACC 4804 UGCCCGCGCCGGGGCcACCdTsdT antis  424-443 4805 GUGGCCCCGGCGCGGGCAC 4806 GuGGccccGGcGcGGGcAcdTsdT sense  424-443 4807 GUGCCCGCGCCGGGGCCAC 4808 GUGCCCGCGCCGGGGCcACdTsdT antis  443-462 4809 UAGCUUCCCGCCGCCGGGA 4810 uAGcuucccGccGccGGGAdTsdT sense  443-462 4811 UCCCGGCGGCGGGAAGCUA 4812 UCCCGGCGGCGGGAAGCuAdTsdT antis  450-469 4813 CCGCCGCCGGGAGUGAAGC 4814 ccGccGccGGGAGuGAAGcdTsdT sense  450-469 4815 GCUUCACUCCCGGCGGCGG 4816 GCUUcACUCCCGGCGGCGGdTsdT antis  455-474 4817 GCCGGGAGUGAAGCUGGGC 4818 GccGGGAGuGAAGcuGGGcdTsdT sense  455-474 4819 GCCCAGCUUCACUCCCGGC 4820 GCCcAGCUUcACUCCCGGCdTsdT antis  457-476 4821 CGGGAGUGAAGCUGGGCCG 4822 cGGGAGuGAAGcuGGGccGdTsdT sense  457-476 4823 CGGCCCAGCUUCACUCCCG 4824 CGGCCcAGCUUcACUCCCGdTsdT antis  462-481 4825 GUGAAGCUGGGCCGUGACA 4826 GuGAAGcuGGGccGuGAcAdTsdT sense  462-481 4827 UGUCACGGCCCAGCUUCAC 4828 UGUcACGGCCcAGCUUcACdTsdT antis  467-486 4829 GCUGGGCCGUGACAGCGGG 4830 GcuGGGccGuGAcAGcGGGdTsdT sense  467-486 4831 CCCGCUGUCACGGCCCAGC 4832 CCCGCUGUcACGGCCcAGCdTsdT antis  478-497 4833 ACAGCGGGAAGGUGACCAC 4834 AcAGcGGGAAGGuGAccAcdTsdT sense  478-497 4835 GUGGUCACCUUCCCGCUGU 4836 GUGGUcACCUUCCCGCUGUdTsdT antis  482-501 4837 CGGGAAGGUGACCACAGUG 4838 cGGGAAGGuGAccAcAGuGdTsdT sense  482-501 4839 CACUGUGGUCACCUUCCCG 4840 cACUGUGGUcACCUUCCCGdTsdT antis  498-517 4841 GUGGUAGCCACUGUAGGCC 4842 GuGGuAGccAcuGuAGGccdTsdT sense  498-517 4843 GGCCUACAGUGGCUACCAC 4844 GGCCuAcAGUGGCuACcACdTsdT antis  499-518 4845 UGGUAGCCACUGUAGGCCA 4846 uGGuAGccAcuGuAGGccAdTsdT sense  499-518 4847 UGGCCUACAGUGGCUACCA 4848 UGGCCuAcAGUGGCuACcAdTsdT antis  500-519 4849 GGUAGCCACUGUAGGCCAA 4850 GGuAGccAcuGuAGGccAAdTsdT sense  500-519 4851 UUGGCCUACAGUGGCUACC 4852 UUGGCCuAcAGUGGCuACCdTsdT antis  501-520 4853 GUAGCCACUGUAGGCCAAG 4854 GuAGccAcuGuAGGccAAGdTsdT sense  501-520 4855 CUUGGCCUACAGUGGCUAC 4856 CUUGGCCuAcAGUGGCuACdTsdT antis  508-527 4857 CUGUAGGCCAAGGCCCAGA 4858 cuGuAGGccAAGGcccAGAdTsdT sense  508-527 4859 UCUGGGCCUUGGCCUACAG 4860 UCUGGGCCUUGGCCuAcAGdTsdT antis  514-533 4861 GCCAAGGCCCAGAGCGUUC 4862 GccAAGGcccAGAGcGuucdTsdT sense  514-533 4863 GAACGCUCUGGGCCUUGGC 4864 GAACGCUCUGGGCCUUGGCdTsdT antis  515-534 4865 CCAAGGCCCAGAGCGUUCC 4866 ccAAGGcccAGAGcGuuccdTsdT sense  515-534 4867 GGAACGCUCUGGGCCUUGG 4868 GGAACGCUCUGGGCCUUGGdTsdT antis  540-559 4869 GUGGCUUACACUGACAUCA 4870 GuGGcuuAcAcuGAcAucAdTsdT sense  540-559 4871 UGAUGUCAGUGUAAGCCAC 4872 UGAUGUcAGUGuAAGCcACdTsdT antis  541-560 4873 UGGCUUACACUGACAUCAA 4874 uGGcuuAcAcuGAcAucAAdTsdT sense  541-560 4875 UUGAUGUCAGUGUAAGCCA 4876 UUGAUGUcAGUGuAAGCcAdTsdT antis  543-562 4877 GCUUACACUGACAUCAAAG 4878 GcuuAcAcuGAcAucAAAGdTsdT sense  543-562 4879 CUUUGAUGUCAGUGUAAGC 4880 CUUUGAUGUcAGUGuAAGCdTsdT antis  546-565 4881 UACACUGACAUCAAAGUGA 4882 uAcAcuGAcAucAAAGuGAdTsdT sense  546-565 4883 UCACUUUGAUGUCAGUGUA 4884 UcACUUUGAUGUcAGUGuAdTsdT antis  594-613 4885 CAGGCACGGCUGGCAGAGA 4886 cAGGcAcGGcuGGcAGAGAdTsdT sense  594-613 4887 UCUCUGCCAGCCGUGCCUG 4888 UCUCUGCcAGCCGUGCCUGdTsdT antis  605-624 4889 GGCAGAGACGAGGGAACUG 4890 GGcAGAGAcGAGGGAAcuGdTsdT sense  605-624 4891 CAGUUCCCUCGUCUCUGCC 4892 cAGUUCCCUCGUCUCUGCCdTsdT antis  607-626 4893 CAGAGACGAGGGAACUGGU 4894 cAGAGAcGAGGGAAcuGGudTsdT sense  607-626 4895 ACCAGUUCCCUCGUCUCUG 4896 ACcAGUUCCCUCGUCUCUGdTsdT antis  617-636 4897 GGAACUGGUGGCCAUCAAG 4898 GGAAcuGGuGGccAucAAGdTsdT sense  617-636 4899 CUUGAUGGCCACCAGUUCC 4900 CUUGAUGGCcACcAGUUCCdTsdT antis  618-637 4901 GAACUGGUGGCCAUCAAGA 4902 GAAcuGGuGGccAucAAGAdTsdT sense  618-637 4903 UCUUGAUGGCCACCAGUUC 4904 UCUUGAUGGCcACcAGUUCdTsdT antis  619-638 4905 AACUGGUGGCCAUCAAGAA 4906 AAcuGGuGGccAucAAGAAdTsdT sense  619-638 4907 UUCUUGAUGGCCACCAGUU 4908 UUCUUGAUGGCcACcAGUUdTsdT antis  624-643 4909 GUGGCCAUCAAGAAGGUUC 4910 GuGGccAucAAGAAGGuucdTsdT sense  624-643 4911 GAACCUUCUUGAUGGCCAC 4912 GAACCUUCUUGAUGGCcACdTsdT antis  625-644 4913 UGGCCAUCAAGAAGGUUCU 4914 uGGccAucAAGAAGGuucudTsdT sense  625-644 4915 AGAACCUUCUUGAUGGCCA 4916 AGAACCUUCUUGAUGGCcAdTsdT antis  647-666 4917 GGACAAAAGGUUCAAGAAC 4918 GGAcAAAAGGuucAAGAAcdTsdT sense  647-666 4919 GUUCUUGAACCUUUUGUCC 4920 GUUCUUGAACCUUUUGUCCdTsdT antis  648-667 4921 GACAAAAGGUUCAAGAACC 4922 GAcAAAAGGuucAAGAAccdTsdT sense  648-667 4923 GGUUCUUGAACCUUUUGUC 4924 GGUUCUUGAACCUUUUGUCdTsdT antis  666-685 4925 CGAGAACUGCAGAUUAUGC 4926 cGAGAAcuGcAGAuuAuGcdTsdT sense  666-685 4927 GCAUAAUCUGCAGUUCUCG 4928 GcAuAAUCUGcAGUUCUCGdTsdT antis  713-732 4929 GCUGCGGUACUUUUUCUAC 4930 GcuGcGGuAcuuuuucuAcdTsdT sense  713-732 4931 GUAGAAAAAGUACCGCAGC 4932 GuAGAAAAAGuACCGcAGCdTsdT antis  717-736 4933 CGGUACUUUUUCUACUCCA 4934 cGGuAcuuuuucuAcuccAdTsdT sense  717-736 4935 UGGAGUAGAAAAAGUACCG 4936 UGGAGuAGAAAAAGuACCGdTsdT antis  739-758 4937 GGGAGAAGAAGGACGAGCU 4938 GGGAGAAGAAGGAcGAGcudTsdT sense  739-758 4939 AGCUCGUCCUUCUUCUCCC 4940 AGCUCGUCCUUCUUCUCCCdTsdT antis  740-759 4941 GGAGAAGAAGGACGAGCUG 4942 GGAGAAGAAGGAcGAGcuGdTsdT sense  740-759 4943 CAGCUCGUCCUUCUUCUCC 4944 cAGCUCGUCCUUCUUCUCCdTsdT antis  794-813 4945 GGUGUACCGAGUGGCCCGC 4946 GGuGuAccGAGuGGcccGcdTsdT sense  794-813 4947 GCGGGCCACUCGGUACACC 4948 GCGGGCcACUCGGuAcACCdTsdT antis  798-817 4949 UACCGAGUGGCCCGCCACU 4950 uAccGAGuGGcccGccAcudTsdT sense  798-817 4951 AGUGGCGGGCCACUCGGUA 4952 AGUGGCGGGCcACUCGGuAdTsdT antis  822-841 4953 AAGGCCAAGCUGAUCACCC 4954 AAGGccAAGcuGAucAcccdTsdT sense  822-841 4955 GGGUGAUCAGCUUGGCCUU 4956 GGGUGAUcAGCUUGGCCUUdTsdT antis  823-842 4957 AGGCCAAGCUGAUCACCCC 4958 AGGccAAGcuGAucAccccdTsdT sense  823-842 4959 GGGGUGAUCAGCUUGGCCU 4960 GGGGUGAUcAGCUUGGCCUdTsdT antis  846-865 4961 AUCUACAUCAAGGUGUACA 4962 AucuAcAucAAGGuGuAcAdTsdT sense  846-865 4963 UGUACACCUUGAUGUAGAU 4964 UGuAcACCUUGAUGuAGAUdTsdT antis  847-866 4965 UCUACAUCAAGGUGUACAU 4966 ucuAcAucAAGGuGuAcAudTsdT sense  847-866 4967 AUGUACACCUUGAUGUAGA 4968 AUGuAcACCUUGAUGuAGAdTsdT antis  848-867 4969 CUACAUCAAGGUGUACAUG 4970 cuAcAucAAGGuGuAcAuGdTsdT sense  848-867 4971 CAUGUACACCUUGAUGUAG 4972 cAUGuAcACCUUGAUGuAGdTsdT antis  849-868 4973 UACAUCAAGGUGUACAUGU 4974 uAcAucAAGGuGuAcAuGudTsdT sense  849-868 4975 ACAUGUACACCUUGAUGUA 4976 AcAUGuAcACCUUGAUGuAdTsdT antis  889-908 4977 CCUACAUCCACUCCCAAGG 4978 ccuAcAuccAcucccAAGGdTsdT sense  889-908 4979 CCUUGGGAGUGGAUGUAGG 4980 CCUUGGGAGUGGAUGuAGGdTsdT antis  892-911 4981 ACAUCCACUCCCAAGGUGU 4982 AcAuccAcucccAAGGuGudTsdT sense  892-911 4983 ACACCUUGGGAGUGGAUGU 4984 AcACCUUGGGAGUGGAUGUdTsdT antis  893-912 4985 CAUCCACUCCCAAGGUGUG 4986 cAuccAcucccAAGGuGuGdTsdT sense  893-912 4987 CACACCUUGGGAGUGGAUG 4988 cAcACCUUGGGAGUGGAUGdTsdT antis  904-923 4989 AAGGUGUGUGUCACCGUGA 4990 AAGGuGuGuGucAccGuGAdTsdT sense  904-923 4991 UCACGGUGACACACACCUU 4992 UcACGGUGAcAcAcACCUUdTsdT antis  905-924 4993 AGGUGUGUGUCACCGUGAC 4994 AGGuGuGuGucAccGuGAcdTsdT sense  905-924 4995 GUCACGGUGACACACACCU 4996 GUcACGGUGAcAcAcACCUdTsdT antis  906-925 4997 GGUGUGUGUCACCGUGACA 4998 GGuGuGuGucAccGuGAcAdTsdT sense  906-925 4999 UGUCACGGUGACACACACC 5000 UGUcACGGUGAcAcAcACCdTsdT antis  907-926 5001 GUGUGUGUCACCGUGACAU 5002 GuGuGuGucAccGuGAcAudTsdT sense  907-926 5003 AUGUCACGGUGACACACAC 5004 AUGUcACGGUGAcAcAcACdTsdT antis  908-927 5005 UGUGUGUCACCGUGACAUC 5006 uGuGuGucAccGuGAcAucdTsdT sense  908-927 5007 GAUGUCACGGUGACACACA 5008 GAUGUcACGGUGAcAcAcAdTsdT antis  909-928 5009 GUGUGUCACCGUGACAUCA 5010 GuGuGucAccGuGAcAucAdTsdT sense  909-928 5011 UGAUGUCACGGUGACACAC 5012 UGAUGUcACGGUGAcAcACdTsdT antis  910-929 5013 UGUGUCACCGUGACAUCAA 5014 uGuGucAccGuGAcAucAAdTsdT sense  910-929 5015 UUGAUGUCACGGUGACACA 5016 UUGAUGUcACGGUGAcAcAdTsdT antis  919-938 5017 GUGACAUCAAGCCCCAGAA 5018 GuGAcAucAAGccccAGAAdTsdT sense  919-938 5019 UUCUGGGGCUUGAUGUCAC 5020 UUCUGGGGCUUGAUGUcACdTsdT antis  946-965 5021 UGGACCCUGACACUGCUGU 5022 uGGAcccuGAcAcuGcuGudTsdT sense  946-965 5023 ACAGCAGUGUCAGGGUCCA 5024 AcAGcAGUGUcAGGGUCcAdTsdT antis  950-969 5025 CCCUGACACUGCUGUCCUC 5026 cccuGAcAcuGcuGuccucdTsdT sense  950-969 5027 GAGGACAGCAGUGUCAGGG 5028 GAGGAcAGcAGUGUcAGGGdTsdT antis  957-976 5029 ACUGCUGUCCUCAAGCUCU 5030 AcuGcuGuccucAAGcucudTsdT sense  957-976 5031 AGAGCUUGAGGACAGCAGU 5032 AGAGCUUGAGGAcAGcAGUdTsdT antis  961-980 5033 CUGUCCUCAAGCUCUGCGA 5034 cuGuccucAAGcucuGcGAdTsdT sense  961-980 5035 UCGCAGAGCUUGAGGACAG 5036 UCGcAGAGCUUGAGGAcAGdTsdT antis  962-981 5037 UGUCCUCAAGCUCUGCGAU 5038 uGuccucAAGcucuGcGAudTsdT sense  962-981 5039 AUCGCAGAGCUUGAGGACA 5040 AUCGcAGAGCUUGAGGAcAdTsdT antis 1020-1039 5041 GUGUCCUACAUCUGCUCUC 5042 GuGuccuAcAucuGcucucdTsdT sense 1020-1039 5043 GAGAGCAGAUGUAGGACAC 5044 GAGAGcAGAUGuAGGAcACdTsdT antis 1029-1048 5045 AUCUGCUCUCGGUACUACC 5046 AucuGcucucGGuAcuAccdTsdT sense 1029-1048 5047 GGUAGUACCGAGAGCAGAU 5048 GGuAGuACCGAGAGcAGAUdTsdT antis 1048-1067 5049 GUGCUCCAGAACUCAUCUU 5050 GuGcuccAGAAcucAucuudTsdT sense 1048-1067 5051 AAGAUGAGUUCUGGAGCAC 5052 AAGAUGAGUUCUGGAGcACdTsdT antis 1049-1068 5053 UGCUCCAGAACUCAUCUUU 5054 uGcuccAGAAcucAucuuudTsdT sense 1049-1068 5055 AAAGAUGAGUUCUGGAGCA 5056 AAAGAUGAGUUCUGGAGcAdTsdT antis 1050-1069 5057 GCUCCAGAACUCAUCUUUG 5058 GcuccAGAAcucAucuuuGdTsdT sense 1050-1069 5059 CAAAGAUGAGUUCUGGAGC 5060 cAAAGAUGAGUUCUGGAGCdTsdT antis 1059-1078 5061 CUCAUCUUUGGAGCCACAG 5062 cucAucuuuGGAGccAcAGdTsdT sense 1059-1078 5063 CUGUGGCUCCAAAGAUGAG 5064 CUGUGGCUCcAAAGAUGAGdTsdT antis 1087-1106 5065 CGUCCAUCGAUGUGUGGUC 5066 cGuccAucGAuGuGuGGucdTsdT sense 1087-1106 5067 GACCACACAUCGAUGGACG 5068 GACcAcAcAUCGAUGGACGdTsdT antis 1096-1115 5069 AUGUGUGGUCGGCUGGCUG 5070 AuGuGuGGucGGcuGGcuGdTsdT sense 1096-1115 5071 CAGCCAGCCGACCACACAU 5072 cAGCcAGCCGACcAcAcAUdTsdT antis 1130-1149 5073 ACUUCUCGGCCAGCCCAUC 5074 AcuucucGGccAGcccAucdTsdT sense 1130-1149 5075 GAUGGGCUGGCCGAGAAGU 5076 GAUGGGCUGGCCGAGAAGUdTsdT antis 1134-1153 5077 CUCGGCCAGCCCAUCUUCC 5078 cucGGccAGcccAucuuccdTsdT sense 1134-1153 5079 GGAAGAUGGGCUGGCCGAG 5080 GGAAGAUGGGCUGGCCGAGdTsdT antis 1141-1160 5081 AGCCCAUCUUCCCUGGGGA 5082 AGcccAucuucccuGGGGAdTsdT sense 1141-1160 5083 UCCCCAGGGAAGAUGGGCU 5084 UCCCcAGGGAAGAUGGGCUdTsdT antis 1144-1163 5085 CCAUCUUCCCUGGGGACAG 5086 ccAucuucccuGGGGAcAGdTsdT sense 1144-1163 5087 CUGUCCCCAGGGAAGAUGG 5088 CUGUCCCcAGGGAAGAUGGdTsdT antis 1151-1170 5089 CCCUGGGGACAGUGGGGUG 5090 cccuGGGGAcAGuGGGGuGdTsdT sense 1151-1170 5091 CACCCCACUGUCCCCAGGG 5092 cACCCcACUGUCCCcAGGGdTsdT antis 1156-1175 5093 GGGACAGUGGGGUGGACCA 5094 GGGAcAGuGGGGuGGAccAdTsdT sense 1156-1175 5095 UGGUCCACCCCACUGUCCC 5096 UGGUCcACCCcACUGUCCCdTsdT antis 1157-1176 5097 GGACAGUGGGGUGGACCAG 5098 GGAcAGuGGGGuGGAccAGdTsdT sense 1157-1176 5099 CUGGUCCACCCCACUGUCC 5100 CUGGUCcACCCcACUGUCCdTsdT antis 1158-1177 5101 GACAGUGGGGUGGACCAGC 5102 GAcAGuGGGGuGGAccAGcdTsdT sense 1158-1177 5103 GCUGGUCCACCCCACUGUC 5104 GCUGGUCcACCCcACUGUCdTsdT antis 1159-1178 5105 ACAGUGGGGUGGACCAGCU 5106 AcAGuGGGGuGGAccAGcudTsdT sense 1159-1178 5107 AGCUGGUCCACCCCACUGU 5108 AGCUGGUCcACCCcACUGUdTsdT antis 1160-1179 5109 CAGUGGGGUGGACCAGCUU 5110 cAGuGGGGuGGAccAGcuudTsdT sense 1160-1179 5111 AAGCUGGUCCACCCCACUG 5112 AAGCUGGUCcACCCcACUGdTsdT antis 1244-1263 5113 UACGGAGUUCAAGUUCCCC 5114 uAcGGAGuucAAGuuccccdTsdT sense 1244-1263 5115 GGGGAACUUGAACUCCGUA 5116 GGGGAACUUGAACUCCGuAdTsdT antis 1246-1265 5117 CGGAGUUCAAGUUCCCCCA 5118 cGGAGuucAAGuucccccAdTsdT sense 1246-1265 5119 UGGGGGAACUUGAACUCCG 5120 UGGGGGAACUUGAACUCCGdTsdT antis 1273-1292 5121 CUCACCCUUGGACAAAGGU 5122 cucAcccuuGGAcAAAGGudTsdT sense 1273-1292 5123 ACCUUUGUCCAAGGGUGAG 5124 ACCUUUGUCcAAGGGUGAGdTsdT antis 1275-1294 5125 CACCCUUGGACAAAGGUGU 5126 cAcccuuGGAcAAAGGuGudTsdT sense 1275-1294 5127 ACACCUUUGUCCAAGGGUG 5128 AcACCUUUGUCcAAGGGUGdTsdT antis 1278-1297 5129 CCUUGGACAAAGGUGUUCA 5130 ccuuGGAcAAAGGuGuucAdTsdT sense 1278-1297 5131 UGAACACCUUUGUCCAAGG 5132 UGAAcACCUUUGUCcAAGGdTsdT antis 1279-1298 5133 CUUGGACAAAGGUGUUCAA 5134 cuuGGAcAAAGGuGuucAAdTsdT sense 1279-1298 5135 UUGAACACCUUUGUCCAAG 5136 UUGAAcACCUUUGUCcAAGdTsdT antis 1288-1307 5137 AGGUGUUCAAAUCUUCAAA 5138 AGGuGuucAAAucuucAAAdTsdT sense 1288-1307 5139 UUUGAAGAUUUGAACACCU 5140 UUUGAAGAUUUGAAcACCUdTsdT antis 1291-1310 5141 UGUUCAAAUCUUCAAAGAC 5142 uGuucAAAucuucAAAGAcdTsdT sense 1291-1310 5143 GUCUUUGAAGAUUUGAACA 5144 GUCUUUGAAGAUUUGAAcAdTsdT antis 1292-1311 5145 GUUCAAAUCUUCAAAGACA 5146 GuucAAAucuucAAAGAcAdTsdT sense 1292-1311 5147 UGUCUUUGAAGAUUUGAAC 5148 UGUCUUUGAAGAUUUGAACdTsdT antis 1293-1312 5149 UUCAAAUCUUCAAAGACAC 5150 uucAAAucuucAAAGAcAcdTsdT sense 1293-1312 5151 GUGUCUUUGAAGAUUUGAA 5152 GUGUCUUUGAAGAUUUGAAdTsdT antis 1294-1313 5153 UCAAAUCUUCAAAGACACC 5154 ucAAAucuucAAAGAcAccdTsdT sense 1294-1313 5155 GGUGUCUUUGAAGAUUUGA 5156 GGUGUCUUUGAAGAUUUGAdTsdT antis 1314-1333 5157 CCUGAGGCCAUUGCACUCU 5158 ccuGAGGccAuuGcAcucudTsdT sense 1314-1333 5159 AGAGUGCAAUGGCCUCAGG 5160 AGAGUGcAAUGGCCUcAGGdTsdT antis 1320-1339 5161 GCCAUUGCACUCUGCUCUA 5162 GccAuuGcAcucuGcucuAdTsdT sense 1320-1339 5163 UAGAGCAGAGUGCAAUGGC 5164 uAGAGcAGAGUGcAAUGGCdTsdT antis 1336-1355 5165 CUAGCCUACUGGAGUACAC 5166 cuAGccuAcuGGAGuAcAcdTsdT sense 1336-1355 5167 GUGUACUCCAGUAGGCUAG 5168 GUGuACUCcAGuAGGCuAGdTsdT antis 1353-1372 5169 ACGCCAUCCUCAAGGCUCU 5170 AcGccAuccucAAGGcucudTsdT sense 1353-1372 5171 AGAGCCUUGAGGAUGGCGU 5172 AGAGCCUUGAGGAUGGCGUdTsdT antis 1355-1374 5173 GCCAUCCUCAAGGCUCUCC 5174 GccAuccucAAGGcucuccdTsdT sense 1355-1374 5175 GGAGAGCCUUGAGGAUGGC 5176 GGAGAGCCUUGAGGAUGGCdTsdT antis 1359-1378 5177 UCCUCAAGGCUCUCCCCAC 5178 uccucAAGGcucuccccAcdTsdT sense 1359-1378 5179 GUGGGGAGAGCCUUGAGGA 5180 GUGGGGAGAGCCUUGAGGAdTsdT antis 1372-1391 5181 CCCCACUCGAGGCUUGUGC 5182 ccccAcucGAGGcuuGuGcdTsdT sense 1372-1391 5183 GCACAAGCCUCGAGUGGGG 5184 GcAcAAGCCUCGAGUGGGGdTsdT antis 1373-1392 5185 CCCACUCGAGGCUUGUGCC 5186 cccAcucGAGGcuuGuGccdTsdT sense 1373-1392 5187 GGCACAAGCCUCGAGUGGG 5188 GGcAcAAGCCUCGAGUGGGdTsdT antis 1374-1393 5189 CCACUCGAGGCUUGUGCCC 5190 ccAcucGAGGcuuGuGcccdTsdT sense 1374-1393 5191 GGGCACAAGCCUCGAGUGG 5192 GGGcAcAAGCCUCGAGUGGdTsdT antis 1376-1395 5193 ACUCGAGGCUUGUGCCCAC 5194 AcucGAGGcuuGuGcccAcdTsdT sense 1376-1395 5195 GUGGGCACAAGCCUCGAGU 5196 GUGGGcAcAAGCCUCGAGUdTsdT antis 1377-1396 5197 CUCGAGGCUUGUGCCCACA 5198 cucGAGGcuuGuGcccAcAdTsdT sense 1377-1396 5199 UGUGGGCACAAGCCUCGAG 5200 UGUGGGcAcAAGCCUCGAGdTsdT antis 1378-1397 5201 UCGAGGCUUGUGCCCACAG 5202 ucGAGGcuuGuGcccAcAGdTsdT sense 1378-1397 5203 CUGUGGGCACAAGCCUCGA 5204 CUGUGGGcAcAAGCCUCGAdTsdT antis 1389-1408 5205 GCCCACAGCUUCUUCGAUG 5206 GcccAcAGcuucuucGAuGdTsdT sense 1389-1408 5207 CAUCGAAGAAGCUGUGGGC 5208 cAUCGAAGAAGCUGUGGGCdTsdT antis 1391-1410 5209 CCACAGCUUCUUCGAUGAA 5210 ccAcAGcuucuucGAuGAAdTsdT sense 1391-1410 5211 UUCAUCGAAGAAGCUGUGG 5212 UUcAUCGAAGAAGCUGUGGdTsdT antis 1423-1442 5213 GAGCCCAGCUCCCCAACGA 5214 GAGcccAGcuccccAAcGAdTsdT sense 1423-1442 5215 UCGUUGGGGAGCUGGGCUC 5216 UCGUUGGGGAGCUGGGCUCdTsdT antis 1469-1488 5217 CAGUCCUGGUGAACUGUCC 5218 cAGuccuGGuGAAcuGuccdTsdT sense 1469-1488 5219 GGACAGUUCACCAGGACUG 5220 GGAcAGUUcACcAGGACUGdTsdT antis 1484-1503 5221 GUCCAUCCAACCAUCUCUC 5222 GuccAuccAAccAucucucdTsdT sense 1484-1503 5223 GAGAGAUGGUUGGAUGGAC 5224 GAGAGAUGGUUGGAUGGACdTsdT antis 1496-1515 5225 AUCUCUCAAUGCCAUUCUC 5226 AucucucAAuGccAuucucdTsdT sense 1496-1515 5227 GAGAAUGGCAUUGAGAGAU 5228 GAGAAUGGcAUUGAGAGAUdTsdT antis 1498-1517 5229 CUCUCAAUGCCAUUCUCAU 5230 cucucAAuGccAuucucAudTsdT sense 1498-1517 5231 AUGAGAAUGGCAUUGAGAG 5232 AUGAGAAUGGcAUUGAGAGdTsdT antis 1499-1518 5233 UCUCAAUGCCAUUCUCAUC 5234 ucucAAuGccAuucucAucdTsdT sense 1499-1518 5235 GAUGAGAAUGGCAUUGAGA 5236 GAUGAGAAUGGcAUUGAGAdTsdT antis 1502-1521 5237 CAAUGCCAUUCUCAUCCCU 5238 cAAuGccAuucucAucccudTsdT sense 1502-1521 5239 AGGGAUGAGAAUGGCAUUG 5240 AGGGAUGAGAAUGGcAUUGdTsdT antis 1541-1560 5241 AGGCCCUGCUUCUCCCCUC 5242 AGGcccuGcuucuccccucdTsdT sense 1541-1560 5243 GAGGGGAGAAGCAGGGCCU 5244 GAGGGGAGAAGcAGGGCCUdTsdT antis 1542-1561 5245 GGCCCUGCUUCUCCCCUCA 5246 GGcccuGcuucuccccucAdTsdT sense 1542-1561 5247 UGAGGGGAGAAGCAGGGCC 5248 UGAGGGGAGAAGcAGGGCCdTsdT antis 1548-1567 5249 GCUUCUCCCCUCACCACUU 5250 GcuucuccccucAccAcuudTsdT sense 1548-1567 5251 AAGUGGUGAGGGGAGAAGC 5252 AAGUGGUGAGGGGAGAAGCdTsdT antis 1549-1568 5253 CUUCUCCCCUCACCACUUC 5254 cuucuccccucAccAcuucdTsdT sense 1549-1568 5255 GAAGUGGUGAGGGGAGAAG 5256 GAAGUGGUGAGGGGAGAAGdTsdT antis 1552-1571 5257 CUCCCCUCACCACUUCCUA 5258 cuccccucAccAcuuccuAdTsdT sense 1552-1571 5259 UAGGAAGUGGUGAGGGGAG 5260 uAGGAAGUGGUGAGGGGAGdTsdT antis 1557-1576 5261 CUCACCACUUCCUACAACC 5262 cucAccAcuuccuAcAAccdTsdT sense 1557-1576 5263 GGUUGUAGGAAGUGGUGAG 5264 GGUUGuAGGAAGUGGUGAGdTsdT antis 1575-1594 5265 CCAUCCUCACAAGCUUUAA 5266 ccAuccucAcAAGcuuuAAdTsdT sense 1575-1594 5267 UUAAAGCUUGUGAGGAUGG 5268 UuAAAGCUUGUGAGGAUGGdTsdT antis 1600-1619 5269 CUCAGACUGGCCAAGAUUG 5270 cucAGAcuGGccAAGAuuGdTsdT sense 1600-1619 5271 CAAUCUUGGCCAGUCUGAG 5272 cAAUCUUGGCcAGUCUGAGdTsdT antis 1616-1635 5273 UUGGCAGCCAUCUGAUGCC 5274 uuGGcAGccAucuGAuGccdTsdT sense 1616-1635 5275 GGCAUCAGAUGGCUGCCAA 5276 GGcAUcAGAUGGCUGCcAAdTsdT antis 1617-1636 5277 UGGCAGCCAUCUGAUGCCA 5278 uGGcAGccAucuGAuGccAdTsdT sense 1617-1636 5279 UGGCAUCAGAUGGCUGCCA 5280 UGGcAUcAGAUGGCUGCcAdTsdT antis 1618-1637 5281 GGCAGCCAUCUGAUGCCAC 5282 GGcAGccAucuGAuGccAcdTsdT sense 1618-1637 5283 GUGGCAUCAGAUGGCUGCC 5284 GUGGcAUcAGAUGGCUGCCdTsdT antis 1619-1638 5285 GCAGCCAUCUGAUGCCACA 5286 GcAGccAucuGAuGccAcAdTsdT sense 1619-1638 5287 UGUGGCAUCAGAUGGCUGC 5288 UGUGGcAUcAGAUGGCUGCdTsdT antis 1622-1641 5289 GCCAUCUGAUGCCACAACU 5290 GccAucuGAuGccAcAAcudTsdT sense 1622-1641 5291 AGUUGUGGCAUCAGAUGGC 5292 AGUUGUGGcAUcAGAUGGCdTsdT antis 1647-1666 5293 CUCGCUAGCUCUUCCUGAG 5294 cucGcuAGcucuuccuGAGdTsdT sense 1647-1666 5295 CUCAGGAAGAGCUAGCGAG 5296 CUcAGGAAGAGCuAGCGAGdTsdT antis 1648-1667 5297 UCGCUAGCUCUUCCUGAGG 5298 ucGcuAGcucuuccuGAGGdTsdT sense 1648-1667 5299 CCUCAGGAAGAGCUAGCGA 5300 CCUcAGGAAGAGCuAGCGAdTsdT antis 1649-1668 5301 CGCUAGCUCUUCCUGAGGG 5302 cGcuAGcucuuccuGAGGGdTsdT sense 1649-1668 5303 CCCUCAGGAAGAGCUAGCG 5304 CCCUcAGGAAGAGCuAGCGdTsdT antis 1658-1677 5305 UUCCUGAGGGCCCCACCGA 5306 uuccuGAGGGccccAccGAdTsdT sense 1658-1677 5307 UCGGUGGGGCCCUCAGGAA 5308 UCGGUGGGGCCCUcAGGAAdTsdT antis 1661-1680 5309 CUGAGGGCCCCACCGACUA 5310 cuGAGGGccccAccGAcuAdTsdT sense 1661-1680 5311 UAGUCGGUGGGGCCCUCAG 5312 uAGUCGGUGGGGCCCUcAGdTsdT antis 1662-1681 5313 UGAGGGCCCCACCGACUAC 5314 uGAGGGccccAccGAcuAcdTsdT sense 1662-1681 5315 GUAGUCGGUGGGGCCCUCA 5316 GuAGUCGGUGGGGCCCUcAdTsdT antis 1663-1682 5317 GAGGGCCCCACCGACUACC 5318 GAGGGccccAccGAcuAccdTsdT sense 1663-1682 5319 GGUAGUCGGUGGGGCCCUC 5320 GGuAGUCGGUGGGGCCCUCdTsdT antis 1800-1819 5321 AUCUAGGCCUCCCUCAGCA 5322 AucuAGGccucccucAGcAdTsdT sense 1800-1819 5323 UGCUGAGGGAGGCCUAGAU 5324 UGCUGAGGGAGGCCuAGAUdTsdT antis 1807-1826 5325 CCUCCCUCAGCAGCCUAAC 5326 ccucccucAGcAGccuAAcdTsdT sense 1807-1826 5327 GUUAGGCUGCUGAGGGAGG 5328 GUuAGGCUGCUGAGGGAGGdTsdT antis 1819-1838 5329 GCCUAACCUCUGUGGUGGG 5330 GccuAAccucuGuGGuGGGdTsdT sense 1819-1838 5331 CCCACCACAGAGGUUAGGC 5332 CCcACcAcAGAGGUuAGGCdTsdT antis 1856-1875 5333 AACUGUUUGUAGGGGAGGG 5334 AAcuGuuuGuAGGGGAGGGdTsdT sense 1856-1875 5335 CCCUCCCCUACAAACAGUU 5336 CCCUCCCCuAcAAAcAGUUdTsdT antis 1860-1879 5337 GUUUGUAGGGGAGGGGAGA 5338 GuuuGuAGGGGAGGGGAGAdTsdT sense 1860-1879 5339 UCUCCCCUCCCCUACAAAC 5340 UCUCCCCUCCCCuAcAAACdTsdT antis 1864-1883 5341 GUAGGGGAGGGGAGAAAAG 5342 GuAGGGGAGGGGAGAAAAGdTsdT sense 1864-1883 5343 CUUUUCUCCCCUCCCCUAC 5344 CUUUUCUCCCCUCCCCuACdTsdT antis 1879-1898 5345 AAAGGAAGGACGGGGUUUG 5346 AAAGGAAGGAcGGGGuuuGdTsdT sense 1879-1898 5347 CAAACCCCGUCCUUCCUUU 5348 cAAACCCCGUCCUUCCUUUdTsdT antis 1880-1899 5349 AAGGAAGGACGGGGUUUGG 5350 AAGGAAGGAcGGGGuuuGGdTsdT sense 1880-1899 5351 CCAAACCCCGUCCUUCCUU 5352 CcAAACCCCGUCCUUCCUUdTsdT antis 1881-1900 5353 AGGAAGGACGGGGUUUGGG 5354 AGGAAGGAcGGGGuuuGGGdTsdT sense 1881-1900 5355 CCCAAACCCCGUCCUUCCU 5356 CCcAAACCCCGUCCUUCCUdTsdT antis 1906-1925 5357 AGGACCUUCUACCCCCUUG 5358 AGGAccuucuAcccccuuGdTsdT sense 1906-1925 5359 CAAGGGGGUAGAAGGUCCU 5360 cAAGGGGGuAGAAGGUCCUdTsdT antis 1907-1926 5361 GGACCUUCUACCCCCUUGG 5362 GGAccuucuAcccccuuGGdTsdT sense 1907-1926 5363 CCAAGGGGGUAGAAGGUCC 5364 CcAAGGGGGuAGAAGGUCCdTsdT antis 1908-1927 5365 GACCUUCUACCCCCUUGGU 5366 GAccuucuAcccccuuGGudTsdT sense 1908-1927 5367 ACCAAGGGGGUAGAAGGUC 5368 ACcAAGGGGGuAGAAGGUCdTsdT antis 1909-1928 5369 ACCUUCUACCCCCUUGGUC 5370 AccuucuAcccccuuGGucdTsdT sense 1909-1928 5371 GACCAAGGGGGUAGAAGGU 5372 GACcAAGGGGGuAGAAGGUdTsdT antis 1910-1929 5373 CCUUCUACCCCCUUGGUCC 5374 ccuucuAcccccuuGGuccdTsdT sense 1910-1929 5375 GGACCAAGGGGGUAGAAGG 5376 GGACcAAGGGGGuAGAAGGdTsdT antis 1911-1930 5377 CUUCUACCCCCUUGGUCCC 5378 cuucuAcccccuuGGucccdTsdT sense 1911-1930 5379 GGGACCAAGGGGGUAGAAG 5380 GGGACcAAGGGGGuAGAAGdTsdT antis 1932-1951 5381 CCCCUCCCCCAGGCUACCA 5382 ccccucccccAGGcuAccAdTsdT sense 1932-1951 5383 UGGUAGCCUGGGGGAGGGG 5384 UGGuAGCCUGGGGGAGGGGdTsdT antis 1942-1961 5385 AGGCUACCACUCCUUCCCU 5386 AGGcuAccAcuccuucccudTsdT sense 1942-1961 5387 AGGGAAGGAGUGGUAGCCU 5388 AGGGAAGGAGUGGuAGCCUdTsdT antis 1943-1962 5389 GGCUACCACUCCUUCCCUC 5390 GGcuAccAcuccuucccucdTsdT sense 1943-1962 5391 GAGGGAAGGAGUGGUAGCC 5392 GAGGGAAGGAGUGGuAGCCdTsdT antis 1958-1977 5393 CCUCCCCCCCUCUCCCAGG 5394 ccucccccccucucccAGGdTsdT sense 1958-1977 5395 CCUGGGAGAGGGGGGGAGG 5396 CCUGGGAGAGGGGGGGAGGdTsdT antis 1961-1980 5397 CCCCCCCUCUCCCAGGUCC 5398 cccccccucucccAGGuccdTsdT sense 1961-1980 5399 GGACCUGGGAGAGGGGGGG 5400 GGACCUGGGAGAGGGGGGGdTsdT antis 1966-1985 5401 CCUCUCCCAGGUCCCUUGU 5402 ccucucccAGGucccuuGudTsdT sense 1966-1985 5403 ACAAGGGACCUGGGAGAGG 5404 AcAAGGGACCUGGGAGAGGdTsdT antis 1972-1991 5405 CCAGGUCCCUUGUAAAUAG 5406 ccAGGucccuuGuAAAuAGdTsdT sense 1972-1991 5407 CUAUUUACAAGGGACCUGG 5408 CuAUUuAcAAGGGACCUGGdTsdT antis 1989-2008 5409 AGAACCAGCCCAGCCCAUC 5410 AGAAccAGcccAGcccAucdTsdT sense 1989-2008 5411 GAUGGGCUGGGCUGGUUCU 5412 GAUGGGCUGGGCUGGUUCUdTsdT antis 1990-2009 5413 GAACCAGCCCAGCCCAUCU 5414 GAAccAGcccAGcccAucudTsdT sense 1990-2009 5415 AGAUGGGCUGGGCUGGUUC 5416 AGAUGGGCUGGGCUGGUUCdTsdT antis 1991-2010 5417 AACCAGCCCAGCCCAUCUC 5418 AAccAGcccAGcccAucucdTsdT sense 1991-2010 5419 GAGAUGGGCUGGGCUGGUU 5420 GAGAUGGGCUGGGCUGGUUdTsdT antis 1992-2011 5421 ACCAGCCCAGCCCAUCUCU 5422 AccAGcccAGcccAucucudTsdT sense 1992-2011 5423 AGAGAUGGGCUGGGCUGGU 5424 AGAGAUGGGCUGGGCUGGUdTsdT antis 1993-2012 5425 CCAGCCCAGCCCAUCUCUC 5426 ccAGcccAGcccAucucucdTsdT sense 1993-2012 5427 GAGAGAUGGGCUGGGCUGG 5428 GAGAGAUGGGCUGGGCUGGdTsdT antis 2007-2026 5429 CUCUCGUCUUCCCUUCCCU 5430 cucucGucuucccuucccudTsdT sense 2007-2026 5431 AGGGAAGGGAAGACGAGAG 5432 AGGGAAGGGAAGACGAGAGdTsdT antis 2008-2027 5433 UCUCGUCUUCCCUUCCCUG 5434 ucucGucuucccuucccuGdTsdT sense 2008-2027 5435 CAGGGAAGGGAAGACGAGA 5436 cAGGGAAGGGAAGACGAGAdTsdT antis 2013-2032 5437 UCUUCCCUUCCCUGGCCCC 5438 ucuucccuucccuGGccccdTsdT sense 2013-2032 5439 GGGGCCAGGGAAGGGAAGA 5440 GGGGCcAGGGAAGGGAAGAdTsdT antis 2014-2033 5441 CUUCCCUUCCCUGGCCCCC 5442 cuucccuucccuGGcccccdTsdT sense 2014-2033 5443 GGGGGCCAGGGAAGGGAAG 5444 GGGGGCcAGGGAAGGGAAGdTsdT antis 2021-2040 5445 UCCCUGGCCCCCUGGGUGU 5446 ucccuGGcccccuGGGuGudTsdT sense 2021-2040 5447 ACACCCAGGGGGCCAGGGA 5448 AcACCcAGGGGGCcAGGGAdTsdT antis 2038-2057 5449 GUAAAUAGAUUGUUAUAAU 5450 GuAAAuAGAuuGuuAuAAudTsdT sense 2038-2057 5451 AUUAUAACAAUCUAUUUAC 5452 AUuAuAAcAAUCuAUUuACdTsdT antis 2048-2067 5453 UGUUAUAAUUUUUUCUUAA 5454 uGuuAuAAuuuuuucuuAAdTsdT sense 2048-2067 5455 UUAAGAAAAAAUUAUAACA 5456 UuAAGAAAAAAUuAuAAcAdTsdT antis 2106-2125 5457 GCUGUACCCCUUCUUGUCC 5458 GcuGuAccccuucuuGuccdTsdT sense 2106-2125 5459 GGACAAGAAGGGGUACAGC 5460 GGAcAAGAAGGGGuAcAGCdTsdT antis 2109-2128 5461 GUACCCCUUCUUGUCCUCU 5462 GuAccccuucuuGuccucudTsdT sense 2109-2128 5463 AGAGGACAAGAAGGGGUAC 5464 AGAGGAcAAGAAGGGGuACdTsdT antis 2120-2139 5465 UGUCCUCUGCUCCCAAGGC 5466 uGuccucuGcucccAAGGcdTsdT sense 2120-2139 5467 GCCUUGGGAGCAGAGGACA 5468 GCCUUGGGAGcAGAGGAcAdTsdT antis 2170-2189 5469 AGUAGAGAGAGUCCCUGGU 5470 AGuAGAGAGAGucccuGGudTsdT sense 2170-2189 5471 ACCAGGGACUCUCUCUACU 5472 ACcAGGGACUCUCUCuACUdTsdT antis 2180-2199 5473 GUCCCUGGUGUCUUAGUUU 5474 GucccuGGuGucuuAGuuudTsdT sense 2180-2199 5475 AAACUAAGACACCAGGGAC 5476 AAACuAAGAcACcAGGGACdTsdT antis 2187-2206 5477 GUGUCUUAGUUUCCACAGU 5478 GuGucuuAGuuuccAcAGudTsdT sense 2187-2206 5479 ACUGUGGAAACUAAGACAC 5480 ACUGUGGAAACuAAGAcACdTsdT antis 2189-2208 5481 GUCUUAGUUUCCACAGUAA 5482 GucuuAGuuuccAcAGuAAdTsdT sense 2189-2208 5483 UUACUGUGGAAACUAAGAC 5484 UuACUGUGGAAACuAAGACdTsdT antis 2190-2209 5485 UCUUAGUUUCCACAGUAAG 5486 ucuuAGuuuccAcAGuAAGdTsdT sense 2190-2209 5487 CUUACUGUGGAAACUAAGA 5488 CUuACUGUGGAAACuAAGAdTsdT antis 2225-2244 5489 ACCUCUGUUCAAUAAAUUA 5490 AccucuGuucAAuAAAuuAdTsdT sense 2225-2244 5491 UAAUUUAUUGAACAGAGGU 5492 uAAUUuAUUGAAcAGAGGUdTsdT antis 2238-2257 5493 AAAUUAUUGGCAUGAAACC 5494 AAAuuAuuGGcAuGAAAccdTsdT sense 2238-2257 5495 GGUUUCAUGCCAAUAAUUU 5496 GGUUUcAUGCcAAuAAUUUdTsdT antis 2239-2258 5497 AAUUAUUGGCAUGAAACCC 5498 AAuuAuuGGcAuGAAAcccdTsdT sense 2239-2258 5499 GGGUUUCAUGCCAAUAAUU 5500 GGGUUUcAUGCcAAuAAUUdTsdT antis 2241-2260 5501 UUAUUGGCAUGAAACCCUU 5502 uuAuuGGcAuGAAAcccuudTsdT sense 2241-2260 5503 AAGGGUUUCAUGCCAAUAA 5504 AAGGGUUUcAUGCcAAuAAdTsdT antis   34-53 5505 CAUCUCCCGGCGUGCCCCG 5506 cAucucccGGcGuGccccGdTsdT sense   34-53 5507 CGGGGCACGCCGGGAGAUG 5508 CGGGGcACGCCGGGAGAUGdTsdT antis   35-54 5509 AUCUCCCGGCGUGCCCCGC 5510 AucucccGGcGuGccccGcdTsdT sense   35-54 5511 GCGGGGCACGCCGGGAGAU 5512 GCGGGGcACGCCGGGAGAUdTsdT antis   97-116 5513 GAAGAGGCCGGAGCCCAGG 5514 GAAGAGGccGGAGcccAGGdTsdT sense   97-116 5515 CCUGGGCUCCGGCCUCUUC 5516 CCUGGGCUCCGGCCUCUUCdTsdT antis  163-182 5517 CCCCGCGGCCUGGGCCUGC 5518 ccccGcGGccuGGGccuGcdTsdT sense  163-182 5519 GCAGGCCCAGGCCGCGGGG 5520 GcAGGCCcAGGCCGCGGGGdTsdT antis  164-183 5521 CCCGCGGCCUGGGCCUGCG 5522 cccGcGGccuGGGccuGcGdTsdT sense  164-183 5523 CGCAGGCCCAGGCCGCGGG 5524 CGcAGGCCcAGGCCGCGGGdTsdT antis  228-247 5525 GGCUCGGGCCGGGCGCGGA 5526 GGcucGGGccGGGcGcGGAdTsdT sense  228-247 5527 UCCGCGCCCGGCCCGAGCC 5528 UCCGCGCCCGGCCCGAGCCdTsdT antis  235-254 5529 GCCGGGCGCGGACCAGCUC 5530 GccGGGcGcGGAccAGcucdTsdT sense  235-254 5531 GAGCUGGUCCGCGCCCGGC 5532 GAGCUGGUCCGCGCCCGGCdTsdT antis  247-266 5533 CCAGCUCGUUCGCGGAGCC 5534 ccAGcucGuucGcGGAGccdTsdT sense  247-266 5535 GGCUCCGCGAACGAGCUGG 5536 GGCUCCGCGAACGAGCUGGdTsdT antis  262-281 5537 AGCCAGGAGGCGGAGGCGG 5538 AGccAGGAGGcGGAGGcGGdTsdT sense  262-281 5539 CCGCCUCCGCCUCCUGGCU 5540 CCGCCUCCGCCUCCUGGCUdTsdT antis  301-320 5541 GGGGCUCGGCCUCUGGCCC 5542 GGGGcucGGccucuGGcccdTsdT sense  301-320 5543 GGGCCAGAGGCCGAGCCCC 5544 GGGCcAGAGGCCGAGCCCCdTsdT antis  393-412 5545 GGCCCCAGCGGCAGCGGCG 5546 GGccccAGcGGcAGcGGcGdTsdT sense  393-412 5547 CGCCGCUGCCGCUGGGGCC 5548 CGCCGCUGCCGCUGGGGCCdTsdT antis  403-422 5549 GCAGCGGCGGAGGAGGCAG 5550 GcAGcGGcGGAGGAGGcAGdTsdT sense  403-422 5551 CUGCCUCCUCCGCCGCUGC 5552 CUGCCUCCUCCGCCGCUGCdTsdT antis  420-439 5553 AGCGGUGGCCCCGGCGCGG 5554 AGcGGuGGccccGGcGcGGdTsdT sense  420-439 5555 CCGCGCCGGGGCCACCGCU 5556 CCGCGCCGGGGCcACCGCUdTsdT antis  502-521 5557 UAGCCACUGUAGGCCAAGG 5558 uAGccAcuGuAGGccAAGGdTsdT sense  502-521 5559 CCUUGGCCUACAGUGGCUA 5560 CCUUGGCCuAcAGUGGCuAdTsdT antis  531-550 5561 UCCCAAGAAGUGGCUUACA 5562 ucccAAGAAGuGGcuuAcAdTsdT sense  531-550 5563 UGUAAGCCACUUCUUGGGA 5564 UGuAAGCcACUUCUUGGGAdTsdT antis  665-684 5565 CCGAGAACUGCAGAUUAUG 5566 ccGAGAAcuGcAGAuuAuGdTsdT sense  665-684 5567 CAUAAUCUGCAGUUCUCGG 5568 cAuAAUCUGcAGUUCUCGGdTsdT antis 1148-1167 5569 CUUCCCUGGGGACAGUGGG 5570 cuucccuGGGGAcAGuGGGdTsdT sense 1148-1167 5571 CCCACUGUCCCCAGGGAAG 5572 CCcACUGUCCCcAGGGAAGdTsdT antis 1356-1375 5573 CCAUCCUCAAGGCUCUCCC 5574 ccAuccucAAGGcucucccdTsdT sense 1356-1375 5575 GGGAGAGCCUUGAGGAUGG 5576 GGGAGAGCCUUGAGGAUGGdTsdT antis 1358-1377 5577 AUCCUCAAGGCUCUCCCCA 5578 AuccucAAGGcucuccccAdTsdT sense 1358-1377 5579 UGGGGAGAGCCUUGAGGAU 5580 UGGGGAGAGCCUUGAGGAUdTsdT antis 1485-1504 5581 UCCAUCCAACCAUCUCUCA 5582 uccAuccAAccAucucucAdTsdT sense 1485-1504 5583 UGAGAGAUGGUUGGAUGGA 5584 UGAGAGAUGGUUGGAUGGAdTsdT antis 1620-1639 5585 CAGCCAUCUGAUGCCACAA 5586 cAGccAucuGAuGccAcAAdTsdT sense 1620-1639 5587 UUGUGGCAUCAGAUGGCUG 5588 UUGUGGcAUcAGAUGGCUGdTsdT antis 1813-1832 5589 UCAGCAGCCUAACCUCUGU 5590 ucAGcAGccuAAccucuGudTsdT sense 1813-1832 5591 ACAGAGGUUAGGCUGCUGA 5592 AcAGAGGUuAGGCUGCUGAdTsdT antis 1954-1973 5593 CUUCCCUCCCCCCCUCUCC 5594 cuucccucccccccucuccdTsdT sense 1954-1973 5595 GGAGAGGGGGGGAGGGAAG 5596 GGAGAGGGGGGGAGGGAAGdTsdT antis 1957-1976 5597 CCCUCCCCCCCUCUCCCAG 5598 cccucccccccucucccAGdTsdT sense 1957-1976 5599 CUGGGAGAGGGGGGGAGGG 5600 CUGGGAGAGGGGGGGAGGGdTsdT antis 2103-2122 5601 CCAGCUGUACCCCUUCUUG 5602 ccAGcuGuAccccuucuuGdTsdT sense 2103-2122 5603 CAAGAAGGGGUACAGCUGG 5604 cAAGAAGGGGuAcAGCUGGdTsdT antis 2119-2138 5605 UUGUCCUCUGCUCCCAAGG 5606 uuGuccucuGcucccAAGGdTsdT sense 2119-2138 5607 CCUUGGGAGCAGAGGACAA 5608 CCUUGGGAGcAGAGGAcAAdTsdT antis 2122-2141 5609 UCCUCUGCUCCCAAGGCUU 5610 uccucuGcucccAAGGcuudTsdT sense 2122-2141 5611 AAGCCUUGGGAGCAGAGGA 5612 AAGCCUUGGGAGcAGAGGAdTsdT antis 2125-2144 5613 UCUGCUCCCAAGGCUUCCU 5614 ucuGcucccAAGGcuuccudTsdT sense 2125-2144 5615 AGGAAGCCUUGGGAGCAGA 5616 AGGAAGCCUUGGGAGcAGAdTsdT antis 2154-2173 5617 AUCCUGGAAGGAGGGGAGU 5618 AuccuGGAAGGAGGGGAGudTsdT sense 2154-2173 5619 ACUCCCCUCCUUCCAGGAU 5620 ACUCCCCUCCUUCcAGGAUdTsdT antis   33-52 5621 UCAUCUCCCGGCGUGCCCC 5622 ucAucucccGGcGuGccccdTsdT sense   33-52 5623 GGGGCACGCCGGGAGAUGA 5624 GGGGcACGCCGGGAGAUGAdTsdT antis   46-65 5625 UGCCCCGCGGCGGGCGCUG 5626 uGccccGcGGcGGGcGcuGdTsdT sense   46-65 5627 CAGCGCCCGCCGCGGGGCA 5628 cAGCGCCCGCCGCGGGGcAdTsdT antis   47-66 5629 GCCCCGCGGCGGGCGCUGG 5630 GccccGcGGcGGGcGcuGGdTsdT sense   47-66 5631 CCAGCGCCCGCCGCGGGGC 5632 CcAGCGCCCGCCGCGGGGCdTsdT antis   53-72 5633 CGGCGGGCGCUGGGCCGGA 5634 cGGcGGGcGcuGGGccGGAdTsdT sense   53-72 5635 UCCGGCCCAGCGCCCGCCG 5636 UCCGGCCcAGCGCCCGCCGdTsdT antis   54-73 5637 GGCGGGCGCUGGGCCGGAG 5638 GGcGGGcGcuGGGccGGAGdTsdT sense   54-73 5639 CUCCGGCCCAGCGCCCGCC 5640 CUCCGGCCcAGCGCCCGCCdTsdT antis   55-74 5641 GCGGGCGCUGGGCCGGAGC 5642 GcGGGcGcuGGGccGGAGcdTsdT sense   55-74 5643 GCUCCGGCCCAGCGCCCGC 5644 GCUCCGGCCcAGCGCCCGCdTsdT antis   61-80 5645 GCUGGGCCGGAGCCGGAGC 5646 GcuGGGccGGAGccGGAGcdTsdT sense   61-80 5647 GCUCCGGCUCCGGCCCAGC 5648 GCUCCGGCUCCGGCCcAGCdTsdT antis   64-83 5649 GGGCCGGAGCCGGAGCCCG 5650 GGGccGGAGccGGAGcccGdTsdT sense   64-83 5651 CGGGCUCCGGCUCCGGCCC 5652 CGGGCUCCGGCUCCGGCCCdTsdT antis   67-86 5653 CCGGAGCCGGAGCCCGAAC 5654 ccGGAGccGGAGcccGAAcdTsdT sense   67-86 5655 GUUCGGGCUCCGGCUCCGG 5656 GUUCGGGCUCCGGCUCCGGdTsdT antis   92-111 5657 GCCUGGAAGAGGCCGGAGC 5658 GccuGGAAGAGGccGGAGcdTsdT sense   92-111 5659 GCUCCGGCCUCUUCCAGGC 5660 GCUCCGGCCUCUUCcAGGCdTsdT antis   93-112 5661 CCUGGAAGAGGCCGGAGCC 5662 ccuGGAAGAGGccGGAGccdTsdT sense   93-112 5663 GGCUCCGGCCUCUUCCAGG 5664 GGCUCCGGCCUCUUCcAGGdTsdT antis  101-120 5665 AGGCCGGAGCCCAGGGGAG 5666 AGGccGGAGcccAGGGGAGdTsdT sense  101-120 5667 CUCCCCUGGGCUCCGGCCU 5668 CUCCCCUGGGCUCCGGCCUdTsdT antis  102-121 5669 GGCCGGAGCCCAGGGGAGG 5670 GGccGGAGcccAGGGGAGGdTsdT sense  102-121 5671 CCUCCCCUGGGCUCCGGCC 5672 CCUCCCCUGGGCUCCGGCCdTsdT antis  106-125 5673 GGAGCCCAGGGGAGGCGGC 5674 GGAGcccAGGGGAGGcGGcdTsdT sense  106-125 5675 GCCGCCUCCCCUGGGCUCC 5676 GCCGCCUCCCCUGGGCUCCdTsdT antis  110-129 5677 CCCAGGGGAGGCGGCGGCA 5678 cccAGGGGAGGcGGcGGcAdTsdT sense  110-129 5679 UGCCGCCGCCUCCCCUGGG 5680 UGCCGCCGCCUCCCCUGGGdTsdT antis  111-130 5681 CCAGGGGAGGCGGCGGCAG 5682 ccAGGGGAGGcGGcGGcAGdTsdT sense  111-130 5683 CUGCCGCCGCCUCCCCUGG 5684 CUGCCGCCGCCUCCCCUGGdTsdT antis  122-141 5685 GGCGGCAGAGGCAGCGGCG 5686 GGcGGcAGAGGcAGcGGcGdTsdT sense  122-141 5687 CGCCGCUGCCUCUGCCGCC 5688 CGCCGCUGCCUCUGCCGCCdTsdT antis  123-142 5689 GCGGCAGAGGCAGCGGCGG 5690 GcGGcAGAGGcAGcGGcGGdTsdT sense  123-142 5691 CCGCCGCUGCCUCUGCCGC 5692 CCGCCGCUGCCUCUGCCGCdTsdT antis  124-143 5693 CGGCAGAGGCAGCGGCGGG 5694 cGGcAGAGGcAGcGGcGGGdTsdT sense  124-143 5695 CCCGCCGCUGCCUCUGCCG 5696 CCCGCCGCUGCCUCUGCCGdTsdT antis  125-144 5697 GGCAGAGGCAGCGGCGGGG 5698 GGcAGAGGcAGcGGcGGGGdTsdT sense  125-144 5699 CCCCGCCGCUGCCUCUGCC 5700 CCCCGCCGCUGCCUCUGCCdTsdT antis  132-151 5701 GCAGCGGCGGGGGCAGCCC 5702 GcAGcGGcGGGGGcAGcccdTsdT sense  132-151 5703 GGGCUGCCCCCGCCGCUGC 5704 GGGCUGCCCCCGCCGCUGCdTsdT antis  139-158 5705 CGGGGGCAGCCCAGGCAGC 5706 cGGGGGcAGcccAGGcAGcdTsdT sense  139-158 5707 GCUGCCUGGGCUGCCCCCG 5708 GCUGCCUGGGCUGCCCCCGdTsdT antis  143-162 5709 GGCAGCCCAGGCAGCCCGA 5710 GGcAGcccAGGcAGcccGAdTsdT sense  143-162 5711 UCGGGCUGCCUGGGCUGCC 5712 UCGGGCUGCCUGGGCUGCCdTsdT antis  146-165 5713 AGCCCAGGCAGCCCGAGCC 5714 AGcccAGGcAGcccGAGccdTsdT sense  146-165 5715 GGCUCGGGCUGCCUGGGCU 5716 GGCUCGGGCUGCCUGGGCUdTsdT antis  152-171 5717 GGCAGCCCGAGCCCCGCGG 5718 GGcAGcccGAGccccGcGGdTsdT sense  152-171 5719 CCGCGGGGCUCGGGCUGCC 5720 CCGCGGGGCUCGGGCUGCCdTsdT antis  154-173 5721 CAGCCCGAGCCCCGCGGCC 5722 cAGcccGAGccccGcGGccdTsdT sense  154-173 5723 GGCCGCGGGGCUCGGGCUG 5724 GGCCGCGGGGCUCGGGCUGdTsdT antis  155-174 5725 AGCCCGAGCCCCGCGGCCU 5726 AGcccGAGccccGcGGccudTsdT sense  155-174 5727 AGGCCGCGGGGCUCGGGCU 5728 AGGCCGCGGGGCUCGGGCUdTsdT antis  156-175 5729 GCCCGAGCCCCGCGGCCUG 5730 GcccGAGccccGcGGccuGdTsdT sense  156-175 5731 CAGGCCGCGGGGCUCGGGC 5732 cAGGCCGCGGGGCUCGGGCdTsdT antis  159-178 5733 CGAGCCCCGCGGCCUGGGC 5734 cGAGccccGcGGccuGGGcdTsdT sense  159-178 5735 GCCCAGGCCGCGGGGCUCG 5736 GCCcAGGCCGCGGGGCUCGdTsdT antis  160-179 5737 GAGCCCCGCGGCCUGGGCC 5738 GAGccccGcGGccuGGGccdTsdT sense  160-179 5739 GGCCCAGGCCGCGGGGCUC 5740 GGCCcAGGCCGCGGGGCUCdTsdT antis  161-180 5741 AGCCCCGCGGCCUGGGCCU 5742 AGccccGcGGccuGGGccudTsdT sense  161-180 5743 AGGCCCAGGCCGCGGGGCU 5744 AGGCCcAGGCCGCGGGGCUdTsdT antis  162-181 5745 GCCCCGCGGCCUGGGCCUG 5746 GccccGcGGccuGGGccuGdTsdT sense  162-181 5747 CAGGCCCAGGCCGCGGGGC 5748 cAGGCCcAGGCCGCGGGGCdTsdT antis  174-193 5749 GGGCCUGCGCUCGGCGCCA 5750 GGGccuGcGcucGGcGccAdTsdT sense  174-193 5751 UGGCGCCGAGCGCAGGCCC 5752 UGGCGCCGAGCGcAGGCCCdTsdT antis  210-229 5753 UCGGGAGGCGGCCCUGGGG 5754 ucGGGAGGcGGcccuGGGGdTsdT sense  210-229 5755 CCCCAGGGCCGCCUCCCGA 5756 CCCcAGGGCCGCCUCCCGAdTsdT antis  211-230 5757 CGGGAGGCGGCCCUGGGGG 5758 cGGGAGGcGGcccuGGGGGdTsdT sense  211-230 5759 CCCCCAGGGCCGCCUCCCG 5760 CCCCcAGGGCCGCCUCCCGdTsdT antis  212-231 5761 GGGAGGCGGCCCUGGGGGC 5762 GGGAGGcGGcccuGGGGGcdTsdT sense  212-231 5763 GCCCCCAGGGCCGCCUCCC 5764 GCCCCcAGGGCCGCCUCCCdTsdT antis  217-236 5765 GCGGCCCUGGGGGCUCGGG 5766 GcGGcccuGGGGGcucGGGdTsdT sense  217-236 5767 CCCGAGCCCCCAGGGCCGC 5768 CCCGAGCCCCcAGGGCCGCdTsdT antis  218-237 5769 CGGCCCUGGGGGCUCGGGC 5770 cGGcccuGGGGGcucGGGcdTsdT sense  218-237 5771 GCCCGAGCCCCCAGGGCCG 5772 GCCCGAGCCCCcAGGGCCGdTsdT antis  225-244 5773 GGGGGCUCGGGCCGGGCGC 5774 GGGGGcucGGGccGGGcGcdTsdT sense  225-244 5775 GCGCCCGGCCCGAGCCCCC 5776 GCGCCCGGCCCGAGCCCCCdTsdT antis  226-245 5777 GGGGCUCGGGCCGGGCGCG 5778 GGGGcucGGGccGGGcGcGdTsdT sense  226-245 5779 CGCGCCCGGCCCGAGCCCC 5780 CGCGCCCGGCCCGAGCCCCdTsdT antis  232-251 5781 CGGGCCGGGCGCGGACCAG 5782 cGGGccGGGcGcGGAccAGdTsdT sense  232-251 5783 CUGGUCCGCGCCCGGCCCG 5784 CUGGUCCGCGCCCGGCCCGdTsdT antis  260-279 5785 GGAGCCAGGAGGCGGAGGC 5786 GGAGccAGGAGGcGGAGGcdTsdT sense  260-279 5787 GCCUCCGCCUCCUGGCUCC 5788 GCCUCCGCCUCCUGGCUCCdTsdT antis  263-282 5789 GCCAGGAGGCGGAGGCGGA 5790 GccAGGAGGcGGAGGcGGAdTsdT sense  263-282 5791 UCCGCCUCCGCCUCCUGGC 5792 UCCGCCUCCGCCUCCUGGCdTsdT antis  264-283 5793 CCAGGAGGCGGAGGCGGAG 5794 ccAGGAGGcGGAGGcGGAGdTsdT sense  264-283 5795 CUCCGCCUCCGCCUCCUGG 5796 CUCCGCCUCCGCCUCCUGGdTsdT antis  270-289 5797 GGCGGAGGCGGAGGUGGUG 5798 GGcGGAGGcGGAGGuGGuGdTsdT sense  270-289 5799 CACCACCUCCGCCUCCGCC 5800 cACcACCUCCGCCUCCGCCdTsdT antis  280-299 5801 GAGGUGGUGGCGGCGGCCC 5802 GAGGuGGuGGcGGcGGcccdTsdT sense  280-299 5803 GGGCCGCCGCCACCACCUC 5804 GGGCCGCCGCcACcACCUCdTsdT antis  281-300 5805 AGGUGGUGGCGGCGGCCCC 5806 AGGuGGuGGcGGcGGccccdTsdT sense  281-300 5807 GGGGCCGCCGCCACCACCU 5808 GGGGCCGCCGCcACcACCUdTsdT antis  282-301 5809 GGUGGUGGCGGCGGCCCCG 5810 GGuGGuGGcGGcGGccccGdTsdT sense  282-301 5811 CGGGGCCGCCGCCACCACC 5812 CGGGGCCGCCGCcACcACCdTsdT antis  283-302 5813 GUGGUGGCGGCGGCCCCGG 5814 GuGGuGGcGGcGGccccGGdTsdT sense  283-302 5815 CCGGGGCCGCCGCCACCAC 5816 CCGGGGCCGCCGCcACcACdTsdT antis  289-308 5817 GCGGCGGCCCCGGGGGCUC 5818 GcGGcGGccccGGGGGcucdTsdT sense  289-308 5819 GAGCCCCCGGGGCCGCCGC 5820 GAGCCCCCGGGGCCGCCGCdTsdT antis  291-310 5821 GGCGGCCCCGGGGGCUCGG 5822 GGcGGccccGGGGGcucGGdTsdT sense  291-310 5823 CCGAGCCCCCGGGGCCGCC 5824 CCGAGCCCCCGGGGCCGCCdTsdT antis  296-315 5825 CCCCGGGGGCUCGGCCUCU 5826 ccccGGGGGcucGGccucudTsdT sense  296-315 5827 AGAGGCCGAGCCCCCGGGG 5828 AGAGGCCGAGCCCCCGGGGdTsdT antis  303-322 5829 GGCUCGGCCUCUGGCCCAG 5830 GGcucGGccucuGGcccAGdTsdT sense  303-322 5831 CUGGGCCAGAGGCCGAGCC 5832  CUGGGCcAGAGGCCGAGCCdTsdT antis  320-339 5833 AGGAGGCACUGGCGGCGGG 5834  AGGAGGcAcuGGcGGcGGGdTsdT sense  320-339 5835 CCCGCCGCCAGUGCCUCCU 5836  CCCGCCGCcAGUGCCUCCUdTsdT antis  382-401 5837 GCUCCGGGGGUGGCCCCAG 5838  GcuccGGGGGuGGccccAGdTsdT sense  382-401 5839 CUGGGGCCACCCCCGGAGC 5840  CUGGGGCcACCCCCGGAGCdTsdT antis  383-402 5841 CUCCGGGGGUGGCCCCAGC 5842  cuccGGGGGuGGccccAGcdTsdT sense  383-402 5843 GCUGGGGCCACCCCCGGAG 5844  GCUGGGGCcACCCCCGGAGdTsdT antis  395-414 5845 CCCCAGCGGCAGCGGCGGA 5846  ccccAGcGGcAGcGGcGGAdTsdT sense  395-414 5847 UCCGCCGCUGCCGCUGGGG 5848  UCCGCCGCUGCCGCUGGGGdTsdT antis  396-415 5849 CCCAGCGGCAGCGGCGGAG 5850  cccAGcGGcAGcGGcGGAGdTsdT sense  396-415 5851 CUCCGCCGCUGCCGCUGGG 5852  CUCCGCCGCUGCCGCUGGGdTsdT antis  397-416 5853 CCAGCGGCAGCGGCGGAGG 5854  ccAGcGGcAGcGGcGGAGGdTsdT sense  397-416 5855 CCUCCGCCGCUGCCGCUGG 5856  CCUCCGCCGCUGCCGCUGGdTsdT antis  398-417 5857 CAGCGGCAGCGGCGGAGGA 5858  cAGcGGcAGcGGcGGAGGAdTsdT sense  398-417 5859 UCCUCCGCCGCUGCCGCUG 5860  UCCUCCGCCGCUGCCGCUGdTsdT antis  400-419 5861 GCGGCAGCGGCGGAGGAGG 5862  GcGGcAGcGGcGGAGGAGGdTsdT sense  400-419 5863 CCUCCUCCGCCGCUGCCGC 5864  CCUCCUCCGCCGCUGCCGCdTsdT antis  405-424 5865 AGCGGCGGAGGAGGCAGCG 5866  AGcGGcGGAGGAGGcAGcGdTsdT sense  405-424 5867 CGCUGCCUCCUCCGCCGCU 5868  CGCUGCCUCCUCCGCCGCUdTsdT antis  406-425 5869 GCGGCGGAGGAGGCAGCGG 5870  GcGGcGGAGGAGGcAGcGGdTsdT sense  406-425 5871 CCGCUGCCUCCUCCGCCGC 5872  CCGCUGCCUCCUCCGCCGCdTsdT antis  407-426 5873 CGGCGGAGGAGGCAGCGGU 5874  cGGcGGAGGAGGcAGcGGudTsdT sense  407-426 5875 ACCGCUGCCUCCUCCGCCG 5876  ACCGCUGCCUCCUCCGCCGdTsdT antis  408-427 5877 GGCGGAGGAGGCAGCGGUG 5878  GGcGGAGGAGGcAGcGGuGdTsdT sense  408-427 5879 CACCGCUGCCUCCUCCGCC 5880  cACCGCUGCCUCCUCCGCCdTsdT antis  444-463 5881 AGCUUCCCGCCGCCGGGAG 5882  AGcuucccGccGccGGGAGdTsdT sense  444-463 5883 CUCCCGGCGGCGGGAAGCU 5884  CUCCCGGCGGCGGGAAGCUdTsdT antis  461-480 5885 AGUGAAGCUGGGCCGUGAC 5886  AGuGAAGcuGGGccGuGAcdTsdT sense  461-480 5887 GUCACGGCCCAGCUUCACU 5888  GUcACGGCCcAGCUUcACUdTsdT antis  493-512 5889 CCACAGUGGUAGCCACUGU 5890  ccAcAGuGGuAGccAcuGudTsdT sense  493-512 5891 ACAGUGGCUACCACUGUGG 5892  AcAGUGGCuACcACUGUGGdTsdT antis  513-532 5893 GGCCAAGGCCCAGAGCGUU 5894  GGccAAGGcccAGAGcGuudTsdT sense  513-532 5895 AACGCUCUGGGCCUUGGCC 5896  AACGCUCUGGGCCUUGGCCdTsdT antis  606-625 5897 GCAGAGACGAGGGAACUGG 5898  GcAGAGAcGAGGGAAcuGGdTsdT sense  606-625 5899 CCAGUUCCCUCGUCUCUGC 5900  CcAGUUCCCUCGUCUCUGCdTsdT antis  616-635 5901 GGGAACUGGUGGCCAUCAA 5902  GGGAAcuGGuGGccAucAAdTsdT sense  616-635 5903 UUGAUGGCCACCAGUUCCC 5904  UUGAUGGCcACcAGUUCCCdTsdT antis  620-639 5905 ACUGGUGGCCAUCAAGAAG 5906  AcuGGuGGccAucAAGAAGdTsdT sense  620-639 5907 CUUCUUGAUGGCCACCAGU 5908  CUUCUUGAUGGCcACcAGUdTsdT antis  621-640 5909 CUGGUGGCCAUCAAGAAGG 5910  cuGGuGGccAucAAGAAGGdTsdT sense  621-640 5911 CCUUCUUGAUGGCCACCAG 5912  CCUUCUUGAUGGCcACcAGdTsdT antis  711-730 5913 AGGCUGCGGUACUUUUUCU 5914  AGGcuGcGGuAcuuuuucudTsdT sense  711-730 5915 AGAAAAAGUACCGCAGCCU 5916  AGAAAAAGuACCGcAGCCUdTsdT antis  712-731 5917 GGCUGCGGUACUUUUUCUA 5918  GGcuGcGGuAcuuuuucuAdTsdT sense  712-731 5919 UAGAAAAAGUACCGCAGCC 5920  uAGAAAAAGuACCGcAGCCdTsdT antis  716-735 5921 GCGGUACUUUUUCUACUCC 5922 GcGGuAcuuuuucuAcuccdTsdT sense  716-735 5923 GGAGUAGAAAAAGUACCGC 5924 GGAGuAGAAAAAGuACCGCdTsdT antis  851-870 5925 CAUCAAGGUGUACAUGUAC 5926 cAucAAGGuGuAcAuGuAcdTsdT sense  851-870 5927 GUACAUGUACACCUUGAUG 5928 GuAcAUGuAcACCUUGAUGdTsdT antis  891-910 5929 UACAUCCACUCCCAAGGUG 5930 uAcAuccAcucccAAGGuGdTsdT sense  891-910 5931 CACCUUGGGAGUGGAUGUA 5932 cACCUUGGGAGUGGAUGuAdTsdT antis  948-967 5933 GACCCUGACACUGCUGUCC 5934 GAcccuGAcAcuGcuGuccdTsdT sense  948-967 5935 GGACAGCAGUGUCAGGGUC 5936 GGAcAGcAGUGUcAGGGUCdTsdT antis  951-970 5937 CCUGACACUGCUGUCCUCA 5938 ccuGAcAcuGcuGuccucAdTsdT sense  951-970 5939 UGAGGACAGCAGUGUCAGG 5940 UGAGGAcAGcAGUGUcAGGdTsdT antis  955-974 5941 ACACUGCUGUCCUCAAGCU 5942 AcAcuGcuGuccucAAGcudTsdT sense  955-974 5943 AGCUUGAGGACAGCAGUGU 5944 AGCUUGAGGAcAGcAGUGUdTsdT antis  956-975 5945 CACUGCUGUCCUCAAGCUC 5946 cAcuGcuGuccucAAGcucdTsdT sense  956-975 5947 GAGCUUGAGGACAGCAGUG 5948 GAGCUUGAGGAcAGcAGUGdTsdT antis  958-977 5949 CUGCUGUCCUCAAGCUCUG 5950 cuGcuGuccucAAGcucuGdTsdT sense  958-977 5951 CAGAGCUUGAGGACAGCAG 5952 cAGAGCUUGAGGAcAGcAGdTsdT antis  959-978 5953 UGCUGUCCUCAAGCUCUGC 5954 uGcuGuccucAAGcucuGcdTsdT sense  959-978 5955 GCAGAGCUUGAGGACAGCA 5956 GcAGAGCUUGAGGAcAGcAdTsdT antis 1028-1047 5957 CAUCUGCUCUCGGUACUAC 5958 cAucuGcucucGGuAcuAcdTsdT sense 1028-1047 5959 GUAGUACCGAGAGCAGAUG 5960 GuAGuACCGAGAGcAGAUGdTsdT antis 1052-1071 5961 UCCAGAACUCAUCUUUGGA 5962 uccAGAAcucAucuuuGGAdTsdT sense 1052-1071 5963 UCCAAAGAUGAGUUCUGGA 5964 UCcAAAGAUGAGUUCUGGAdTsdT antis 1084-1103 5965 CCUCGUCCAUCGAUGUGUG 5966 ccucGuccAucGAuGuGuGdTsdT sense 1084-1103 5967 CACACAUCGAUGGACGAGG 5968 cAcAcAUCGAUGGACGAGGdTsdT antis 1103-1122 5969 GUCGGCUGGCUGUGUACUU 5970 GucGGcuGGcuGuGuAcuudTsdT sense 1103-1122 5971 AAGUACACAGCCAGCCGAC 5972 AAGuAcAcAGCcAGCCGACdTsdT antis 1111-1130 5973 GCUGUGUACUUGCUGAGCU 5974 GcuGuGuAcuuGcuGAGcudTsdT sense 1111-1130 5975 AGCUCAGCAAGUACACAGC 5976 AGCUcAGcAAGuAcAcAGCdTsdT antis 1116-1135 5977 GUACUUGCUGAGCUACUUC 5978 GuAcuuGcuGAGcuAcuucdTsdT sense 1116-1135 5979 GAAGUAGCUCAGCAAGUAC 5980 GAAGuAGCUcAGcAAGuACdTsdT antis 1132-1151 5981 UUCUCGGCCAGCCCAUCUU 5982 uucucGGccAGcccAucuudTsdT sense 1132-1151 5983 AAGAUGGGCUGGCCGAGAA 5984 AAGAUGGGCUGGCCGAGAAdTsdT antis 1133-1152 5985 UCUCGGCCAGCCCAUCUUC 5986 ucucGGccAGcccAucuucdTsdT sense 1133-1152 5987 GAAGAUGGGCUGGCCGAGA 5988 GAAGAUGGGCUGGCCGAGAdTsdT antis 1136-1155 5989 CGGCCAGCCCAUCUUCCCU 5990 cGGccAGcccAucuucccudTsdT sense 1136-1155 5991 AGGGAAGAUGGGCUGGCCG 5992 AGGGAAGAUGGGCUGGCCGdTsdT antis 1143-1162 5993 CCCAUCUUCCCUGGGGACA 5994 cccAucuucccuGGGGAcAdTsdT sense 1143-1162 5995 UGUCCCCAGGGAAGAUGGG 5996 UGUCCCcAGGGAAGAUGGGdTsdT antis 1147-1166 5997 UCUUCCCUGGGGACAGUGG 5998 ucuucccuGGGGAcAGuGGdTsdT sense 1147-1166 5999 CCACUGUCCCCAGGGAAGA 6000 CcACUGUCCCcAGGGAAGAdTsdT antis 1152-1171 6001 CCUGGGGACAGUGGGGUGG 6002 ccuGGGGAcAGuGGGGuGGdTsdT sense 1152-1171 6003 CCACCCCACUGUCCCCAGG 6004 CcACCCcACUGUCCCcAGGdTsdT antis 1161-1180 6005 AGUGGGGUGGACCAGCUUG 6006 AGuGGGGuGGAccAGcuuGdTsdT sense 1161-1180 6007 CAAGCUGGUCCACCCCACU 6008 cAAGCUGGUCcACCCcACUdTsdT antis 1277-1296 6009 CCCUUGGACAAAGGUGUUC 6010 cccuuGGAcAAAGGuGuucdTsdT sense 1277-1296 6011 GAACACCUUUGUCCAAGGG 6012 GAAcACCUUUGUCcAAGGGdTsdT antis 1298-1317 6013 AUCUUCAAAGACACCACCU 6014 AucuucAAAGAcAccAccudTsdT sense 1298-1317 6015 AGGUGGUGUCUUUGAAGAU 6016 AGGUGGUGUCUUUGAAGAUdTsdT antis 1300-1319 6017 CUUCAAAGACACCACCUGA 6018 cuucAAAGAcAccAccuGAdTsdT sense 1300-1319 6019 UCAGGUGGUGUCUUUGAAG 6020 UcAGGUGGUGUCUUUGAAGdTsdT antis 1301-1320 6021 UUCAAAGACACCACCUGAG 6022 uucAAAGAcAccAccuGAGdTsdT sense 1301-1320 6023 CUCAGGUGGUGUCUUUGAA 6024 CUcAGGUGGUGUCUUUGAAdTsdT antis 1357-1376 6025 CAUCCUCAAGGCUCUCCCC 6026 cAuccucAAGGcucuccccdTsdT sense 1357-1376 6027 GGGGAGAGCCUUGAGGAUG 6028 GGGGAGAGCCUUGAGGAUGdTsdT antis 1390-1409 6029 CCCACAGCUUCUUCGAUGA 6030 cccAcAGcuucuucGAuGAdTsdT sense 1390-1409 6031 UCAUCGAAGAAGCUGUGGG 6032 UcAUCGAAGAAGCUGUGGGdTsdT antis 1419-1438 6033 CUCGGAGCCCAGCUCCCCA 6034 cucGGAGcccAGcuccccAdTsdT sense 1419-1438 6035 UGGGGAGCUGGGCUCCGAG 6036 UGGGGAGCUGGGCUCCGAGdTsdT antis 1421-1440 6037 CGGAGCCCAGCUCCCCAAC 6038 cGGAGcccAGcuccccAAcdTsdT sense 1421-1440 6039 GUUGGGGAGCUGGGCUCCG 6040 GUUGGGGAGCUGGGCUCCGdTsdT antis 1497-1516 6041 UCUCUCAAUGCCAUUCUCA 6042 ucucucAAuGccAuucucAdTsdT sense 1497-1516 6043 UGAGAAUGGCAUUGAGAGA 6044 UGAGAAUGGcAUUGAGAGAdTsdT antis 1500-1519 6045 CUCAAUGCCAUUCUCAUCC 6046 cucAAuGccAuucucAuccdTsdT sense 1500-1519 6047 GGAUGAGAAUGGCAUUGAG 6048 GGAUGAGAAUGGcAUUGAGdTsdT antis 1501-1520 6049 UCAAUGCCAUUCUCAUCCC 6050 ucAAuGccAuucucAucccdTsdT sense 1501-1520 6051 GGGAUGAGAAUGGCAUUGA 6052 GGGAUGAGAAUGGcAUUGAdTsdT antis 1540-1559 6053 CAGGCCCUGCUUCUCCCCU 6054 cAGGcccuGcuucuccccudTsdT sense 1540-1559 6055 AGGGGAGAAGCAGGGCCUG 6056 AGGGGAGAAGcAGGGCCUGdTsdT antis 1547-1566 6057 UGCUUCUCCCCUCACCACU 6058 uGcuucuccccucAccAcudTsdT sense 1547-1566 6059 AGUGGUGAGGGGAGAAGCA 6060 AGUGGUGAGGGGAGAAGcAdTsdT antis 1586-1605 6061 AGCUUUAACUGAAGCUCAG 6062 AGcuuuAAcuGAAGcucAGdTsdT sense 1586-1605 6063 CUGAGCUUCAGUUAAAGCU 6064 CUGAGCUUcAGUuAAAGCUdTsdT antis 1621-1640 6065 AGCCAUCUGAUGCCACAAC 6066 AGccAucuGAuGccAcAAcdTsdT sense 1621-1640 6067 GUUGUGGCAUCAGAUGGCU 6068 GUUGUGGcAUcAGAUGGCUdTsdT antis 1818-1837 6069 AGCCUAACCUCUGUGGUGG 6070 AGccuAAccucuGuGGuGGdTsdT sense 1818-1837 6071 CCACCACAGAGGUUAGGCU 6072 CcACcAcAGAGGUuAGGCUdTsdT antis 1865-1884 6073 UAGGGGAGGGGAGAAAAGG 6074 uAGGGGAGGGGAGAAAAGGdTsdT sense 1865-1884 6075 CCUUUUCUCCCCUCCCCUA 6076 CCUUUUCUCCCCUCCCCuAdTsdT antis 1866-1885 6077 AGGGGAGGGGAGAAAAGGA 6078 AGGGGAGGGGAGAAAAGGAdTsdT sense 1866-1885 6079 UCCUUUUCUCCCCUCCCCU 6080 UCCUUUUCUCCCCUCCCCUdTsdT antis 1867-1886 6081 GGGGAGGGGAGAAAAGGAA 6082 GGGGAGGGGAGAAAAGGAAdTsdT sense 1867-1886 6083 UUCCUUUUCUCCCCUCCCC 6084 UUCCUUUUCUCCCCUCCCCdTsdT antis 1868-1887 6085 GGGAGGGGAGAAAAGGAAG 6086 GGGAGGGGAGAAAAGGAAGdTsdT sense 1868-1887 6087 CUUCCUUUUCUCCCCUCCC 6088 CUUCCUUUUCUCCCCUCCCdTsdT antis 1872-1891 6089 GGGGAGAAAAGGAAGGACG 6090 GGGGAGAAAAGGAAGGAcGdTsdT sense 1872-1891 6091 CGUCCUUCCUUUUCUCCCC 6092 CGUCCUUCCUUUUCUCCCCdTsdT antis 1901-1920 6093 GUGUGAGGACCUUCUACCC 6094 GuGuGAGGAccuucuAcccdTsdT sense 1901-1920 6095 GGGUAGAAGGUCCUCACAC 6096 GGGuAGAAGGUCCUcAcACdTsdT antis 1929-1948 6097 CCUCCCCUCCCCCAGGCUA 6098 ccuccccucccccAGGcuAdTsdT sense 1929-1948 6099 UAGCCUGGGGGAGGGGAGG 6100 uAGCCUGGGGGAGGGGAGGdTsdT antis 1930-1949 6101 CUCCCCUCCCCCAGGCUAC 6102 cuccccucccccAGGcuAcdTsdT sense 1930-1949 6103 GUAGCCUGGGGGAGGGGAG 6104 GuAGCCUGGGGGAGGGGAGdTsdT antis 1947-1966 6105 ACCACUCCUUCCCUCCCCC 6106 AccAcuccuucccucccccdTsdT sense 1947-1966 6107 GGGGGAGGGAAGGAGUGGU 6108 GGGGGAGGGAAGGAGUGGUdTsdT antis 1948-1967 6109 CCACUCCUUCCCUCCCCCC 6110 ccAcuccuucccuccccccdTsdT sense 1948-1967 6111 GGGGGGAGGGAAGGAGUGG 6112 GGGGGGAGGGAAGGAGUGGdTsdT antis 1949-1968 6113 CACUCCUUCCCUCCCCCCC 6114 cAcuccuucccucccccccdTsdT sense 1949-1968 6115 GGGGGGGAGGGAAGGAGUG 6116 GGGGGGGAGGGAAGGAGUGdTsdT antis 1950-1969 6117 ACUCCUUCCCUCCCCCCCU 6118 AcuccuucccucccccccudTsdT sense 1950-1969 6119 AGGGGGGGAGGGAAGGAGU 6120 AGGGGGGGAGGGAAGGAGUdTsdT antis 1951-1970 6121 CUCCUUCCCUCCCCCCCUC 6122 cuccuucccucccccccucdTsdT sense 1951-1970 6123 GAGGGGGGGAGGGAAGGAG 6124 GAGGGGGGGAGGGAAGGAGdTsdT antis 1955-1974 6125 UUCCCUCCCCCCCUCUCCC 6126 uucccucccccccucucccdTsdT sense 1955-1974 6127 GGGAGAGGGGGGGAGGGAA 6128 GGGAGAGGGGGGGAGGGAAdTsdT antis 1956-1975 6129 UCCCUCCCCCCCUCUCCCA 6130 ucccucccccccucucccAdTsdT sense 1956-1975 6131 UGGGAGAGGGGGGGAGGGA 6132 UGGGAGAGGGGGGGAGGGAdTsdT antis 1965-1984 6133 CCCUCUCCCAGGUCCCUUG 6134 cccucucccAGGucccuuGdTsdT sense 1965-1984 6135 CAAGGGACCUGGGAGAGGG 6136 cAAGGGACCUGGGAGAGGGdTsdT antis 1971-1990 6137 CCCAGGUCCCUUGUAAAUA 6138 cccAGGucccuuGuAAAuAdTsdT sense 1971-1990 6139 UAUUUACAAGGGACCUGGG 6140 uAUUuAcAAGGGACCUGGGdTsdT antis 1988-2007 6141 UAGAACCAGCCCAGCCCAU 6142 uAGAAccAGcccAGcccAudTsdT sense 1988-2007 6143 AUGGGCUGGGCUGGUUCUA 6144 AUGGGCUGGGCUGGUUCuAdTsdT antis 2005-2024 6145 AUCUCUCGUCUUCCCUUCC 6146 AucucucGucuucccuuccdTsdT sense 2005-2024 6147 GGAAGGGAAGACGAGAGAU 6148 GGAAGGGAAGACGAGAGAUdTsdT antis 2006-2025 6149 UCUCUCGUCUUCCCUUCCC 6150 ucucucGucuucccuucccdTsdT sense 2006-2025 6151 GGGAAGGGAAGACGAGAGA 6152 GGGAAGGGAAGACGAGAGAdTsdT antis 2020-2039 6153 UUCCCUGGCCCCCUGGGUG 6154 uucccuGGcccccuGGGuGdTsdT sense 2020-2039 6155 CACCCAGGGGGCCAGGGAA 6156 cACCcAGGGGGCcAGGGAAdTsdT antis 2039-2058 6157 UAAAUAGAUUGUUAUAAUU 6158 uAAAuAGAuuGuuAuAAuudTsdT sense 2039-2058 6159 AAUUAUAACAAUCUAUUUA 6160 AAUuAuAAcAAUCuAUUuAdTsdT antis 2050-2069 6161 UUAUAAUUUUUUCUUAAAG 6162 uuAuAAuuuuuucuuAAAGdTsdT sense 2050-2069 6163 CUUUAAGAAAAAAUUAUAA 6164 CUUuAAGAAAAAAUuAuAAdTsdT antis 2052-2071 6165 AUAAUUUUUUCUUAAAGAA 6166 AuAAuuuuuucuuAAAGAAdTsdT sense 2052-2071 6167 UUCUUUAAGAAAAAAUUAU 6168 UUCUUuAAGAAAAAAUuAUdTsdT antis 2053-2072 6169 UAAUUUUUUCUUAAAGAAA 6170 uAAuuuuuucuuAAAGAAAdTsdT sense 2053-2072 6171 UUUCUUUAAGAAAAAAUUA 6172 UUUCUUuAAGAAAAAAUuAdTsdT antis 2054-2073 6173 AAUUUUUUCUUAAAGAAAA 6174 AAuuuuuucuuAAAGAAAAdTsdT sense 2054-2073 6175 UUUUCUUUAAGAAAAAAUU 6176 UUUUCUUuAAGAAAAAAUUdTsdT antis 2110-2129 6177 UACCCCUUCUUGUCCUCUG 6178 uAccccuucuuGuccucuGdTsdT sense 2110-2129 6179 CAGAGGACAAGAAGGGGUA 6180 cAGAGGAcAAGAAGGGGuAdTsdT antis 2112-2131 6181 CCCCUUCUUGUCCUCUGCU 6182 ccccuucuuGuccucuGcudTsdT sense 2112-2131 6183 AGCAGAGGACAAGAAGGGG 6184 AGcAGAGGAcAAGAAGGGGdTsdT antis 2113-2132 6185 CCCUUCUUGUCCUCUGCUC 6186 cccuucuuGuccucuGcucdTsdT sense 2113-2132 6187 GAGCAGAGGACAAGAAGGG 6188 GAGcAGAGGAcAAGAAGGGdTsdT antis 2114-2133 6189 CCUUCUUGUCCUCUGCUCC 6190 ccuucuuGuccucuGcuccdTsdT sense 2114-2133 6191 GGAGCAGAGGACAAGAAGG 6192 GGAGcAGAGGAcAAGAAGGdTsdT antis 2115-2134 6193 CUUCUUGUCCUCUGCUCCC 6194 cuucuuGuccucuGcucccdTsdT sense 2115-2134 6195 GGGAGCAGAGGACAAGAAG 6196 GGGAGcAGAGGAcAAGAAGdTsdT antis 2126-2145 6197 CUGCUCCCAAGGCUUCCUC 6198 cuGcucccAAGGcuuccucdTsdT sense 2126-2145 6199 GAGGAAGCCUUGGGAGCAG 6200 GAGGAAGCCUUGGGAGcAGdTsdT antis 2131-2150 6201 CCCAAGGCUUCCUCCCUCU 6202 cccAAGGcuuccucccucudTsdT sense 2131-2150 6203 AGAGGGAGGAAGCCUUGGG 6204 AGAGGGAGGAAGCCUUGGGdTsdT antis 2137-2156 6205 GCUUCCUCCCUCUCCCCAU 6206 GcuuccucccucuccccAudTsdT sense 2137-2156 6207 AUGGGGAGAGGGAGGAAGC 6208 AUGGGGAGAGGGAGGAAGCdTsdT antis 2138-2157 6209 CUUCCUCCCUCUCCCCAUC 6210 cuuccucccucuccccAucdTsdT sense 2138-2157 6211 GAUGGGGAGAGGGAGGAAG 6212 GAUGGGGAGAGGGAGGAAGdTsdT antis 2140-2159 6213 UCCUCCCUCUCCCCAUCCU 6214 uccucccucuccccAuccudTsdT sense 2140-2159 6215 AGGAUGGGGAGAGGGAGGA 6216 AGGAUGGGGAGAGGGAGGAdTsdT antis 2141-2160 6217 CCUCCCUCUCCCCAUCCUG 6218 ccucccucuccccAuccuGdTsdT sense 2141-2160 6219 CAGGAUGGGGAGAGGGAGG 6220 cAGGAUGGGGAGAGGGAGGdTsdT antis 2145-2164 6221 CCUCUCCCCAUCCUGGAAG 6222 ccucuccccAuccuGGAAGdTsdT sense 2145-2164 6223 CUUCCAGGAUGGGGAGAGG 6224 CUUCcAGGAUGGGGAGAGGdTsdT antis 2153-2172 6225 CAUCCUGGAAGGAGGGGAG 6226 cAuccuGGAAGGAGGGGAGdTsdT sense 2153-2172 6227 CUCCCCUCCUUCCAGGAUG 6228 CUCCCCUCCUUCcAGGAUGdTsdT antis 2172-2191 6229 UAGAGAGAGUCCCUGGUGU 6230 uAGAGAGAGucccuGGuGudTsdT sense 2172-2191 6231 ACACCAGGGACUCUCUCUA 6232 AcACcAGGGACUCUCUCuAdTsdT antis 2186-2205 6233 GGUGUCUUAGUUUCCACAG 6234 GGuGucuuAGuuuccAcAGdTsdT sense 2186-2205 6235 CUGUGGAAACUAAGACACC 6236 CUGUGGAAACuAAGAcACCdTsdT antis 2193-2212 6237 UAGUUUCCACAGUAAGGUU 6238 uAGuuuccAcAGuAAGGuudTsdT sense 2193-2212 6239 AACCUUACUGUGGAAACUA 6240 AACCUuACUGUGGAAACuAdTsdT antis 2240-2259 6241 AUUAUUGGCAUGAAACCCU 6242 AuuAuuGGcAuGAAAcccudTsdT sense 2240-2259 6243 AGGGUUUCAUGCCAAUAAU 6244 AGGGUUUcAUGCcAAuAAUdTsdT antis   62-81 6245 CUGGGCCGGAGCCGGAGCC 6246 cuGGGccGGAGccGGAGccdTsdT sense   62-81 6247 GGCUCCGGCUCCGGCCCAG 6248 GGCUCCGGCUCCGGCCcAGdTsdT antis  120-139 6249 GCGGCGGCAGAGGCAGCGG 6250 GcGGcGGcAGAGGcAGcGGdTsdT sense  120-139 6251 CCGCUGCCUCUGCCGCCGC 6252 CCGCUGCCUCUGCCGCCGCdTsdT antis  121-140 6253 CGGCGGCAGAGGCAGCGGC 6254 cGGcGGcAGAGGcAGcGGcdTsdT sense  121-140 6255 GCCGCUGCCUCUGCCGCCG 6256 GCCGCUGCCUCUGCCGCCGdTsdT antis  127-146 6257 CAGAGGCAGCGGCGGGGGC 6258 cAGAGGcAGcGGcGGGGGcdTsdT sense  127-146 6259 GCCCCCGCCGCUGCCUCUG 6260 GCCCCCGCCGCUGCCUCUGdTsdT antis  142-161 6261 GGGCAGCCCAGGCAGCCCG 6262 GGGcAGcccAGGcAGcccGdTsdT sense  142-161 6263 CGGGCUGCCUGGGCUGCCC 6264 CGGGCUGCCUGGGCUGCCCdTsdT antis  267-286 6265 GGAGGCGGAGGCGGAGGUG 6266 GGAGGcGGAGGcGGAGGuGdTsdT sense  267-286 6267 CACCUCCGCCUCCGCCUCC 6268 cACCUCCGCCUCCGCCUCCdTsdT antis  268-287 6269 GAGGCGGAGGCGGAGGUGG 6270 GAGGcGGAGGcGGAGGuGGdTsdT sense  268-287 6271 CCACCUCCGCCUCCGCCUC 6272 CcACCUCCGCCUCCGCCUCdTsdT antis  271-290 6273 GCGGAGGCGGAGGUGGUGG 6274 GcGGAGGcGGAGGuGGuGGdTsdT sense  271-290 6275 CCACCACCUCCGCCUCCGC 6276 CcACcACCUCCGCCUCCGCdTsdT antis  284-303 6277 UGGUGGCGGCGGCCCCGGG 6278 uGGuGGcGGcGGccccGGGdTsdT sense  284-303 6279 CCCGGGGCCGCCGCCACCA 6280 CCCGGGGCCGCCGCcACcAdTsdT antis  591-610 6281 UACCAGGCACGGCUGGCAG 6282 uAccAGGcAcGGcuGGcAGdTsdT sense  591-610 6283 CUGCCAGCCGUGCCUGGUA 6284 CUGCcAGCCGUGCCUGGuAdTsdT antis 1131-1150 6285 CUUCUCGGCCAGCCCAUCU 6286 cuucucGGccAGcccAucudTsdT sense 1131-1150 6287 AGAUGGGCUGGCCGAGAAG 6288 AGAUGGGCUGGCCGAGAAGdTsdT antis 1299-1318 6289 UCUUCAAAGACACCACCUG 6290 ucuucAAAGAcAccAccuGdTsdT sense 1299-1318 6291 CAGGUGGUGUCUUUGAAGA 6292 cAGGUGGUGUCUUUGAAGAdTsdT antis 1558-1577 6293 UCACCACUUCCUACAACCC 6294 ucAccAcuuccuAcAAcccdTsdT sense 1558-1577 6295 GGGUUGUAGGAAGUGGUGA 6296 GGGUUGuAGGAAGUGGUGAdTsdT antis 1927-1946 6297 CCCCUCCCCUCCCCCAGGC 6298 ccccuccccucccccAGGcdTsdT sense 1927-1946 6299 GCCUGGGGGAGGGGAGGGG 6300 GCCUGGGGGAGGGGAGGGGdTsdT antis 1928-1947 6301 CCCUCCCCUCCCCCAGGCU 6302 cccuccccucccccAGGcudTsdT sense 1928-1947 6303 AGCCUGGGGGAGGGGAGGG 6304 AGCCUGGGGGAGGGGAGGGdTsdT antis 2111-2130 6305 ACCCCUUCUUGUCCUCUGC 6306 AccccuucuuGuccucuGcdTsdT sense 2111-2130 6307 GCAGAGGACAAGAAGGGGU 6308 GcAGAGGAcAAGAAGGGGUdTsdT antis 2142-2161 6309 CUCCCUCUCCCCAUCCUGG 6310 cucccucuccccAuccuGGdTsdT sense 2142-2161 6311 CCAGGAUGGGGAGAGGGAG 6312 CcAGGAUGGGGAGAGGGAGdTsdT antis 2144-2163 6313 CCCUCUCCCCAUCCUGGAA 6314 cccucuccccAuccuGGAAdTsdT sense 2144-2163 6315 UUCCAGGAUGGGGAGAGGG 6316 UUCcAGGAUGGGGAGAGGGdTsdT antis 1671-1690 6317 CACCGACUACCCCUCCACG 6318 cAccGAcuAccccuccAcGdTsdT sense 1671-1690 6319 CGUGGAGGGGUAGUCGGUG 6320 CGUGGAGGGGuAGUCGGUGdTsdT antis 1673-1692 6321 CCGACUACCCCUCCACGUC 6322 ccGAcuAccccuccAcGucdTsdT sense 1673-1692 6323 GACGUGGAGGGGUAGUCGG 6324 GACGUGGAGGGGuAGUCGGdTsdT antis 1036-1055 6325 CUCGGUACUACCGUGCUCC 6326 cucGGuAcuAccGuGcuccdTsdT sense 1036-1055 6327 GGAGCACGGUAGUACCGAG 6328 GGAGcACGGuAGuACCGAGdTsdT antis 1035-1054 6329 UCUCGGUACUACCGUGCUC 6330 ucucGGuAcuAccGuGcucdTsdT sense 1035-1054 6331 GAGCACGGUAGUACCGAGA 6332 GAGcACGGuAGuACCGAGAdTsdT antis 1042-1061 6333 ACUACCGUGCUCCAGAACU 6334 AcuAccGuGcuccAGAAcudTsdT sense 1042-1061 6335 AGUUCUGGAGCACGGUAGU 6336 AGUUCUGGAGcACGGuAGUdTsdT antis 1674-1693 6337 CGACUACCCCUCCACGUCC 6338 cGAcuAccccuccAcGuccdTsdT sense 1674-1693 6339 GGACGUGGAGGGGUAGUCG 6340 GGACGUGGAGGGGuAGUCGdTsdT antis 1787-1806 6341 AACUACCCCCAGCAUCUAG 6342 AAcuAcccccAGcAucuAGdTsdT sense 1787-1806 6343 CUAGAUGCUGGGGGUAGUU 6344 CuAGAUGCUGGGGGuAGUUdTsdT antis 1034-1053 6345 CUCUCGGUACUACCGUGCU 6346 cucucGGuAcuAccGuGcudTsdT sense 1034-1053 6347 AGCACGGUAGUACCGAGAG 6348 AGcACGGuAGuACCGAGAGdTsdT antis 1202-1221 6349 AACGCCAACCAGGGAACAA 6350 AAcGccAAccAGGGAAcAAdTsdT sense 1202-1221 6351 UUGUUCCCUGGUUGGCGUU 6352 UUGUUCCCUGGUUGGCGUUdTsdT antis  776-795 6353 GGAGUAUGUGCCCGAGACG 6354 GGAGuAuGuGcccGAGAcGdTsdT sense  776-795 6355 CGUCUCGGGCACAUACUCC 6356 CGUCUCGGGcAcAuACUCCdTsdT antis  779-798 6357 GUAUGUGCCCGAGACGGUG 6358 GuAuGuGcccGAGAcGGuGdTsdT sense  779-798 6359 CACCGUCUCGGGCACAUAC 6360 cACCGUCUCGGGcAcAuACdTsdT antis  780-799 6361 UAUGUGCCCGAGACGGUGU 6362 uAuGuGcccGAGAcGGuGudTsdT sense  780-799 6363 ACACCGUCUCGGGCACAUA 6364 AcACCGUCUCGGGcAcAuAdTsdT antis  973-992 6365 UCUGCGAUUUUGGCAGUGC 6366 ucuGcGAuuuuGGcAGuGcdTsdT sense  973-992 6367 GCACUGCCAAAAUCGCAGA 6368 GcACUGCcAAAAUCGcAGAdTsdT antis 1038-1057 6369 CGGUACUACCGUGCUCCAG 6370 cGGuAcuAccGuGcuccAGdTsdT sense 1038-1057 6371 CUGGAGCACGGUAGUACCG 6372 CUGGAGcACGGuAGuACCGdTsdT antis 1041-1060 6373 UACUACCGUGCUCCAGAAC 6374 uAcuAccGuGcuccAGAAcdTsdT sense 1041-1060 6375 GUUCUGGAGCACGGUAGUA 6376 GUUCUGGAGcACGGuAGuAdTsdT antis 1043-1062 6377 CUACCGUGCUCCAGAACUC 6378 cuAccGuGcuccAGAAcucdTsdT sense 1043-1062 6379 GAGUUCUGGAGCACGGUAG 6380 GAGUUCUGGAGcACGGuAGdTsdT antis 1189-1208 6381 UCAAGGUACUAGGAACGCC 6382 ucAAGGuAcuAGGAAcGccdTsdT sense 1189-1208 6383 GGCGUUCCUAGUACCUUGA 6384 GGCGUUCCuAGuACCUUGAdTsdT antis 1190-1209 6385 CAAGGUACUAGGAACGCCA 6386 cAAGGuAcuAGGAAcGccAdTsdT sense 1190-1209 6387 UGGCGUUCCUAGUACCUUG 6388 UGGCGUUCCuAGuACCUUGdTsdT antis 1191-1210 6389 AAGGUACUAGGAACGCCAA 6390 AAGGuAcuAGGAAcGccAAdTsdT sense 1191-1210 6391 UUGGCGUUCCUAGUACCUU 6392 UUGGCGUUCCuAGuACCUUdTsdT antis 1192-1211 6393 AGGUACUAGGAACGCCAAC 6394 AGGuAcuAGGAAcGccAAcdTsdT sense 1192-1211 6395 GUUGGCGUUCCUAGUACCU 6396 GUUGGCGUUCCuAGuACCUdTsdT antis 1197-1216 6397 CUAGGAACGCCAACCAGGG 6398 cuAGGAAcGccAAccAGGGdTsdT sense 1197-1216 6399 CCCUGGUUGGCGUUCCUAG 6400 CCCUGGUUGGCGUUCCuAGdTsdT antis 1203-1222 6401 ACGCCAACCAGGGAACAAA 6402 AcGccAAccAGGGAAcAAAdTsdT sense 1203-1222 6403 UUUGUUCCCUGGUUGGCGU 6404 UUUGUUCCCUGGUUGGCGUdTsdT antis 1670-1689 6405 CCACCGACUACCCCUCCAC 6406 ccAccGAcuAccccuccAcdTsdT sense 1670-1689 6407 GUGGAGGGGUAGUCGGUGG 6408 GUGGAGGGGuAGUCGGUGGdTsdT antis 1672-1691 6409 ACCGACUACCCCUCCACGU 6410 AccGAcuAccccuccAcGudTsdT sense 1672-1691 6411 ACGUGGAGGGGUAGUCGGU 6412 ACGUGGAGGGGuAGUCGGUdTsdT antis 1780-1799 6413 GUAAAUGAACUACCCCCAG 6414 GuAAAuGAAcuAcccccAGdTsdT sense 1780-1799 6415 CUGGGGGUAGUUCAUUUAC 6416 CUGGGGGuAGUUcAUUuACdTsdT antis 1786-1805 6417 GAACUACCCCCAGCAUCUA 6418 GAAcuAcccccAGcAucuAdTsdT sense 1786-1805 6419 UAGAUGCUGGGGGUAGUUC 6420 uAGAUGCUGGGGGuAGUUCdTsdT antis  352-371 6421 GGGCUAUGGGUGGGGGCGU 6422 GGGcuAuGGGuGGGGGcGudTsdT sense  352-371 6423 ACGCCCCCACCCAUAGCCC 6424 ACGCCCCcACCcAuAGCCCdTsdT antis  354-373 6425 GCUAUGGGUGGGGGCGUGG 6426 GcuAuGGGuGGGGGcGuGGdTsdT sense  354-373 6427 CCACGCCCCCACCCAUAGC 6428 CcACGCCCCcACCcAuAGCdTsdT antis  521-540 6429 CCCAGAGCGUUCCCAAGAA 6430 cccAGAGcGuucccAAGAAdTsdT sense  521-540 6431 UUCUUGGGAACGCUCUGGG 6432 UUCUUGGGAACGCUCUGGGdTsdT antis  523-542 6433 CAGAGCGUUCCCAAGAAGU 6434 cAGAGcGuucccAAGAAGudTsdT sense  523-542 6435 ACUUCUUGGGAACGCUCUG 6436 ACUUCUUGGGAACGCUCUGdTsdT antis  524-543 6437 AGAGCGUUCCCAAGAAGUG 6438 AGAGcGuucccAAGAAGuGdTsdT sense  524-543 6439 CACUUCUUGGGAACGCUCU 6440 cACUUCUUGGGAACGCUCUdTsdT antis  527-546 6441 GCGUUCCCAAGAAGUGGCU 6442 GcGuucccAAGAAGuGGcudTsdT sense  527-546 6443 AGCCACUUCUUGGGAACGC 6444 AGCcACUUCUUGGGAACGCdTsdT antis  550-569 6445 CUGACAUCAAAGUGAUUGG 6446 cuGAcAucAAAGuGAuuGGdTsdT sense  550-569 6447 CCAAUCACUUUGAUGUCAG 6448 CcAAUcACUUUGAUGUcAGdTsdT antis  568-587 6449 GUAAUGGCUCAUUCGGAGU 6450 GuAAuGGcucAuucGGAGudTsdT sense  568-587 6451 ACUCCGAAUGAGCCAUUAC 6452 ACUCCGAAUGAGCcAUuACdTsdT antis  569-588 6453 UAAUGGCUCAUUCGGAGUA 6454 uAAuGGcucAuucGGAGuAdTsdT sense  569-588 6455 UACUCCGAAUGAGCCAUUA 6456 uACUCCGAAUGAGCcAUuAdTsdT antis  570-589 6457 AAUGGCUCAUUCGGAGUAG 6458 AAuGGcucAuucGGAGuAGdTsdT sense  570-589 6459 CUACUCCGAAUGAGCCAUU 6460 CuACUCCGAAUGAGCcAUUdTsdT antis  572-591 6461 UGGCUCAUUCGGAGUAGUA 6462 uGGcucAuucGGAGuAGuAdTsdT sense  572-591 6463 UACUACUCCGAAUGAGCCA 6464 uACuACUCCGAAUGAGCcAdTsdT antis  626-645 6465 GGCCAUCAAGAAGGUUCUU 6466 GGccAucAAGAAGGuucuudTsdT sense  626-645 6467 AAGAACCUUCUUGAUGGCC 6468 AAGAACCUUCUUGAUGGCCdTsdT antis  688-707 6469 AGCUGGACCACUGCAAUAU 6470 AGcuGGAccAcuGcAAuAudTsdT sense  688-707 6471 AUAUUGCAGUGGUCCAGCU 6472 AuAUUGcAGUGGUCcAGCUdTsdT antis  693-712 6473 GACCACUGCAAUAUUGUGA 6474 GAccAcuGcAAuAuuGuGAdTsdT sense  693-712 6475 UCACAAUAUUGCAGUGGUC 6476 UcAcAAuAUUGcAGUGGUCdTsdT antis  697-716 6477 ACUGCAAUAUUGUGAGGCU 6478 AcuGcAAuAuuGuGAGGcudTsdT sense  697-716 6479 AGCCUCACAAUAUUGCAGU 6480 AGCCUcAcAAuAUUGcAGUdTsdT antis  724-743 6481 UUUUCUACUCCAGUGGGGA 6482 uuuucuAcuccAGuGGGGAdTsdT sense  724-743 6483 UCCCCACUGGAGUAGAAAA 6484 UCCCcACUGGAGuAGAAAAdTsdT antis  725-744 6485 UUUCUACUCCAGUGGGGAG 6486 uuucuAcuccAGuGGGGAGdTsdT sense  725-744 6487 CUCCCCACUGGAGUAGAAA 6488 CUCCCcACUGGAGuAGAAAdTsdT antis  726-745 6489 UUCUACUCCAGUGGGGAGA 6490 uucuAcuccAGuGGGGAGAdTsdT sense  726-745 6491 UCUCCCCACUGGAGUAGAA 6492 UCUCCCcACUGGAGuAGAAdTsdT antis  727-746 6493 UCUACUCCAGUGGGGAGAA 6494 ucuAcuccAGuGGGGAGAAdTsdT sense  727-746 6495 UUCUCCCCACUGGAGUAGA 6496 UUCUCCCcACUGGAGuAGAdTsdT antis  757-776 6497 UGUAUUUGAAUCUGGUGCU 6498 uGuAuuuGAAucuGGuGcudTsdT sense  757-776 6499 AGCACCAGAUUCAAAUACA 6500 AGcACcAGAUUcAAAuAcAdTsdT antis  759-778 6501 UAUUUGAAUCUGGUGCUGG 6502 uAuuuGAAucuGGuGcuGGdTsdT sense  759-778 6503 CCAGCACCAGAUUCAAAUA 6504 CcAGcACcAGAUUcAAAuAdTsdT antis  760-779 6505 AUUUGAAUCUGGUGCUGGA 6506 AuuuGAAucuGGuGcuGGAdTsdT sense  760-779 6507 UCCAGCACCAGAUUCAAAU 6508 UCcAGcACcAGAUUcAAAUdTsdT antis  762-781 6509 UUGAAUCUGGUGCUGGAGU 6510 uuGAAucuGGuGcuGGAGudTsdT sense  762-781 6511 ACUCCAGCACCAGAUUCAA 6512 ACUCcAGcACcAGAUUcAAdTsdT antis  763-782 6513 UGAAUCUGGUGCUGGAGUA 6514 uGAAucuGGuGcuGGAGuAdTsdT sense  763-782 6515 UACUCCAGCACCAGAUUCA 6516 uACUCcAGcACcAGAUUcAdTsdT antis  775-794 6517 UGGAGUAUGUGCCCGAGAC 6518 uGGAGuAuGuGcccGAGAcdTsdT sense  775-794 6519 GUCUCGGGCACAUACUCCA 6520 GUCUCGGGcAcAuACUCcAdTsdT antis  778-797 6521 AGUAUGUGCCCGAGACGGU 6522 AGuAuGuGcccGAGAcGGudTsdT sense  778-797 6523 ACCGUCUCGGGCACAUACU 6524 ACCGUCUCGGGcAcAuACUdTsdT antis  854-873 6525 CAAGGUGUACAUGUACCAG 6526 cAAGGuGuAcAuGuAccAGdTsdT sense  854-873 6527 CUGGUACAUGUACACCUUG 6528 CUGGuAcAUGuAcACCUUGdTsdT antis  855-874 6529 AAGGUGUACAUGUACCAGC 6530 AAGGuGuAcAuGuAccAGcdTsdT sense  855-874 6531 GCUGGUACAUGUACACCUU 6532 GCUGGuAcAUGuAcACCUUdTsdT antis  856-875 6533 AGGUGUACAUGUACCAGCU 6534 AGGuGuAcAuGuAccAGcudTsdT sense  856-875 6535 AGCUGGUACAUGUACACCU 6536 AGCUGGuAcAUGuAcACCUdTsdT antis  857-876 6537 GGUGUACAUGUACCAGCUC 6538 GGuGuAcAuGuAccAGcucdTsdT sense  857-876 6539 GAGCUGGUACAUGUACACC 6540 GAGCUGGuAcAUGuAcACCdTsdT antis  915-934 6541 CACCGUGACAUCAAGCCCC 6542 cAccGuGAcAucAAGccccdTsdT sense  915-934 6543 GGGGCUUGAUGUCACGGUG 6544 GGGGCUUGAUGUcACGGUGdTsdT antis  938-957 6545 UUUGCUUGUGGACCCUGAC 6546 uuuGcuuGuGGAcccuGAcdTsdT sense  938-957 6547 GUCAGGGUCCACAAGCAAA 6548 GUcAGGGUCcAcAAGcAAAdTsdT antis  945-964 6549 GUGGACCCUGACACUGCUG 6550 GuGGAcccuGAcAcuGcuGdTsdT sense  945-964 6551 CAGCAGUGUCAGGGUCCAC 6552 cAGcAGUGUcAGGGUCcACdTsdT antis  971-990 6553 GCUCUGCGAUUUUGGCAGU 6554 GcucuGcGAuuuuGGcAGudTsdT sense  971-990 6555 ACUGCCAAAAUCGCAGAGC 6556 ACUGCcAAAAUCGcAGAGCdTsdT antis  972-991 6557 CUCUGCGAUUUUGGCAGUG 6558 cucuGcGAuuuuGGcAGuGdTsdT sense  972-991 6559 CACUGCCAAAAUCGCAGAG 6560 cACUGCcAAAAUCGcAGAGdTsdT antis  975-994 6561 UGCGAUUUUGGCAGUGCAA 6562 uGcGAuuuuGGcAGuGcAAdTsdT sense  975-994 6563 UUGCACUGCCAAAAUCGCA 6564 UUGcACUGCcAAAAUCGcAdTsdT antis  979-998 6565 AUUUUGGCAGUGCAAAGCA 6566 AuuuuGGcAGuGcAAAGcAdTsdT sense  979-998 6567 UGCUUUGCACUGCCAAAAU 6568 UGCUUUGcACUGCcAAAAUdTsdT antis 1037-1056 6569 UCGGUACUACCGUGCUCCA 6570 ucGGuAcuAccGuGcuccAdTsdT sense 1037-1056 6571 UGGAGCACGGUAGUACCGA 6572 UGGAGcACGGuAGuACCGAdTsdT antis 1040-1059 6573 GUACUACCGUGCUCCAGAA 6574 GuAcuAccGuGcuccAGAAdTsdT sense 1040-1059 6575 UUCUGGAGCACGGUAGUAC 6576 UUCUGGAGcACGGuAGuACdTsdT antis 1169-1188 6577 GGACCAGCUUGUGGAGAUC 6578 GGAccAGcuuGuGGAGAucdTsdT sense 1169-1188 6579 GAUCUCCACAAGCUGGUCC 6580 GAUCUCcAcAAGCUGGUCCdTsdT antis 1174-1193 6581 AGCUUGUGGAGAUCAUCAA 6582 AGcuuGuGGAGAucAucAAdTsdT sense 1174-1193 6583 UUGAUGAUCUCCACAAGCU 6584 UUGAUGAUCUCcAcAAGCUdTsdT antis 1178-1197 6585 UGUGGAGAUCAUCAAGGUA 6586 uGuGGAGAucAucAAGGuAdTsdT sense 1178-1197 6587 UACCUUGAUGAUCUCCACA 6588 uACCUUGAUGAUCUCcAcAdTsdT antis 1183-1202 6589 AGAUCAUCAAGGUACUAGG 6590 AGAucAucAAGGuAcuAGGdTsdT sense 1183-1202 6591 CCUAGUACCUUGAUGAUCU 6592 CCuAGuACCUUGAUGAUCUdTsdT antis 1193-1212 6593 GGUACUAGGAACGCCAACC 6594 GGuAcuAGGAAcGccAAccdTsdT sense 1193-1212 6595 GGUUGGCGUUCCUAGUACC 6596 GGUUGGCGUUCCuAGuACCdTsdT antis 1194-1213 6597 GUACUAGGAACGCCAACCA 6598 GuAcuAGGAAcGccAAccAdTsdT sense 1194-1213 6599 UGGUUGGCGUUCCUAGUAC 6600 UGGUUGGCGUUCCuAGuACdTsdT antis 1195-1214 6601 UACUAGGAACGCCAACCAG 6602 uAcuAGGAAcGccAAccAGdTsdT sense 1195-1214 6603 CUGGUUGGCGUUCCUAGUA 6604 CUGGUUGGCGUUCCuAGuAdTsdT antis 1198-1217 6605 UAGGAACGCCAACCAGGGA 6606 uAGGAAcGccAAccAGGGAdTsdT sense 1198-1217 6607 UCCCUGGUUGGCGUUCCUA 6608 UCCCUGGUUGGCGUUCCuAdTsdT antis 1199-1218 6609 AGGAACGCCAACCAGGGAA 6610 AGGAAcGccAAccAGGGAAdTsdT sense 1199-1218 6611 UUCCCUGGUUGGCGUUCCU 6612 UUCCCUGGUUGGCGUUCCUdTsdT antis 1200-1219 6613 GGAACGCCAACCAGGGAAC 6614 GGAAcGccAAccAGGGAAcdTsdT sense 1200-1219 6615 GUUCCCUGGUUGGCGUUCC 6616 GUUCCCUGGUUGGCGUUCCdTsdT antis 1201-1220 6617 GAACGCCAACCAGGGAACA 6618 GAAcGccAAccAGGGAAcAdTsdT sense 1201-1220 6619 UGUUCCCUGGUUGGCGUUC 6620 UGUUCCCUGGUUGGCGUUCdTsdT antis 1206-1225 6621 CCAACCAGGGAACAAAUCC 6622 ccAAccAGGGAAcAAAuccdTsdT sense 1206-1225 6623 GGAUUUGUUCCCUGGUUGG 6624 GGAUUUGUUCCCUGGUUGGdTsdT antis 1208-1227 6625 AACCAGGGAACAAAUCCGA 6626 AAccAGGGAAcAAAuccGAdTsdT sense 1208-1227 6627 UCGGAUUUGUUCCCUGGUU 6628 UCGGAUUUGUUCCCUGGUUdTsdT antis 1218-1237 6629 CAAAUCCGAGAGAUGAACC 6630 cAAAuccGAGAGAuGAAccdTsdT sense 1218-1237 6631 GGUUCAUCUCUCGGAUUUG 6632 GGUUcAUCUCUCGGAUUUGdTsdT antis 1220-1239 6633 AAUCCGAGAGAUGAACCCU 6634 AAuccGAGAGAuGAAcccudTsdT sense 1220-1239 6635 AGGGUUCAUCUCUCGGAUU 6636 AGGGUUcAUCUCUCGGAUUdTsdT antis 1221-1240 6637 AUCCGAGAGAUGAACCCUA 6638 AuccGAGAGAuGAAcccuAdTsdT sense 1221-1240 6639 UAGGGUUCAUCUCUCGGAU 6640 uAGGGUUcAUCUCUCGGAUdTsdT antis 1453-1472 6641 CCCCCCUGUUCAACUUCAG 6642 ccccccuGuucAAcuucAGdTsdT sense 1453-1472 6643 CUGAAGUUGAACAGGGGGG 6644 CUGAAGUUGAAcAGGGGGGdTsdT antis 1675-1694 6645 GACUACCCCUCCACGUCCA 6646 GAcuAccccuccAcGuccAdTsdT sense 1675-1694 6647 UGGACGUGGAGGGGUAGUC 6648 UGGACGUGGAGGGGuAGUCdTsdT antis 1676-1695 6649 ACUACCCCUCCACGUCCAU 6650 AcuAccccuccAcGuccAudTsdT sense 1676-1695 6651 AUGGACGUGGAGGGGUAGU 6652 AUGGACGUGGAGGGGuAGUdTsdT antis 1677-1696 6653 CUACCCCUCCACGUCCAUC 6654 cuAccccuccAcGuccAucdTsdT sense 1677-1696 6655 GAUGGACGUGGAGGGGUAG 6656 GAUGGACGUGGAGGGGuAGdTsdT antis 1703-1722 6657 GCCCAAGUGGCGCUGGGAA 6658 GcccAAGuGGcGcuGGGAAdTsdT sense 1703-1722 6659 UUCCCAGCGCCACUUGGGC 6660 UUCCcAGCGCcACUUGGGCdTsdT antis 1706-1725 6661 CAAGUGGCGCUGGGAAGGG 6662 cAAGuGGcGcuGGGAAGGGdTsdT sense 1706-1725 6663 CCCUUCCCAGCGCCACUUG 6664 CCCUUCCcAGCGCcACUUGdTsdT antis 1752-1771 6665 GGCUGGGCCCCUAGACUAG 6666 GGcuGGGccccuAGAcuAGdTsdT sense 1752-1771 6667 CUAGUCUAGGGGCCCAGCC 6668 CuAGUCuAGGGGCCcAGCCdTsdT antis 1755-1774 6669 UGGGCCCCUAGACUAGAGG 6670 uGGGccccuAGAcuAGAGGdTsdT sense 1755-1774 6671 CCUCUAGUCUAGGGGCCCA 6672 CCUCuAGUCuAGGGGCCcAdTsdT antis 1758-1777 6673 GCCCCUAGACUAGAGGGCA 6674 GccccuAGAcuAGAGGGcAdTsdT sense 1758-1777 6675 UGCCCUCUAGUCUAGGGGC 6676 UGCCCUCuAGUCuAGGGGCdTsdT antis 1761-1780 6677 CCUAGACUAGAGGGCAGAG 6678 ccuAGAcuAGAGGGcAGAGdTsdT sense 1761-1780 6679 CUCUGCCCUCUAGUCUAGG 6680 CUCUGCCCUCuAGUCuAGGdTsdT antis 1765-1784 6681 GACUAGAGGGCAGAGGUAA 6682 GAcuAGAGGGcAGAGGuAAdTsdT sense 1765-1784 6683 UUACCUCUGCCCUCUAGUC 6684 UuACCUCUGCCCUCuAGUCdTsdT antis 1777-1796 6685 GAGGUAAAUGAACUACCCC 6686 GAGGuAAAuGAAcuAccccdTsdT sense 1777-1796 6687 GGGGUAGUUCAUUUACCUC 6688 GGGGuAGUUcAUUuACCUCdTsdT antis 1778-1797 6689 AGGUAAAUGAACUACCCCC 6690 AGGuAAAuGAAcuAcccccdTsdT sense 1778-1797 6691 GGGGGUAGUUCAUUUACCU 6692 GGGGGuAGUUcAUUuACCUdTsdT antis 1779-1798 6693 GGUAAAUGAACUACCCCCA 6694 GGuAAAuGAAcuAcccccAdTsdT sense 1779-1798 6695 UGGGGGUAGUUCAUUUACC 6696 UGGGGGuAGUUcAUUuACCdTsdT antis 1781-1800 6697 UAAAUGAACUACCCCCAGC 6698 uAAAuGAAcuAcccccAGcdTsdT sense 1781-1800 6699 GCUGGGGGUAGUUCAUUUA 6700 GCUGGGGGuAGUUcAUUuAdTsdT antis 1792-1811 6701 CCCCCAGCAUCUAGGCCUC 6702 cccccAGcAucuAGGccucdTsdT sense 1792-1811 6703 GAGGCCUAGAUGCUGGGGG 6704 GAGGCCuAGAUGCUGGGGGdTsdT antis 1796-1815 6705 CAGCAUCUAGGCCUCCCUC 6706 cAGcAucuAGGccucccucdTsdT sense 1796-1815 6707 GAGGGAGGCCUAGAUGCUG 6708 GAGGGAGGCCuAGAUGCUGdTsdT antis 1885-1904 6709 AGGACGGGGUUUGGGGGUG 6710 AGGAcGGGGuuuGGGGGuGdTsdT sense 1885-1904 6711 CACCCCCAAACCCCGUCCU 6712 cACCCCcAAACCCCGUCCUdTsdT antis  522-541 6713 CCAGAGCGUUCCCAAGAAG 6714 ccAGAGcGuucccAAGAAGdTsdT sense  522-541 6715 CUUCUUGGGAACGCUCUGG 6716 CUUCUUGGGAACGCUCUGGdTsdT antis  526-545 6717 AGCGUUCCCAAGAAGUGGC 6718 AGcGuucccAAGAAGuGGcdTsdT sense  526-545 6719 GCCACUUCUUGGGAACGCU 6720 GCcACUUCUUGGGAACGCUdTsdT antis  700-719 6721 GCAAUAUUGUGAGGCUGCG 6722 GcAAuAuuGuGAGGcuGcGdTsdT sense  700-719 6723 CGCAGCCUCACAAUAUUGC 6724 CGcAGCCUcAcAAuAUUGCdTsdT antis  873-892 6725 CUCUUCCGGAGCUUGGCCU 6726 cucuuccGGAGcuuGGccudTsdT sense  873-892 6727 AGGCCAAGCUCCGGAAGAG 6728 AGGCcAAGCUCCGGAAGAGdTsdT antis 1256-1275 6729 GUUCCCCCAGAUCAAAGCU 6730 GuucccccAGAucAAAGcudTsdT sense 1256-1275 6731 AGCUUUGAUCUGGGGGAAC 6732 AGCUUUGAUCUGGGGGAACdTsdT antis 1317-1336 6733 GAGGCCAUUGCACUCUGCU 6734 GAGGccAuuGcAcucuGcudTsdT sense 1317-1336 6735 AGCAGAGUGCAAUGGCCUC 6736 AGcAGAGUGcAAUGGCCUCdTsdT antis 1512-1531 6737 CUCAUCCCUCCUCACUUGA 6738 cucAucccuccucAcuuGAdTsdT sense 1512-1531 6739 UCAAGUGAGGAGGGAUGAG 6740 UcAAGUGAGGAGGGAUGAGdTsdT antis 1764-1783 6741 AGACUAGAGGGCAGAGGUA 6742 AGAcuAGAGGGcAGAGGuAdTsdT sense 1764-1783 6743 UACCUCUGCCCUCUAGUCU 6744 uACCUCUGCCCUCuAGUCUdTsdT antis  236-255 6745 CCGGGCGCGGACCAGCUCG 6746 ccGGGcGcGGAccAGcucGdTsdT sense  236-255 6747 CGAGCUGGUCCGCGCCCGG 6748 CGAGCUGGUCCGCGCCCGGdTsdT antis  914-933 6749 UCACCGUGACAUCAAGCCC 6750 ucAccGuGAcAucAAGcccdTsdT sense  914-933 6751 GGGCUUGAUGUCACGGUGA 6752 GGGCUUGAUGUcACGGUGAdTsdT antis  234-253 6753 GGCCGGGCGCGGACCAGCU 6754 GGccGGGcGcGGAccAGcudTsdT sense  234-253 6755 AGCUGGUCCGCGCCCGGCC 6756 AGCUGGUCCGCGCCCGGCCdTsdT antis  520-539 6757 GCCCAGAGCGUUCCCAAGA 6758 GcccAGAGcGuucccAAGAdTsdT sense  520-539 6759 UCUUGGGAACGCUCUGGGC 6760 UCUUGGGAACGCUCUGGGCdTsdT antis  525-544 6761 GAGCGUUCCCAAGAAGUGG 6762 GAGcGuucccAAGAAGuGGdTsdT sense  525-544 6763 CCACUUCUUGGGAACGCUC 6764 CcACUUCUUGGGAACGCUCdTsdT antis  549-568 6765 ACUGACAUCAAAGUGAUUG 6766 AcuGAcAucAAAGuGAuuGdTsdT sense  549-568 6767 CAAUCACUUUGAUGUCAGU 6768 cAAUcACUUUGAUGUcAGUdTsdT antis  555-574 6769 AUCAAAGUGAUUGGUAAUG 6770 AucAAAGuGAuuGGuAAuGdTsdT sense  555-574 6771 CAUUACCAAUCACUUUGAU 6772 cAUuACcAAUcACUUUGAUdTsdT antis  558-577 6773 AAAGUGAUUGGUAAUGGCU 6774 AAAGuGAuuGGuAAuGGcudTsdT sense  558-577 6775 AGCCAUUACCAAUCACUUU 6776 AGCcAUuACcAAUcACUUUdTsdT antis  567-586 6777 GGUAAUGGCUCAUUCGGAG 6778 GGuAAuGGcucAuucGGAGdTsdT sense  567-586 6779 CUCCGAAUGAGCCAUUACC 6780 CUCCGAAUGAGCcAUuACCdTsdT antis  571-590 6781 AUGGCUCAUUCGGAGUAGU 6782 AuGGcucAuucGGAGuAGudTsdT sense  571-590 6783 ACUACUCCGAAUGAGCCAU 6784 ACuACUCCGAAUGAGCcAUdTsdT antis  685-704 6785 GUAAGCUGGACCACUGCAA 6786 GuAAGcuGGAccAcuGcAAdTsdT sense  685-704 6787 UUGCAGUGGUCCAGCUUAC 6788 UUGcAGUGGUCcAGCUuACdTsdT antis  764-783 6789 GAAUCUGGUGCUGGAGUAU 6790 GAAucuGGuGcuGGAGuAudTsdT sense  764-783 6791 AUACUCCAGCACCAGAUUC 6792 AuACUCcAGcACcAGAUUCdTsdT antis  777-796 6793 GAGUAUGUGCCCGAGACGG 6794 GAGuAuGuGcccGAGAcGGdTsdT sense  777-796 6795 CCGUCUCGGGCACAUACUC 6796 CCGUCUCGGGcAcAuACUCdTsdT antis  783-802 6797 GUGCCCGAGACGGUGUACC 6798 GuGcccGAGAcGGuGuAccdTsdT sense  783-802 6799 GGUACACCGUCUCGGGCAC 6800 GGuAcACCGUCUCGGGcACdTsdT antis  802-821 6801 GAGUGGCCCGCCACUUCAC 6802 GAGuGGcccGccAcuucAcdTsdT sense  802-821 6803 GUGAAGUGGCGGGCCACUC 6804 GUGAAGUGGCGGGCcACUCdTsdT antis  818-837 6805 CACCAAGGCCAAGCUGAUC 6806 cAccAAGGccAAGcuGAucdTsdT sense  818-837 6807 GAUCAGCUUGGCCUUGGUG 6808 GAUcAGCUUGGCCUUGGUGdTsdT antis  852-871 6809 AUCAAGGUGUACAUGUACC 6810 AucAAGGuGuAcAuGuAccdTsdT sense  852-871 6811 GGUACAUGUACACCUUGAU 6812 GGuAcAUGuAcACCUUGAUdTsdT antis  853-872 6813 UCAAGGUGUACAUGUACCA 6814 ucAAGGuGuAcAuGuAccAdTsdT sense  853-872 6815 UGGUACAUGUACACCUUGA 6816 UGGuAcAUGuAcACCUUGAdTsdT antis  937-956 6817 AUUUGCUUGUGGACCCUGA 6818 AuuuGcuuGuGGAcccuGAdTsdT sense  937-956 6819 UCAGGGUCCACAAGCAAAU 6820 UcAGGGUCcAcAAGcAAAUdTsdT antis  942-961 6821 CUUGUGGACCCUGACACUG 6822 cuuGuGGAcccuGAcAcuGdTsdT sense  942-961 6823 CAGUGUCAGGGUCCACAAG 6824 cAGUGUcAGGGUCcAcAAGdTsdT antis  967-986 6825 UCAAGCUCUGCGAUUUUGG 6826 ucAAGcucuGcGAuuuuGGdTsdT sense  967-986 6827 CCAAAAUCGCAGAGCUUGA 6828 CcAAAAUCGcAGAGCUUGAdTsdT antis  968-987 6829 CAAGCUCUGCGAUUUUGGC 6830 cAAGcucuGcGAuuuuGGcdTsdT sense  968-987 6831 GCCAAAAUCGCAGAGCUUG 6832 GCcAAAAUCGcAGAGCUUGdTsdT antis  976-995 6833 GCGAUUUUGGCAGUGCAAA 6834 GcGAuuuuGGcAGuGcAAAdTsdT sense  976-995 6835 UUUGCACUGCCAAAAUCGC 6836 UUUGcACUGCcAAAAUCGCdTsdT antis  984-1003 6837 GGCAGUGCAAAGCAGCUGG 6838 GGcAGuGcAAAGcAGcuGGdTsdT sense  984-1003 6839 CCAGCUGCUUUGCACUGCC 6840 CcAGCUGCUUUGcACUGCCdTsdT antis 1039-1058 6841 GGUACUACCGUGCUCCAGA 6842 GGuAcuAccGuGcuccAGAdTsdT sense 1039-1058 6843 UCUGGAGCACGGUAGUACC 6844 UCUGGAGcACGGuAGuACCdTsdT antis 1044-1063 6845 UACCGUGCUCCAGAACUCA 6846 uAccGuGcuccAGAAcucAdTsdT sense 1044-1063 6847 UGAGUUCUGGAGCACGGUA 6848 UGAGUUCUGGAGcACGGuAdTsdT antis 1185-1204 6849 AUCAUCAAGGUACUAGGAA 6850 AucAucAAGGuAcuAGGAAdTsdT sense 1185-1204 6851 UUCCUAGUACCUUGAUGAU 6852 UUCCuAGuACCUUGAUGAUdTsdT antis 1188-1207 6853 AUCAAGGUACUAGGAACGC 6854 AucAAGGuAcuAGGAAcGcdTsdT sense 1188-1207 6855 GCGUUCCUAGUACCUUGAU 6856 GCGUUCCuAGuACCUUGAUdTsdT antis 1196-1215 6857 ACUAGGAACGCCAACCAGG 6858 AcuAGGAAcGccAAccAGGdTsdT sense 1196-1215 6859 CCUGGUUGGCGUUCCUAGU 6860 CCUGGUUGGCGUUCCuAGUdTsdT antis 1204-1223 6861 CGCCAACCAGGGAACAAAU 6862 cGccAAccAGGGAAcAAAudTsdT sense 1204-1223 6863 AUUUGUUCCCUGGUUGGCG 6864 AUUUGUUCCCUGGUUGGCGdTsdT antis 1213-1232 6865 GGGAACAAAUCCGAGAGAU 6866 GGGAAcAAAuccGAGAGAudTsdT sense 1213-1232 6867 AUCUCUCGGAUUUGUUCCC 6868 AUCUCUCGGAUUUGUUCCCdTsdT antis 1215-1234 6869 GAACAAAUCCGAGAGAUGA 6870 GAAcAAAuccGAGAGAuGAdTsdT sense 1215-1234 6871 UCAUCUCUCGGAUUUGUUC 6872 UcAUCUCUCGGAUUUGUUCdTsdT antis 1216-1235 6873 AACAAAUCCGAGAGAUGAA 6874 AAcAAAuccGAGAGAuGAAdTsdT sense 1216-1235 6875 UUCAUCUCUCGGAUUUGUU 6876 UUcAUCUCUCGGAUUUGUUdTsdT antis 1217-1236 6877 ACAAAUCCGAGAGAUGAAC 6878 AcAAAuccGAGAGAuGAAcdTsdT sense 1217-1236 6879 GUUCAUCUCUCGGAUUUGU 6880 GUUcAUCUCUCGGAUUUGUdTsdT antis 1429-1448 6881 AGCUCCCCAACGACCGCCC 6882 AGcuccccAAcGAccGcccdTsdT sense 1429-1448 6883 GGGCGGUCGUUGGGGAGCU 6884 GGGCGGUCGUUGGGGAGCUdTsdT antis 1430-1449 6885 GCUCCCCAACGACCGCCCG 6886 GcuccccAAcGAccGcccGdTsdT sense 1430-1449 6887 CGGGCGGUCGUUGGGGAGC 6888 CGGGCGGUCGUUGGGGAGCdTsdT antis 1580-1599 6889 CUCACAAGCUUUAACUGAA 6890 cucAcAAGcuuuAAcuGAAdTsdT sense 1580-1599 6891 UUCAGUUAAAGCUUGUGAG 6892 UUcAGUuAAAGCUUGUGAGdTsdT antis 1667-1686 6893 GCCCCACCGACUACCCCUC 6894 GccccAccGAcuAccccucdTsdT sense 1667-1686 6895 GAGGGGUAGUCGGUGGGGC 6896 GAGGGGuAGUCGGUGGGGCdTsdT antis 1669-1688 6897 CCCACCGACUACCCCUCCA 6898 cccAccGAcuAccccuccAdTsdT sense 1669-1688 6899 UGGAGGGGUAGUCGGUGGG 6900 UGGAGGGGuAGUCGGUGGGdTsdT antis 1682-1701 6901 CCUCCACGUCCAUCUGGGA 6902 ccuccAcGuccAucuGGGAdTsdT sense 1682-1701 6903 UCCCAGAUGGACGUGGAGG 6904 UCCcAGAUGGACGUGGAGGdTsdT antis 1685-1704 6905 CCACGUCCAUCUGGGAAGG 6906 ccAcGuccAucuGGGAAGGdTsdT sense 1685-1704 6907 CCUUCCCAGAUGGACGUGG 6908 CCUUCCcAGAUGGACGUGGdTsdT antis 1704-1723 6909 CCCAAGUGGCGCUGGGAAG 6910 cccAAGuGGcGcuGGGAAGdTsdT sense 1704-1723 6911 CUUCCCAGCGCCACUUGGG 6912 CUUCCcAGCGCcACUUGGGdTsdT antis 1705-1724 6913 CCAAGUGGCGCUGGGAAGG 6914 ccAAGuGGcGcuGGGAAGGdTsdT sense 1705-1724 6915 CCUUCCCAGCGCCACUUGG 6916 CCUUCCcAGCGCcACUUGGdTsdT antis 1730-1749 6917 CAGCCCAUCAAGCUCCUGC 6918 cAGcccAucAAGcuccuGcdTsdT sense 1730-1749 6919 GCAGGAGCUUGAUGGGCUG 6920 GcAGGAGCUUGAUGGGCUGdTsdT antis 1753-1772 6921 GCUGGGCCCCUAGACUAGA 6922 GcuGGGccccuAGAcuAGAdTsdT sense 1753-1772 6923 UCUAGUCUAGGGGCCCAGC 6924 UCuAGUCuAGGGGCCcAGCdTsdT antis 1759-1778 6925 CCCCUAGACUAGAGGGCAG 6926 ccccuAGAcuAGAGGGcAGdTsdT sense 1759-1778 6927 CUGCCCUCUAGUCUAGGGG 6928 CUGCCCUCuAGUCuAGGGGdTsdT antis 1760-1779 6929 CCCUAGACUAGAGGGCAGA 6930 cccuAGAcuAGAGGGcAGAdTsdT sense 1760-1779 6931 UCUGCCCUCUAGUCUAGGG 6932 UCUGCCCUCuAGUCuAGGGdTsdT antis 1763-1782 6933 UAGACUAGAGGGCAGAGGU 6934 uAGAcuAGAGGGcAGAGGudTsdT sense 1763-1782 6935 ACCUCUGCCCUCUAGUCUA 6936 ACCUCUGCCCUCuAGUCuAdTsdT antis 1773-1792 6937 GGCAGAGGUAAAUGAACUA 6938 GGcAGAGGuAAAuGAAcuAdTsdT sense 1773-1792 6939 UAGUUCAUUUACCUCUGCC 6940 uAGUUcAUUuACCUCUGCCdTsdT antis 1774-1793 6941 GCAGAGGUAAAUGAACUAC 6942 GcAGAGGuAAAuGAAcuAcdTsdT sense 1774-1793 6943 GUAGUUCAUUUACCUCUGC 6944 GuAGUUcAUUuACCUCUGCdTsdT antis 1782-1801 6945 AAAUGAACUACCCCCAGCA 6946 AAAuGAAcuAcccccAGcAdTsdT sense 1782-1801 6947 UGCUGGGGGUAGUUCAUUU 6948 UGCUGGGGGuAGUUcAUUUdTsdT antis 1784-1803 6949 AUGAACUACCCCCAGCAUC 6950 AuGAAcuAcccccAGcAucdTsdT sense 1784-1803 6951 GAUGCUGGGGGUAGUUCAU 6952 GAUGCUGGGGGuAGUUcAUdTsdT antis 1785-1804 6953 UGAACUACCCCCAGCAUCU 6954 uGAAcuAcccccAGcAucudTsdT sense 1785-1804 6955 AGAUGCUGGGGGUAGUUCA 6956 AGAUGCUGGGGGuAGUUcAdTsdT antis 1790-1809 6957 UACCCCCAGCAUCUAGGCC 6958 uAcccccAGcAucuAGGccdTsdT sense 1790-1809 6959 GGCCUAGAUGCUGGGGGUA 6960 GGCCuAGAUGCUGGGGGuAdTsdT antis 1794-1813 6961 CCCAGCAUCUAGGCCUCCC 6962 cccAGcAucuAGGccucccdTsdT sense 1794-1813 6963 GGGAGGCCUAGAUGCUGGG 6964 GGGAGGCCuAGAUGCUGGGdTsdT antis 1795-1814 6965 CCAGCAUCUAGGCCUCCCU 6966 ccAGcAucuAGGccucccudTsdT sense 1795-1814 6967 AGGGAGGCCUAGAUGCUGG 6968 AGGGAGGCCuAGAUGCUGGdTsdT antis 1882-1901 6969 GGAAGGACGGGGUUUGGGG 6970 GGAAGGAcGGGGuuuGGGGdTsdT sense 1882-1901 6971 CCCCAAACCCCGUCCUUCC 6972 CCCcAAACCCCGUCCUUCCdTsdT antis 1883-1902 6973 GAAGGACGGGGUUUGGGGG 6974 GAAGGAcGGGGuuuGGGGGdTsdT sense 1883-1902 6975 CCCCCAAACCCCGUCCUUC 6976 CCCCcAAACCCCGUCCUUCdTsdT antis 1913-1932 6977 UCUACCCCCUUGGUCCCCU 6978 ucuAcccccuuGGuccccudTsdT sense 1913-1932 6979 AGGGGACCAAGGGGGUAGA 6980 AGGGGACcAAGGGGGuAGAdTsdT antis   68-87 6981 CGGAGCCGGAGCCCGAACG 6982 cGGAGccGGAGcccGAAcGdTsdT sense   68-87 6983 CGUUCGGGCUCCGGCUCCG 6984 CGUUCGGGCUCCGGCUCCGdTsdT antis  117-136 6985 GAGGCGGCGGCAGAGGCAG 6986 GAGGcGGcGGcAGAGGcAGdTsdT sense  117-136 6987 CUGCCUCUGCCGCCGCCUC 6988 CUGCCUCUGCCGCCGCCUCdTsdT antis  188-207 6989 CGCCAUGAGCGGCGGCGGG 6990 cGccAuGAGcGGcGGcGGGdTsdT sense  188-207 6991 CCCGCCGCCGCUCAUGGCG 6992 CCCGCCGCCGCUcAUGGCGdTsdT antis  219-238 6993 GGCCCUGGGGGCUCGGGCC 6994 GGcccuGGGGGcucGGGccdTsdT sense  219-238 6995 GGCCCGAGCCCCCAGGGCC 6996 GGCCCGAGCCCCcAGGGCCdTsdT antis  220-239 6997 GCCCUGGGGGCUCGGGCCG 6998 GcccuGGGGGcucGGGccGdTsdT sense  220-239 6999 CGGCCCGAGCCCCCAGGGC 7000 CGGCCCGAGCCCCcAGGGCdTsdT antis  233-252 7001 GGGCCGGGCGCGGACCAGC 7002 GGGccGGGcGcGGAccAGcdTsdT sense  233-252 7003 GCUGGUCCGCGCCCGGCCC 7004 GCUGGUCCGCGCCCGGCCCdTsdT antis  237-256 7005 CGGGCGCGGACCAGCUCGU 7006 cGGGcGcGGAccAGcucGudTsdT sense  237-256 7007 ACGAGCUGGUCCGCGCCCG 7008 ACGAGCUGGUCCGCGCCCGdTsdT antis  308-327 7009 GGCCUCUGGCCCAGGAGGC 7010 GGccucuGGcccAGGAGGcdTsdT sense  308-327 7011 GCCUCCUGGGCCAGAGGCC 7012 GCCUCCUGGGCcAGAGGCCdTsdT antis  311-330 7013 CUCUGGCCCAGGAGGCACU 7014 cucuGGcccAGGAGGcAcudTsdT sense  311-330 7015 AGUGCCUCCUGGGCCAGAG 7016 AGUGCCUCCUGGGCcAGAGdTsdT antis  351-370 7017 GGGGCUAUGGGUGGGGGCG 7018 GGGGcuAuGGGuGGGGGcGdTsdT sense  351-370 7019 CGCCCCCACCCAUAGCCCC 7020 CGCCCCcACCcAuAGCCCCdTsdT antis  353-372 7021 GGCUAUGGGUGGGGGCGUG 7022 GGcuAuGGGuGGGGGcGuGdTsdT sense  353-372 7023 CACGCCCCCACCCAUAGCC 7024 cACGCCCCcACCcAuAGCCdTsdT antis  355-374 7025 CUAUGGGUGGGGGCGUGGG 7026 cuAuGGGuGGGGGcGuGGGdTsdT sense  355-374 7027 CCCACGCCCCCACCCAUAG 7028 CCcACGCCCCcACCcAuAGdTsdT antis  357-376 7029 AUGGGUGGGGGCGUGGGAG 7030 AuGGGuGGGGGcGuGGGAGdTsdT sense  357-376 7031 CUCCCACGCCCCCACCCAU 7032 CUCCcACGCCCCcACCcAUdTsdT antis  361-380 7033 GUGGGGGCGUGGGAGCCUC 7034 GuGGGGGcGuGGGAGccucdTsdT sense  361-380 7035 GAGGCUCCCACGCCCCCAC 7036 GAGGCUCCcACGCCCCcACdTsdT antis  363-382 7037 GGGGGCGUGGGAGCCUCGA 7038 GGGGGcGuGGGAGccucGAdTsdT sense  363-382 7039 UCGAGGCUCCCACGCCCCC 7040 UCGAGGCUCCcACGCCCCCdTsdT antis  364-383 7041 GGGGCGUGGGAGCCUCGAG 7042 GGGGcGuGGGAGccucGAGdTsdT sense  364-383 7043 CUCGAGGCUCCCACGCCCC 7044 CUCGAGGCUCCcACGCCCCdTsdT antis  365-384 7045 GGGCGUGGGAGCCUCGAGC 7046 GGGcGuGGGAGccucGAGcdTsdT sense  365-384 7047 GCUCGAGGCUCCCACGCCC 7048 GCUCGAGGCUCCcACGCCCdTsdT antis  366-385 7049 GGCGUGGGAGCCUCGAGCU 7050 GGcGuGGGAGccucGAGcudTsdT sense  366-385 7051 AGCUCGAGGCUCCCACGCC 7052 AGCUCGAGGCUCCcACGCCdTsdT antis  368-387 7053 CGUGGGAGCCUCGAGCUCC 7054 cGuGGGAGccucGAGcuccdTsdT sense  368-387 7055 GGAGCUCGAGGCUCCCACG 7056 GGAGCUCGAGGCUCCcACGdTsdT antis  485-504 7057 GAAGGUGACCACAGUGGUA 7058 GAAGGuGAccAcAGuGGuAdTsdT sense  485-504 7059 UACCACUGUGGUCACCUUC 7060 uACcACUGUGGUcACCUUCdTsdT antis  487-506 7061 AGGUGACCACAGUGGUAGC 7062 AGGuGAccAcAGuGGuAGcdTsdT sense  487-506 7063 GCUACCACUGUGGUCACCU 7064 GCuACcACUGUGGUcACCUdTsdT antis  488-507 7065 GGUGACCACAGUGGUAGCC 7066 GGuGAccAcAGuGGuAGccdTsdT sense  488-507 7067 GGCUACCACUGUGGUCACC 7068 GGCuACcACUGUGGUcACCdTsdT antis  547-566 7069 ACACUGACAUCAAAGUGAU 7070 AcAcuGAcAucAAAGuGAudTsdT sense  547-566 7071 AUCACUUUGAUGUCAGUGU 7072 AUcACUUUGAUGUcAGUGUdTsdT antis  548-567 7073 CACUGACAUCAAAGUGAUU 7074 cAcuGAcAucAAAGuGAuudTsdT sense  548-567 7075 AAUCACUUUGAUGUCAGUG 7076 AAUcACUUUGAUGUcAGUGdTsdT antis  551-570 7077 UGACAUCAAAGUGAUUGGU 7078 uGAcAucAAAGuGAuuGGudTsdT sense  551-570 7079 ACCAAUCACUUUGAUGUCA 7080 ACcAAUcACUUUGAUGUcAdTsdT antis  552-571 7081 GACAUCAAAGUGAUUGGUA 7082 GAcAucAAAGuGAuuGGuAdTsdT sense  552-571 7083 UACCAAUCACUUUGAUGUC 7084 uACcAAUcACUUUGAUGUCdTsdT antis  553-572 7085 ACAUCAAAGUGAUUGGUAA 7086 AcAucAAAGuGAuuGGuAAdTsdT sense  553-572 7087 UUACCAAUCACUUUGAUGU 7088 UuACcAAUcACUUUGAUGUdTsdT antis  554-573 7089 CAUCAAAGUGAUUGGUAAU 7090 cAucAAAGuGAuuGGuAAudTsdT sense  554-573 7091 AUUACCAAUCACUUUGAUG 7092 AUuACcAAUcACUUUGAUGdTsdT antis  556-575 7093 UCAAAGUGAUUGGUAAUGG 7094 ucAAAGuGAuuGGuAAuGGdTsdT sense  556-575 7095 CCAUUACCAAUCACUUUGA 7096 CcAUuACcAAUcACUUUGAdTsdT antis  557-576 7097 CAAAGUGAUUGGUAAUGGC 7098 cAAAGuGAuuGGuAAuGGcdTsdT sense  557-576 7099 GCCAUUACCAAUCACUUUG 7100 GCcAUuACcAAUcACUUUGdTsdT antis  562-581 7101 UGAUUGGUAAUGGCUCAUU 7102 uGAuuGGuAAuGGcucAuudTsdT sense  562-581 7103 AAUGAGCCAUUACCAAUCA 7104 AAUGAGCcAUuACcAAUcAdTsdT antis  563-582 7105 GAUUGGUAAUGGCUCAUUC 7106 GAuuGGuAAuGGcucAuucdTsdT sense  563-582 7107 GAAUGAGCCAUUACCAAUC 7108 GAAUGAGCcAUuACcAAUCdTsdT antis  564-583 7109 AUUGGUAAUGGCUCAUUCG 7110 AuuGGuAAuGGcucAuucGdTsdT sense  564-583 7111 CGAAUGAGCCAUUACCAAU 7112 CGAAUGAGCcAUuACcAAUdTsdT antis  565-584 7113 UUGGUAAUGGCUCAUUCGG 7114 uuGGuAAuGGcucAuucGGdTsdT sense  565-584 7115 CCGAAUGAGCCAUUACCAA 7116 CCGAAUGAGCcAUuACcAAdTsdT antis  566-585 7117 UGGUAAUGGCUCAUUCGGA 7118 uGGuAAuGGcucAuucGGAdTsdT sense  566-585 7119 UCCGAAUGAGCCAUUACCA 7120 UCCGAAUGAGCcAUuACcAdTsdT antis  627-646 7121 GCCAUCAAGAAGGUUCUUC 7122 GccAucAAGAAGGuucuucdTsdT sense  627-646 7123 GAAGAACCUUCUUGAUGGC 7124 GAAGAACCUUCUUGAUGGCdTsdT antis  631-650 7125 UCAAGAAGGUUCUUCAGGA 7126 ucAAGAAGGuucuucAGGAdTsdT sense  631-650 7127 UCCUGAAGAACCUUCUUGA 7128 UCCUGAAGAACCUUCUUGAdTsdT antis  632-651 7129 CAAGAAGGUUCUUCAGGAC 7130 cAAGAAGGuucuucAGGAcdTsdT sense  632-651 7131 GUCCUGAAGAACCUUCUUG 7132 GUCCUGAAGAACCUUCUUGdTsdT antis  634-653 7133 AGAAGGUUCUUCAGGACAA 7134 AGAAGGuucuucAGGAcAAdTsdT sense  634-653 7135 UUGUCCUGAAGAACCUUCU 7136 UUGUCCUGAAGAACCUUCUdTsdT antis  635-654 7137 GAAGGUUCUUCAGGACAAA 7138 GAAGGuucuucAGGAcAAAdTsdT sense  635-654 7139 UUUGUCCUGAAGAACCUUC 7140 UUUGUCCUGAAGAACCUUCdTsdT antis  638-657 7141 GGUUCUUCAGGACAAAAGG 7142 GGuucuucAGGAcAAAAGGdTsdT sense  638-657 7143 CCUUUUGUCCUGAAGAACC 7144 CCUUUUGUCCUGAAGAACCdTsdT antis  639-658 7145 GUUCUUCAGGACAAAAGGU 7146 GuucuucAGGAcAAAAGGudTsdT sense  639-658 7147 ACCUUUUGUCCUGAAGAAC 7148 ACCUUUUGUCCUGAAGAACdTsdT antis  640-659 7149 UUCUUCAGGACAAAAGGUU 7150 uucuucAGGAcAAAAGGuudTsdT sense  640-659 7151 AACCUUUUGUCCUGAAGAA 7152 AACCUUUUGUCCUGAAGAAdTsdT antis  641-660 7153 UCUUCAGGACAAAAGGUUC 7154 ucuucAGGAcAAAAGGuucdTsdT sense  641-660 7155 GAACCUUUUGUCCUGAAGA 7156 GAACCUUUUGUCCUGAAGAdTsdT antis  642-661 7157 CUUCAGGACAAAAGGUUCA 7158 cuucAGGAcAAAAGGuucAdTsdT sense  642-661 7159 UGAACCUUUUGUCCUGAAG 7160 UGAACCUUUUGUCCUGAAGdTsdT antis  643-662 7161 UUCAGGACAAAAGGUUCAA 7162 uucAGGAcAAAAGGuucAAdTsdT sense  643-662 7163 UUGAACCUUUUGUCCUGAA 7164 UUGAACCUUUUGUCCUGAAdTsdT antis  644-663 7165 UCAGGACAAAAGGUUCAAG 7166 ucAGGAcAAAAGGuucAAGdTsdT sense  644-663 7167 CUUGAACCUUUUGUCCUGA 7168 CUUGAACCUUUUGUCCUGAdTsdT antis  645-664 7169 CAGGACAAAAGGUUCAAGA 7170 cAGGAcAAAAGGuucAAGAdTsdT sense  645-664 7171 UCUUGAACCUUUUGUCCUG 7172 UCUUGAACCUUUUGUCCUGdTsdT antis  686-705 7173 UAAGCUGGACCACUGCAAU 7174 uAAGcuGGAccAcuGcAAudTsdT sense  686-705 7175 AUUGCAGUGGUCCAGCUUA 7176 AUUGcAGUGGUCcAGCUuAdTsdT antis  687-706 7177 AAGCUGGACCACUGCAAUA 7178 AAGcuGGAccAcuGcAAuAdTsdT sense  687-706 7179 UAUUGCAGUGGUCCAGCUU 7180 uAUUGcAGUGGUCcAGCUUdTsdT antis  689-708 7181 GCUGGACCACUGCAAUAUU 7182 GcuGGAccAcuGcAAuAuudTsdT sense  689-708 7183 AAUAUUGCAGUGGUCCAGC 7184 AAuAUUGcAGUGGUCcAGCdTsdT antis  690-709 7185 CUGGACCACUGCAAUAUUG 7186 cuGGAccAcuGcAAuAuuGdTsdT sense  690-709 7187 CAAUAUUGCAGUGGUCCAG 7188 cAAuAUUGcAGUGGUCcAGdTsdT antis  691-710 7189 UGGACCACUGCAAUAUUGU 7190 uGGAccAcuGcAAuAuuGudTsdT sense  691-710 7191 ACAAUAUUGCAGUGGUCCA 7192 AcAAuAUUGcAGUGGUCcAdTsdT antis  692-711 7193 GGACCACUGCAAUAUUGUG 7194 GGAccAcuGcAAuAuuGuGdTsdT sense  692-711 7195 CACAAUAUUGCAGUGGUCC 7196 cAcAAuAUUGcAGUGGUCCdTsdT antis  694-713 7197 ACCACUGCAAUAUUGUGAG 7198 AccAcuGcAAuAuuGuGAGdTsdT sense  694-713 7199 CUCACAAUAUUGCAGUGGU 7200 CUcAcAAuAUUGcAGUGGUdTsdT antis  696-715 7201 CACUGCAAUAUUGUGAGGC 7202 cAcuGcAAuAuuGuGAGGcdTsdT sense  696-715 7203 GCCUCACAAUAUUGCAGUG 7204 GCCUcAcAAuAUUGcAGUGdTsdT antis  698-717 7205 CUGCAAUAUUGUGAGGCUG 7206 cuGcAAuAuuGuGAGGcuGdTsdT sense  698-717 7207 CAGCCUCACAAUAUUGCAG 7208 cAGCCUcAcAAuAUUGcAGdTsdT antis  699-718 7209 UGCAAUAUUGUGAGGCUGC 7210 uGcAAuAuuGuGAGGcuGcdTsdT sense  699-718 7211 GCAGCCUCACAAUAUUGCA 7212 GcAGCCUcAcAAuAUUGcAdTsdT antis  718-737 7213 GGUACUUUUUCUACUCCAG 7214 GGuAcuuuuucuAcuccAGdTsdT sense  718-737 7215 CUGGAGUAGAAAAAGUACC 7216 CUGGAGuAGAAAAAGuACCdTsdT antis  720-739 7217 UACUUUUUCUACUCCAGUG 7218 uAcuuuuucuAcuccAGuGdTsdT sense  720-739 7219 CACUGGAGUAGAAAAAGUA 7220 cACUGGAGuAGAAAAAGuAdTsdT antis  721-740 7221 ACUUUUUCUACUCCAGUGG 7222 AcuuuuucuAcuccAGuGGdTsdT sense  721-740 7223 CCACUGGAGUAGAAAAAGU 7224 CcACUGGAGuAGAAAAAGUdTsdT antis  723-742 7225 UUUUUCUACUCCAGUGGGG 7226 uuuuucuAcuccAGuGGGGdTsdT sense  723-742 7227 CCCCACUGGAGUAGAAAAA 7228 CCCcACUGGAGuAGAAAAAdTsdT antis  729-748 7229 UACUCCAGUGGGGAGAAGA 7230 uAcuccAGuGGGGAGAAGAdTsdT sense  729-748 7231 UCUUCUCCCCACUGGAGUA 7232 UCUUCUCCCcACUGGAGuAdTsdT antis  730-749 7233 ACUCCAGUGGGGAGAAGAA 7234 AcuccAGuGGGGAGAAGAAdTsdT sense  730-749 7235 UUCUUCUCCCCACUGGAGU 7236 UUCUUCUCCCcACUGGAGUdTsdT antis  736-755 7237 GUGGGGAGAAGAAGGACGA 7238 GuGGGGAGAAGAAGGAcGAdTsdT sense  736-755 7239 UCGUCCUUCUUCUCCCCAC 7240 UCGUCCUUCUUCUCCCcACdTsdT antis  737-756 7241 UGGGGAGAAGAAGGACGAG 7242 uGGGGAGAAGAAGGAcGAGdTsdT sense  737-756 7243 CUCGUCCUUCUUCUCCCCA 7244 CUCGUCCUUCUUCUCCCcAdTsdT antis  755-774 7245 GCUGUAUUUGAAUCUGGUG 7246 GcuGuAuuuGAAucuGGuGdTsdT sense  755-774 7247 CACCAGAUUCAAAUACAGC 7248 cACcAGAUUcAAAuAcAGCdTsdT antis  756-775 7249 CUGUAUUUGAAUCUGGUGC 7250 cuGuAuuuGAAucuGGuGcdTsdT sense  756-775 7251 GCACCAGAUUCAAAUACAG 7252 GcACcAGAUUcAAAuAcAGdTsdT antis  758-777 7253 GUAUUUGAAUCUGGUGCUG 7254 GuAuuuGAAucuGGuGcuGdTsdT sense  758-777 7255 CAGCACCAGAUUCAAAUAC 7256 cAGcACcAGAUUcAAAuACdTsdT antis  761-780 7257 UUUGAAUCUGGUGCUGGAG 7258 uuuGAAucuGGuGcuGGAGdTsdT sense  761-780 7259 CUCCAGCACCAGAUUCAAA 7260 CUCcAGcACcAGAUUcAAAdTsdT antis  765-784 7261 AAUCUGGUGCUGGAGUAUG 7262 AAucuGGuGcuGGAGuAuGdTsdT sense  765-784 7263 CAUACUCCAGCACCAGAUU 7264 cAuACUCcAGcACcAGAUUdTsdT antis  769-788 7265 UGGUGCUGGAGUAUGUGCC 7266 uGGuGcuGGAGuAuGuGccdTsdT sense  769-788 7267 GGCACAUACUCCAGCACCA 7268 GGcAcAuACUCcAGcACcAdTsdT antis  770-789 7269 GGUGCUGGAGUAUGUGCCC 7270 GGuGcuGGAGuAuGuGcccdTsdT sense  770-789 7271 GGGCACAUACUCCAGCACC 7272 GGGcAcAuACUCcAGcACCdTsdT antis  771-790 7273 GUGCUGGAGUAUGUGCCCG 7274 GuGcuGGAGuAuGuGcccGdTsdT sense  771-790 7275 CGGGCACAUACUCCAGCAC 7276 CGGGcAcAuACUCcAGcACdTsdT antis  772-791 7277 UGCUGGAGUAUGUGCCCGA 7278 uGcuGGAGuAuGuGcccGAdTsdT sense  772-791 7279 UCGGGCACAUACUCCAGCA 7280 UCGGGcAcAuACUCcAGcAdTsdT antis  773-792 7281 GCUGGAGUAUGUGCCCGAG 7282 GcuGGAGuAuGuGcccGAGdTsdT sense  773-792 7283 CUCGGGCACAUACUCCAGC 7284 CUCGGGcAcAuACUCcAGCdTsdT antis  774-793 7285 CUGGAGUAUGUGCCCGAGA 7286 cuGGAGuAuGuGcccGAGAdTsdT sense  774-793 7287 UCUCGGGCACAUACUCCAG 7288 UCUCGGGcAcAuACUCcAGdTsdT antis  781-800 7289 AUGUGCCCGAGACGGUGUA 7290 AuGuGcccGAGAcGGuGuAdTsdT sense  781-800 7291 UACACCGUCUCGGGCACAU 7292 uAcACCGUCUCGGGcAcAUdTsdT antis  782-801 7293 UGUGCCCGAGACGGUGUAC 7294 uGuGcccGAGAcGGuGuAcdTsdT sense  782-801 7295 GUACACCGUCUCGGGCACA 7296 GuAcACCGUCUCGGGcAcAdTsdT antis  803-822 7297 AGUGGCCCGCCACUUCACC 7298 AGuGGcccGccAcuucAccdTsdT sense  803-822 7299 GGUGAAGUGGCGGGCCACU 7300 GGUGAAGUGGCGGGCcACUdTsdT antis  804-823 7301 GUGGCCCGCCACUUCACCA 7302 GuGGcccGccAcuucAccAdTsdT sense  804-823 7303 UGGUGAAGUGGCGGGCCAC 7304 UGGUGAAGUGGCGGGCcACdTsdT antis  805-824 7305 UGGCCCGCCACUUCACCAA 7306 uGGcccGccAcuucAccAAdTsdT sense  805-824 7307 UUGGUGAAGUGGCGGGCCA 7308 UUGGUGAAGUGGCGGGCcAdTsdT antis  806-825 7309 GGCCCGCCACUUCACCAAG 7310 GGcccGccAcuucAccAAGdTsdT sense  806-825 7311 CUUGGUGAAGUGGCGGGCC 7312 CUUGGUGAAGUGGCGGGCCdTsdT antis  807-826 7313 GCCCGCCACUUCACCAAGG 7314 GcccGccAcuucAccAAGGdTsdT sense  807-826 7315 CCUUGGUGAAGUGGCGGGC 7316 CCUUGGUGAAGUGGCGGGCdTsdT antis  808-827 7317 CCCGCCACUUCACCAAGGC 7318 cccGccAcuucAccAAGGcdTsdT sense  808-827 7319 GCCUUGGUGAAGUGGCGGG 7320 GCCUUGGUGAAGUGGCGGGdTsdT antis  809-828 7321 CCGCCACUUCACCAAGGCC 7322 ccGccAcuucAccAAGGccdTsdT sense  809-828 7323 GGCCUUGGUGAAGUGGCGG 7324 GGCCUUGGUGAAGUGGCGGdTsdT antis  810-829 7325 CGCCACUUCACCAAGGCCA 7326 cGccAcuucAccAAGGccAdTsdT sense  810-829 7327 UGGCCUUGGUGAAGUGGCG 7328 UGGCCUUGGUGAAGUGGCGdTsdT antis  811-830 7329 GCCACUUCACCAAGGCCAA 7330 GccAcuucAccAAGGccAAdTsdT sense  811-830 7331 UUGGCCUUGGUGAAGUGGC 7332 UUGGCCUUGGUGAAGUGGCdTsdT antis  813-832 7333 CACUUCACCAAGGCCAAGC 7334 cAcuucAccAAGGccAAGcdTsdT sense  813-832 7335 GCUUGGCCUUGGUGAAGUG 7336 GCUUGGCCUUGGUGAAGUGdTsdT antis  815-834 7337 CUUCACCAAGGCCAAGCUG 7338 cuucAccAAGGccAAGcuGdTsdT sense  815-834 7339 CAGCUUGGCCUUGGUGAAG 7340 cAGCUUGGCCUUGGUGAAGdTsdT antis  817-836 7341 UCACCAAGGCCAAGCUGAU 7342 ucAccAAGGccAAGcuGAudTsdT sense  817-836 7343 AUCAGCUUGGCCUUGGUGA 7344 AUcAGCUUGGCCUUGGUGAdTsdT antis  858-877 7345 GUGUACAUGUACCAGCUCU 7346 GuGuAcAuGuAccAGcucudTsdT sense  858-877 7347 AGAGCUGGUACAUGUACAC 7348 AGAGCUGGuAcAUGuAcACdTsdT antis  860-879 7349 GUACAUGUACCAGCUCUUC 7350 GuAcAuGuAccAGcucuucdTsdT sense  860-879 7351 GAAGAGCUGGUACAUGUAC 7352 GAAGAGCUGGuAcAUGuACdTsdT antis  861-880 7353 UACAUGUACCAGCUCUUCC 7354 uAcAuGuAccAGcucuuccdTsdT sense  861-880 7355 GGAAGAGCUGGUACAUGUA 7356 GGAAGAGCUGGuAcAUGuAdTsdT antis  862-881 7357 ACAUGUACCAGCUCUUCCG 7358 AcAuGuAccAGcucuuccGdTsdT sense  862-881 7359 CGGAAGAGCUGGUACAUGU 7360 CGGAAGAGCUGGuAcAUGUdTsdT antis  863-882 7361 CAUGUACCAGCUCUUCCGG 7362 cAuGuAccAGcucuuccGGdTsdT sense  863-882 7363 CCGGAAGAGCUGGUACAUG 7364 CCGGAAGAGCUGGuAcAUGdTsdT antis  865-884 7365 UGUACCAGCUCUUCCGGAG 7366 uGuAccAGcucuuccGGAGdTsdT sense  865-884 7367 CUCCGGAAGAGCUGGUACA 7368 CUCCGGAAGAGCUGGuAcAdTsdT antis  866-885 7369 GUACCAGCUCUUCCGGAGC 7370 GuAccAGcucuuccGGAGcdTsdT sense  866-885 7371 GCUCCGGAAGAGCUGGUAC 7372 GCUCCGGAAGAGCUGGuACdTsdT antis  867-886 7373 UACCAGCUCUUCCGGAGCU 7374 uAccAGcucuuccGGAGcudTsdT sense  867-886 7375 AGCUCCGGAAGAGCUGGUA 7376 AGCUCCGGAAGAGCUGGuAdTsdT antis  868-887 7377 ACCAGCUCUUCCGGAGCUU 7378 AccAGcucuuccGGAGcuudTsdT sense  868-887 7379 AAGCUCCGGAAGAGCUGGU 7380 AAGCUCCGGAAGAGCUGGUdTsdT antis  869-888 7381 CCAGCUCUUCCGGAGCUUG 7382 ccAGcucuuccGGAGcuuGdTsdT sense  869-888 7383 CAAGCUCCGGAAGAGCUGG 7384 cAAGCUCCGGAAGAGCUGGdTsdT antis  870-889 7385 CAGCUCUUCCGGAGCUUGG 7386 cAGcucuuccGGAGcuuGGdTsdT sense  870-889 7387 CCAAGCUCCGGAAGAGCUG 7388 CcAAGCUCCGGAAGAGCUGdTsdT antis  871-890 7389 AGCUCUUCCGGAGCUUGGC 7390 AGcucuuccGGAGcuuGGcdTsdT sense  871-890 7391 GCCAAGCUCCGGAAGAGCU 7392 GCcAAGCUCCGGAAGAGCUdTsdT antis  872-891 7393 GCUCUUCCGGAGCUUGGCC 7394 GcucuuccGGAGcuuGGccdTsdT sense  872-891 7395 GGCCAAGCUCCGGAAGAGC 7396 GGCcAAGCUCCGGAAGAGCdTsdT antis  874-893 7397 UCUUCCGGAGCUUGGCCUA 7398 ucuuccGGAGcuuGGccuAdTsdT sense  874-893 7399 UAGGCCAAGCUCCGGAAGA 7400 uAGGCcAAGCUCCGGAAGAdTsdT antis  876-895 7401 UUCCGGAGCUUGGCCUACA 7402 uuccGGAGcuuGGccuAcAdTsdT sense  876-895 7403 UGUAGGCCAAGCUCCGGAA 7404 UGuAGGCcAAGCUCCGGAAdTsdT antis  877-896 7405 UCCGGAGCUUGGCCUACAU 7406 uccGGAGcuuGGccuAcAudTsdT sense  877-896 7407 AUGUAGGCCAAGCUCCGGA 7408 AUGuAGGCcAAGCUCCGGAdTsdT antis  878-897 7409 CCGGAGCUUGGCCUACAUC 7410 ccGGAGcuuGGccuAcAucdTsdT sense  878-897 7411 GAUGUAGGCCAAGCUCCGG 7412 GAUGuAGGCcAAGCUCCGGdTsdT antis  911-930 7413 GUGUCACCGUGACAUCAAG 7414 GuGucAccGuGAcAucAAGdTsdT sense  911-930 7415 CUUGAUGUCACGGUGACAC 7416 CUUGAUGUcACGGUGAcACdTsdT antis  935-954 7417 GAAUUUGCUUGUGGACCCU 7418 GAAuuuGcuuGuGGAcccudTsdT sense  935-954 7419 AGGGUCCACAAGCAAAUUC 7420 AGGGUCcAcAAGcAAAUUCdTsdT antis  939-958 7421 UUGCUUGUGGACCCUGACA 7422 uuGcuuGuGGAcccuGAcAdTsdT sense  939-958 7423 UGUCAGGGUCCACAAGCAA 7424 UGUcAGGGUCcAcAAGcAAdTsdT antis  940-959 7425 UGCUUGUGGACCCUGACAC 7426 uGcuuGuGGAcccuGAcAcdTsdT sense  940-959 7427 GUGUCAGGGUCCACAAGCA 7428 GUGUcAGGGUCcAcAAGcAdTsdT antis  941-960 7429 GCUUGUGGACCCUGACACU 7430 GcuuGuGGAcccuGAcAcudTsdT sense  941-960 7431 AGUGUCAGGGUCCACAAGC 7432 AGUGUcAGGGUCcAcAAGCdTsdT antis  943-962 7433 UUGUGGACCCUGACACUGC 7434 uuGuGGAcccuGAcAcuGcdTsdT sense  943-962 7435 GCAGUGUCAGGGUCCACAA 7436 GcAGUGUcAGGGUCcAcAAdTsdT antis  949-968 7437 ACCCUGACACUGCUGUCCU 7438 AcccuGAcAcuGcuGuccudTsdT sense  949-968 7439 AGGACAGCAGUGUCAGGGU 7440 AGGAcAGcAGUGUcAGGGUdTsdT antis  952-971 7441 CUGACACUGCUGUCCUCAA 7442 cuGAcAcuGcuGuccucAAdTsdT sense  952-971 7443 UUGAGGACAGCAGUGUCAG 7444 UUGAGGAcAGcAGUGUcAGdTsdT antis  970-989 7445 AGCUCUGCGAUUUUGGCAG 7446 AGcucuGcGAuuuuGGcAGdTsdT sense  970-989 7447 CUGCCAAAAUCGCAGAGCU 7448 CUGCcAAAAUCGcAGAGCUdTsdT antis  974-993 7449 CUGCGAUUUUGGCAGUGCA 7450 cuGcGAuuuuGGcAGuGcAdTsdT sense  974-993 7451 UGCACUGCCAAAAUCGCAG 7452 UGcACUGCcAAAAUCGcAGdTsdT antis  977-996 7453 CGAUUUUGGCAGUGCAAAG 7454 cGAuuuuGGcAGuGcAAAGdTsdT sense  977-996 7455 CUUUGCACUGCCAAAAUCG 7456 CUUUGcACUGCcAAAAUCGdTsdT antis  978-997 7457 GAUUUUGGCAGUGCAAAGC 7458 GAuuuuGGcAGuGcAAAGcdTsdT sense  978-997 7459 GCUUUGCACUGCCAAAAUC 7460 GCUUUGcACUGCcAAAAUCdTsdT antis  986-1005 7461 CAGUGCAAAGCAGCUGGUU 7462 cAGuGcAAAGcAGcuGGuudTsdT sense  986-1005 7463 AACCAGCUGCUUUGCACUG 7464 AACcAGCUGCUUUGcACUGdTsdT antis  987-1006 7465 AGUGCAAAGCAGCUGGUUC 7466 AGuGcAAAGcAGcuGGuucdTsdT sense  987-1006 7467 GAACCAGCUGCUUUGCACU 7468 GAACcAGCUGCUUUGcACUdTsdT antis  988-1007 7469 GUGCAAAGCAGCUGGUUCG 7470 GuGcAAAGcAGcuGGuucGdTsdT sense  988-1007 7471 CGAACCAGCUGCUUUGCAC 7472 CGAACcAGCUGCUUUGcACdTsdT antis 1162-1181 7473 GUGGGGUGGACCAGCUUGU 7474 GuGGGGuGGAccAGcuuGudTsdT sense 1162-1181 7475 ACAAGCUGGUCCACCCCAC 7476 AcAAGCUGGUCcACCCcACdTsdT antis 1163-1182 7477 UGGGGUGGACCAGCUUGUG 7478 uGGGGuGGAccAGcuuGuGdTsdT sense 1163-1182 7479 CACAAGCUGGUCCACCCCA 7480 cAcAAGCUGGUCcACCCcAdTsdT antis 1164-1183 7481 GGGGUGGACCAGCUUGUGG 7482 GGGGuGGAccAGcuuGuGGdTsdT sense 1164-1183 7483 CCACAAGCUGGUCCACCCC 7484 CcAcAAGCUGGUCcACCCCdTsdT antis 1165-1184 7485 GGGUGGACCAGCUUGUGGA 7486 GGGuGGAccAGcuuGuGGAdTsdT sense 1165-1184 7487 UCCACAAGCUGGUCCACCC 7488 UCcAcAAGCUGGUCcACCCdTsdT antis 1168-1187 7489 UGGACCAGCUUGUGGAGAU 7490 uGGAccAGcuuGuGGAGAudTsdT sense 1168-1187 7491 AUCUCCACAAGCUGGUCCA 7492 AUCUCcAcAAGCUGGUCcAdTsdT antis 1172-1191 7493 CCAGCUUGUGGAGAUCAUC 7494 ccAGcuuGuGGAGAucAucdTsdT sense 1172-1191 7495 GAUGAUCUCCACAAGCUGG 7496 GAUGAUCUCcAcAAGCUGGdTsdT antis 1173-1192 7497 CAGCUUGUGGAGAUCAUCA 7498 cAGcuuGuGGAGAucAucAdTsdT sense 1173-1192 7499 UGAUGAUCUCCACAAGCUG 7500 UGAUGAUCUCcAcAAGCUGdTsdT antis 1175-1194 7501 GCUUGUGGAGAUCAUCAAG 7502 GcuuGuGGAGAucAucAAGdTsdT sense 1175-1194 7503 CUUGAUGAUCUCCACAAGC 7504 CUUGAUGAUCUCcAcAAGCdTsdT antis 1176-1195 7505 CUUGUGGAGAUCAUCAAGG 7506 cuuGuGGAGAucAucAAGGdTsdT sense 1176-1195 7507 CCUUGAUGAUCUCCACAAG 7508 CCUUGAUGAUCUCcAcAAGdTsdT antis 1177-1196 7509 UUGUGGAGAUCAUCAAGGU 7510 uuGuGGAGAucAucAAGGudTsdT sense 1177-1196 7511 ACCUUGAUGAUCUCCACAA 7512 ACCUUGAUGAUCUCcAcAAdTsdT antis 1179-1198 7513 GUGGAGAUCAUCAAGGUAC 7514 GuGGAGAucAucAAGGuAcdTsdT sense 1179-1198 7515 GUACCUUGAUGAUCUCCAC 7516 GuACCUUGAUGAUCUCcACdTsdT antis 1180-1199 7517 UGGAGAUCAUCAAGGUACU 7518 uGGAGAucAucAAGGuAcudTsdT sense 1180-1199 7519 AGUACCUUGAUGAUCUCCA 7520 AGuACCUUGAUGAUCUCcAdTsdT antis 1181-1200 7521 GGAGAUCAUCAAGGUACUA 7522 GGAGAucAucAAGGuAcuAdTsdT sense 1181-1200 7523 UAGUACCUUGAUGAUCUCC 7524 uAGuACCUUGAUGAUCUCCdTsdT antis 1182-1201 7525 GAGAUCAUCAAGGUACUAG 7526 GAGAucAucAAGGuAcuAGdTsdT sense 1182-1201 7527 CUAGUACCUUGAUGAUCUC 7528 CuAGuACCUUGAUGAUCUCdTsdT antis 1184-1203 7529 GAUCAUCAAGGUACUAGGA 7530 GAucAucAAGGuAcuAGGAdTsdT sense 1184-1203 7531 UCCUAGUACCUUGAUGAUC 7532 UCCuAGuACCUUGAUGAUCdTsdT antis 1186-1205 7533 UCAUCAAGGUACUAGGAAC 7534 ucAucAAGGuAcuAGGAAcdTsdT sense 1186-1205 7535 GUUCCUAGUACCUUGAUGA 7536 GUUCCuAGuACCUUGAUGAdTsdT antis 1187-1206 7537 CAUCAAGGUACUAGGAACG 7538 cAucAAGGuAcuAGGAAcGdTsdT sense 1187-1206 7539 CGUUCCUAGUACCUUGAUG 7540 CGUUCCuAGuACCUUGAUGdTsdT antis 1205-1224 7541 GCCAACCAGGGAACAAAUC 7542 GccAAccAGGGAAcAAAucdTsdT sense 1205-1224 7543 GAUUUGUUCCCUGGUUGGC 7544 GAUUUGUUCCCUGGUUGGCdTsdT antis 1207-1226 7545 CAACCAGGGAACAAAUCCG 7546 cAAccAGGGAAcAAAuccGdTsdT sense 1207-1226 7547 CGGAUUUGUUCCCUGGUUG 7548 CGGAUUUGUUCCCUGGUUGdTsdT antis 1209-1228 7549 ACCAGGGAACAAAUCCGAG 7550 AccAGGGAAcAAAuccGAGdTsdT sense 1209-1228 7551 CUCGGAUUUGUUCCCUGGU 7552 CUCGGAUUUGUUCCCUGGUdTsdT antis 1212-1231 7553 AGGGAACAAAUCCGAGAGA 7554 AGGGAAcAAAuccGAGAGAdTsdT sense 1212-1231 7555 UCUCUCGGAUUUGUUCCCU 7556 UCUCUCGGAUUUGUUCCCUdTsdT antis 1214-1233 7557 GGAACAAAUCCGAGAGAUG 7558 GGAAcAAAuccGAGAGAuGdTsdT sense 1214-1233 7559 CAUCUCUCGGAUUUGUUCC 7560 cAUCUCUCGGAUUUGUUCCdTsdT antis 1219-1238 7561 AAAUCCGAGAGAUGAACCC 7562 AAAuccGAGAGAuGAAcccdTsdT sense 1219-1238 7563 GGGUUCAUCUCUCGGAUUU 7564 GGGUUcAUCUCUCGGAUUUdTsdT antis 1222-1241 7565 UCCGAGAGAUGAACCCUAA 7566 uccGAGAGAuGAAcccuAAdTsdT sense 1222-1241 7567 UUAGGGUUCAUCUCUCGGA 7568 UuAGGGUUcAUCUCUCGGAdTsdT antis 1223-1242 7569 CCGAGAGAUGAACCCUAAC 7570 ccGAGAGAuGAAcccuAAcdTsdT sense 1223-1242 7571 GUUAGGGUUCAUCUCUCGG 7572 GUuAGGGUUcAUCUCUCGGdTsdT antis 1247-1266 7573 GGAGUUCAAGUUCCCCCAG 7574 GGAGuucAAGuucccccAGdTsdT sense 1247-1266 7575 CUGGGGGAACUUGAACUCC 7576 CUGGGGGAACUUGAACUCCdTsdT antis 1248-1267 7577 GAGUUCAAGUUCCCCCAGA 7578 GAGuucAAGuucccccAGAdTsdT sense 1248-1267 7579 UCUGGGGGAACUUGAACUC 7580 UCUGGGGGAACUUGAACUCdTsdT antis 1249-1268 7581 AGUUCAAGUUCCCCCAGAU 7582 AGuucAAGuucccccAGAudTsdT sense 1249-1268 7583 AUCUGGGGGAACUUGAACU 7584 AUCUGGGGGAACUUGAACUdTsdT antis 1250-1269 7585 GUUCAAGUUCCCCCAGAUC 7586 GuucAAGuucccccAGAucdTsdT sense 1250-1269 7587 GAUCUGGGGGAACUUGAAC 7588 GAUCUGGGGGAACUUGAACdTsdT antis 1251-1270 7589 UUCAAGUUCCCCCAGAUCA 7590 uucAAGuucccccAGAucAdTsdT sense 1251-1270 7591 UGAUCUGGGGGAACUUGAA 7592 UGAUCUGGGGGAACUUGAAdTsdT antis 1252-1271 7593 UCAAGUUCCCCCAGAUCAA 7594 ucAAGuucccccAGAucAAdTsdT sense 1252-1271 7595 UUGAUCUGGGGGAACUUGA 7596 UUGAUCUGGGGGAACUUGAdTsdT antis 1253-1272 7597 CAAGUUCCCCCAGAUCAAA 7598 cAAGuucccccAGAucAAAdTsdT sense 1253-1272 7599 UUUGAUCUGGGGGAACUUG 7600 UUUGAUCUGGGGGAACUUGdTsdT antis 1255-1274 7601 AGUUCCCCCAGAUCAAAGC 7602 AGuucccccAGAucAAAGcdTsdT sense 1255-1274 7603 GCUUUGAUCUGGGGGAACU 7604 GCUUUGAUCUGGGGGAACUdTsdT antis 1257-1276 7605 UUCCCCCAGAUCAAAGCUC 7606 uucccccAGAucAAAGcucdTsdT sense 1257-1276 7607 GAGCUUUGAUCUGGGGGAA 7608 GAGCUUUGAUCUGGGGGAAdTsdT antis 1258-1277 7609 UCCCCCAGAUCAAAGCUCA 7610 ucccccAGAucAAAGcucAdTsdT sense 1258-1277 7611 UGAGCUUUGAUCUGGGGGA 7612 UGAGCUUUGAUCUGGGGGAdTsdT antis 1261-1280 7613 CCCAGAUCAAAGCUCACCC 7614 cccAGAucAAAGcucAcccdTsdT sense 1261-1280 7615 GGGUGAGCUUUGAUCUGGG 7616 GGGUGAGCUUUGAUCUGGGdTsdT antis 1262-1281 7617 CCAGAUCAAAGCUCACCCU 7618 ccAGAucAAAGcucAcccudTsdT sense 1262-1281 7619 AGGGUGAGCUUUGAUCUGG 7620 AGGGUGAGCUUUGAUCUGGdTsdT antis 1280-1299 7621 UUGGACAAAGGUGUUCAAA 7622 uuGGAcAAAGGuGuucAAAdTsdT sense 1280-1299 7623 UUUGAACACCUUUGUCCAA 7624 UUUGAAcACCUUUGUCcAAdTsdT antis 1282-1301 7625 GGACAAAGGUGUUCAAAUC 7626 GGAcAAAGGuGuucAAAucdTsdT sense 1282-1301 7627 GAUUUGAACACCUUUGUCC 7628 GAUUUGAAcACCUUUGUCCdTsdT antis 1283-1302 7629 GACAAAGGUGUUCAAAUCU 7630 GAcAAAGGuGuucAAAucudTsdT sense 1283-1302 7631 AGAUUUGAACACCUUUGUC 7632 AGAUUUGAAcACCUUUGUCdTsdT antis 1284-1303 7633 ACAAAGGUGUUCAAAUCUU 7634 AcAAAGGuGuucAAAucuudTsdT sense 1284-1303 7635 AAGAUUUGAACACCUUUGU 7636 AAGAUUUGAAcACCUUUGUdTsdT antis 1354-1373 7637 CGCCAUCCUCAAGGCUCUC 7638 cGccAuccucAAGGcucucdTsdT sense 1354-1373 7639 GAGAGCCUUGAGGAUGGCG 7640 GAGAGCCUUGAGGAUGGCGdTsdT antis 1361-1380 7641 CUCAAGGCUCUCCCCACUC 7642 cucAAGGcucuccccAcucdTsdT sense 1361-1380 7643 GAGUGGGGAGAGCCUUGAG 7644 GAGUGGGGAGAGCCUUGAGdTsdT antis 1379-1398 7645 CGAGGCUUGUGCCCACAGC 7646 cGAGGcuuGuGcccAcAGcdTsdT sense 1379-1398 7647 GCUGUGGGCACAAGCCUCG 7648 GCUGUGGGcAcAAGCCUCGdTsdT antis 1380-1399 7649 GAGGCUUGUGCCCACAGCU 7650 GAGGcuuGuGcccAcAGcudTsdT sense 1380-1399 7651 AGCUGUGGGCACAAGCCUC 7652 AGCUGUGGGcAcAAGCCUCdTsdT antis 1382-1401 7653 GGCUUGUGCCCACAGCUUC 7654 GGcuuGuGcccAcAGcuucdTsdT sense 1382-1401 7655 GAAGCUGUGGGCACAAGCC 7656 GAAGCUGUGGGcAcAAGCCdTsdT antis 1383-1402 7657 GCUUGUGCCCACAGCUUCU 7658 GcuuGuGcccAcAGcuucudTsdT sense 1383-1402 7659 AGAAGCUGUGGGCACAAGC 7660 AGAAGCUGUGGGcAcAAGCdTsdT antis 1384-1403 7661 CUUGUGCCCACAGCUUCUU 7662 cuuGuGcccAcAGcuucuudTsdT sense 1384-1403 7663 AAGAAGCUGUGGGCACAAG 7664 AAGAAGCUGUGGGcAcAAGdTsdT antis 1386-1405 7665 UGUGCCCACAGCUUCUUCG 7666 uGuGcccAcAGcuucuucGdTsdT sense 1386-1405 7667 CGAAGAAGCUGUGGGCACA 7668 CGAAGAAGCUGUGGGcAcAdTsdT antis 1424-1443 7669 AGCCCAGCUCCCCAACGAC 7670 AGcccAGcuccccAAcGAcdTsdT sense 1424-1443 7671 GUCGUUGGGGAGCUGGGCU 7672 GUCGUUGGGGAGCUGGGCUdTsdT antis 1425-1444 7673 GCCCAGCUCCCCAACGACC 7674 GcccAGcuccccAAcGAccdTsdT sense 1425-1444 7675 GGUCGUUGGGGAGCUGGGC 7676 GGUCGUUGGGGAGCUGGGCdTsdT antis 1426-1445 7677 CCCAGCUCCCCAACGACCG 7678 cccAGcuccccAAcGAccGdTsdT sense 1426-1445 7679 CGGUCGUUGGGGAGCUGGG 7680 CGGUCGUUGGGGAGCUGGGdTsdT antis 1427-1446 7681 CCAGCUCCCCAACGACCGC 7682 ccAGcuccccAAcGAccGcdTsdT sense 1427-1446 7683 GCGGUCGUUGGGGAGCUGG 7684 GCGGUCGUUGGGGAGCUGGdTsdT antis 1428-1447 7685 CAGCUCCCCAACGACCGCC 7686 cAGcuccccAAcGAccGccdTsdT sense 1428-1447 7687 GGCGGUCGUUGGGGAGCUG 7688 GGCGGUCGUUGGGGAGCUGdTsdT antis 1454-1473 7689 CCCCCUGUUCAACUUCAGU 7690 cccccuGuucAAcuucAGudTsdT sense 1454-1473 7691 ACUGAAGUUGAACAGGGGG 7692 ACUGAAGUUGAAcAGGGGGdTsdT antis 1459-1478 7693 UGUUCAACUUCAGUCCUGG 7694 uGuucAAcuucAGuccuGGdTsdT sense 1459-1478 7695 CCAGGACUGAAGUUGAACA 7696 CcAGGACUGAAGUUGAAcAdTsdT antis 1460-1479 7697 GUUCAACUUCAGUCCUGGU 7698 GuucAAcuucAGuccuGGudTsdT sense 1460-1479 7699 ACCAGGACUGAAGUUGAAC 7700 ACcAGGACUGAAGUUGAACdTsdT antis 1461-1480 7701 UUCAACUUCAGUCCUGGUG 7702 uucAAcuucAGuccuGGuGdTsdT sense 1461-1480 7703 CACCAGGACUGAAGUUGAA 7704 cACcAGGACUGAAGUUGAAdTsdT antis 1462-1481 7705 UCAACUUCAGUCCUGGUGA 7706 ucAAcuucAGuccuGGuGAdTsdT sense 1462-1481 7707 UCACCAGGACUGAAGUUGA 7708 UcACcAGGACUGAAGUUGAdTsdT antis 1463-1482 7709 CAACUUCAGUCCUGGUGAA 7710 cAAcuucAGuccuGGuGAAdTsdT sense 1463-1482 7711 UUCACCAGGACUGAAGUUG 7712 UUcACcAGGACUGAAGUUGdTsdT antis 1503-1522 7713 AAUGCCAUUCUCAUCCCUC 7714 AAuGccAuucucAucccucdTsdT sense 1503-1522 7715 GAGGGAUGAGAAUGGCAUU 7716 GAGGGAUGAGAAUGGcAUUdTsdT antis 1504-1523 7717 AUGCCAUUCUCAUCCCUCC 7718 AuGccAuucucAucccuccdTsdT sense 1504-1523 7719 GGAGGGAUGAGAAUGGCAU 7720 GGAGGGAUGAGAAUGGcAUdTsdT antis 1505-1524 7721 UGCCAUUCUCAUCCCUCCU 7722 uGccAuucucAucccuccudTsdT sense 1505-1524 7723 AGGAGGGAUGAGAAUGGCA 7724 AGGAGGGAUGAGAAUGGcAdTsdT antis 1506-1525 7725 GCCAUUCUCAUCCCUCCUC 7726 GccAuucucAucccuccucdTsdT sense 1506-1525 7727 GAGGAGGGAUGAGAAUGGC 7728 GAGGAGGGAUGAGAAUGGCdTsdT antis 1507-1526 7729 CCAUUCUCAUCCCUCCUCA 7730 ccAuucucAucccuccucAdTsdT sense 1507-1526 7731 UGAGGAGGGAUGAGAAUGG 7732 UGAGGAGGGAUGAGAAUGGdTsdT antis 1508-1527 7733 CAUUCUCAUCCCUCCUCAC 7734 cAuucucAucccuccucAcdTsdT sense 1508-1527 7735 GUGAGGAGGGAUGAGAAUG 7736 GUGAGGAGGGAUGAGAAUGdTsdT antis 1509-1528 7737 AUUCUCAUCCCUCCUCACU 7738 AuucucAucccuccucAcudTsdT sense 1509-1528 7739 AGUGAGGAGGGAUGAGAAU 7740 AGUGAGGAGGGAUGAGAAUdTsdT antis 1510-1529 7741 UUCUCAUCCCUCCUCACUU 7742 uucucAucccuccucAcuudTsdT sense 1510-1529 7743 AAGUGAGGAGGGAUGAGAA 7744 AAGUGAGGAGGGAUGAGAAdTsdT antis 1511-1530 7745 UCUCAUCCCUCCUCACUUG 7746 ucucAucccuccucAcuuGdTsdT sense 1511-1530 7747 CAAGUGAGGAGGGAUGAGA 7748 cAAGUGAGGAGGGAUGAGAdTsdT antis 1515-1534 7749 AUCCCUCCUCACUUGAGGU 7750 AucccuccucAcuuGAGGudTsdT sense 1515-1534 7751 ACCUCAAGUGAGGAGGGAU 7752 ACCUcAAGUGAGGAGGGAUdTsdT antis 1516-1535 7753 UCCCUCCUCACUUGAGGUC 7754 ucccuccucAcuuGAGGucdTsdT sense 1516-1535 7755 GACCUCAAGUGAGGAGGGA 7756 GACCUcAAGUGAGGAGGGAdTsdT antis 1520-1539 7757 UCCUCACUUGAGGUCCCCA 7758 uccucAcuuGAGGuccccAdTsdT sense 1520-1539 7759 UGGGGACCUCAAGUGAGGA 7760 UGGGGACCUcAAGUGAGGAdTsdT antis 1522-1541 7761 CUCACUUGAGGUCCCCAGC 7762 cucAcuuGAGGuccccAGcdTsdT sense 1522-1541 7763 GCUGGGGACCUCAAGUGAG 7764 GCUGGGGACCUcAAGUGAGdTsdT antis 1523-1542 7765 UCACUUGAGGUCCCCAGCA 7766 ucAcuuGAGGuccccAGcAdTsdT sense 1523-1542 7767 UGCUGGGGACCUCAAGUGA 7768 UGCUGGGGACCUcAAGUGAdTsdT antis 1524-1543 7769 CACUUGAGGUCCCCAGCAG 7770 cAcuuGAGGuccccAGcAGdTsdT sense 1524-1543 7771 CUGCUGGGGACCUCAAGUG 7772 CUGCUGGGGACCUcAAGUGdTsdT antis 1528-1547 7773 UGAGGUCCCCAGCAGGCCC 7774 uGAGGuccccAGcAGGcccdTsdT sense 1528-1547 7775 GGGCCUGCUGGGGACCUCA 7776 GGGCCUGCUGGGGACCUcAdTsdT antis 1529-1548 7777 GAGGUCCCCAGCAGGCCCU 7778 GAGGuccccAGcAGGcccudTsdT sense 1529-1548 7779 AGGGCCUGCUGGGGACCUC 7780 AGGGCCUGCUGGGGACCUCdTsdT antis 1539-1558 7781 GCAGGCCCUGCUUCUCCCC 7782 GcAGGcccuGcuucuccccdTsdT sense 1539-1558 7783 GGGGAGAAGCAGGGCCUGC 7784 GGGGAGAAGcAGGGCCUGCdTsdT antis 1577-1596 7785 AUCCUCACAAGCUUUAACU 7786 AuccucAcAAGcuuuAAcudTsdT sense 1577-1596 7787 AGUUAAAGCUUGUGAGGAU 7788 AGUuAAAGCUUGUGAGGAUdTsdT antis 1578-1597 7789 UCCUCACAAGCUUUAACUG 7790 uccucAcAAGcuuuAAcuGdTsdT sense 1578-1597 7791 CAGUUAAAGCUUGUGAGGA 7792 cAGUuAAAGCUUGUGAGGAdTsdT antis 1579-1598 7793 CCUCACAAGCUUUAACUGA 7794 ccucAcAAGcuuuAAcuGAdTsdT sense 1579-1598 7795 UCAGUUAAAGCUUGUGAGG 7796 UcAGUuAAAGCUUGUGAGGdTsdT antis 1582-1601 7797 CACAAGCUUUAACUGAAGC 7798 cAcAAGcuuuAAcuGAAGcdTsdT sense 1582-1601 7799 GCUUCAGUUAAAGCUUGUG 7800 GCUUcAGUuAAAGCUUGUGdTsdT antis 1587-1606 7801 GCUUUAACUGAAGCUCAGA 7802 GcuuuAAcuGAAGcucAGAdTsdT sense 1587-1606 7803 UCUGAGCUUCAGUUAAAGC 7804 UCUGAGCUUcAGUuAAAGCdTsdT antis 1623-1642 7805 CCAUCUGAUGCCACAACUG 7806 ccAucuGAuGccAcAAcuGdTsdT sense 1623-1642 7807 CAGUUGUGGCAUCAGAUGG 7808 cAGUUGUGGcAUcAGAUGGdTsdT antis 1624-1643 7809 CAUCUGAUGCCACAACUGC 7810 cAucuGAuGccAcAAcuGcdTsdT sense 1624-1643 7811 GCAGUUGUGGCAUCAGAUG 7812 GcAGUUGUGGcAUcAGAUGdTsdT antis 1625-1644 7813 AUCUGAUGCCACAACUGCU 7814 AucuGAuGccAcAAcuGcudTsdT sense 1625-1644 7815 AGCAGUUGUGGCAUCAGAU 7816 AGcAGUUGUGGcAUcAGAUdTsdT antis 1630-1649 7817 AUGCCACAACUGCUACCCU 7818 AuGccAcAAcuGcuAcccudTsdT sense 1630-1649 7819 AGGGUAGCAGUUGUGGCAU 7820 AGGGuAGcAGUUGUGGcAUdTsdT antis 1631-1650 7821 UGCCACAACUGCUACCCUC 7822 uGccAcAAcuGcuAcccucdTsdT sense 1631-1650 7823 GAGGGUAGCAGUUGUGGCA 7824 GAGGGuAGcAGUUGUGGcAdTsdT antis 1632-1651 7825 GCCACAACUGCUACCCUCG 7826 GccAcAAcuGcuAcccucGdTsdT sense 1632-1651 7827 CGAGGGUAGCAGUUGUGGC 7828 CGAGGGuAGcAGUUGUGGCdTsdT antis 1633-1652 7829 CCACAACUGCUACCCUCGC 7830 ccAcAAcuGcuAcccucGcdTsdT sense 1633-1652 7831 GCGAGGGUAGCAGUUGUGG 7832 GCGAGGGuAGcAGUUGUGGdTsdT antis 1668-1687 7833 CCCCACCGACUACCCCUCC 7834 ccccAccGAcuAccccuccdTsdT sense 1668-1687 7835 GGAGGGGUAGUCGGUGGGG 7836 GGAGGGGuAGUCGGUGGGGdTsdT antis 1678-1697 7837 UACCCCUCCACGUCCAUCU 7838 uAccccuccAcGuccAucudTsdT sense 1678-1697 7839 AGAUGGACGUGGAGGGGUA 7840 AGAUGGACGUGGAGGGGuAdTsdT antis 1681-1700 7841 CCCUCCACGUCCAUCUGGG 7842 cccuccAcGuccAucuGGGdTsdT sense 1681-1700 7843 CCCAGAUGGACGUGGAGGG 7844 CCcAGAUGGACGUGGAGGGdTsdT antis 1683-1702 7845 CUCCACGUCCAUCUGGGAA 7846 cuccAcGuccAucuGGGAAdTsdT sense 1683-1702 7847 UUCCCAGAUGGACGUGGAG 7848 UUCCcAGAUGGACGUGGAGdTsdT antis 1690-1709 7849 UCCAUCUGGGAAGGCCCAA 7850 uccAucuGGGAAGGcccAAdTsdT sense 1690-1709 7851 UUGGGCCUUCCCAGAUGGA 7852 UUGGGCCUUCCcAGAUGGAdTsdT antis 1691-1710 7853 CCAUCUGGGAAGGCCCAAG 7854 ccAucuGGGAAGGcccAAGdTsdT sense 1691-1710 7855 CUUGGGCCUUCCCAGAUGG 7856 CUUGGGCCUUCCcAGAUGGdTsdT antis 1692-1711 7857 CAUCUGGGAAGGCCCAAGU 7858 cAucuGGGAAGGcccAAGudTsdT sense 1692-1711 7859 ACUUGGGCCUUCCCAGAUG 7860 ACUUGGGCCUUCCcAGAUGdTsdT antis 1693-1712 7861 AUCUGGGAAGGCCCAAGUG 7862 AucuGGGAAGGcccAAGuGdTsdT sense 1693-1712 7863 CACUUGGGCCUUCCCAGAU 7864 cACUUGGGCCUUCCcAGAUdTsdT antis 1696-1715 7865 UGGGAAGGCCCAAGUGGCG 7866 uGGGAAGGcccAAGuGGcGdTsdT sense 1696-1715 7867 CGCCACUUGGGCCUUCCCA 7868 CGCcACUUGGGCCUUCCcAdTsdT antis 1697-1716 7869 GGGAAGGCCCAAGUGGCGC 7870 GGGAAGGcccAAGuGGcGcdTsdT sense 1697-1716 7871 GCGCCACUUGGGCCUUCCC 7872 GCGCcACUUGGGCCUUCCCdTsdT antis 1698-1717 7873 GGAAGGCCCAAGUGGCGCU 7874 GGAAGGcccAAGuGGcGcudTsdT sense 1698-1717 7875 AGCGCCACUUGGGCCUUCC 7876 AGCGCcACUUGGGCCUUCCdTsdT antis 1699-1718 7877 GAAGGCCCAAGUGGCGCUG 7878 GAAGGcccAAGuGGcGcuGdTsdT sense 1699-1718 7879 CAGCGCCACUUGGGCCUUC 7880 cAGCGCcACUUGGGCCUUCdTsdT antis 1700-1719 7881 AAGGCCCAAGUGGCGCUGG 7882 AAGGcccAAGuGGcGcuGGdTsdT sense 1700-1719 7883 CCAGCGCCACUUGGGCCUU 7884 CcAGCGCcACUUGGGCCUUdTsdT antis 1701-1720 7885 AGGCCCAAGUGGCGCUGGG 7886 AGGcccAAGuGGcGcuGGGdTsdT sense 1701-1720 7887 CCCAGCGCCACUUGGGCCU 7888 CCcAGCGCcACUUGGGCCUdTsdT antis 1702-1721 7889 GGCCCAAGUGGCGCUGGGA 7890 GGcccAAGuGGcGcuGGGAdTsdT sense 1702-1721 7891 UCCCAGCGCCACUUGGGCC 7892 UCCcAGCGCcACUUGGGCCdTsdT antis 1707-1726 7893 AAGUGGCGCUGGGAAGGGG 7894 AAGuGGcGcuGGGAAGGGGdTsdT sense 1707-1726 7895 CCCCUUCCCAGCGCCACUU 7896 CCCCUUCCcAGCGCcACUUdTsdT antis 1708-1727 7897 AGUGGCGCUGGGAAGGGGG 7898 AGuGGcGcuGGGAAGGGGGdTsdT sense 1708-1727 7899 CCCCCUUCCCAGCGCCACU 7900 CCCCCUUCCcAGCGCcACUdTsdT antis 1712-1731 7901 GCGCUGGGAAGGGGGCCAC 7902 GcGcuGGGAAGGGGGccAcdTsdT sense 1712-1731 7903 GUGGCCCCCUUCCCAGCGC 7904 GUGGCCCCCUUCCcAGCGCdTsdT antis 1713-1732 7905 CGCUGGGAAGGGGGCCACA 7906 cGcuGGGAAGGGGGccAcAdTsdT sense 1713-1732 7907 UGUGGCCCCCUUCCCAGCG 7908 UGUGGCCCCCUUCCcAGCGdTsdT antis 1715-1734 7909 CUGGGAAGGGGGCCACAGC 7910 cuGGGAAGGGGGccAcAGcdTsdT sense 1715-1734 7911 GCUGUGGCCCCCUUCCCAG 7912 GCUGUGGCCCCCUUCCcAGdTsdT antis 1716-1735 7913 UGGGAAGGGGGCCACAGCC 7914 uGGGAAGGGGGccAcAGccdTsdT sense 1716-1735 7915 GGCUGUGGCCCCCUUCCCA 7916 GGCUGUGGCCCCCUUCCcAdTsdT antis 1717-1736 7917 GGGAAGGGGGCCACAGCCC 7918 GGGAAGGGGGccAcAGcccdTsdT sense 1717-1736 7919 GGGCUGUGGCCCCCUUCCC 7920 GGGCUGUGGCCCCCUUCCCdTsdT antis 1718-1737 7921 GGAAGGGGGCCACAGCCCA 7922 GGAAGGGGGccAcAGcccAdTsdT sense 1718-1737 7923 UGGGCUGUGGCCCCCUUCC 7924 UGGGCUGUGGCCCCCUUCCdTsdT antis 1719-1738 7925 GAAGGGGGCCACAGCCCAU 7926 GAAGGGGGccAcAGcccAudTsdT sense 1719-1738 7927 AUGGGCUGUGGCCCCCUUC 7928 AUGGGCUGUGGCCCCCUUCdTsdT antis 1720-1739 7929 AAGGGGGCCACAGCCCAUC 7930 AAGGGGGccAcAGcccAucdTsdT sense 1720-1739 7931 GAUGGGCUGUGGCCCCCUU 7932 GAUGGGCUGUGGCCCCCUUdTsdT antis 1721-1740 7933 AGGGGGCCACAGCCCAUCA 7934 AGGGGGccAcAGcccAucAdTsdT sense 1721-1740 7935 UGAUGGGCUGUGGCCCCCU 7936 UGAUGGGCUGUGGCCCCCUdTsdT antis 1724-1743 7937 GGGCCACAGCCCAUCAAGC 7938 GGGccAcAGcccAucAAGcdTsdT sense 1724-1743 7939 GCUUGAUGGGCUGUGGCCC 7940 GCUUGAUGGGCUGUGGCCCdTsdT antis 1725-1744 7941 GGCCACAGCCCAUCAAGCU 7942 GGccAcAGcccAucAAGcudTsdT sense 1725-1744 7943 AGCUUGAUGGGCUGUGGCC 7944 AGCUUGAUGGGCUGUGGCCdTsdT antis 1727-1746 7945 CCACAGCCCAUCAAGCUCC 7946 ccAcAGcccAucAAGcuccdTsdT sense 1727-1746 7947 GGAGCUUGAUGGGCUGUGG 7948 GGAGCUUGAUGGGCUGUGGdTsdT antis 1728-1747 7949 CACAGCCCAUCAAGCUCCU 7950 cAcAGcccAucAAGcuccudTsdT sense 1728-1747 7951 AGGAGCUUGAUGGGCUGUG 7952 AGGAGCUUGAUGGGCUGUGdTsdT antis 1729-1748 7953 ACAGCCCAUCAAGCUCCUG 7954 AcAGcccAucAAGcuccuGdTsdT sense 1729-1748 7955 CAGGAGCUUGAUGGGCUGU 7956 cAGGAGCUUGAUGGGCUGUdTsdT antis 1733-1752 7957 CCCAUCAAGCUCCUGCCCU 7958 cccAucAAGcuccuGcccudTsdT sense 1733-1752 7959 AGGGCAGGAGCUUGAUGGG 7960 AGGGcAGGAGCUUGAUGGGdTsdT antis 1734-1753 7961 CCAUCAAGCUCCUGCCCUG 7962 ccAucAAGcuccuGcccuGdTsdT sense 1734-1753 7963 CAGGGCAGGAGCUUGAUGG 7964 cAGGGcAGGAGCUUGAUGGdTsdT antis 1735-1754 7965 CAUCAAGCUCCUGCCCUGG 7966 cAucAAGcuccuGcccuGGdTsdT sense 1735-1754 7967 CCAGGGCAGGAGCUUGAUG 7968 CcAGGGcAGGAGCUUGAUGdTsdT antis 1736-1755 7969 AUCAAGCUCCUGCCCUGGC 7970 AucAAGcuccuGcccuGGcdTsdT sense 1736-1755 7971 GCCAGGGCAGGAGCUUGAU 7972 GCcAGGGcAGGAGCUUGAUdTsdT antis 1738-1757 7973 CAAGCUCCUGCCCUGGCUG 7974 cAAGcuccuGcccuGGcuGdTsdT sense 1738-1757 7975 CAGCCAGGGCAGGAGCUUG 7976 cAGCcAGGGcAGGAGCUUGdTsdT antis 1739-1758 7977 AAGCUCCUGCCCUGGCUGG 7978 AAGcuccuGcccuGGcuGGdTsdT sense 1739-1758 7979 CCAGCCAGGGCAGGAGCUU 7980 CcAGCcAGGGcAGGAGCUUdTsdT antis 1742-1761 7981 CUCCUGCCCUGGCUGGGCC 7982 cuccuGcccuGGcuGGGccdTsdT sense 1742-1761 7983 GGCCCAGCCAGGGCAGGAG 7984 GGCCcAGCcAGGGcAGGAGdTsdT antis 1745-1764 7985 CUGCCCUGGCUGGGCCCCU 7986 cuGcccuGGcuGGGccccudTsdT sense 1745-1764 7987 AGGGGCCCAGCCAGGGCAG 7988 AGGGGCCcAGCcAGGGcAGdTsdT antis 1747-1766 7989 GCCCUGGCUGGGCCCCUAG 7990 GcccuGGcuGGGccccuAGdTsdT sense 1747-1766 7991 CUAGGGGCCCAGCCAGGGC 7992 CuAGGGGCCcAGCcAGGGCdTsdT antis 1749-1768 7993 CCUGGCUGGGCCCCUAGAC 7994 ccuGGcuGGGccccuAGAcdTsdT sense 1749-1768 7995 GUCUAGGGGCCCAGCCAGG 7996 GUCuAGGGGCCcAGCcAGGdTsdT antis 1750-1769 7997 CUGGCUGGGCCCCUAGACU 7998 cuGGcuGGGccccuAGAcudTsdT sense 1750-1769 7999 AGUCUAGGGGCCCAGCCAG 8000 AGUCuAGGGGCCcAGCcAGdTsdT antis 1751-1770 8001 UGGCUGGGCCCCUAGACUA 8002 uGGcuGGGccccuAGAcuAdTsdT sense 1751-1770 8003 UAGUCUAGGGGCCCAGCCA 8004 uAGUCuAGGGGCCcAGCcAdTsdT antis 1754-1773 8005 CUGGGCCCCUAGACUAGAG 8006 cuGGGccccuAGAcuAGAGdTsdT sense 1754-1773 8007 CUCUAGUCUAGGGGCCCAG 8008 CUCuAGUCuAGGGGCCcAGdTsdT antis 1756-1775 8009 GGGCCCCUAGACUAGAGGG 8010 GGGccccuAGAcuAGAGGGdTsdT sense 1756-1775 8011 CCCUCUAGUCUAGGGGCCC 8012 CCCUCuAGUCuAGGGGCCCdTsdT antis 1757-1776 8013 GGCCCCUAGACUAGAGGGC 8014 GGccccuAGAcuAGAGGGcdTsdT sense 1757-1776 8015 GCCCUCUAGUCUAGGGGCC 8016 GCCCUCuAGUCuAGGGGCCdTsdT antis 1762-1781 8017 CUAGACUAGAGGGCAGAGG 8018 cuAGAcuAGAGGGcAGAGGdTsdT sense 1762-1781 8019 CCUCUGCCCUCUAGUCUAG 8020 CCUCUGCCCUCuAGUCuAGdTsdT antis 1766-1785 8021 ACUAGAGGGCAGAGGUAAA 8022 AcuAGAGGGcAGAGGuAAAdTsdT sense 1766-1785 8023 UUUACCUCUGCCCUCUAGU 8024 UUuACCUCUGCCCUCuAGUdTsdT antis 1768-1787 8025 UAGAGGGCAGAGGUAAAUG 8026 uAGAGGGcAGAGGuAAAuGdTsdT sense 1768-1787 8027 CAUUUACCUCUGCCCUCUA 8028 cAUUuACCUCUGCCCUCuAdTsdT antis 1771-1790 8029 AGGGCAGAGGUAAAUGAAC 8030 AGGGcAGAGGuAAAuGAAcdTsdT sense 1771-1790 8031 GUUCAUUUACCUCUGCCCU 8032 GUUcAUUuACCUCUGCCCUdTsdT antis 1776-1795 8033 AGAGGUAAAUGAACUACCC 8034 AGAGGuAAAuGAAcuAcccdTsdT sense 1776-1795 8035 GGGUAGUUCAUUUACCUCU 8036 GGGuAGUUcAUUuACCUCUdTsdT antis 1783-1802 8037 AAUGAACUACCCCCAGCAU 8038 AAuGAAcuAcccccAGcAudTsdT sense 1783-1802 8039 AUGCUGGGGGUAGUUCAUU 8040 AUGCUGGGGGuAGUUcAUUdTsdT antis 1788-1807 8041 ACUACCCCCAGCAUCUAGG 8042 AcuAcccccAGcAucuAGGdTsdT sense 1788-1807 8043 CCUAGAUGCUGGGGGUAGU 8044 CCuAGAUGCUGGGGGuAGUdTsdT antis 1789-1808 8045 CUACCCCCAGCAUCUAGGC 8046 cuAcccccAGcAucuAGGcdTsdT sense 1789-1808 8047 GCCUAGAUGCUGGGGGUAG 8048 GCCuAGAUGCUGGGGGuAGdTsdT antis 1791-1810 8049 ACCCCCAGCAUCUAGGCCU 8050 AcccccAGcAucuAGGccudTsdT sense 1791-1810 8051 AGGCCUAGAUGCUGGGGGU 8052 AGGCCuAGAUGCUGGGGGUdTsdT antis 1793-1812 8053 CCCCAGCAUCUAGGCCUCC 8054 ccccAGcAucuAGGccuccdTsdT sense 1793-1812 8055 GGAGGCCUAGAUGCUGGGG 8056 GGAGGCCuAGAUGCUGGGGdTsdT antis 1797-1816 8057 AGCAUCUAGGCCUCCCUCA 8058 AGcAucuAGGccucccucAdTsdT sense 1797-1816 8059 UGAGGGAGGCCUAGAUGCU 8060 UGAGGGAGGCCuAGAUGCUdTsdT antis 1822-1841 8061 UAACCUCUGUGGUGGGCUU 8062 uAAccucuGuGGuGGGcuudTsdT sense 1822-1841 8063 AAGCCCACCACAGAGGUUA 8064 AAGCCcACcAcAGAGGUuAdTsdT antis 1823-1842 8065 AACCUCUGUGGUGGGCUUU 8066 AAccucuGuGGuGGGcuuudTsdT sense 1823-1842 8067 AAAGCCCACCACAGAGGUU 8068 AAAGCCcACcAcAGAGGUUdTsdT antis 1826-1845 8069 CUCUGUGGUGGGCUUUUUA 8070 cucuGuGGuGGGcuuuuuAdTsdT sense 1826-1845 8071 UAAAAAGCCCACCACAGAG 8072 uAAAAAGCCcACcAcAGAGdTsdT antis 1827-1846 8073 UCUGUGGUGGGCUUUUUAA 8074 ucuGuGGuGGGcuuuuuAAdTsdT sense 1827-1846 8075 UUAAAAAGCCCACCACAGA 8076 UuAAAAAGCCcACcAcAGAdTsdT antis 1828-1847 8077 CUGUGGUGGGCUUUUUAAA 8078 cuGuGGuGGGcuuuuuAAAdTsdT sense 1828-1847 8079 UUUAAAAAGCCCACCACAG 8080 UUuAAAAAGCCcACcAcAGdTsdT antis 1829-1848 8081 UGUGGUGGGCUUUUUAAAG 8082 uGuGGuGGGcuuuuuAAAGdTsdT sense 1829-1848 8083 CUUUAAAAAGCCCACCACA 8084 CUUuAAAAAGCCcACcAcAdTsdT antis 1830-1849 8085 GUGGUGGGCUUUUUAAAGA 8086 GuGGuGGGcuuuuuAAAGAdTsdT sense 1830-1849 8087 UCUUUAAAAAGCCCACCAC 8088 UCUUuAAAAAGCCcACcACdTsdT antis 1832-1851 8089 GGUGGGCUUUUUAAAGAGG 8090 GGuGGGcuuuuuAAAGAGGdTsdT sense 1832-1851 8091 CCUCUUUAAAAAGCCCACC 8092 CCUCUUuAAAAAGCCcACCdTsdT antis 1835-1854 8093 GGGCUUUUUAAAGAGGAUU 8094 GGGcuuuuuAAAGAGGAuudTsdT sense 1835-1854 8095 AAUCCUCUUUAAAAAGCCC 8096 AAUCCUCUUuAAAAAGCCCdTsdT antis 1836-1855 8097 GGCUUUUUAAAGAGGAUUU 8098 GGcuuuuuAAAGAGGAuuudTsdT sense 1836-1855 8099 AAAUCCUCUUUAAAAAGCC 8100 AAAUCCUCUUuAAAAAGCCdTsdT antis 1884-1903 8101 AAGGACGGGGUUUGGGGGU 8102 AAGGAcGGGGuuuGGGGGudTsdT sense 1884-1903 8103 ACCCCCAAACCCCGUCCUU 8104 ACCCCcAAACCCCGUCCUUdTsdT antis 1886-1905 8105 GGACGGGGUUUGGGGGUGU 8106 GGAcGGGGuuuGGGGGuGudTsdT sense 1886-1905 8107 ACACCCCCAAACCCCGUCC 8108 AcACCCCcAAACCCCGUCCdTsdT antis 1889-1908 8109 CGGGGUUUGGGGGUGUGAG 8110 cGGGGuuuGGGGGuGuGAGdTsdT sense 1889-1908 8111 CUCACACCCCCAAACCCCG 8112 CUcAcACCCCcAAACCCCGdTsdT antis 1890-1909 8113 GGGGUUUGGGGGUGUGAGG 8114 GGGGuuuGGGGGuGuGAGGdTsdT sense 1890-1909 8115 CCUCACACCCCCAAACCCC 8116 CCUcAcACCCCcAAACCCCdTsdT antis 1891-1910 8117 GGGUUUGGGGGUGUGAGGA 8118 GGGuuuGGGGGuGuGAGGAdTsdT sense 1891-1910 8119 UCCUCACACCCCCAAACCC 8120 UCCUcAcACCCCcAAACCCdTsdT antis 1892-1911 8121 GGUUUGGGGGUGUGAGGAC 8122 GGuuuGGGGGuGuGAGGAcdTsdT sense 1892-1911 8123 GUCCUCACACCCCCAAACC 8124 GUCCUcAcACCCCcAAACCdTsdT antis 1893-1912 8125 GUUUGGGGGUGUGAGGACC 8126 GuuuGGGGGuGuGAGGAccdTsdT sense 1893-1912 8127 GGUCCUCACACCCCCAAAC 8128 GGUCCUcAcACCCCcAAACdTsdT antis 1894-1913 8129 UUUGGGGGUGUGAGGACCU 8130 uuuGGGGGuGuGAGGAccudTsdT sense 1894-1913 8131 AGGUCCUCACACCCCCAAA 8132 AGGUCCUcAcACCCCcAAAdTsdT antis 1895-1914 8133 UUGGGGGUGUGAGGACCUU 8134 uuGGGGGuGuGAGGAccuudTsdT sense 1895-1914 8135 AAGGUCCUCACACCCCCAA 8136 AAGGUCCUcAcACCCCcAAdTsdT antis 1914-1933 8137 CUACCCCCUUGGUCCCCUC 8138 cuAcccccuuGGuccccucdTsdT sense 1914-1933 8139 GAGGGGACCAAGGGGGUAG 8140 GAGGGGACcAAGGGGGuAGdTsdT antis 1915-1934 8141 UACCCCCUUGGUCCCCUCC 8142 uAcccccuuGGuccccuccdTsdT sense 1915-1934 8143 GGAGGGGACCAAGGGGGUA 8144 GGAGGGGACcAAGGGGGuAdTsdT antis 1916-1935 8145 ACCCCCUUGGUCCCCUCCC 8146 AcccccuuGGuccccucccdTsdT sense 1916-1935 8147 GGGAGGGGACCAAGGGGGU 8148 GGGAGGGGACcAAGGGGGUdTsdT antis 1917-1936 8149 CCCCCUUGGUCCCCUCCCC 8150 cccccuuGGuccccuccccdTsdT sense 1917-1936 8151 GGGGAGGGGACCAAGGGGG 8152 GGGGAGGGGACcAAGGGGGdTsdT antis 1918-1937 8153 CCCCUUGGUCCCCUCCCCU 8154 ccccuuGGuccccuccccudTsdT sense 1918-1937 8155 AGGGGAGGGGACCAAGGGG 8156 AGGGGAGGGGACcAAGGGGdTsdT antis 1919-1938 8157 CCCUUGGUCCCCUCCCCUC 8158 cccuuGGuccccuccccucdTsdT sense 1919-1938 8159 GAGGGGAGGGGACCAAGGG 8160 GAGGGGAGGGGACcAAGGGdTsdT antis 1920-1939 8161 CCUUGGUCCCCUCCCCUCC 8162 ccuuGGuccccuccccuccdTsdT sense 1920-1939 8163 GGAGGGGAGGGGACCAAGG 8164 GGAGGGGAGGGGACcAAGGdTsdT antis 1921-1940 8165 CUUGGUCCCCUCCCCUCCC 8166 cuuGGuccccuccccucccdTsdT sense 1921-1940 8167 GGGAGGGGAGGGGACCAAG 8168 GGGAGGGGAGGGGACcAAGdTsdT antis 1922-1941 8169 UUGGUCCCCUCCCCUCCCC 8170 uuGGuccccuccccuccccdTsdT sense 1922-1941 8171 GGGGAGGGGAGGGGACCAA 8172 GGGGAGGGGAGGGGACcAAdTsdT antis 2116-2135 8173 UUCUUGUCCUCUGCUCCCA 8174 uucuuGuccucuGcucccAdTsdT sense 2116-2135 8175 UGGGAGCAGAGGACAAGAA 8176 UGGGAGcAGAGGAcAAGAAdTsdT antis  213-232 8177 GGAGGCGGCCCUGGGGGCU 8178 GGAGGcGGcccuGGGGGcudTsdT sense  213-232 8179 AGCCCCCAGGGCCGCCUCC 8180 AGCCCCcAGGGCCGCCUCCdTsdT antis  358-377 8181 UGGGUGGGGGCGUGGGAGC 8182 uGGGuGGGGGcGuGGGAGcdTsdT sense  358-377 8183 GCUCCCACGCCCCCACCCA 8184 GCUCCcACGCCCCcACCcAdTsdT antis  528-547 8185 CGUUCCCAAGAAGUGGCUU 8186 cGuucccAAGAAGuGGcuudTsdT sense  528-547 8187 AAGCCACUUCUUGGGAACG 8188 AAGCcACUUCUUGGGAACGdTsdT antis  559-578 8189 AAGUGAUUGGUAAUGGCUC 8190 AAGuGAuuGGuAAuGGcucdTsdT sense  559-578 8191 GAGCCAUUACCAAUCACUU 8192 GAGCcAUuACcAAUcACUUdTsdT antis  623-642 8193 GGUGGCCAUCAAGAAGGUU 8194 GGuGGccAucAAGAAGGuudTsdT sense  623-642 8195 AACCUUCUUGAUGGCCACC 8196 AACCUUCUUGAUGGCcACCdTsdT antis  630-649 8197 AUCAAGAAGGUUCUUCAGG 8198 AucAAGAAGGuucuucAGGdTsdT sense  630-649 8199 CCUGAAGAACCUUCUUGAU 8200 CCUGAAGAACCUUCUUGAUdTsdT antis  633-652 8201 AAGAAGGUUCUUCAGGACA 8202 AAGAAGGuucuucAGGAcAdTsdT sense  633-652 8203 UGUCCUGAAGAACCUUCUU 8204 UGUCCUGAAGAACCUUCUUdTsdT antis  801-820 8205 CGAGUGGCCCGCCACUUCA 8206 cGAGuGGcccGccAcuucAdTsdT sense  801-820 8207 UGAAGUGGCGGGCCACUCG 8208 UGAAGUGGCGGGCcACUCGdTsdT antis  859-878 8209 UGUACAUGUACCAGCUCUU 8210 uGuAcAuGuAccAGcucuudTsdT sense  859-878 8211 AAGAGCUGGUACAUGUACA 8212 AAGAGCUGGuAcAUGuAcAdTsdT antis  936-955 8213 AAUUUGCUUGUGGACCCUG 8214 AAuuuGcuuGuGGAcccuGdTsdT sense  936-955 8215 CAGGGUCCACAAGCAAAUU 8216 cAGGGUCcAcAAGcAAAUUdTsdT antis  944-963 8217 UGUGGACCCUGACACUGCU 8218 uGuGGAcccuGAcAcuGcudTsdT sense  944-963 8219 AGCAGUGUCAGGGUCCACA 8220 AGcAGUGUcAGGGUCcAcAdTsdT antis  960-979 8221 GCUGUCCUCAAGCUCUGCG 8222 GcuGuccucAAGcucuGcGdTsdT sense  960-979 8223 CGCAGAGCUUGAGGACAGC 8224 CGcAGAGCUUGAGGAcAGCdTsdT antis  966-985 8225 CUCAAGCUCUGCGAUUUUG 8226 cucAAGcucuGcGAuuuuGdTsdT sense  966-985 8227 CAAAAUCGCAGAGCUUGAG 8228 cAAAAUCGcAGAGCUUGAGdTsdT antis  982-1001 8229 UUGGCAGUGCAAAGCAGCU 8230 uuGGcAGuGcAAAGcAGcudTsdT sense  982-1001 8231 AGCUGCUUUGCACUGCCAA 8232 AGCUGCUUUGcACUGCcAAdTsdT antis  983-1002 8233 UGGCAGUGCAAAGCAGCUG 8234 uGGcAGuGcAAAGcAGcuGdTsdT sense  983-1002 8235 CAGCUGCUUUGCACUGCCA 8236 cAGCUGCUUUGcACUGCcAdTsdT antis 1170-1189 8237 GACCAGCUUGUGGAGAUCA 8238 GAccAGcuuGuGGAGAucAdTsdT sense 1170-1189 8239 UGAUCUCCACAAGCUGGUC 8240 UGAUCUCcAcAAGCUGGUCdTsdT antis 1210-1229 8241 CCAGGGAACAAAUCCGAGA 8242 ccAGGGAAcAAAuccGAGAdTsdT sense 1210-1229 8243 UCUCGGAUUUGUUCCCUGG 8244 UCUCGGAUUUGUUCCCUGGdTsdT antis 1521-1540 8245 CCUCACUUGAGGUCCCCAG 8246 ccucAcuuGAGGuccccAGdTsdT sense 1521-1540 8247 CUGGGGACCUCAAGUGAGG 8248 CUGGGGACCUcAAGUGAGGdTsdT antis 1533-1552 8249 UCCCCAGCAGGCCCUGCUU 8250 uccccAGcAGGcccuGcuudTsdT sense 1533-1552 8251 AAGCAGGGCCUGCUGGGGA 8252 AAGcAGGGCCUGCUGGGGAdTsdT antis 1534-1553 8253 CCCCAGCAGGCCCUGCUUC 8254 ccccAGcAGGcccuGcuucdTsdT sense 1534-1553 8255 GAAGCAGGGCCUGCUGGGG 8256 GAAGcAGGGCCUGCUGGGGdTsdT antis 1679-1698 8257 ACCCCUCCACGUCCAUCUG 8258 AccccuccAcGuccAucuGdTsdT sense 1679-1698 8259 CAGAUGGACGUGGAGGGGU 8260 cAGAUGGACGUGGAGGGGUdTsdT antis 1680-1699 8261 CCCCUCCACGUCCAUCUGG 8262 ccccuccAcGuccAucuGGdTsdT sense 1680-1699 8263 CCAGAUGGACGUGGAGGGG 8264 CcAGAUGGACGUGGAGGGGdTsdT antis 1684-1703 8265 UCCACGUCCAUCUGGGAAG 8266 uccAcGuccAucuGGGAAGdTsdT sense 1684-1703 8267 CUUCCCAGAUGGACGUGGA 8268 CUUCCcAGAUGGACGUGGAdTsdT antis 1710-1729 8269 UGGCGCUGGGAAGGGGGCC 8270 uGGcGcuGGGAAGGGGGccdTsdT sense 1710-1729 8271 GGCCCCCUUCCCAGCGCCA 8272 GGCCCCCUUCCcAGCGCcAdTsdT antis 1711-1730 8273 GGCGCUGGGAAGGGGGCCA 8274 GGcGcuGGGAAGGGGGccAdTsdT sense 1711-1730 8275 UGGCCCCCUUCCCAGCGCC 8276 UGGCCCCCUUCCcAGCGCCdTsdT antis 1726-1745 8277 GCCACAGCCCAUCAAGCUC 8278 GccAcAGcccAucAAGcucdTsdT sense 1726-1745 8279 GAGCUUGAUGGGCUGUGGC 8280 GAGCUUGAUGGGCUGUGGCdTsdT antis 1731-1750 8281 AGCCCAUCAAGCUCCUGCC 8282 AGcccAucAAGcuccuGccdTsdT sense 1731-1750 8283 GGCAGGAGCUUGAUGGGCU 8284 GGcAGGAGCUUGAUGGGCUdTsdT antis 1740-1759 8285 AGCUCCUGCCCUGGCUGGG 8286 AGcuccuGcccuGGcuGGGdTsdT sense 1740-1759 8287 CCCAGCCAGGGCAGGAGCU 8288 CCcAGCcAGGGcAGGAGCUdTsdT antis 1741-1760 8289 GCUCCUGCCCUGGCUGGGC 8290 GcuccuGcccuGGcuGGGcdTsdT sense 1741-1760 8291 GCCCAGCCAGGGCAGGAGC 8292 GCCcAGCcAGGGcAGGAGCdTsdT antis 1767-1786 8293 CUAGAGGGCAGAGGUAAAU 8294 cuAGAGGGcAGAGGuAAAudTsdT sense 1767-1786 8295 AUUUACCUCUGCCCUCUAG 8296 AUUuACCUCUGCCCUCuAGdTsdT antis 1772-1791 8297 GGGCAGAGGUAAAUGAACU 8298 GGGcAGAGGuAAAuGAAcudTsdT sense 1772-1791 8299 AGUUCAUUUACCUCUGCCC 8300 AGUUcAUUuACCUCUGCCCdTsdT antis 1775-1794 8301 CAGAGGUAAAUGAACUACC 8302 cAGAGGuAAAuGAAcuAccdTsdT sense 1775-1794 8303 GGUAGUUCAUUUACCUCUG 8304 GGuAGUUcAUUuACCUCUGdTsdT antis 1824-1843 8305 ACCUCUGUGGUGGGCUUUU 8306 AccucuGuGGuGGGcuuuudTsdT sense 1824-1843 8307 AAAAGCCCACCACAGAGGU 8308 AAAAGCCcACcAcAGAGGUdTsdT antis 1834-1853 8309 UGGGCUUUUUAAAGAGGAU 8310 uGGGcuuuuuAAAGAGGAudTsdT sense 1834-1853 8311 AUCCUCUUUAAAAAGCCCA 8312 AUCCUCUUuAAAAAGCCcAdTsdT antis 2015-2034 8313 UUCCCUUCCCUGGCCCCCU 8314 uucccuucccuGGcccccudTsdT sense 2015-2034 8315 AGGGGGCCAGGGAAGGGAA 8316 AGGGGGCcAGGGAAGGGAAdTsdT antis   69-88 8317 GGAGCCGGAGCCCGAACGG 8318 GGAGccGGAGcccGAAcGGdTsdT sense   69-88 8319 CCGUUCGGGCUCCGGCUCC 8320 CCGUUCGGGCUCCGGCUCCdTsdT antis  112-131 8321 CAGGGGAGGCGGCGGCAGA 8322 cAGGGGAGGcGGcGGcAGAdTsdT sense  112-131 8323 UCUGCCGCCGCCUCCCCUG 8324 UCUGCCGCCGCCUCCCCUGdTsdT antis  113-132 8325 AGGGGAGGCGGCGGCAGAG 8326 AGGGGAGGcGGcGGcAGAGdTsdT sense  113-132 8327 CUCUGCCGCCGCCUCCCCU 8328 CUCUGCCGCCGCCUCCCCUdTsdT antis  114-133 8329 GGGGAGGCGGCGGCAGAGG 8330 GGGGAGGcGGcGGcAGAGGdTsdT sense  114-133 8331 CCUCUGCCGCCGCCUCCCC 8332 CCUCUGCCGCCGCCUCCCCdTsdT antis  116-135 8333 GGAGGCGGCGGCAGAGGCA 8334 GGAGGcGGcGGcAGAGGcAdTsdT sense  116-135 8335 UGCCUCUGCCGCCGCCUCC 8336 UGCCUCUGCCGCCGCCUCCdTsdT antis  130-149 8337 AGGCAGCGGCGGGGGCAGC 8338 AGGcAGcGGcGGGGGcAGcdTsdT sense  130-149 8339 GCUGCCCCCGCCGCUGCCU 8340 GCUGCCCCCGCCGCUGCCUdTsdT antis  131-150 8341 GGCAGCGGCGGGGGCAGCC 8342 GGcAGcGGcGGGGGcAGccdTsdT sense  131-150 8343 GGCUGCCCCCGCCGCUGCC 8344 GGCUGCCCCCGCCGCUGCCdTsdT antis  166-185 8345 CGCGGCCUGGGCCUGCGCU 8346 cGcGGccuGGGccuGcGcudTsdT sense  166-185 8347 AGCGCAGGCCCAGGCCGCG 8348 AGCGcAGGCCcAGGCCGCGdTsdT antis  272-291 8349 CGGAGGCGGAGGUGGUGGC 8350 cGGAGGcGGAGGuGGuGGcdTsdT sense  272-291 8351 GCCACCACCUCCGCCUCCG 8352 GCcACcACCUCCGCCUCCGdTsdT antis  273-292 8353 GGAGGCGGAGGUGGUGGCG 8354 GGAGGcGGAGGuGGuGGcGdTsdT sense  273-292 8355 CGCCACCACCUCCGCCUCC 8356 CGCcACcACCUCCGCCUCCdTsdT antis  274-293 8357 GAGGCGGAGGUGGUGGCGG 8358 GAGGcGGAGGuGGuGGcGGdTsdT sense  274-293 8359 CCGCCACCACCUCCGCCUC 8360 CCGCcACcACCUCCGCCUCdTsdT antis  276-295 8361 GGCGGAGGUGGUGGCGGCG 8362 GGcGGAGGuGGuGGcGGcGdTsdT sense  276-295 8363 CGCCGCCACCACCUCCGCC 8364 CGCCGCcACcACCUCCGCCdTsdT antis  277-296 8365 GCGGAGGUGGUGGCGGCGG 8366 GcGGAGGuGGuGGcGGcGGdTsdT sense  277-296 8367 CCGCCGCCACCACCUCCGC 8368 CCGCCGCcACcACCUCCGCdTsdT antis  285-304 8369 GGUGGCGGCGGCCCCGGGG 8370 GGuGGcGGcGGccccGGGGdTsdT sense  285-304 8371 CCCCGGGGCCGCCGCCACC 8372 CCCCGGGGCCGCCGCcACCdTsdT antis  286-305 8373 GUGGCGGCGGCCCCGGGGG 8374 GuGGcGGcGGccccGGGGGdTsdT sense  286-305 8375 CCCCCGGGGCCGCCGCCAC 8376 CCCCCGGGGCCGCCGCcACdTsdT antis  287-306 8377 UGGCGGCGGCCCCGGGGGC 8378 uGGcGGcGGccccGGGGGcdTsdT sense  287-306 8379 GCCCCCGGGGCCGCCGCCA 8380 GCCCCCGGGGCCGCCGCcAdTsdT antis  288-307 8381 GGCGGCGGCCCCGGGGGCU 8382 GGcGGcGGccccGGGGGcudTsdT sense  288-307 8383 AGCCCCCGGGGCCGCCGCC 8384 AGCCCCCGGGGCCGCCGCCdTsdT antis  309-328 8385 GCCUCUGGCCCAGGAGGCA 8386 GccucuGGcccAGGAGGcAdTsdT sense  309-328 8387 UGCCUCCUGGGCCAGAGGC 8388 UGCCUCCUGGGCcAGAGGCdTsdT antis  310-329 8389 CCUCUGGCCCAGGAGGCAC 8390 ccucuGGcccAGGAGGcAcdTsdT sense  310-329 8391 GUGCCUCCUGGGCCAGAGG 8392 GUGCCUCCUGGGCcAGAGGdTsdT antis  312-331 8393 UCUGGCCCAGGAGGCACUG 8394 ucuGGcccAGGAGGcAcuGdTsdT sense  312-331 8395 CAGUGCCUCCUGGGCCAGA 8396 cAGUGCCUCCUGGGCcAGAdTsdT antis  313-332 8397 CUGGCCCAGGAGGCACUGG 8398 cuGGcccAGGAGGcAcuGGdTsdT sense  313-332 8399 CCAGUGCCUCCUGGGCCAG 8400 CcAGUGCCUCCUGGGCcAGdTsdT antis  315-334 8401 GGCCCAGGAGGCACUGGCG 8402 GGcccAGGAGGcAcuGGcGdTsdT sense  315-334 8403 CGCCAGUGCCUCCUGGGCC 8404 CGCcAGUGCCUCCUGGGCCdTsdT antis  356-375 8405 UAUGGGUGGGGGCGUGGGA 8406 uAuGGGuGGGGGcGuGGGAdTsdT sense  356-375 8407 UCCCACGCCCCCACCCAUA 8408 UCCcACGCCCCcACCcAuAdTsdT antis  359-378 8409 GGGUGGGGGCGUGGGAGCC 8410 GGGuGGGGGcGuGGGAGccdTsdT sense  359-378 8411 GGCUCCCACGCCCCCACCC 8412 GGCUCCcACGCCCCcACCCdTsdT antis  360-379 8413 GGUGGGGGCGUGGGAGCCU 8414 GGuGGGGGcGuGGGAGccudTsdT sense  360-379 8415 AGGCUCCCACGCCCCCACC 8416 AGGCUCCcACGCCCCcACCdTsdT antis  362-381 8417 UGGGGGCGUGGGAGCCUCG 8418 uGGGGGcGuGGGAGccucGdTsdT sense  362-381 8419 CGAGGCUCCCACGCCCCCA 8420 CGAGGCUCCcACGCCCCcAdTsdT antis  367-386 8421 GCGUGGGAGCCUCGAGCUC 8422 GcGuGGGAGccucGAGcucdTsdT sense  367-386 8423 GAGCUCGAGGCUCCCACGC 8424 GAGCUCGAGGCUCCcACGCdTsdT antis  401-420 8425 CGGCAGCGGCGGAGGAGGC 8426 cGGcAGcGGcGGAGGAGGcdTsdT sense  401-420 8427 GCCUCCUCCGCCGCUGCCG 8428 GCCUCCUCCGCCGCUGCCGdTsdT antis  402-421 8429 GGCAGCGGCGGAGGAGGCA 8430 GGcAGcGGcGGAGGAGGcAdTsdT sense  402-421 8431 UGCCUCCUCCGCCGCUGCC 8432 UGCCUCCUCCGCCGCUGCCdTsdT antis  409-428 8433 GCGGAGGAGGCAGCGGUGG 8434 GcGGAGGAGGcAGcGGuGGdTsdT sense  409-428 8435 CCACCGCUGCCUCCUCCGC 8436 CcACCGCUGCCUCCUCCGCdTsdT antis  410-429 8437 CGGAGGAGGCAGCGGUGGC 8438 cGGAGGAGGcAGcGGuGGcdTsdT sense  410-429 8439 GCCACCGCUGCCUCCUCCG 8440 GCcACCGCUGCCUCCUCCGdTsdT antis  415-434 8441 GAGGCAGCGGUGGCCCCGG 8442 GAGGcAGcGGuGGccccGGdTsdT sense  415-434 8443 CCGGGGCCACCGCUGCCUC 8444 CCGGGGCcACCGCUGCCUCdTsdT antis  416-435 8445 AGGCAGCGGUGGCCCCGGC 8446 AGGcAGcGGuGGccccGGcdTsdT sense  416-435 8447 GCCGGGGCCACCGCUGCCU 8448 GCCGGGGCcACCGCUGCCUdTsdT antis  483-502 8449 GGGAAGGUGACCACAGUGG 8450 GGGAAGGuGAccAcAGuGGdTsdT sense  483-502 8451 CCACUGUGGUCACCUUCCC 8452 CcACUGUGGUcACCUUCCCdTsdT antis  484-503 8453 GGAAGGUGACCACAGUGGU 8454 GGAAGGuGAccAcAGuGGudTsdT sense  484-503 8455 ACCACUGUGGUCACCUUCC 8456 ACcACUGUGGUcACCUUCCdTsdT antis  486-505 8457 AAGGUGACCACAGUGGUAG 8458 AAGGuGAccAcAGuGGuAGdTsdT sense  486-505 8459 CUACCACUGUGGUCACCUU 8460 CuACcACUGUGGUcACCUUdTsdT antis  529-548 8461 GUUCCCAAGAAGUGGCUUA 8462 GuucccAAGAAGuGGcuuAdTsdT sense  529-548 8463 UAAGCCACUUCUUGGGAAC 8464 uAAGCcACUUCUUGGGAACdTsdT antis  560-579 8465 AGUGAUUGGUAAUGGCUCA 8466 AGuGAuuGGuAAuGGcucAdTsdT sense  560-579 8467 UGAGCCAUUACCAAUCACU 8468 UGAGCcAUuACcAAUcACUdTsdT antis  561-580 8469 GUGAUUGGUAAUGGCUCAU 8470 GuGAuuGGuAAuGGcucAudTsdT sense  561-580 8471 AUGAGCCAUUACCAAUCAC 8472 AUGAGCcAUuACcAAUcACdTsdT antis  622-641 8473 UGGUGGCCAUCAAGAAGGU 8474 uGGuGGccAucAAGAAGGudTsdT sense  622-641 8475 ACCUUCUUGAUGGCCACCA 8476 ACCUUCUUGAUGGCcACcAdTsdT antis  628-647 8477 CCAUCAAGAAGGUUCUUCA 8478 ccAucAAGAAGGuucuucAdTsdT sense  628-647 8479 UGAAGAACCUUCUUGAUGG 8480 UGAAGAACCUUCUUGAUGGdTsdT antis  629-648 8481 CAUCAAGAAGGUUCUUCAG 8482 cAucAAGAAGGuucuucAGdTsdT sense  629-648 8483 CUGAAGAACCUUCUUGAUG 8484 CUGAAGAACCUUCUUGAUGdTsdT antis  637-656 8485 AGGUUCUUCAGGACAAAAG 8486 AGGuucuucAGGAcAAAAGdTsdT sense  637-656 8487 CUUUUGUCCUGAAGAACCU 8488 CUUUUGUCCUGAAGAACCUdTsdT antis  684-703 8489 CGUAAGCUGGACCACUGCA 8490 cGuAAGcuGGAccAcuGcAdTsdT sense  684-703 8491 UGCAGUGGUCCAGCUUACG 8492 UGcAGUGGUCcAGCUuACGdTsdT antis  695-714 8493 CCACUGCAAUAUUGUGAGG 8494 ccAcuGcAAuAuuGuGAGGdTsdT sense  695-714 8495 CCUCACAAUAUUGCAGUGG 8496 CCUcAcAAuAUUGcAGUGGdTsdT antis  719-738 8497 GUACUUUUUCUACUCCAGU 8498 GuAcuuuuucuAcuccAGudTsdT sense  719-738 8499 ACUGGAGUAGAAAAAGUAC 8500 ACUGGAGuAGAAAAAGuACdTsdT antis  722-741 8501 CUUUUUCUACUCCAGUGGG 8502 cuuuuucuAcuccAGuGGGdTsdT sense  722-741 8503 CCCACUGGAGUAGAAAAAG 8504 CCcACUGGAGuAGAAAAAGdTsdT antis  728-747 8505 CUACUCCAGUGGGGAGAAG 8506 cuAcuccAGuGGGGAGAAGdTsdT sense  728-747 8507 CUUCUCCCCACUGGAGUAG 8508 CUUCUCCCcACUGGAGuAGdTsdT antis  732-751 8509 UCCAGUGGGGAGAAGAAGG 8510 uccAGuGGGGAGAAGAAGGdTsdT sense  732-751 8511 CCUUCUUCUCCCCACUGGA 8512 CCUUCUUCUCCCcACUGGAdTsdT antis  734-753 8513 CAGUGGGGAGAAGAAGGAC 8514 cAGuGGGGAGAAGAAGGAcdTsdT sense  734-753 8515 GUCCUUCUUCUCCCCACUG 8516 GUCCUUCUUCUCCCcACUGdTsdT antis  735-754 8517 AGUGGGGAGAAGAAGGACG 8518 AGuGGGGAGAAGAAGGAcGdTsdT sense  735-754 8519 CGUCCUUCUUCUCCCCACU 8520 CGUCCUUCUUCUCCCcACUdTsdT antis  766-785 8521 AUCUGGUGCUGGAGUAUGU 8522 AucuGGuGcuGGAGuAuGudTsdT sense  766-785 8523 ACAUACUCCAGCACCAGAU 8524 AcAuACUCcAGcACcAGAUdTsdT antis  767-786 8525 UCUGGUGCUGGAGUAUGUG 8526 ucuGGuGcuGGAGuAuGuGdTsdT sense  767-786 8527 CACAUACUCCAGCACCAGA 8528 cAcAuACUCcAGcACcAGAdTsdT antis  768-787 8529 CUGGUGCUGGAGUAUGUGC 8530 cuGGuGcuGGAGuAuGuGcdTsdT sense  768-787 8531 GCACAUACUCCAGCACCAG 8532 GcAcAuACUCcAGcACcAGdTsdT antis  812-831 8533 CCACUUCACCAAGGCCAAG 8534 ccAcuucAccAAGGccAAGdTsdT sense  812-831 8535 CUUGGCCUUGGUGAAGUGG 8536 CUUGGCCUUGGUGAAGUGGdTsdT antis  814-833 8537 ACUUCACCAAGGCCAAGCU 8538 AcuucAccAAGGccAAGcudTsdT sense  814-833 8539 AGCUUGGCCUUGGUGAAGU 8540 AGCUUGGCCUUGGUGAAGUdTsdT antis  816-835 8541 UUCACCAAGGCCAAGCUGA 8542 uucAccAAGGccAAGcuGAdTsdT sense  816-835 8543 UCAGCUUGGCCUUGGUGAA 8544 UcAGCUUGGCCUUGGUGAAdTsdT antis  819-838 8545 ACCAAGGCCAAGCUGAUCA 8546 AccAAGGccAAGcuGAucAdTsdT sense  819-838 8547 UGAUCAGCUUGGCCUUGGU 8548 UGAUcAGCUUGGCCUUGGUdTsdT antis  820-839 8549 CCAAGGCCAAGCUGAUCAC 8550 ccAAGGccAAGcuGAucAcdTsdT sense  820-839 8551 GUGAUCAGCUUGGCCUUGG 8552 GUGAUcAGCUUGGCCUUGGdTsdT antis  864-883 8553 AUGUACCAGCUCUUCCGGA 8554 AuGuAccAGcucuuccGGAdTsdT sense  864-883 8555 UCCGGAAGAGCUGGUACAU 8556 UCCGGAAGAGCUGGuAcAUdTsdT antis  875-894 8557 CUUCCGGAGCUUGGCCUAC 8558 cuuccGGAGcuuGGccuAcdTsdT sense  875-894 8559 GUAGGCCAAGCUCCGGAAG 8560 GuAGGCcAAGCUCCGGAAGdTsdT antis  964-983 8561 UCCUCAAGCUCUGCGAUUU 8562 uccucAAGcucuGcGAuuudTsdT sense  964-983 8563 AAAUCGCAGAGCUUGAGGA 8564 AAAUCGcAGAGCUUGAGGAdTsdT antis  965-984 8565 CCUCAAGCUCUGCGAUUUU 8566 ccucAAGcucuGcGAuuuudTsdT sense  965-984 8567 AAAAUCGCAGAGCUUGAGG 8568 AAAAUCGcAGAGCUUGAGGdTsdT antis  969-988 8569 AAGCUCUGCGAUUUUGGCA 8570 AAGcucuGcGAuuuuGGcAdTsdT sense  969-988 8571 UGCCAAAAUCGCAGAGCUU 8572 UGCcAAAAUCGcAGAGCUUdTsdT antis  980-999 8573 UUUUGGCAGUGCAAAGCAG 8574 uuuuGGcAGuGcAAAGcAGdTsdT sense  980-999 8575 CUGCUUUGCACUGCCAAAA 8576 CUGCUUUGcACUGCcAAAAdTsdT antis  981-1000 8577 UUUGGCAGUGCAAAGCAGC 8578 uuuGGcAGuGcAAAGcAGcdTsdT sense  981-1000 8579 GCUGCUUUGCACUGCCAAA 8580 GCUGCUUUGcACUGCcAAAdTsdT antis  985-1004 8581 GCAGUGCAAAGCAGCUGGU 8582 GcAGuGcAAAGcAGcuGGudTsdT sense  985-1004 8583 ACCAGCUGCUUUGCACUGC 8584 ACcAGCUGCUUUGcACUGCdTsdT antis 1166-1185 8585 GGUGGACCAGCUUGUGGAG 8586 GGuGGAccAGcuuGuGGAGdTsdT sense 1166-1185 8587 CUCCACAAGCUGGUCCACC 8588 CUCcAcAAGCUGGUCcACCdTsdT antis 1167-1186 8589 GUGGACCAGCUUGUGGAGA 8590 GuGGAccAGcuuGuGGAGAdTsdT sense 1167-1186 8591 UCUCCACAAGCUGGUCCAC 8592 UCUCcAcAAGCUGGUCcACdTsdT antis 1171-1190 8593 ACCAGCUUGUGGAGAUCAU 8594 AccAGcuuGuGGAGAucAudTsdT sense 1171-1190 8595 AUGAUCUCCACAAGCUGGU 8596 AUGAUCUCcAcAAGCUGGUdTsdT antis 1211-1230 8597 CAGGGAACAAAUCCGAGAG 8598 cAGGGAAcAAAuccGAGAGdTsdT sense 1211-1230 8599 CUCUCGGAUUUGUUCCCUG 8600 CUCUCGGAUUUGUUCCCUGdTsdT antis 1254-1273 8601 AAGUUCCCCCAGAUCAAAG 8602 AAGuucccccAGAucAAAGdTsdT sense 1254-1273 8603 CUUUGAUCUGGGGGAACUU 8604 CUUUGAUCUGGGGGAACUUdTsdT antis 1259-1278 8605 CCCCCAGAUCAAAGCUCAC 8606 cccccAGAucAAAGcucAcdTsdT sense 1259-1278 8607 GUGAGCUUUGAUCUGGGGG 8608 GUGAGCUUUGAUCUGGGGGdTsdT antis 1260-1279 8609 CCCCAGAUCAAAGCUCACC 8610 ccccAGAucAAAGcucAccdTsdT sense 1260-1279 8611 GGUGAGCUUUGAUCUGGGG 8612 GGUGAGCUUUGAUCUGGGGdTsdT antis 1281-1300 8613 UGGACAAAGGUGUUCAAAU 8614 uGGAcAAAGGuGuucAAAudTsdT sense 1281-1300 8615 AUUUGAACACCUUUGUCCA 8616 AUUUGAAcACCUUUGUCcAdTsdT antis 1360-1379 8617 CCUCAAGGCUCUCCCCACU 8618 ccucAAGGcucuccccAcudTsdT sense 1360-1379 8619 AGUGGGGAGAGCCUUGAGG 8620 AGUGGGGAGAGCCUUGAGGdTsdT antis 1381-1400 8621 AGGCUUGUGCCCACAGCUU 8622 AGGcuuGuGcccAcAGcuudTsdT sense 1381-1400 8623 AAGCUGUGGGCACAAGCCU 8624 AAGCUGUGGGcAcAAGCCUdTsdT antis 1385-1404 8625 UUGUGCCCACAGCUUCUUC 8626 uuGuGcccAcAGcuucuucdTsdT sense 1385-1404 8627 GAAGAAGCUGUGGGCACAA 8628 GAAGAAGCUGUGGGcAcAAdTsdT antis 1387-1406 8629 GUGCCCACAGCUUCUUCGA 8630 GuGcccAcAGcuucuucGAdTsdT sense 1387-1406 8631 UCGAAGAAGCUGUGGGCAC 8632 UCGAAGAAGCUGUGGGcACdTsdT antis 1388-1407 8633 UGCCCACAGCUUCUUCGAU 8634 uGcccAcAGcuucuucGAudTsdT sense 1388-1407 8635 AUCGAAGAAGCUGUGGGCA 8636 AUCGAAGAAGCUGUGGGcAdTsdT antis 1455-1474 8637 CCCCUGUUCAACUUCAGUC 8638 ccccuGuucAAcuucAGucdTsdT sense 1455-1474 8639 GACUGAAGUUGAACAGGGG 8640 GACUGAAGUUGAAcAGGGGdTsdT antis 1456-1475 8641 CCCUGUUCAACUUCAGUCC 8642 cccuGuucAAcuucAGuccdTsdT sense 1456-1475 8643 GGACUGAAGUUGAACAGGG 8644 GGACUGAAGUUGAAcAGGGdTsdT antis 1457-1476 8645 CCUGUUCAACUUCAGUCCU 8646 ccuGuucAAcuucAGuccudTsdT sense 1457-1476 8647 AGGACUGAAGUUGAACAGG 8648 AGGACUGAAGUUGAAcAGGdTsdT antis 1458-1477 8649 CUGUUCAACUUCAGUCCUG 8650 cuGuucAAcuucAGuccuGdTsdT sense 1458-1477 8651 CAGGACUGAAGUUGAACAG 8652 cAGGACUGAAGUUGAAcAGdTsdT antis 1513-1532 8653 UCAUCCCUCCUCACUUGAG 8654 ucAucccuccucAcuuGAGdTsdT sense 1513-1532 8655 CUCAAGUGAGGAGGGAUGA 8656 CUcAAGUGAGGAGGGAUGAdTsdT antis 1514-1533 8657 CAUCCCUCCUCACUUGAGG 8658 cAucccuccucAcuuGAGGdTsdT sense 1514-1533 8659 CCUCAAGUGAGGAGGGAUG 8660 CCUcAAGUGAGGAGGGAUGdTsdT antis 1517-1536 8661 CCCUCCUCACUUGAGGUCC 8662 cccuccucAcuuGAGGuccdTsdT sense 1517-1536 8663 GGACCUCAAGUGAGGAGGG 8664 GGACCUcAAGUGAGGAGGGdTsdT antis 1518-1537 8665 CCUCCUCACUUGAGGUCCC 8666 ccuccucAcuuGAGGucccdTsdT sense 1518-1537 8667 GGGACCUCAAGUGAGGAGG 8668 GGGACCUcAAGUGAGGAGGdTsdT antis 1519-1538 8669 CUCCUCACUUGAGGUCCCC 8670 cuccucAcuuGAGGuccccdTsdT sense 1519-1538 8671 GGGGACCUCAAGUGAGGAG 8672 GGGGACCUcAAGUGAGGAGdTsdT antis 1525-1544 8673 ACUUGAGGUCCCCAGCAGG 8674 AcuuGAGGuccccAGcAGGdTsdT sense 1525-1544 8675 CCUGCUGGGGACCUCAAGU 8676 CCUGCUGGGGACCUcAAGUdTsdT antis 1526-1545 8677 CUUGAGGUCCCCAGCAGGC 8678 cuuGAGGuccccAGcAGGcdTsdT sense 1526-1545 8679 GCCUGCUGGGGACCUCAAG 8680 GCCUGCUGGGGACCUcAAGdTsdT antis 1527-1546 8681 UUGAGGUCCCCAGCAGGCC 8682 uuGAGGuccccAGcAGGccdTsdT sense 1527-1546 8683 GGCCUGCUGGGGACCUCAA 8684 GGCCUGCUGGGGACCUcAAdTsdT antis 1530-1549 8685 AGGUCCCCAGCAGGCCCUG 8686 AGGuccccAGcAGGcccuGdTsdT sense 1530-1549 8687 CAGGGCCUGCUGGGGACCU 8688 cAGGGCCUGCUGGGGACCUdTsdT antis 1531-1550 8689 GGUCCCCAGCAGGCCCUGC 8690 GGuccccAGcAGGcccuGcdTsdT sense 1531-1550 8691 GCAGGGCCUGCUGGGGACC 8692 GcAGGGCCUGCUGGGGACCdTsdT antis 1532-1551 8693 GUCCCCAGCAGGCCCUGCU 8694 GuccccAGcAGGcccuGcudTsdT sense 1532-1551 8695 AGCAGGGCCUGCUGGGGAC 8696 AGcAGGGCCUGCUGGGGACdTsdT antis 1538-1557 8697 AGCAGGCCCUGCUUCUCCC 8698 AGcAGGcccuGcuucucccdTsdT sense 1538-1557 8699 GGGAGAAGCAGGGCCUGCU 8700 GGGAGAAGcAGGGCCUGCUdTsdT antis 1588-1607 8701 CUUUAACUGAAGCUCAGAC 8702 cuuuAAcuGAAGcucAGAcdTsdT sense 1588-1607 8703 GUCUGAGCUUCAGUUAAAG 8704 GUCUGAGCUUcAGUuAAAGdTsdT antis 1626-1645 8705 UCUGAUGCCACAACUGCUA 8706 ucuGAuGccAcAAcuGcuAdTsdT sense 1626-1645 8707 UAGCAGUUGUGGCAUCAGA 8708 uAGcAGUUGUGGcAUcAGAdTsdT antis 1627-1646 8709 CUGAUGCCACAACUGCUAC 8710 cuGAuGccAcAAcuGcuAcdTsdT sense 1627-1646 8711 GUAGCAGUUGUGGCAUCAG 8712 GuAGcAGUUGUGGcAUcAGdTsdT antis 1628-1647 8713 UGAUGCCACAACUGCUACC 8714 uGAuGccAcAAcuGcuAccdTsdT sense 1628-1647 8715 GGUAGCAGUUGUGGCAUCA 8716 GGuAGcAGUUGUGGcAUcAdTsdT antis 1629-1648 8717 GAUGCCACAACUGCUACCC 8718 GAuGccAcAAcuGcuAcccdTsdT sense 1629-1648 8719 GGGUAGCAGUUGUGGCAUC 8720 GGGuAGcAGUUGUGGcAUCdTsdT antis 1686-1705 8721 CACGUCCAUCUGGGAAGGC 8722 cAcGuccAucuGGGAAGGcdTsdT sense 1686-1705 8723 GCCUUCCCAGAUGGACGUG 8724 GCCUUCCcAGAUGGACGUGdTsdT antis 1687-1706 8725 ACGUCCAUCUGGGAAGGCC 8726 AcGuccAucuGGGAAGGccdTsdT sense 1687-1706 8727 GGCCUUCCCAGAUGGACGU 8728 GGCCUUCCcAGAUGGACGUdTsdT antis 1688-1707 8729 CGUCCAUCUGGGAAGGCCC 8730 cGuccAucuGGGAAGGcccdTsdT sense 1688-1707 8731 GGGCCUUCCCAGAUGGACG 8732 GGGCCUUCCcAGAUGGACGdTsdT antis 1689-1708 8733 GUCCAUCUGGGAAGGCCCA 8734 GuccAucuGGGAAGGcccAdTsdT sense 1689-1708 8735 UGGGCCUUCCCAGAUGGAC 8736 UGGGCCUUCCcAGAUGGACdTsdT antis 1694-1713 8737 UCUGGGAAGGCCCAAGUGG 8738 ucuGGGAAGGcccAAGuGGdTsdT sense 1694-1713 8739 CCACUUGGGCCUUCCCAGA 8740 CcACUUGGGCCUUCCcAGAdTsdT antis 1695-1714 8741 CUGGGAAGGCCCAAGUGGC 8742 cuGGGAAGGcccAAGuGGcdTsdT sense 1695-1714 8743 GCCACUUGGGCCUUCCCAG 8744 GCcACUUGGGCCUUCCcAGdTsdT antis 1709-1728 8745 GUGGCGCUGGGAAGGGGGC 8746 GuGGcGcuGGGAAGGGGGcdTsdT sense 1709-1728 8747 GCCCCCUUCCCAGCGCCAC 8748 GCCCCCUUCCcAGCGCcACdTsdT antis 1714-1733 8749 GCUGGGAAGGGGGCCACAG 8750 GcuGGGAAGGGGGccAcAGdTsdT sense 1714-1733 8751 CUGUGGCCCCCUUCCCAGC 8752 CUGUGGCCCCCUUCCcAGCdTsdT antis 1722-1741 8753 GGGGGCCACAGCCCAUCAA 8754 GGGGGccAcAGcccAucAAdTsdT sense 1722-1741 8755 UUGAUGGGCUGUGGCCCCC 8756 UUGAUGGGCUGUGGCCCCCdTsdT antis 1723-1742 8757 GGGGCCACAGCCCAUCAAG 8758 GGGGccAcAGcccAucAAGdTsdT sense 1723-1742 8759 CUUGAUGGGCUGUGGCCCC 8760 CUUGAUGGGCUGUGGCCCCdTsdT antis 1732-1751 8761 GCCCAUCAAGCUCCUGCCC 8762 GcccAucAAGcuccuGcccdTsdT sense 1732-1751 8763 GGGCAGGAGCUUGAUGGGC 8764 GGGcAGGAGCUUGAUGGGCdTsdT antis 1737-1756 8765 UCAAGCUCCUGCCCUGGCU 8766 ucAAGcuccuGcccuGGcudTsdT sense 1737-1756 8767 AGCCAGGGCAGGAGCUUGA 8768 AGCcAGGGcAGGAGCUUGAdTsdT antis 1743-1762 8769 UCCUGCCCUGGCUGGGCCC 8770 uccuGcccuGGcuGGGcccdTsdT sense 1743-1762 8771 GGGCCCAGCCAGGGCAGGA 8772 GGGCCcAGCcAGGGcAGGAdTsdT antis 1744-1763 8773 CCUGCCCUGGCUGGGCCCC 8774 ccuGcccuGGcuGGGccccdTsdT sense 1744-1763 8775 GGGGCCCAGCCAGGGCAGG 8776 GGGGCCcAGCcAGGGcAGGdTsdT antis 1746-1765 8777 UGCCCUGGCUGGGCCCCUA 8778 uGcccuGGcuGGGccccuAdTsdT sense 1746-1765 8779 UAGGGGCCCAGCCAGGGCA 8780 uAGGGGCCcAGCcAGGGcAdTsdT antis 1748-1767 8781 CCCUGGCUGGGCCCCUAGA 8782 cccuGGcuGGGccccuAGAdTsdT sense 1748-1767 8783 UCUAGGGGCCCAGCCAGGG 8784 UCuAGGGGCCcAGCcAGGGdTsdT antis 1769-1788 8785 AGAGGGCAGAGGUAAAUGA 8786 AGAGGGcAGAGGuAAAuGAdTsdT sense 1769-1788 8787 UCAUUUACCUCUGCCCUCU 8788 UcAUUuACCUCUGCCCUCUdTsdT antis 1770-1789 8789 GAGGGCAGAGGUAAAUGAA 8790 GAGGGcAGAGGuAAAuGAAdTsdT sense 1770-1789 8791 UUCAUUUACCUCUGCCCUC 8792 UUcAUUuACCUCUGCCCUCdTsdT antis 1798-1817 8793 GCAUCUAGGCCUCCCUCAG 8794 GcAucuAGGccucccucAGdTsdT sense 1798-1817 8795 CUGAGGGAGGCCUAGAUGC 8796 CUGAGGGAGGCCuAGAUGCdTsdT antis 1825-1844 8797 CCUCUGUGGUGGGCUUUUU 8798 ccucuGuGGuGGGcuuuuudTsdT sense 1825-1844 8799 AAAAAGCCCACCACAGAGG 8800 AAAAAGCCcACcAcAGAGGdTsdT antis 1831-1850 8801 UGGUGGGCUUUUUAAAGAG 8802 uGGuGGGcuuuuuAAAGAGdTsdT sense 1831-1850 8803 CUCUUUAAAAAGCCCACCA 8804 CUCUUuAAAAAGCCcACcAdTsdT antis 1833-1852 8805 GUGGGCUUUUUAAAGAGGA 8806 GuGGGcuuuuuAAAGAGGAdTsdT sense 1833-1852 8807 UCCUCUUUAAAAAGCCCAC 8808 UCCUCUUuAAAAAGCCcACdTsdT antis 1837-1856 8809 GCUUUUUAAAGAGGAUUUU 8810 GcuuuuuAAAGAGGAuuuudTsdT sense 1837-1856 8811 AAAAUCCUCUUUAAAAAGC 8812 AAAAUCCUCUUuAAAAAGCdTsdT antis 1838-1857 8813 CUUUUUAAAGAGGAUUUUA 8814 cuuuuuAAAGAGGAuuuuAdTsdT sense 1838-1857 8815 UAAAAUCCUCUUUAAAAAG 8816 uAAAAUCCUCUUuAAAAAGdTsdT antis 1869-1888 8817 GGAGGGGAGAAAAGGAAGG 8818 GGAGGGGAGAAAAGGAAGGdTsdT sense 1869-1888 8819 CCUUCCUUUUCUCCCCUCC 8820 CCUUCCUUUUCUCCCCUCCdTsdT antis 1870-1889 8821 GAGGGGAGAAAAGGAAGGA 8822 GAGGGGAGAAAAGGAAGGAdTsdT sense 1870-1889 8823 UCCUUCCUUUUCUCCCCUC 8824 UCCUUCCUUUUCUCCCCUCdTsdT antis 1888-1907 8825 ACGGGGUUUGGGGGUGUGA 8826 AcGGGGuuuGGGGGuGuGAdTsdT sense 1888-1907 8827 UCACACCCCCAAACCCCGU 8828 UcAcACCCCcAAACCCCGUdTsdT antis 1923-1942 8829 UGGUCCCCUCCCCUCCCCC 8830 uGGuccccuccccucccccdTsdT sense 1923-1942 8831 GGGGGAGGGGAGGGGACCA 8832 GGGGGAGGGGAGGGGACcAdTsdT antis 1924-1943 8833 GGUCCCCUCCCCUCCCCCA 8834 GGuccccuccccucccccAdTsdT sense 1924-1943 8835 UGGGGGAGGGGAGGGGACC 8836 UGGGGGAGGGGAGGGGACCdTsdT antis 1931-1950 8837 UCCCCUCCCCCAGGCUACC 8838 uccccucccccAGGcuAccdTsdT sense 1931-1950 8839 GGUAGCCUGGGGGAGGGGA 8840 GGuAGCCUGGGGGAGGGGAdTsdT antis 1962-1981 8841 CCCCCCUCUCCCAGGUCCC 8842 ccccccucucccAGGucccdTsdT sense 1962-1981 8843 GGGACCUGGGAGAGGGGGG 8844 GGGACCUGGGAGAGGGGGGdTsdT antis 1963-1982 8845 CCCCCUCUCCCAGGUCCCU 8846 cccccucucccAGGucccudTsdT sense 1963-1982 8847 AGGGACCUGGGAGAGGGGG 8848 AGGGACCUGGGAGAGGGGGdTsdT antis 2132-2151 8849 CCAAGGCUUCCUCCCUCUC 8850 ccAAGGcuuccucccucucdTsdT sense 2132-2151 8851 GAGAGGGAGGAAGCCUUGG 8852 GAGAGGGAGGAAGCCUUGGdTsdT antis 2139-2158 8853 UUCCUCCCUCUCCCCAUCC 8854 uuccucccucuccccAuccdTsdT sense 2139-2158 8855 GGAUGGGGAGAGGGAGGAA 8856 GGAUGGGGAGAGGGAGGAAdTsdT antis   63-82 8857 UGGGCCGGAGCCGGAGCCC 8858 uGGGccGGAGccGGAGcccdTsdT sense   63-82 8859 GGGCUCCGGCUCCGGCCCA 8860 GGGCUCCGGCUCCGGCCcAdTsdT antis   65-84 8861 GGCCGGAGCCGGAGCCCGA 8862 GGccGGAGccGGAGcccGAdTsdT sense   65-84 8863 UCGGGCUCCGGCUCCGGCC 8864 UCGGGCUCCGGCUCCGGCCdTsdT antis   66-85 8865 GCCGGAGCCGGAGCCCGAA 8866 GccGGAGccGGAGcccGAAdTsdT sense   66-85 8867 UUCGGGCUCCGGCUCCGGC 8868 UUCGGGCUCCGGCUCCGGCdTsdT antis  115-134 8869 GGGAGGCGGCGGCAGAGGC 8870 GGGAGGcGGcGGcAGAGGcdTsdT sense  115-134 8871 GCCUCUGCCGCCGCCUCCC 8872 GCCUCUGCCGCCGCCUCCCdTsdT antis  118-137 8873 AGGCGGCGGCAGAGGCAGC 8874 AGGcGGcGGcAGAGGcAGcdTsdT sense  118-137 8875 GCUGCCUCUGCCGCCGCCU 8876 GCUGCCUCUGCCGCCGCCUdTsdT antis  119-138 8877 GGCGGCGGCAGAGGCAGCG 8878 GGcGGcGGcAGAGGcAGcGdTsdT sense  119-138 8879 CGCUGCCUCUGCCGCCGCC 8880 CGCUGCCUCUGCCGCCGCCdTsdT antis  128-147 8881 AGAGGCAGCGGCGGGGGCA 8882 AGAGGcAGcGGcGGGGGcAdTsdT sense  128-147 8883 UGCCCCCGCCGCUGCCUCU 8884 UGCCCCCGCCGCUGCCUCUdTsdT antis  129-148 8885 GAGGCAGCGGCGGGGGCAG 8886 GAGGcAGcGGcGGGGGcAGdTsdT sense  129-148 8887 CUGCCCCCGCCGCUGCCUC 8888 CUGCCCCCGCCGCUGCCUCdTsdT antis  265-284 8889 CAGGAGGCGGAGGCGGAGG 8890 cAGGAGGcGGAGGcGGAGGdTsdT sense  265-284 8891 CCUCCGCCUCCGCCUCCUG 8892 CCUCCGCCUCCGCCUCCUGdTsdT antis  266-285 8893 AGGAGGCGGAGGCGGAGGU 8894 AGGAGGcGGAGGcGGAGGudTsdT sense  266-285 8895 ACCUCCGCCUCCGCCUCCU 8896 ACCUCCGCCUCCGCCUCCUdTsdT antis  269-288 8897 AGGCGGAGGCGGAGGUGGU 8898 AGGcGGAGGcGGAGGuGGudTsdT sense  269-288 8899 ACCACCUCCGCCUCCGCCU 8900 ACcACCUCCGCCUCCGCCUdTsdT antis  275-294 8901 AGGCGGAGGUGGUGGCGGC 8902 AGGcGGAGGuGGuGGcGGcdTsdT sense  275-294 8903 GCCGCCACCACCUCCGCCU 8904 GCCGCcACcACCUCCGCCUdTsdT antis  278-297 8905 CGGAGGUGGUGGCGGCGGC 8906 cGGAGGuGGuGGcGGcGGcdTsdT sense  278-297 8907 GCCGCCGCCACCACCUCCG 8908 GCCGCCGCcACcACCUCCGdTsdT antis  279-298 8909 GGAGGUGGUGGCGGCGGCC 8910 GGAGGuGGuGGcGGcGGccdTsdT sense  279-298 8911 GGCCGCCGCCACCACCUCC 8912 GGCCGCCGCcACcACCUCCdTsdT antis  314-333 8913 UGGCCCAGGAGGCACUGGC 8914 uGGcccAGGAGGcAcuGGcdTsdT sense  314-333 8915 GCCAGUGCCUCCUGGGCCA 8916 GCcAGUGCCUCCUGGGCcAdTsdT antis  399-418 8917 AGCGGCAGCGGCGGAGGAG 8918 AGcGGcAGcGGcGGAGGAGdTsdT sense  399-418 8919 CUCCUCCGCCGCUGCCGCU 8920 CUCCUCCGCCGCUGCCGCUdTsdT antis  411-430 8921 GGAGGAGGCAGCGGUGGCC 8922 GGAGGAGGcAGcGGuGGccdTsdT sense  411-430 8923 GGCCACCGCUGCCUCCUCC 8924 GGCcACCGCUGCCUCCUCCdTsdT antis  412-431 8925 GAGGAGGCAGCGGUGGCCC 8926 GAGGAGGcAGcGGuGGcccdTsdT sense  412-431 8927 GGGCCACCGCUGCCUCCUC 8928 GGGCcACCGCUGCCUCCUCdTsdT antis  413-432 8929 AGGAGGCAGCGGUGGCCCC 8930 AGGAGGcAGcGGuGGccccdTsdT sense  413-432 8931 GGGGCCACCGCUGCCUCCU 8932 GGGGCcACCGCUGCCUCCUdTsdT antis  414-433 8933 GGAGGCAGCGGUGGCCCCG 8934 GGAGGcAGcGGuGGccccGdTsdT sense  414-433 8935 CGGGGCCACCGCUGCCUCC 8936 CGGGGCcACCGCUGCCUCCdTsdT antis  636-655 8937 AAGGUUCUUCAGGACAAAA 8938 AAGGuucuucAGGAcAAAAdTsdT sense  636-655 8939 UUUUGUCCUGAAGAACCUU 8940 UUUUGUCCUGAAGAACCUUdTsdT antis  731-750 8941 CUCCAGUGGGGAGAAGAAG 8942 cuccAGuGGGGAGAAGAAGdTsdT sense  731-750 8943 CUUCUUCUCCCCACUGGAG 8944 CUUCUUCUCCCcACUGGAGdTsdT antis  733-752 8945 CCAGUGGGGAGAAGAAGGA 8946 ccAGuGGGGAGAAGAAGGAdTsdT sense  733-752 8947 UCCUUCUUCUCCCCACUGG 8948 UCCUUCUUCUCCCcACUGGdTsdT antis  963-982 8949 GUCCUCAAGCUCUGCGAUU 8950 GuccucAAGcucuGcGAuudTsdT sense  963-982 8951 AAUCGCAGAGCUUGAGGAC 8952 AAUCGcAGAGCUUGAGGACdTsdT antis 1535-1554 8953 CCCAGCAGGCCCUGCUUCU 8954 cccAGcAGGcccuGcuucudTsdT sense 1535-1554 8955 AGAAGCAGGGCCUGCUGGG 8956 AGAAGcAGGGCCUGCUGGGdTsdT antis 1536-1555 8957 CCAGCAGGCCCUGCUUCUC 8958 ccAGcAGGcccuGcuucucdTsdT sense 1536-1555 8959 GAGAAGCAGGGCCUGCUGG 8960 GAGAAGcAGGGCCUGCUGGdTsdT antis 1537-1556 8961 CAGCAGGCCCUGCUUCUCC 8962 cAGcAGGcccuGcuucuccdTsdT sense 1537-1556 8963 GGAGAAGCAGGGCCUGCUG 8964 GGAGAAGcAGGGCCUGCUGdTsdT antis 1887-1906 8965 GACGGGGUUUGGGGGUGUG 8966 GAcGGGGuuuGGGGGuGuGdTsdT sense 1887-1906 8967 CACACCCCCAAACCCCGUC 8968 cAcACCCCcAAACCCCGUCdTsdT antis 1925-1944 8969 GUCCCCUCCCCUCCCCCAG 8970 GuccccuccccucccccAGdTsdT sense 1925-1944 8971 CUGGGGGAGGGGAGGGGAC 8972 CUGGGGGAGGGGAGGGGACdTsdT antis 1926-1945 8973 UCCCCUCCCCUCCCCCAGG 8974 uccccuccccucccccAGGdTsdT sense 1926-1945 8975 CCUGGGGGAGGGGAGGGGA 8976 CCUGGGGGAGGGGAGGGGAdTsdT antis 2055-2074 8977 AUUUUUUCUUAAAGAAAAC 8978 AuuuuuucuuAAAGAAAAcdTsdT sense 2055-2074 8979 GUUUUCUUUAAGAAAAAAU 8980 GUUUUCUUuAAGAAAAAAUdTsdT antis 2143-2162 8981 UCCCUCUCCCCAUCCUGGA 8982 ucccucuccccAuccuGGAdTsdT sense 2143-2162 8983 UCCAGGAUGGGGAGAGGGA 8984 UCcAGGAUGGGGAGAGGGAdTsdT antis

TABLE 2 Sequences of duplexes targeting Mouse GSK3-beta Sequences of duplexes targeting mouse GSK3-beta. Target sequence location identifies target sequence in mouse GSK3-beta mRNA NM_019827.6. Sense strand is identical to target sequence. Antisense strand is complementary to target sequence. Target SEQ SEQ sequence ID Unmodified sequence ID Modified sequence location NO: 5′ to 3′ NO: 5′ to 3′ Strand 1842-1861  8985 ACUGUAACAUAGUCCGACU 10985 AcuGuAAcAuAGuccGAcudTsdT sense 1842-1861  8986 AGUCGGACUAUGUUACAGU 10986 AGUCGGACuAUGUuAcAGUdTsdT antis 1843-1862  8987 CUGUAACAUAGUCCGACUG 10987 cuGuAAcAuAGuccGAcuGdTsdT sense 1843-1862  8988 CAGUCGGACUAUGUUACAG 10988 cAGUCGGACuAUGUuAcAGdTsdT antis 1952-1971  8989 GCCAGACACUAUAGUCGAG 10989 GccAGAcAcuAuAGucGAGdTsdT sense 1952-1971  8990 CUCGACUAUAGUGUCUGGC 10990 CUCGACuAuAGUGUCUGGCdTsdT antis 1847-1866  8991 AACAUAGUCCGACUGCGGU 10991 AAcAuAGuccGAcuGcGGudTsdT sense 1847-1866  8992 ACCGCAGUCGGACUAUGUU 10992 ACCGcAGUCGGACuAUGUUdTsdT antis 1838-1857  8993 GACCACUGUAACAUAGUCC 10993 GAccAcuGuAAcAuAGuccdTsdT sense 1838-1857  8994 GGACUAUGUUACAGUGGUC 10994 GGACuAUGUuAcAGUGGUCdTsdT antis 1846-1865  8995 UAACAUAGUCCGACUGCGG 10995 uAAcAuAGuccGAcuGcGGdTsdT sense 1846-1865  8996 CCGCAGUCGGACUAUGUUA 10996 CCGcAGUCGGACuAUGUuAdTsdT antis 1849-1868  8997 CAUAGUCCGACUGCGGUAU 10997 cAuAGuccGAcuGcGGuAudTsdT sense 1849-1868  8998 AUACCGCAGUCGGACUAUG 10998 AuACCGcAGUCGGACuAUGdTsdT antis 1955-1974  8999 AGACACUAUAGUCGAGCCA 10999 AGAcAcuAuAGucGAGccAdTsdT sense 1955-1974  9000 UGGCUCGACUAUAGUGUCU 11000 UGGCUCGACuAuAGUGUCUdTsdT antis 1957-1976  9001 ACACUAUAGUCGAGCCAAG 11001 AcAcuAuAGucGAGccAAGdTsdT sense 1957-1976  9002 CUUGGCUCGACUAUAGUGU 11002 CUUGGCUCGACuAuAGUGUdTsdT antis 2169-2188  9003 CAUAUAUCUGUUCUCGGUA 11003 cAuAuAucuGuucucGGuAdTsdT sense 2169-2188  9004 UACCGAGAACAGAUAUAUG 11004 uACCGAGAAcAGAuAuAUGdTsdT antis 1788-1807  9005 UACAGGACAAGCGAUUUAA 11005 uAcAGGAcAAGcGAuuuAAdTsdT sense 1788-1807  9006 UUAAAUCGCUUGUCCUGUA 11006 UuAAAUCGCUUGUCCUGuAdTsdT antis 1862-1881  9007 CGGUAUUUCUUCUACUCGA 11007 cGGuAuuucuucuAcucGAdTsdT sense 1862-1881  9008 UCGAGUAGAAGAAAUACCG 11008 UCGAGuAGAAGAAAuACCGdTsdT antis 2021-2040  9009 UUCAGAAGUCUAGCCUAUA 11009 uucAGAAGucuAGccuAuAdTsdT sense 2021-2040  9010 UAUAGGCUAGACUUCUGAA 11010 uAuAGGCuAGACUUCUGAAdTsdT antis 1863-1882  9011 GGUAUUUCUUCUACUCGAG 11011 GGuAuuucuucuAcucGAGdTsdT sense 1863-1882  9012 CUCGAGUAGAAGAAAUACC 11012 CUCGAGuAGAAGAAAuACCdTsdT antis 2496-2515  9013 CACCUACCGCCCGGCUAAC 11013 cAccuAccGcccGGcuAAcdTsdT sense 2496-2515  9014 GUUAGCCGGGCGGUAGGUG 11014 GUuAGCCGGGCGGuAGGUGdTsdT antis 1796-1815  9015 AAGCGAUUUAAGAACCGAG 11015 AAGcGAuuuAAGAAccGAGdTsdT sense 1796-1815  9016 CUCGGUUCUUAAAUCGCUU 11016 CUCGGUUCUuAAAUCGCUUdTsdT antis 1844-1863  9017 UGUAACAUAGUCCGACUGC 11017 uGuAAcAuAGuccGAcuGcdTsdT sense 1844-1863  9018 GCAGUCGGACUAUGUUACA 11018 GcAGUCGGACuAUGUuAcAdTsdT antis 2221-2240  9019 UGAUUACACGUCCAGUAUA 11019 uGAuuAcAcGuccAGuAuAdTsdT sense 2221-2240  9020 UAUACUGGACGUGUAAUCA 11020 uAuACUGGACGUGuAAUcAdTsdT antis 2228-2247  9021 ACGUCCAGUAUAGAUGUAU 11021 AcGuccAGuAuAGAuGuAudTsdT sense 2228-2247  9022 AUACAUCUAUACUGGACGU 11022 AuAcAUCuAuACUGGACGUdTsdT antis 1697-1716  9023 GACACGAAAGUGAUUGGAA 11023 GAcAcGAAAGuGAuuGGAAdTsdT sense 1697-1716  9024 UUCCAAUCACUUUCGUGUC 11024 UUCcAAUcACUUUCGUGUCdTsdT antis 1845-1864  9025 GUAACAUAGUCCGACUGCG 11025 GuAAcAuAGuccGAcuGcGdTsdT sense 1845-1864  9026 CGCAGUCGGACUAUGUUAC 11026 CGcAGUCGGACuAUGUuACdTsdT antis 1851-1870  9027 UAGUCCGACUGCGGUAUUU 11027 uAGuccGAcuGcGGuAuuudTsdT sense 1851-1870  9028 AAAUACCGCAGUCGGACUA 11028 AAAuACCGcAGUCGGACuAdTsdT antis 1871-1890  9029 UUCUACUCGAGUGGUGAGA 11029 uucuAcucGAGuGGuGAGAdTsdT sense 1871-1890  9030 UCUCACCACUCGAGUAGAA 11030 UCUcACcACUCGAGuAGAAdTsdT antis 2022-2041  9031 UCAGAAGUCUAGCCUAUAU 11031 ucAGAAGucuAGccuAuAudTsdT sense 2022-2041  9032 AUAUAGGCUAGACUUCUGA 11032 AuAuAGGCuAGACUUCUGAdTsdT antis 2024-2043  9033 AGAAGUCUAGCCUAUAUCC 11033 AGAAGucuAGccuAuAuccdTsdT sense 2024-2043  9034 GGAUAUAGGCUAGACUUCU 11034 GGAuAuAGGCuAGACUUCUdTsdT antis 2220-2239  9035 CUGAUUACACGUCCAGUAU 11035 cuGAuuAcAcGuccAGuAudTsdT sense 2220-2239  9036 AUACUGGACGUGUAAUCAG 11036 AuACUGGACGUGuAAUcAGdTsdT antis 1789-1808  9037 ACAGGACAAGCGAUUUAAG 11037 AcAGGAcAAGcGAuuuAAGdTsdT sense 1789-1808  9038 CUUAAAUCGCUUGUCCUGU 11038 CUuAAAUCGCUUGUCCUGUdTsdT antis 1922-1941  9039 GACUAUGUUCCGGAGACAG 11039 GAcuAuGuuccGGAGAcAGdTsdT sense 1922-1941  9040 CUGUCUCCGGAACAUAGUC 11040 CUGUCUCCGGAAcAuAGUCdTsdT antis 2020-2039  9041 GUUCAGAAGUCUAGCCUAU 11041 GuucAGAAGucuAGccuAudTsdT sense 2020-2039  9042 AUAGGCUAGACUUCUGAAC 11042 AuAGGCuAGACUUCUGAACdTsdT antis 2492-2511  9043 UACACACCUACCGCCCGGC 11043 uAcAcAccuAccGcccGGcdTsdT sense 2492-2511  9044 GCCGGGCGGUAGGUGUGUA 11044 GCCGGGCGGuAGGUGUGuAdTsdT antis 1678-1697  9045 ACAGGAAGUCAGUUAUACA 11045 AcAGGAAGucAGuuAuAcAdTsdT sense 1678-1697  9046 UGUAUAACUGACUUCCUGU 11046 UGuAuAACUGACUUCCUGUdTsdT antis 1840-1859  9047 CCACUGUAACAUAGUCCGA 11047 ccAcuGuAAcAuAGuccGAdTsdT sense 1840-1859  9048 UCGGACUAUGUUACAGUGG 11048 UCGGACuAUGUuAcAGUGGdTsdT antis 2487-2506  9049 UGGAGUACACACCUACCGC 11049 uGGAGuAcAcAccuAccGcdTsdT sense 2487-2506  9050 GCGGUAGGUGUGUACUCCA 11050 GCGGuAGGUGUGuACUCcAdTsdT antis 1924-1943  9051 CUAUGUUCCGGAGACAGUG 11051 cuAuGuuccGGAGAcAGuGdTsdT sense 1924-1943  9052 CACUGUCUCCGGAACAUAG 11052 cACUGUCUCCGGAAcAuAGdTsdT antis 2176-2195  9053 CUGUUCUCGGUACUACAGG 11053 cuGuucucGGuAcuAcAGGdTsdT sense 2176-2195  9054 CCUGUAGUACCGAGAACAG 11054 CCUGuAGuACCGAGAAcAGdTsdT antis 2177-2196  9055 UGUUCUCGGUACUACAGGG 11055 uGuucucGGuAcuAcAGGGdTsdT sense 2177-2196  9056 CCCUGUAGUACCGAGAACA 11056 CCCUGuAGuACCGAGAAcAdTsdT antis 2502-2521  9057 CCGCCCGGCUAACACCACU 11057 ccGcccGGcuAAcAccAcudTsdT sense 2502-2521  9058 AGUGGUGUUAGCCGGGCGG 11058 AGUGGUGUuAGCCGGGCGGdTsdT antis 2499-2518  9059 CUACCGCCCGGCUAACACC 11059 cuAccGcccGGcuAAcAccdTsdT sense 2499-2518  9060 GGUGUUAGCCGGGCGGUAG 11060 GGUGUuAGCCGGGCGGuAGdTsdT antis 2223-2242  9061 AUUACACGUCCAGUAUAGA 11061 AuuAcAcGuccAGuAuAGAdTsdT sense 2223-2242  9062 UCUAUACUGGACGUGUAAU 11062 UCuAuACUGGACGUGuAAUdTsdT antis 1873-1892  9063 CUACUCGAGUGGUGAGAAG 11063 cuAcucGAGuGGuGAGAAGdTsdT sense 1873-1892  9064 CUUCUCACCACUCGAGUAG 11064 CUUCUcACcACUCGAGuAGdTsdT antis 1918-1937  9065 GCUGGACUAUGUUCCGGAG 11065 GcuGGAcuAuGuuccGGAGdTsdT sense 1918-1937  9066 CUCCGGAACAUAGUCCAGC 11066 CUCCGGAAcAuAGUCcAGCdTsdT antis 1919-1938  9067 CUGGACUAUGUUCCGGAGA 11067 cuGGAcuAuGuuccGGAGAdTsdT sense 1919-1938  9068 UCUCCGGAACAUAGUCCAG 11068 UCUCCGGAAcAuAGUCcAGdTsdT antis 1950-1969  9069 UCGCCAGACACUAUAGUCG 11069 ucGccAGAcAcuAuAGucGdTsdT sense 1950-1969  9070 CGACUAUAGUGUCUGGCGA 11070 CGACuAuAGUGUCUGGCGAdTsdT antis 1958-1977  9071 CACUAUAGUCGAGCCAAGC 11071 cAcuAuAGucGAGccAAGcdTsdT sense 1958-1977  9072 GCUUGGCUCGACUAUAGUG 11072 GCUUGGCUCGACuAuAGUGdTsdT antis 2222-2241  9073 GAUUACACGUCCAGUAUAG 11073 GAuuAcAcGuccAGuAuAGdTsdT sense 2222-2241  9074 CUAUACUGGACGUGUAAUC 11074 CuAuACUGGACGUGuAAUCdTsdT antis 2224-2243  9075 UUACACGUCCAGUAUAGAU 11075 uuAcAcGuccAGuAuAGAudTsdT sense 2224-2243  9076 AUCUAUACUGGACGUGUAA 11076 AUCuAuACUGGACGUGuAAdTsdT antis 2440-2459  9077 CCGGCCCCGAACUCCACCA 11077 ccGGccccGAAcuccAccAdTsdT sense 2440-2459  9078 UGGUGGAGUUCGGGGCCGG 11078 UGGUGGAGUUCGGGGCCGGdTsdT antis 2493-2512  9079 ACACACCUACCGCCCGGCU 11079 AcAcAccuAccGcccGGcudTsdT sense 2493-2512  9080 AGCCGGGCGGUAGGUGUGU 11080 AGCCGGGCGGuAGGUGUGUdTsdT antis 2494-2513  9081 CACACCUACCGCCCGGCUA 11081 cAcAccuAccGcccGGcuAdTsdT sense 2494-2513  9082 UAGCCGGGCGGUAGGUGUG 11082 uAGCCGGGCGGuAGGUGUGdTsdT antis 2497-2516  9083 ACCUACCGCCCGGCUAACA 11083 AccuAccGcccGGcuAAcAdTsdT sense 2497-2516  9084 UGUUAGCCGGGCGGUAGGU 11084 UGUuAGCCGGGCGGuAGGUdTsdT antis 2498-2517  9085 CCUACCGCCCGGCUAACAC 11085 ccuAccGcccGGcuAAcAcdTsdT sense 2498-2517  9086 GUGUUAGCCGGGCGGUAGG 11086 GUGUuAGCCGGGCGGuAGGdTsdT antis 1525-1544  9087 CAUGUCGGGGCGACCGAGA 11087 cAuGucGGGGcGAccGAGAdTsdT sense 1525-1544  9088 UCUCGGUCGCCCCGACAUG 11088 UCUCGGUCGCCCCGAcAUGdTsdT antis 1528-1547  9089 GUCGGGGCGACCGAGAACC 11089 GucGGGGcGAccGAGAAccdTsdT sense 1528-1547  9090 GGUUCUCGGUCGCCCCGAC 11090 GGUUCUCGGUCGCCCCGACdTsdT antis 1533-1552  9091 GGCGACCGAGAACCACCUC 11091 GGcGAccGAGAAccAccucdTsdT sense 1533-1552  9092 GAGGUGGUUCUCGGUCGCC 11092 GAGGUGGUUCUCGGUCGCCdTsdT antis 1793-1812  9093 GACAAGCGAUUUAAGAACC 11093 GAcAAGcGAuuuAAGAAccdTsdT sense 1793-1812  9094 GGUUCUUAAAUCGCUUGUC 11094 GGUUCUuAAAUCGCUUGUCdTsdT antis 1797-1816  9095 AGCGAUUUAAGAACCGAGA 11095 AGcGAuuuAAGAAccGAGAdTsdT sense 1797-1816  9096 UCUCGGUUCUUAAAUCGCU 11096 UCUCGGUUCUuAAAUCGCUdTsdT antis 1798-1817  9097 GCGAUUUAAGAACCGAGAG 11097 GcGAuuuAAGAAccGAGAGdTsdT sense 1798-1817  9098 CUCUCGGUUCUUAAAUCGC 11098 CUCUCGGUUCUuAAAUCGCdTsdT antis 1799-1818  9099 CGAUUUAAGAACCGAGAGC 11099 cGAuuuAAGAAccGAGAGcdTsdT sense 1799-1818  9100 GCUCUCGGUUCUUAAAUCG 11100 GCUCUCGGUUCUuAAAUCGdTsdT antis 1832-1851  9101 AAGCUAGACCACUGUAACA 11101 AAGcuAGAccAcuGuAAcAdTsdT sense 1832-1851  9102 UGUUACAGUGGUCUAGCUU 11102 UGUuAcAGUGGUCuAGCUUdTsdT antis 1836-1855  9103 UAGACCACUGUAACAUAGU 11103 uAGAccAcuGuAAcAuAGudTsdT sense 1836-1855  9104 ACUAUGUUACAGUGGUCUA 11104 ACuAUGUuAcAGUGGUCuAdTsdT antis 1850-1869  9105 AUAGUCCGACUGCGGUAUU 11105 AuAGuccGAcuGcGGuAuudTsdT sense 1850-1869  9106 AAUACCGCAGUCGGACUAU 11106 AAuACCGcAGUCGGACuAUdTsdT antis 1852-1871  9107 AGUCCGACUGCGGUAUUUC 11107 AGuccGAcuGcGGuAuuucdTsdT sense 1852-1871  9108 GAAAUACCGCAGUCGGACU 11108 GAAAuACCGcAGUCGGACUdTsdT antis 1853-1872  9109 GUCCGACUGCGGUAUUUCU 11109 GuccGAcuGcGGuAuuucudTsdT sense 1853-1872  9110 AGAAAUACCGCAGUCGGAC 11110 AGAAAuACCGcAGUCGGACdTsdT antis 1855-1874  9111 CCGACUGCGGUAUUUCUUC 11111 ccGAcuGcGGuAuuucuucdTsdT sense 1855-1874  9112 GAAGAAAUACCGCAGUCGG 11112 GAAGAAAuACCGcAGUCGGdTsdT antis 1870-1889  9113 CUUCUACUCGAGUGGUGAG 11113 cuucuAcucGAGuGGuGAGdTsdT sense 1870-1889  9114 CUCACCACUCGAGUAGAAG 11114 CUcACcACUCGAGuAGAAGdTsdT antis 1895-1914  9115 GAUGAGGUCUACCUUAACC 11115 GAuGAGGucuAccuuAAccdTsdT sense 1895-1914  9116 GGUUAAGGUAGACCUCAUC 11116 GGUuAAGGuAGACCUcAUCdTsdT antis 1916-1935  9117 GUGCUGGACUAUGUUCCGG 11117 GuGcuGGAcuAuGuuccGGdTsdT sense 1916-1935  9118 CCGGAACAUAGUCCAGCAC 11118 CCGGAAcAuAGUCcAGcACdTsdT antis 1927-1946  9119 UGUUCCGGAGACAGUGUAC 11119 uGuuccGGAGAcAGuGuAcdTsdT sense 1927-1946  9120 GUACACUGUCUCCGGAACA 11120 GuAcACUGUCUCCGGAAcAdTsdT antis 1953-1972  9121 CCAGACACUAUAGUCGAGC 11121 ccAGAcAcuAuAGucGAGcdTsdT sense 1953-1972  9122 GCUCGACUAUAGUGUCUGG 11122 GCUCGACuAuAGUGUCUGGdTsdT antis 1959-1978  9123 ACUAUAGUCGAGCCAAGCA 11123 AcuAuAGucGAGccAAGcAdTsdT sense 1959-1978  9124 UGCUUGGCUCGACUAUAGU 11124 UGCUUGGCUCGACuAuAGUdTsdT antis 1960-1979  9125 CUAUAGUCGAGCCAAGCAG 11125 cuAuAGucGAGccAAGcAGdTsdT sense 1960-1979  9126 CUGCUUGGCUCGACUAUAG 11126 CUGCUUGGCUCGACuAuAGdTsdT antis 2023-2042  9127 CAGAAGUCUAGCCUAUAUC 11127 cAGAAGucuAGccuAuAucdTsdT sense 2023-2042  9128 GAUAUAGGCUAGACUUCUG 11128 GAuAuAGGCuAGACUUCUGdTsdT antis 2089-2108  9129 GUUGGAUCCUGAUACAGCU 11129 GuuGGAuccuGAuAcAGcudTsdT sense 2089-2108  9130 AGCUGUAUCAGGAUCCAAC 11130 AGCUGuAUcAGGAUCcAACdTsdT antis 2179-2198  9131 UUCUCGGUACUACAGGGCA 11131 uucucGGuAcuAcAGGGcAdTsdT sense 2179-2198  9132 UGCCCUGUAGUACCGAGAA 11132 UGCCCUGuAGuACCGAGAAdTsdT antis 2188-2207  9133 CUACAGGGCACCAGAGUUG 11133 cuAcAGGGcAccAGAGuuGdTsdT sense 2188-2207  9134 CAACUCUGGUGCCCUGUAG 11134 cAACUCUGGUGCCCUGuAGdTsdT antis 2218-2237  9135 CACUGAUUACACGUCCAGU 11135 cAcuGAuuAcAcGuccAGudTsdT sense 2218-2237  9136 ACUGGACGUGUAAUCAGUG 11136 ACUGGACGUGuAAUcAGUGdTsdT antis 2219-2238  9137 ACUGAUUACACGUCCAGUA 11137 AcuGAuuAcAcGuccAGuAdTsdT sense 2219-2238  9138 UACUGGACGUGUAAUCAGU 11138 uACUGGACGUGuAAUcAGUdTsdT antis 2226-2245  9139 ACACGUCCAGUAUAGAUGU 11139 AcAcGuccAGuAuAGAuGudTsdT sense 2226-2245  9140 ACAUCUAUACUGGACGUGU 11140 AcAUCuAuACUGGACGUGUdTsdT antis 2227-2246  9141 CACGUCCAGUAUAGAUGUA 11141 cAcGuccAGuAuAGAuGuAdTsdT sense 2227-2246  9142 UACAUCUAUACUGGACGUG 11142 uAcAUCuAuACUGGACGUGdTsdT antis 2276-2295  9143 UUGCUAGGACAACCAAUAU 11143 uuGcuAGGAcAAccAAuAudTsdT sense 2276-2295  9144 AUAUUGGUUGUCCUAGCAA 11144 AuAUUGGUUGUCCuAGcAAdTsdT antis 2277-2296  9145 UGCUAGGACAACCAAUAUU 11145 uGcuAGGAcAAccAAuAuudTsdT sense 2277-2296  9146 AAUAUUGGUUGUCCUAGCA 11146 AAuAUUGGUUGUCCuAGcAdTsdT antis 2279-2298  9147 CUAGGACAACCAAUAUUUC 11147 cuAGGAcAAccAAuAuuucdTsdT sense 2279-2298  9148 GAAAUAUUGGUUGUCCUAG 11148 GAAAuAUUGGUUGUCCuAGdTsdT antis 2306-2325  9149 AGUGGUGUGGAUCAGUUGG 11149 AGuGGuGuGGAucAGuuGGdTsdT sense 2306-2325  9150 CCAACUGAUCCACACCACU 11150 CcAACUGAUCcAcACcACUdTsdT antis 2488-2507  9151 GGAGUACACACCUACCGCC 11151 GGAGuAcAcAccuAccGccdTsdT sense 2488-2507  9152 GGCGGUAGGUGUGUACUCC 11152 GGCGGuAGGUGUGuACUCCdTsdT antis 2491-2510  9153 GUACACACCUACCGCCCGG 11153 GuAcAcAccuAccGcccGGdTsdT sense 2491-2510  9154 CCGGGCGGUAGGUGUGUAC 11154 CCGGGCGGuAGGUGUGuACdTsdT antis 2501-2520  9155 ACCGCCCGGCUAACACCAC 11155 AccGcccGGcuAAcAccAcdTsdT sense 2501-2520  9156 GUGGUGUUAGCCGGGCGGU 11156 GUGGUGUuAGCCGGGCGGUdTsdT antis 2506-2525  9157 CCGGCUAACACCACUGGAA 11157 ccGGcuAAcAccAcuGGAAdTsdT sense 2506-2525  9158 UUCCAGUGGUGUUAGCCGG 11158 UUCcAGUGGUGUuAGCCGGdTsdT antis 1695-1714  9159 CAGACACGAAAGUGAUUGG 11159 cAGAcAcGAAAGuGAuuGGdTsdT sense 1695-1714  9160 CCAAUCACUUUCGUGUCUG 11160 CcAAUcACUUUCGUGUCUGdTsdT antis 1720-1739  9161 AUCAUUUGGUGUGGUAUAU 11161 AucAuuuGGuGuGGuAuAudTsdT sense 1720-1739  9162 AUAUACCACACCAAAUGAU 11162 AuAuACcAcACcAAAUGAUdTsdT antis 1722-1741  9163 CAUUUGGUGUGGUAUAUCA 11163 cAuuuGGuGuGGuAuAucAdTsdT sense 1722-1741  9164 UGAUAUACCACACCAAAUG 11164 UGAuAuACcAcACcAAAUGdTsdT antis 1833-1852  9165 AGCUAGACCACUGUAACAU 11165 AGcuAGAccAcuGuAAcAudTsdT sense 1833-1852  9166 AUGUUACAGUGGUCUAGCU 11166 AUGUuAcAGUGGUCuAGCUdTsdT antis 1848-1867  9167 ACAUAGUCCGACUGCGGUA 11167 AcAuAGuccGAcuGcGGuAdTsdT sense 1848-1867  9168 UACCGCAGUCGGACUAUGU 11168 uACCGcAGUCGGACuAUGUdTsdT antis 1872-1891  9169 UCUACUCGAGUGGUGAGAA 11169 ucuAcucGAGuGGuGAGAAdTsdT sense 1872-1891  9170 UUCUCACCACUCGAGUAGA 11170 UUCUcACcACUCGAGuAGAdTsdT antis 1998-2017  9171 UCAAGUUGUAUAUGUAUCA 11171 ucAAGuuGuAuAuGuAucAdTsdT sense 1998-2017  9172 UGAUACAUAUACAACUUGA 11172 UGAuAcAuAuAcAACUUGAdTsdT antis 2011-2030  9173 GUAUCAGCUGUUCAGAAGU 11173 GuAucAGcuGuucAGAAGudTsdT sense 2011-2030  9174 ACUUCUGAACAGCUGAUAC 11174 ACUUCUGAAcAGCUGAuACdTsdT antis 2054-2073  9175 AUCUGCCAUCGAGACAUUA 11175 AucuGccAucGAGAcAuuAdTsdT sense 2054-2073  9176 UAAUGUCUCGAUGGCAGAU 11176 uAAUGUCUCGAUGGcAGAUdTsdT antis 2153-2172  9177 GGAGAGCCCAAUGUUUCAU 11177 GGAGAGcccAAuGuuucAudTsdT sense 2153-2172  9178 AUGAAACAUUGGGCUCUCC 11178 AUGAAAcAUUGGGCUCUCCdTsdT antis 2168-2187  9179 UCAUAUAUCUGUUCUCGGU 11179 ucAuAuAucuGuucucGGudTsdT sense 2168-2187  9180 ACCGAGAACAGAUAUAUGA 11180 ACCGAGAAcAGAuAuAUGAdTsdT antis 2181-2200  9181 CUCGGUACUACAGGGCACC 11181 cucGGuAcuAcAGGGcAccdTsdT sense 2181-2200  9182 GGUGCCCUGUAGUACCGAG 11182 GGUGCCCUGuAGuACCGAGdTsdT antis 2305-2324  9183 CAGUGGUGUGGAUCAGUUG 11183 cAGuGGuGuGGAucAGuuGdTsdT sense 2305-2324  9184 CAACUGAUCCACACCACUG 11184 cAACUGAUCcAcACcACUGdTsdT antis 2354-2373  9185 ACAAGGGAGCAAAUUAGAG 11185 AcAAGGGAGcAAAuuAGAGdTsdT sense 2354-2373  9186 CUCUAAUUUGCUCCCUUGU 11186 CUCuAAUUUGCUCCCUUGUdTsdT antis 2427-2446  9187 GGACAAAGGUCUUCCGGCC 11187 GGAcAAAGGucuuccGGccdTsdT sense 2427-2446  9188 GGCCGGAAGACCUUUGUCC 11188 GGCCGGAAGACCUUUGUCCdTsdT antis 1529-1548  9189 UCGGGGCGACCGAGAACCA 11189 ucGGGGcGAccGAGAAccAdTsdT sense 1529-1548  9190 UGGUUCUCGGUCGCCCCGA 11190 UGGUUCUCGGUCGCCCCGAdTsdT antis 1532-1551  9191 GGGCGACCGAGAACCACCU 11191 GGGcGAccGAGAAccAccudTsdT sense 1532-1551  9192 AGGUGGUUCUCGGUCGCCC 11192 AGGUGGUUCUCGGUCGCCCdTsdT antis 1541-1560  9193 AGAACCACCUCCUUUGCGG 11193 AGAAccAccuccuuuGcGGdTsdT sense 1541-1560  9194 CCGCAAAGGAGGUGGUUCU 11194 CCGcAAAGGAGGUGGUUCUdTsdT antis 1591-1610  9195 UUUUGGUAGCAUGAAAGUU 11195 uuuuGGuAGcAuGAAAGuudTsdT sense 1591-1610  9196 AACUUUCAUGCUACCAAAA 11196 AACUUUcAUGCuACcAAAAdTsdT antis 1677-1696  9197 CACAGGAAGUCAGUUAUAC 11197 cAcAGGAAGucAGuuAuAcdTsdT sense 1677-1696  9198 GUAUAACUGACUUCCUGUG 11198 GuAuAACUGACUUCCUGUGdTsdT antis 1679-1698  9199 CAGGAAGUCAGUUAUACAG 11199 cAGGAAGucAGuuAuAcAGdTsdT sense 1679-1698  9200 CUGUAUAACUGACUUCCUG 11200 CUGuAuAACUGACUUCCUGdTsdT antis 1680-1699  9201 AGGAAGUCAGUUAUACAGA 11201 AGGAAGucAGuuAuAcAGAdTsdT sense 1680-1699  9202 UCUGUAUAACUGACUUCCU 11202 UCUGuAuAACUGACUUCCUdTsdT antis 1681-1700  9203 GGAAGUCAGUUAUACAGAC 11203 GGAAGucAGuuAuAcAGAcdTsdT sense 1681-1700  9204 GUCUGUAUAACUGACUUCC 11204 GUCUGuAuAACUGACUUCCdTsdT antis 1705-1724  9205 AGUGAUUGGAAAUGGAUCA 11205 AGuGAuuGGAAAuGGAucAdTsdT sense 1705-1724  9206 UGAUCCAUUUCCAAUCACU 11206 UGAUCcAUUUCcAAUcACUdTsdT antis 1706-1725  9207 GUGAUUGGAAAUGGAUCAU 11207 GuGAuuGGAAAuGGAucAudTsdT sense 1706-1725  9208 AUGAUCCAUUUCCAAUCAC 11208 AUGAUCcAUUUCcAAUcACdTsdT antis 1708-1727  9209 GAUUGGAAAUGGAUCAUUU 11209 GAuuGGAAAuGGAucAuuudTsdT sense 1708-1727  9210 AAAUGAUCCAUUUCCAAUC 11210 AAAUGAUCcAUUUCcAAUCdTsdT antis 1724-1743  9211 UUUGGUGUGGUAUAUCAAG 11211 uuuGGuGuGGuAuAucAAGdTsdT sense 1724-1743  9212 CUUGAUAUACCACACCAAA 11212 CUUGAuAuACcAcACcAAAdTsdT antis 1725-1744  9213 UUGGUGUGGUAUAUCAAGC 11213 uuGGuGuGGuAuAucAAGcdTsdT sense 1725-1744  9214 GCUUGAUAUACCACACCAA 11214 GCUUGAuAuACcAcACcAAdTsdT antis 1727-1746  9215 GGUGUGGUAUAUCAAGCCA 11215 GGuGuGGuAuAucAAGccAdTsdT sense 1727-1746  9216 UGGCUUGAUAUACCACACC 11216 UGGCUUGAuAuACcAcACCdTsdT antis 1739-1758  9217 CAAGCCAAACUUUGUGAUU 11217 cAAGccAAAcuuuGuGAuudTsdT sense 1739-1758  9218 AAUCACAAAGUUUGGCUUG 11218 AAUcAcAAAGUUUGGCUUGdTsdT antis 1785-1804  9219 UUCUACAGGACAAGCGAUU 11219 uucuAcAGGAcAAGcGAuudTsdT sense 1785-1804  9220 AAUCGCUUGUCCUGUAGAA 11220 AAUCGCUUGUCCUGuAGAAdTsdT antis 1828-1847  9221 GAGAAAGCUAGACCACUGU 11221 GAGAAAGcuAGAccAcuGudTsdT sense 1828-1847  9222 ACAGUGGUCUAGCUUUCUC 11222 AcAGUGGUCuAGCUUUCUCdTsdT antis 1829-1848  9223 AGAAAGCUAGACCACUGUA 11223 AGAAAGcuAGAccAcuGuAdTsdT sense 1829-1848  9224 UACAGUGGUCUAGCUUUCU 11224 uAcAGUGGUCuAGCUUUCUdTsdT antis 1837-1856  9225 AGACCACUGUAACAUAGUC 11225 AGAccAcuGuAAcAuAGucdTsdT sense 1837-1856  9226 GACUAUGUUACAGUGGUCU 11226 GACuAUGUuAcAGUGGUCUdTsdT antis 1839-1858  9227 ACCACUGUAACAUAGUCCG 11227 AccAcuGuAAcAuAGuccGdTsdT sense 1839-1858  9228 CGGACUAUGUUACAGUGGU 11228 CGGACuAUGUuAcAGUGGUdTsdT antis 1841-1860  9229 CACUGUAACAUAGUCCGAC 11229 cAcuGuAAcAuAGuccGAcdTsdT sense 1841-1860  9230 GUCGGACUAUGUUACAGUG 11230 GUCGGACuAUGUuAcAGUGdTsdT antis 1864-1883  9231 GUAUUUCUUCUACUCGAGU 11231 GuAuuucuucuAcucGAGudTsdT sense 1864-1883  9232 ACUCGAGUAGAAGAAAUAC 11232 ACUCGAGuAGAAGAAAuACdTsdT antis 1865-1884  9233 UAUUUCUUCUACUCGAGUG 11233 uAuuucuucuAcucGAGuGdTsdT sense 1865-1884  9234 CACUCGAGUAGAAGAAAUA 11234 cACUCGAGuAGAAGAAAuAdTsdT antis 1867-1886  9235 UUUCUUCUACUCGAGUGGU 11235 uuucuucuAcucGAGuGGudTsdT sense 1867-1886  9236 ACCACUCGAGUAGAAGAAA 11236 ACcACUCGAGuAGAAGAAAdTsdT antis 1874-1893  9237 UACUCGAGUGGUGAGAAGA 11237 uAcucGAGuGGuGAGAAGAdTsdT sense 1874-1893  9238 UCUUCUCACCACUCGAGUA 11238 UCUUCUcACcACUCGAGuAdTsdT antis 1894-1913  9239 AGAUGAGGUCUACCUUAAC 11239 AGAuGAGGucuAccuuAAcdTsdT sense 1894-1913  9240 GUUAAGGUAGACCUCAUCU 11240 GUuAAGGuAGACCUcAUCUdTsdT antis 1921-1940  9241 GGACUAUGUUCCGGAGACA 11241 GGAcuAuGuuccGGAGAcAdTsdT sense 1921-1940  9242 UGUCUCCGGAACAUAGUCC 11242 UGUCUCCGGAAcAuAGUCCdTsdT antis 1954-1973  9243 CAGACACUAUAGUCGAGCC 11243 cAGAcAcuAuAGucGAGccdTsdT sense 1954-1973  9244 GGCUCGACUAUAGUGUCUG 11244 GGCUCGACuAuAGUGUCUGdTsdT antis 2006-2025  9245 UAUAUGUAUCAGCUGUUCA 11245 uAuAuGuAucAGcuGuucAdTsdT sense 2006-2025  9246 UGAACAGCUGAUACAUAUA 11246 UGAAcAGCUGAuAcAuAuAdTsdT antis 2017-2036  9247 GCUGUUCAGAAGUCUAGCC 11247 GcuGuucAGAAGucuAGccdTsdT sense 2017-2036  9248 GGCUAGACUUCUGAACAGC 11248 GGCuAGACUUCUGAAcAGCdTsdT antis 2019-2038  9249 UGUUCAGAAGUCUAGCCUA 11249 uGuucAGAAGucuAGccuAdTsdT sense 2019-2038  9250 UAGGCUAGACUUCUGAACA 11250 uAGGCuAGACUUCUGAAcAdTsdT antis 2026-2045  9251 AAGUCUAGCCUAUAUCCAU 11251 AAGucuAGccuAuAuccAudTsdT sense 2026-2045  9252 AUGGAUAUAGGCUAGACUU 11252 AUGGAuAuAGGCuAGACUUdTsdT antis 2052-2071  9253 GAAUCUGCCAUCGAGACAU 11253 GAAucuGccAucGAGAcAudTsdT sense 2052-2071  9254 AUGUCUCGAUGGCAGAUUC 11254 AUGUCUCGAUGGcAGAUUCdTsdT antis 2072-2091  9255 AAACCACAGAACCUCUUGU 11255 AAAccAcAGAAccucuuGudTsdT sense 2072-2091  9256 ACAAGAGGUUCUGUGGUUU 11256 AcAAGAGGUUCUGUGGUUUdTsdT antis 2082-2101  9257 ACCUCUUGUUGGAUCCUGA 11257 AccucuuGuuGGAuccuGAdTsdT sense 2082-2101  9258 UCAGGAUCCAACAAGAGGU 11258 UcAGGAUCcAAcAAGAGGUdTsdT antis 2088-2107  9259 UGUUGGAUCCUGAUACAGC 11259 uGuuGGAuccuGAuAcAGcdTsdT sense 2088-2107  9260 GCUGUAUCAGGAUCCAACA 11260 GCUGuAUcAGGAUCcAAcAdTsdT antis 2096-2115  9261 CCUGAUACAGCUGUAUUAA 11261 ccuGAuAcAGcuGuAuuAAdTsdT sense 2096-2115  9262 UUAAUACAGCUGUAUCAGG 11262 UuAAuAcAGCUGuAUcAGGdTsdT antis 2167-2186  9263 UUCAUAUAUCUGUUCUCGG 11263 uucAuAuAucuGuucucGGdTsdT sense 2167-2186  9264 CCGAGAACAGAUAUAUGAA 11264 CCGAGAAcAGAuAuAUGAAdTsdT antis 2192-2211  9265 AGGGCACCAGAGUUGAUCU 11265 AGGGcAccAGAGuuGAucudTsdT sense 2192-2211  9266 AGAUCAACUCUGGUGCCCU 11266 AGAUcAACUCUGGUGCCCUdTsdT antis 2213-2232  9267 GGAGCCACUGAUUACACGU 11267 GGAGccAcuGAuuAcAcGudTsdT sense 2213-2232  9268 ACGUGUAAUCAGUGGCUCC 11268 ACGUGuAAUcAGUGGCUCCdTsdT antis 2214-2233  9269 GAGCCACUGAUUACACGUC 11269 GAGccAcuGAuuAcAcGucdTsdT sense 2214-2233  9270 GACGUGUAAUCAGUGGCUC 11270 GACGUGuAAUcAGUGGCUCdTsdT antis 2225-2244  9271 UACACGUCCAGUAUAGAUG 11271 uAcAcGuccAGuAuAGAuGdTsdT sense 2225-2244  9272 CAUCUAUACUGGACGUGUA 11272 cAUCuAuACUGGACGUGuAdTsdT antis 2229-2248  9273 CGUCCAGUAUAGAUGUAUG 11273 cGuccAGuAuAGAuGuAuGdTsdT sense 2229-2248  9274 CAUACAUCUAUACUGGACG 11274 cAuAcAUCuAuACUGGACGdTsdT antis 2230-2249  9275 GUCCAGUAUAGAUGUAUGG 11275 GuccAGuAuAGAuGuAuGGdTsdT sense 2230-2249  9276 CCAUACAUCUAUACUGGAC 11276 CcAuAcAUCuAuACUGGACdTsdT antis 2233-2252  9277 CAGUAUAGAUGUAUGGUCU 11277 cAGuAuAGAuGuAuGGucudTsdT sense 2233-2252  9278 AGACCAUACAUCUAUACUG 11278 AGACcAuAcAUCuAuACUGdTsdT antis 2236-2255  9279 UAUAGAUGUAUGGUCUGCA 11279 uAuAGAuGuAuGGucuGcAdTsdT sense 2236-2255  9280 UGCAGACCAUACAUCUAUA 11280 UGcAGACcAuAcAUCuAuAdTsdT antis 2239-2258  9281 AGAUGUAUGGUCUGCAGGC 11281 AGAuGuAuGGucuGcAGGcdTsdT sense 2239-2258  9282 GCCUGCAGACCAUACAUCU 11282 GCCUGcAGACcAuAcAUCUdTsdT antis 2268-2287  9283 CUGAAUUGUUGCUAGGACA 11283 cuGAAuuGuuGcuAGGAcAdTsdT sense 2268-2287  9284 UGUCCUAGCAACAAUUCAG 11284 UGUCCuAGcAAcAAUUcAGdTsdT antis 2278-2297  9285 GCUAGGACAACCAAUAUUU 11285 GcuAGGAcAAccAAuAuuudTsdT sense 2278-2297  9286 AAAUAUUGGUUGUCCUAGC 11286 AAAuAUUGGUUGUCCuAGCdTsdT antis 2286-2305  9287 AACCAAUAUUUCCUGGGGA 11287 AAccAAuAuuuccuGGGGAdTsdT sense 2286-2305  9288 UCCCCAGGAAAUAUUGGUU 11288 UCCCcAGGAAAuAUUGGUUdTsdT antis 2339-2358  9289 GUCCUAGGAACACCAACAA 11289 GuccuAGGAAcAccAAcAAdTsdT sense 2339-2358  9290 UUGUUGGUGUUCCUAGGAC 11290 UUGUUGGUGUUCCuAGGACdTsdT antis 2340-2359  9291 UCCUAGGAACACCAACAAG 11291 uccuAGGAAcAccAAcAAGdTsdT sense 2340-2359  9292 CUUGUUGGUGUUCCUAGGA 11292 CUUGUUGGUGUUCCuAGGAdTsdT antis 2342-2361   9293 CUAGGAACACCAACAAGGG 11293 cuAGGAAcAccAAcAAGGGdTsdT sense 2342-2361  9294 CCCUUGUUGGUGUUCCUAG 11294 CCCUUGUUGGUGUUCCuAGdTsdT antis 2344-2363  9295 AGGAACACCAACAAGGGAG 11295 AGGAAcAccAAcAAGGGAGdTsdT sense 2344-2363  9296 CUCCCUUGUUGGUGUUCCU 11296 CUCCCUUGUUGGUGUUCCUdTsdT antis 2355-2374  9297 CAAGGGAGCAAAUUAGAGA 11297 cAAGGGAGcAAAuuAGAGAdTsdT sense 2355-2374  9298 UCUCUAAUUUGCUCCCUUG 11298 UCUCuAAUUUGCUCCCUUGdTsdT antis 2397-2416  9299 UCAAAUUCCCUCAAAUCAA 11299 ucAAAuucccucAAAucAAdTsdT sense 2397-2416  9300 UUGAUUUGAGGGAAUUUGA 11300 UUGAUUUGAGGGAAUUUGAdTsdT antis 2434-2453  9301 GGUCUUCCGGCCCCGAACU 11301 GGucuuccGGccccGAAcudTsdT sense 2434-2453  9302 AGUUCGGGGCCGGAAGACC 11302 AGUUCGGGGCCGGAAGACCdTsdT antis 2435-2454  9303 GUCUUCCGGCCCCGAACUC 11303 GucuuccGGccccGAAcucdTsdT sense 2435-2454  9304 GAGUUCGGGGCCGGAAGAC 11304 GAGUUCGGGGCCGGAAGACdTsdT antis 2437-2456  9305 CUUCCGGCCCCGAACUCCA 11305 cuuccGGccccGAAcuccAdTsdT sense 2437-2456  9306 UGGAGUUCGGGGCCGGAAG 11306 UGGAGUUCGGGGCCGGAAGdTsdT antis 2453-2472  9307 CCACCAGAGGCAAUUGCAC 11307 ccAccAGAGGcAAuuGcAcdTsdT sense 2453-2472  9308 GUGCAAUUGCCUCUGGUGG 11308 GUGcAAUUGCCUCUGGUGGdTsdT antis 2467-2486  9309 UGCACUGUGCAGCCGUCUG 11309 uGcAcuGuGcAGccGucuGdTsdT sense 2467-2486  9310 CAGACGGCUGCACAGUGCA 11310 cAGACGGCUGcAcAGUGcAdTsdT antis 2486-2505  9311 CUGGAGUACACACCUACCG 11311 cuGGAGuAcAcAccuAccGdTsdT sense 2486-2505  9312 CGGUAGGUGUGUACUCCAG 11312 CGGuAGGUGUGuACUCcAGdTsdT antis 2490-2509  9313 AGUACACACCUACCGCCCG 11313 AGuAcAcAccuAccGcccGdTsdT sense 2490-2509  9314 CGGGCGGUAGGUGUGUACU 11314 CGGGCGGuAGGUGUGuACUdTsdT antis 2505-2524  9315 CCCGGCUAACACCACUGGA 11315 cccGGcuAAcAccAcuGGAdTsdT sense 2505-2524  9316 UCCAGUGGUGUUAGCCGGG 11316 UCcAGUGGUGUuAGCCGGGdTsdT antis 2508-2527  9317 GGCUAACACCACUGGAAGC 11317 GGcuAAcAccAcuGGAAGcdTsdT sense 2508-2527  9318 GCUUCCAGUGGUGUUAGCC 11318 GCUUCcAGUGGUGUuAGCCdTsdT antis 1938-1957  9319 CAGUGUACAGAGUCGCCAG 11319 cAGuGuAcAGAGucGccAGdTsdT sense 1938-1957  9320 CUGGCGACUCUGUACACUG 11320 CUGGCGACUCUGuAcACUGdTsdT antis 1985-2004  9321 CCUGUGAUCUAUGUCAAGU 11321 ccuGuGAucuAuGucAAGudTsdT sense 1985-2004  9322 ACUUGACAUAGAUCACAGG 11322 ACUUGAcAuAGAUcAcAGGdTsdT antis 2164-2183  9323 UGUUUCAUAUAUCUGUUCU 11323 uGuuucAuAuAucuGuucudTsdT sense 2164-2183  9324 AGAACAGAUAUAUGAAACA 11324 AGAAcAGAuAuAUGAAAcAdTsdT antis 2263-2282  9325 GUUGGCUGAAUUGUUGCUA 11325 GuuGGcuGAAuuGuuGcuAdTsdT sense 2263-2282  9326 UAGCAACAAUUCAGCCAAC 11326 uAGcAAcAAUUcAGCcAACdTsdT antis 2367-2386  9327 UUAGAGAAAUGAACCCAAA 11327 uuAGAGAAAuGAAcccAAAdTsdT sense 2367-2386  9328 UUUGGGUUCAUUUCUCUAA 11328 UUUGGGUUcAUUUCUCuAAdTsdT antis 2395-2414  9329 AUUCAAAUUCCCUCAAAUC 11329 AuucAAAuucccucAAAucdTsdT sense 2395-2414  9330 GAUUUGAGGGAAUUUGAAU 11330 GAUUUGAGGGAAUUUGAAUdTsdT antis 1624-1643  9331 UGGCAGCAAGGUAACCACA 11331 uGGcAGcAAGGuAAccAcAdTsdT sense 1624-1643  9332 UGUGGUUACCUUGCUGCCA 11332 UGUGGUuACCUUGCUGCcAdTsdT antis 1686-1705  9333 UCAGUUAUACAGACACGAA 11333 ucAGuuAuAcAGAcAcGAAdTsdT sense 1686-1705  9334 UUCGUGUCUGUAUAACUGA 11334 UUCGUGUCUGuAuAACUGAdTsdT antis 1979-1998  9335 ACACUCCCUGUGAUCUAUG 11335 AcAcucccuGuGAucuAuGdTsdT sense 1979-1998  9336 CAUAGAUCACAGGGAGUGU 11336 cAuAGAUcAcAGGGAGUGUdTsdT antis 2080-2099  9337 GAACCUCUUGUUGGAUCCU 11337 GAAccucuuGuuGGAuccudTsdT sense 2080-2099  9338 AGGAUCCAACAAGAGGUUC 11338 AGGAUCcAAcAAGAGGUUCdTsdT antis 2091-2110  9339 UGGAUCCUGAUACAGCUGU 11339 uGGAuccuGAuAcAGcuGudTsdT sense 2091-2110  9340 ACAGCUGUAUCAGGAUCCA 11340 AcAGCUGuAUcAGGAUCcAdTsdT antis 2162-2181  9341 AAUGUUUCAUAUAUCUGUU 11341 AAuGuuucAuAuAucuGuudTsdT sense 2162-2181  9342 AACAGAUAUAUGAAACAUU 11342 AAcAGAuAuAUGAAAcAUUdTsdT antis 2175-2194  9343 UCUGUUCUCGGUACUACAG 11343 ucuGuucucGGuAcuAcAGdTsdT sense 2175-2194  9344 CUGUAGUACCGAGAACAGA 11344 CUGuAGuACCGAGAAcAGAdTsdT antis 2267-2286  9345 GCUGAAUUGUUGCUAGGAC 11345 GcuGAAuuGuuGcuAGGAcdTsdT sense 2267-2286  9346 GUCCUAGCAACAAUUCAGC 11346 GUCCuAGcAAcAAUUcAGCdTsdT antis 2309-2328  9347 GGUGUGGAUCAGUUGGUGG 11347 GGuGuGGAucAGuuGGuGGdTsdT sense 2309-2328  9348 CCACCAACUGAUCCACACC 11348 CcACcAACUGAUCcAcACCdTsdT antis 2451-2470  9349 CUCCACCAGAGGCAAUUGC 11349 cuccAccAGAGGcAAuuGcdTsdT sense 2451-2470  9350 GCAAUUGCCUCUGGUGGAG 11350 GcAAUUGCCUCUGGUGGAGdTsdT antis 1546-1565  9351 CACCUCCUUUGCGGAGAGC 11351 cAccuccuuuGcGGAGAGcdTsdT sense 1546-1565  9352 GCUCUCCGCAAAGGAGGUG 11352 GCUCUCCGcAAAGGAGGUGdTsdT antis 1936-1955  9353 GACAGUGUACAGAGUCGCC 11353 GAcAGuGuAcAGAGucGccdTsdT sense 1936-1955  9354 GGCGACUCUGUACACUGUC 11354 GGCGACUCUGuAcACUGUCdTsdT antis 1592-1611  9355 UUUGGUAGCAUGAAAGUUA 11355 uuuGGuAGcAuGAAAGuuAdTsdT sense 1592-1611  9356 UAACUUUCAUGCUACCAAA 11356 uAACUUUcAUGCuACcAAAdTsdT antis 1620-1639  9357 AAGAUGGCAGCAAGGUAAC 11357 AAGAuGGcAGcAAGGuAAcdTsdT sense 1620-1639  9358 GUUACCUUGCUGCCAUCUU 11358 GUuACCUUGCUGCcAUCUUdTsdT antis 1675-1694  9359 GCCACAGGAAGUCAGUUAU 11359 GccAcAGGAAGucAGuuAudTsdT sense 1675-1694  9360 AUAACUGACUUCCUGUGGC 11360 AuAACUGACUUCCUGUGGCdTsdT antis 1723-1742  9361 AUUUGGUGUGGUAUAUCAA 11361 AuuuGGuGuGGuAuAucAAdTsdT sense 1723-1742  9362 UUGAUAUACCACACCAAAU 11362 UUGAuAuACcAcACcAAAUdTsdT antis 1738-1757  9363 UCAAGCCAAACUUUGUGAU 11363 ucAAGccAAAcuuuGuGAudTsdT sense 1738-1757  9364 AUCACAAAGUUUGGCUUGA 11364 AUcAcAAAGUUUGGCUUGAdTsdT antis 1758-1777  9365 CUGGAGAACUGGUUGCCAU 11365 cuGGAGAAcuGGuuGccAudTsdT sense 1758-1777  9366 AUGGCAACCAGUUCUCCAG 11366 AUGGcAACcAGUUCUCcAGdTsdT antis 2027-2046  9367 AGUCUAGCCUAUAUCCAUU 11367 AGucuAGccuAuAuccAuudTsdT sense 2027-2046  9368 AAUGGAUAUAGGCUAGACU 11368 AAUGGAuAuAGGCuAGACUdTsdT antis 2083-2102  9369 CCUCUUGUUGGAUCCUGAU 11369 ccucuuGuuGGAuccuGAudTsdT sense 2083-2102  9370 AUCAGGAUCCAACAAGAGG 11370 AUcAGGAUCcAAcAAGAGGdTsdT antis 2097-2116  9371 CUGAUACAGCUGUAUUAAA 11371 cuGAuAcAGcuGuAuuAAAdTsdT sense 2097-2116  9372 UUUAAUACAGCUGUAUCAG 11372 UUuAAuAcAGCUGuAUcAGdTsdT antis 2104-2123  9373 AGCUGUAUUAAAACUCUGU 11373 AGcuGuAuuAAAAcucuGudTsdT sense 2104-2123  9374 ACAGAGUUUUAAUACAGCU 11374 AcAGAGUUUuAAuAcAGCUdTsdT antis 2208-2227  9375 UCUUUGGAGCCACUGAUUA 11375 ucuuuGGAGccAcuGAuuAdTsdT sense 2208-2227  9376 UAAUCAGUGGCUCCAAAGA 11376 uAAUcAGUGGCUCcAAAGAdTsdT antis 2210-2229  9377 UUUGGAGCCACUGAUUACA 11377 uuuGGAGccAcuGAuuAcAdTsdT sense 2210-2229  9378 UGUAAUCAGUGGCUCCAAA 11378 UGuAAUcAGUGGCUCcAAAdTsdT antis 2304-2323  9379 ACAGUGGUGUGGAUCAGUU 11379 AcAGuGGuGuGGAucAGuudTsdT sense 2304-2323  9380 AACUGAUCCACACCACUGU 11380 AACUGAUCcAcACcACUGUdTsdT antis 2328-2347  9381 AAAUAAUAAAGGUCCUAGG 11381 AAAuAAuAAAGGuccuAGGdTsdT sense 2328-2347  9382 CCUAGGACCUUUAUUAUUU 11382 CCuAGGACCUUuAUuAUUUdTsdT antis 2390-2409  9383 ACAGAAUUCAAAUUCCCUC 11383 AcAGAAuucAAAuucccucdTsdT sense 2390-2409  9384 GAGGGAAUUUGAAUUCUGU 11384 GAGGGAAUUUGAAUUCUGUdTsdT antis 2018-2037  9385 CUGUUCAGAAGUCUAGCCU 11385 cuGuucAGAAGucuAGccudTsdT sense 2018-2037  9386 AGGCUAGACUUCUGAACAG 11386 AGGCuAGACUUCUGAAcAGdTsdT antis 2338-2357  9387 GGUCCUAGGAACACCAACA 11387 GGuccuAGGAAcAccAAcAdTsdT sense 2338-2357  9388 UGUUGGUGUUCCUAGGACC 11388 UGUUGGUGUUCCuAGGACCdTsdT antis 2351-2370  9389 CCAACAAGGGAGCAAAUUA 11389 ccAAcAAGGGAGcAAAuuAdTsdT sense 2351-2370  9390 UAAUUUGCUCCCUUGUUGG 11390 uAAUUUGCUCCCUUGUUGGdTsdT antis 2433-2452  9391 AGGUCUUCCGGCCCCGAAC 11391 AGGucuuccGGccccGAAcdTsdT sense 2433-2452  9392 GUUCGGGGCCGGAAGACCU 11392 GUUCGGGGCCGGAAGACCUdTsdT antis 2180-2199  9393 UCUCGGUACUACAGGGCAC 11393 ucucGGuAcuAcAGGGcAcdTsdT sense 2180-2199  9394 GUGCCCUGUAGUACCGAGA 11394 GUGCCCUGuAGuACCGAGAdTsdT antis 1644-1663  9395 UAGUGGCAACUCCUGGCCA 11395 uAGuGGcAAcuccuGGccAdTsdT sense 1644-1663  9396 UGGCCAGGAGUUGCCACUA 11396 UGGCcAGGAGUUGCcACuAdTsdT antis 1827-1846  9397 UGAGAAAGCUAGACCACUG 11397 uGAGAAAGcuAGAccAcuGdTsdT sense 1827-1846  9398 CAGUGGUCUAGCUUUCUCA 11398 cAGUGGUCuAGCUUUCUcAdTsdT antis 2098-2117  9399 UGAUACAGCUGUAUUAAAA 11399 uGAuAcAGcuGuAuuAAAAdTsdT sense 2098-2117  9400 UUUUAAUACAGCUGUAUCA 11400 UUUuAAuAcAGCUGuAUcAdTsdT antis 2254-2273  9401 AGGCUGUGUGUUGGCUGAA 11401 AGGcuGuGuGuuGGcuGAAdTsdT sense 2254-2273  9402 UUCAGCCAACACACAGCCU 11402 UUcAGCcAAcAcAcAGCCUdTsdT antis 1674-1693  9403 GGCCACAGGAAGUCAGUUA 11403 GGccAcAGGAAGucAGuuAdTsdT sense 1674-1693  9404 UAACUGACUUCCUGUGGCC 11404 uAACUGACUUCCUGUGGCCdTsdT antis 2495-2514  9405 ACACCUACCGCCCGGCUAA 11405 AcAccuAccGcccGGcuAAdTsdT sense 2495-2514  9406 UUAGCCGGGCGGUAGGUGU 11406 UuAGCCGGGCGGuAGGUGUdTsdT antis 1794-1813  9407 ACAAGCGAUUUAAGAACCG 11407 AcAAGcGAuuuAAGAAccGdTsdT sense 1794-1813  9408 CGGUUCUUAAAUCGCUUGU 11408 CGGUUCUuAAAUCGCUUGUdTsdT antis 1861-1880  9409 GCGGUAUUUCUUCUACUCG 11409 GcGGuAuuucuucuAcucGdTsdT sense 1861-1880  9410 CGAGUAGAAGAAAUACCGC 11410 CGAGuAGAAGAAAuACCGCdTsdT antis 1989-2008  9411 UGAUCUAUGUCAAGUUGUA 11411 uGAucuAuGucAAGuuGuAdTsdT sense 1989-2008  9412 UACAACUUGACAUAGAUCA 11412 uAcAACUUGAcAuAGAUcAdTsdT antis 2025-2044  9413 GAAGUCUAGCCUAUAUCCA 11413 GAAGucuAGccuAuAuccAdTsdT sense 2025-2044  9414 UGGAUAUAGGCUAGACUUC 11414 UGGAuAuAGGCuAGACUUCdTsdT antis 2028-2047  9415 GUCUAGCCUAUAUCCAUUC 11415 GucuAGccuAuAuccAuucdTsdT sense 2028-2047  9416 GAAUGGAUAUAGGCUAGAC 11416 GAAUGGAuAuAGGCuAGACdTsdT antis 2029-2048  9417 UCUAGCCUAUAUCCAUUCC 11417 ucuAGccuAuAuccAuuccdTsdT sense 2029-2048  9418 GGAAUGGAUAUAGGCUAGA 11418 GGAAUGGAuAuAGGCuAGAdTsdT antis 2275-2294  9419 GUUGCUAGGACAACCAAUA 11419 GuuGcuAGGAcAAccAAuAdTsdT sense 2275-2294  9420 UAUUGGUUGUCCUAGCAAC 11420 uAUUGGUUGUCCuAGcAACdTsdT antis 1593-1612  9421 UUGGUAGCAUGAAAGUUAG 11421 uuGGuAGcAuGAAAGuuAGdTsdT sense 1593-1612  9422 CUAACUUUCAUGCUACCAA 11422 CuAACUUUcAUGCuACcAAdTsdT antis 1690-1709  9423 UUAUACAGACACGAAAGUG 11423 uuAuAcAGAcAcGAAAGuGdTsdT sense 1690-1709  9424 CACUUUCGUGUCUGUAUAA 11424 cACUUUCGUGUCUGuAuAAdTsdT antis 1795-1814  9425 CAAGCGAUUUAAGAACCGA 11425 cAAGcGAuuuAAGAAccGAdTsdT sense 1795-1814  9426 UCGGUUCUUAAAUCGCUUG 11426 UCGGUUCUuAAAUCGCUUGdTsdT antis 1822-1841  9427 GAUCAUGAGAAAGCUAGAC 11427 GAucAuGAGAAAGcuAGAcdTsdT sense 1822-1841  9428 GUCUAGCUUUCUCAUGAUC 11428 GUCuAGCUUUCUcAUGAUCdTsdT antis 1901-1920  9429 GUCUACCUUAACCUGGUGC 11429 GucuAccuuAAccuGGuGcdTsdT sense 1901-1920  9430 GCACCAGGUUAAGGUAGAC 11430 GcACcAGGUuAAGGuAGACdTsdT antis 1926-1945  9431 AUGUUCCGGAGACAGUGUA 11431 AuGuuccGGAGAcAGuGuAdTsdT sense 1926-1945  9432 UACACUGUCUCCGGAACAU 11432 uAcACUGUCUCCGGAAcAUdTsdT antis 1947-1966  9433 GAGUCGCCAGACACUAUAG 11433 GAGucGccAGAcAcuAuAGdTsdT sense 1947-1966  9434 CUAUAGUGUCUGGCGACUC 11434 CuAuAGUGUCUGGCGACUCdTsdT antis 1949-1968  9435 GUCGCCAGACACUAUAGUC 11435 GucGccAGAcAcuAuAGucdTsdT sense 1949-1968  9436 GACUAUAGUGUCUGGCGAC 11436 GACuAuAGUGUCUGGCGACdTsdT antis 1956-1975  9437 GACACUAUAGUCGAGCCAA 11437 GAcAcuAuAGucGAGccAAdTsdT sense 1956-1975  9438 UUGGCUCGACUAUAGUGUC 11438 UUGGCUCGACuAuAGUGUCdTsdT antis 1977-1996  9439 AGACACUCCCUGUGAUCUA 11439 AGAcAcucccuGuGAucuAdTsdT sense 1977-1996  9440 UAGAUCACAGGGAGUGUCU 11440 uAGAUcAcAGGGAGUGUCUdTsdT antis 1990-2009  9441 GAUCUAUGUCAAGUUGUAU 11441 GAucuAuGucAAGuuGuAudTsdT sense 1990-2009  9442 AUACAACUUGACAUAGAUC 11442 AuAcAACUUGAcAuAGAUCdTsdT antis 2008-2027  9443 UAUGUAUCAGCUGUUCAGA 11443 uAuGuAucAGcuGuucAGAdTsdT sense 2008-2027  9444 UCUGAACAGCUGAUACAUA 11444 UCUGAAcAGCUGAuAcAuAdTsdT antis 2047-2066  9445 CUUUGGAAUCUGCCAUCGA 11445 cuuuGGAAucuGccAucGAdTsdT sense 2047-2066  9446 UCGAUGGCAGAUUCCAAAG 11446 UCGAUGGcAGAUUCcAAAGdTsdT antis 2187-2206  9447 ACUACAGGGCACCAGAGUU 11447 AcuAcAGGGcAccAGAGuudTsdT sense 2187-2206  9448 AACUCUGGUGCCCUGUAGU 11448 AACUCUGGUGCCCUGuAGUdTsdT antis 2307-2326  9449 GUGGUGUGGAUCAGUUGGU 11449 GuGGuGuGGAucAGuuGGudTsdT sense 2307-2326  9450 ACCAACUGAUCCACACCAC 11450 ACcAACUGAUCcAcACcACdTsdT antis 2357-2376  9451 AGGGAGCAAAUUAGAGAAA 11451 AGGGAGcAAAuuAGAGAAAdTsdT sense 2357-2376  9452 UUUCUCUAAUUUGCUCCCU 11452 UUUCUCuAAUUUGCUCCCUdTsdT antis 2405-2424  9453 CCUCAAAUCAAGGCACAUC 11453 ccucAAAucAAGGcAcAucdTsdT sense 2405-2424  9454 GAUGUGCCUUGAUUUGAGG 11454 GAUGUGCCUUGAUUUGAGGdTsdT antis 2483-2502  9455 CUGCUGGAGUACACACCUA 11455 cuGcuGGAGuAcAcAccuAdTsdT sense 2483-2502  9456 UAGGUGUGUACUCCAGCAG 11456 uAGGUGUGuACUCcAGcAGdTsdT antis 1629-1648  9457 GCAAGGUAACCACAGUAGU 11457 GcAAGGuAAccAcAGuAGudTsdT sense 1629-1648  9458 ACUACUGUGGUUACCUUGC 11458 ACuACUGUGGUuACCUUGCdTsdT antis 1972-1991  9459 CAAGCAGACACUCCCUGUG 11459 cAAGcAGAcAcucccuGuGdTsdT sense 1972-1991  9460 CACAGGGAGUGUCUGCUUG 11460 cAcAGGGAGUGUCUGCUUGdTsdT antis 1622-1641  9461 GAUGGCAGCAAGGUAACCA 11461 GAuGGcAGcAAGGuAAccAdTsdT sense 1622-1641  9462 UGGUUACCUUGCUGCCAUC 11462 UGGUuACCUUGCUGCcAUCdTsdT antis 1635-1654  9463 UAACCACAGUAGUGGCAAC 11463 uAAccAcAGuAGuGGcAAcdTsdT sense 1635-1654  9464 GUUGCCACUACUGUGGUUA 11464 GUUGCcACuACUGUGGUuAdTsdT antis 1790-1809  9465 CAGGACAAGCGAUUUAAGA 11465 cAGGAcAAGcGAuuuAAGAdTsdT sense 1790-1809  9466 UCUUAAAUCGCUUGUCCUG 11466 UCUuAAAUCGCUUGUCCUGdTsdT antis 1818-1837  9467 UCCAGAUCAUGAGAAAGCU 11467 uccAGAucAuGAGAAAGcudTsdT sense 1818-1837  9468 AGCUUUCUCAUGAUCUGGA 11468 AGCUUUCUcAUGAUCUGGAdTsdT antis 1854-1873  9469 UCCGACUGCGGUAUUUCUU 11469 uccGAcuGcGGuAuuucuudTsdT sense 1854-1873  9470 AAGAAAUACCGCAGUCGGA 11470 AAGAAAuACCGcAGUCGGAdTsdT antis 1942-1961  9471 GUACAGAGUCGCCAGACAC 11471 GuAcAGAGucGccAGAcAcdTsdT sense 1942-1961  9472 GUGUCUGGCGACUCUGUAC 11472 GUGUCUGGCGACUCUGuACdTsdT antis 1988-2007  9473 GUGAUCUAUGUCAAGUUGU 11473 GuGAucuAuGucAAGuuGudTsdT sense 1988-2007  9474 ACAACUUGACAUAGAUCAC 11474 AcAACUUGAcAuAGAUcACdTsdT antis 2055-2074  9475 UCUGCCAUCGAGACAUUAA 11475 ucuGccAucGAGAcAuuAAdTsdT sense 2055-2074  9476 UUAAUGUCUCGAUGGCAGA 11476 UuAAUGUCUCGAUGGcAGAdTsdT antis 2217-2236  9477 CCACUGAUUACACGUCCAG 11477 ccAcuGAuuAcAcGuccAGdTsdT sense 2217-2236  9478 CUGGACGUGUAAUCAGUGG 11478 CUGGACGUGuAAUcAGUGGdTsdT antis 2235-2254  9479 GUAUAGAUGUAUGGUCUGC 11479 GuAuAGAuGuAuGGucuGcdTsdT sense 2235-2254  9480 GCAGACCAUACAUCUAUAC 11480 GcAGACcAuAcAUCuAuACdTsdT antis 2258-2277  9481 UGUGUGUUGGCUGAAUUGU 11481 uGuGuGuuGGcuGAAuuGudTsdT sense 2258-2277  9482 ACAAUUCAGCCAACACACA 11482 AcAAUUcAGCcAAcAcAcAdTsdT antis 2269-2288  9483 UGAAUUGUUGCUAGGACAA 11483 uGAAuuGuuGcuAGGAcAAdTsdT sense 2269-2288  9484 UUGUCCUAGCAACAAUUCA 11484 UUGUCCuAGcAAcAAUUcAdTsdT antis 2404-2423  9485 CCCUCAAAUCAAGGCACAU 11485 cccucAAAucAAGGcAcAudTsdT sense 2404-2423  9486 AUGUGCCUUGAUUUGAGGG 11486 AUGUGCCUUGAUUUGAGGGdTsdT antis 2423-2442   9487 CCUUGGACAAAGGUCUUCC 11487 ccuuGGAcAAAGGucuuccdTsdT sense 2423-2442  9488 GGAAGACCUUUGUCCAAGG 11488 GGAAGACCUUUGUCcAAGGdTsdT antis 2455-2474  9489 ACCAGAGGCAAUUGCACUG 11489 AccAGAGGcAAuuGcAcuGdTsdT sense 2455-2474  9490 CAGUGCAAUUGCCUCUGGU 11490 cAGUGcAAUUGCCUCUGGUdTsdT antis 1586-1605  9491 UCAGCUUUUGGUAGCAUGA 11491 ucAGcuuuuGGuAGcAuGAdTsdT sense 1586-1605  9492 UCAUGCUACCAAAAGCUGA 11492 UcAUGCuACcAAAAGCUGAdTsdT antis 1601-1620  9493 AUGAAAGUUAGCAGAGAUA 11493 AuGAAAGuuAGcAGAGAuAdTsdT sense 1601-1620  9494 UAUCUCUGCUAACUUUCAU 11494 uAUCUCUGCuAACUUUcAUdTsdT antis 1621-1640  9495 AGAUGGCAGCAAGGUAACC 11495 AGAuGGcAGcAAGGuAAccdTsdT sense 1621-1640  9496 GGUUACCUUGCUGCCAUCU 11496 GGUuACCUUGCUGCcAUCUdTsdT antis 1626-1645  9497 GCAGCAAGGUAACCACAGU 11497 GcAGcAAGGuAAccAcAGudTsdT sense 1626-1645  9498 ACUGUGGUUACCUUGCUGC 11498 ACUGUGGUuACCUUGCUGCdTsdT antis 1658-1677  9499 GGCCAGGGUCCUGACAGGC 11499 GGccAGGGuccuGAcAGGcdTsdT sense 1658-1677  9500 GCCUGUCAGGACCCUGGCC 11500 GCCUGUcAGGACCCUGGCCdTsdT antis 1683-1702  9501 AAGUCAGUUAUACAGACAC 11501 AAGucAGuuAuAcAGAcAcdTsdT sense 1683-1702  9502 GUGUCUGUAUAACUGACUU 11502 GUGUCUGuAuAACUGACUUdTsdT antis 1709-1728  9503 AUUGGAAAUGGAUCAUUUG 11503 AuuGGAAAuGGAucAuuuGdTsdT sense 1709-1728  9504 CAAAUGAUCCAUUUCCAAU 11504 cAAAUGAUCcAUUUCcAAUdTsdT antis 1710-1729  9505 UUGGAAAUGGAUCAUUUGG 11505 uuGGAAAuGGAucAuuuGGdTsdT sense 1710-1729  9506 CCAAAUGAUCCAUUUCCAA 11506 CcAAAUGAUCcAUUUCcAAdTsdT antis 1726-1745  9507 UGGUGUGGUAUAUCAAGCC 11507 uGGuGuGGuAuAucAAGccdTsdT sense 1726-1745  9508 GGCUUGAUAUACCACACCA 11508 GGCUUGAuAuACcAcACcAdTsdT antis 1740-1759  9509 AAGCCAAACUUUGUGAUUC 11509 AAGccAAAcuuuGuGAuucdTsdT sense 1740-1759  9510 GAAUCACAAAGUUUGGCUU 11510 GAAUcAcAAAGUUUGGCUUdTsdT antis 1754-1773  9511 GAUUCUGGAGAACUGGUUG 11511 GAuucuGGAGAAcuGGuuGdTsdT sense 1754-1773  9512 CAACCAGUUCUCCAGAAUC 11512 cAACcAGUUCUCcAGAAUCdTsdT antis 1755-1774  9513 AUUCUGGAGAACUGGUUGC 11513 AuucuGGAGAAcuGGuuGcdTsdT sense 1755-1774  9514 GCAACCAGUUCUCCAGAAU 11514 GcAACcAGUUCUCcAGAAUdTsdT antis 1757-1776  9515 UCUGGAGAACUGGUUGCCA 11515 ucuGGAGAAcuGGuuGccAdTsdT sense 1757-1776  9516 UGGCAACCAGUUCUCCAGA 11516 UGGcAACcAGUUCUCcAGAdTsdT antis 1786-1805  9517 UCUACAGGACAAGCGAUUU 11517 ucuAcAGGAcAAGcGAuuudTsdT sense 1786-1805  9518 AAAUCGCUUGUCCUGUAGA 11518 AAAUCGCUUGUCCUGuAGAdTsdT antis 1834-1853  9519 GCUAGACCACUGUAACAUA 11519 GcuAGAccAcuGuAAcAuAdTsdT sense 1834-1853  9520 UAUGUUACAGUGGUCUAGC 11520 uAUGUuAcAGUGGUCuAGCdTsdT antis 1886-1905  9521 GAGAAGAAAGAUGAGGUCU 11521 GAGAAGAAAGAuGAGGucudTsdT sense 1886-1905  9522 AGACCUCAUCUUUCUUCUC 11522 AGACCUcAUCUUUCUUCUCdTsdT antis 1887-1906  9523 AGAAGAAAGAUGAGGUCUA 11523 AGAAGAAAGAuGAGGucuAdTsdT sense 1887-1906  9524 UAGACCUCAUCUUUCUUCU 11524 uAGACCUcAUCUUUCUUCUdTsdT antis 1892-1911  9525 AAAGAUGAGGUCUACCUUA 11525 AAAGAuGAGGucuAccuuAdTsdT sense 1892-1911  9526 UAAGGUAGACCUCAUCUUU 11526 uAAGGuAGACCUcAUCUUUdTsdT antis 1893-1912  9527 AAGAUGAGGUCUACCUUAA 11527 AAGAuGAGGucuAccuuAAdTsdT sense 1893-1912  9528 UUAAGGUAGACCUCAUCUU 11528 UuAAGGuAGACCUcAUCUUdTsdT antis 1925-1944  9529 UAUGUUCCGGAGACAGUGU 11529 uAuGuuccGGAGAcAGuGudTsdT sense 1925-1944  9530 ACACUGUCUCCGGAACAUA 11530 AcACUGUCUCCGGAAcAuAdTsdT antis 1937-1956  9531 ACAGUGUACAGAGUCGCCA 11531 AcAGuGuAcAGAGucGccAdTsdT sense 1937-1956  9532 UGGCGACUCUGUACACUGU 11532 UGGCGACUCUGuAcACUGUdTsdT antis 1978-1997  9533 GACACUCCCUGUGAUCUAU 11533 GAcAcucccuGuGAucuAudTsdT sense 1978-1997  9534 AUAGAUCACAGGGAGUGUC 11534 AuAGAUcAcAGGGAGUGUCdTsdT antis 1980-1999  9535 CACUCCCUGUGAUCUAUGU 11535 cAcucccuGuGAucuAuGudTsdT sense 1980-1999  9536 ACAUAGAUCACAGGGAGUG 11536 AcAuAGAUcAcAGGGAGUGdTsdT antis 2005-2024  9537 GUAUAUGUAUCAGCUGUUC 11537 GuAuAuGuAucAGcuGuucdTsdT sense 2005-2024  9538 GAACAGCUGAUACAUAUAC 11538 GAAcAGCUGAuAcAuAuACdTsdT antis 2074-2093  9539 ACCACAGAACCUCUUGUUG 11539 AccAcAGAAccucuuGuuGdTsdT sense 2074-2093  9540 CAACAAGAGGUUCUGUGGU 11540 cAAcAAGAGGUUCUGUGGUdTsdT antis 2081-2100  9541 AACCUCUUGUUGGAUCCUG 11541 AAccucuuGuuGGAuccuGdTsdT sense 2081-2100  9542 CAGGAUCCAACAAGAGGUU 11542 cAGGAUCcAAcAAGAGGUUdTsdT antis 2094-2113  9543 AUCCUGAUACAGCUGUAUU 11543 AuccuGAuAcAGcuGuAuudTsdT sense 2094-2113  9544 AAUACAGCUGUAUCAGGAU 11544 AAuAcAGCUGuAUcAGGAUdTsdT antis 2101-2120  9545 UACAGCUGUAUUAAAACUC 11545 uAcAGcuGuAuuAAAAcucdTsdT sense 2101-2120  9546 GAGUUUUAAUACAGCUGUA 11546 GAGUUUuAAuAcAGCUGuAdTsdT antis 2138-2157  9547 AAGCAGCUGGUCCGAGGAG 11547 AAGcAGcuGGuccGAGGAGdTsdT sense 2138-2157  9548 CUCCUCGGACCAGCUGCUU 11548 CUCCUCGGACcAGCUGCUUdTsdT antis 2161-2180  9549 CAAUGUUUCAUAUAUCUGU 11549 cAAuGuuucAuAuAucuGudTsdT sense 2161-2180  9550 ACAGAUAUAUGAAACAUUG 11550 AcAGAuAuAUGAAAcAUUGdTsdT antis 2171-2190  9551 UAUAUCUGUUCUCGGUACU 11551 uAuAucuGuucucGGuAcudTsdT sense 2171-2190  9552 AGUACCGAGAACAGAUAUA 11552 AGuACCGAGAAcAGAuAuAdTsdT antis 2178-2197  9553 GUUCUCGGUACUACAGGGC 11553 GuucucGGuAcuAcAGGGcdTsdT sense 2178-2197  9554 GCCCUGUAGUACCGAGAAC 11554 GCCCUGuAGuACCGAGAACdTsdT antis 2193-2212  9555 GGGCACCAGAGUUGAUCUU 11555 GGGcAccAGAGuuGAucuudTsdT sense 2193-2212  9556 AAGAUCAACUCUGGUGCCC 11556 AAGAUcAACUCUGGUGCCCdTsdT antis 2197-2216  9557 ACCAGAGUUGAUCUUUGGA 11557 AccAGAGuuGAucuuuGGAdTsdT sense 2197-2216  9558 UCCAAAGAUCAACUCUGGU 11558 UCcAAAGAUcAACUCUGGUdTsdT antis 2209-2228  9559 CUUUGGAGCCACUGAUUAC 11559 cuuuGGAGccAcuGAuuAcdTsdT sense 2209-2228  9560 GUAAUCAGUGGCUCCAAAG 11560 GuAAUcAGUGGCUCcAAAGdTsdT antis 2215-2234  9561 AGCCACUGAUUACACGUCC 11561 AGccAcuGAuuAcAcGuccdTsdT sense 2215-2234  9562 GGACGUGUAAUCAGUGGCU 11562 GGACGUGuAAUcAGUGGCUdTsdT antis 2231-2250  9563 UCCAGUAUAGAUGUAUGGU 11563 uccAGuAuAGAuGuAuGGudTsdT sense 2231-2250  9564 ACCAUACAUCUAUACUGGA 11564 ACcAuAcAUCuAuACUGGAdTsdT antis 2308-2327  9565 UGGUGUGGAUCAGUUGGUG 11565 uGGuGuGGAucAGuuGGuGdTsdT sense 2308-2327  9566 CACCAACUGAUCCACACCA 11566 cACcAACUGAUCcAcACcAdTsdT antis 2334-2353  9567 UAAAGGUCCUAGGAACACC 11567 uAAAGGuccuAGGAAcAccdTsdT sense 2334-2353  9568 GGUGUUCCUAGGACCUUUA 11568 GGUGUUCCuAGGACCUUuAdTsdT antis 2336-2355  9569 AAGGUCCUAGGAACACCAA 11569 AAGGuccuAGGAAcAccAAdTsdT sense 2336-2355  9570 UUGGUGUUCCUAGGACCUU 11570 UUGGUGUUCCuAGGACCUUdTsdT antis 2337-2356  9571 AGGUCCUAGGAACACCAAC 11571 AGGuccuAGGAAcAccAAcdTsdT sense 2337-2356  9572 GUUGGUGUUCCUAGGACCU 11572 GUUGGUGUUCCuAGGACCUdTsdT antis 2343-2362  9573 UAGGAACACCAACAAGGGA 11573 uAGGAAcAccAAcAAGGGAdTsdT sense 2343-2362  9574 UCCCUUGUUGGUGUUCCUA 11574 UCCCUUGUUGGUGUUCCuAdTsdT antis 2352-2371  9575 CAACAAGGGAGCAAAUUAG 11575 cAAcAAGGGAGcAAAuuAGdTsdT sense 2352-2371  9576 CUAAUUUGCUCCCUUGUUG 11576 CuAAUUUGCUCCCUUGUUGdTsdT antis 2370-2389  9577 GAGAAAUGAACCCAAAUUA 11577 GAGAAAuGAAcccAAAuuAdTsdT sense 2370-2389  9578 UAAUUUGGGUUCAUUUCUC 11578 uAAUUUGGGUUcAUUUCUCdTsdT antis 2385-2404  9579 AUUAUACAGAAUUCAAAUU 11579 AuuAuAcAGAAuucAAAuudTsdT sense 2385-2404  9580 AAUUUGAAUUCUGUAUAAU 11580 AAUUUGAAUUCUGuAuAAUdTsdT antis 2392-2411  9581 AGAAUUCAAAUUCCCUCAA 11581 AGAAuucAAAuucccucAAdTsdT sense 2392-2411  9582 UUGAGGGAAUUUGAAUUCU 11582 UUGAGGGAAUUUGAAUUCUdTsdT antis 2393-2412  9583 GAAUUCAAAUUCCCUCAAA 11583 GAAuucAAAuucccucAAAdTsdT sense 2393-2412  9584 UUUGAGGGAAUUUGAAUUC 11584 UUUGAGGGAAUUUGAAUUCdTsdT antis 2403-2422  9585 UCCCUCAAAUCAAGGCACA 11585 ucccucAAAucAAGGcAcAdTsdT sense 2403-2422  9586 UGUGCCUUGAUUUGAGGGA 11586 UGUGCCUUGAUUUGAGGGAdTsdT antis 2421-2440  9587 AUCCUUGGACAAAGGUCUU 11587 AuccuuGGAcAAAGGucuudTsdT sense 2421-2440  9588 AAGACCUUUGUCCAAGGAU 11588 AAGACCUUUGUCcAAGGAUdTsdT antis 2424-2443  9589 CUUGGACAAAGGUCUUCCG 11589 cuuGGAcAAAGGucuuccGdTsdT sense 2424-2443  9590 CGGAAGACCUUUGUCCAAG 11590 CGGAAGACCUUUGUCcAAGdTsdT antis 2454-2473  9591 CACCAGAGGCAAUUGCACU 11591 cAccAGAGGcAAuuGcAcudTsdT sense 2454-2473  9592 AGUGCAAUUGCCUCUGGUG 11592 AGUGcAAUUGCCUCUGGUGdTsdT antis 2468-2487  9593 GCACUGUGCAGCCGUCUGC 11593 GcAcuGuGcAGccGucuGcdTsdT sense 2468-2487  9594 GCAGACGGCUGCACAGUGC 11594 GcAGACGGCUGcAcAGUGCdTsdT antis 2469-2488  9595 CACUGUGCAGCCGUCUGCU 11595 cAcuGuGcAGccGucuGcudTsdT sense 2469-2488  9596 AGCAGACGGCUGCACAGUG 11596 AGcAGACGGCUGcAcAGUGdTsdT antis 2516-2535  9597 CCACUGGAAGCUUGUGCAC 11597 ccAcuGGAAGcuuGuGcAcdTsdT sense 2516-2535  9598 GUGCACAAGCUUCCAGUGG 11598 GUGcAcAAGCUUCcAGUGGdTsdT antis 1559-1578  9599 GAGAGCUGCAAGCCAGUGC 11599 GAGAGcuGcAAGccAGuGcdTsdT sense 1559-1578  9600 GCACUGGCUUGCAGCUCUC 11600 GcACUGGCUUGcAGCUCUCdTsdT antis 1676-1695  9601 CCACAGGAAGUCAGUUAUA 11601 ccAcAGGAAGucAGuuAuAdTsdT sense 1676-1695  9602 UAUAACUGACUUCCUGUGG 11602 uAuAACUGACUUCCUGUGGdTsdT antis 1896-1915  9603 AUGAGGUCUACCUUAACCU 11603 AuGAGGucuAccuuAAccudTsdT sense 1896-1915  9604 AGGUUAAGGUAGACCUCAU 11604 AGGUuAAGGuAGACCUcAUdTsdT antis 2262-2281  9605 UGUUGGCUGAAUUGUUGCU 11605 uGuuGGcuGAAuuGuuGcudTsdT sense 2262-2281  9606 AGCAACAAUUCAGCCAACA 11606 AGcAAcAAUUcAGCcAAcAdTsdT antis 2270-2289  9607 GAAUUGUUGCUAGGACAAC 11607 GAAuuGuuGcuAGGAcAAcdTsdT sense 2270-2289  9608 GUUGUCCUAGCAACAAUUC 11608 GUUGUCCuAGcAAcAAUUCdTsdT antis 1576-1595  9609 GCAGCAGCCUUCAGCUUUU 11609 GcAGcAGccuucAGcuuuudTsdT sense 1576-1595  9610 AAAAGCUGAAGGCUGCUGC 11610 AAAAGCUGAAGGCUGCUGCdTsdT antis 1577-1596  9611 CAGCAGCCUUCAGCUUUUG 11611 cAGcAGccuucAGcuuuuGdTsdT sense 1577-1596  9612 CAAAAGCUGAAGGCUGCUG 11612 cAAAAGCUGAAGGCUGCUGdTsdT antis 1623-1642  9613 AUGGCAGCAAGGUAACCAC 11613 AuGGcAGcAAGGuAAccAcdTsdT sense 1623-1642  9614 GUGGUUACCUUGCUGCCAU 11614 GUGGUuACCUUGCUGCcAUdTsdT antis 1645-1664  9615 AGUGGCAACUCCUGGCCAG 11615 AGuGGcAAcuccuGGccAGdTsdT sense 1645-1664  9616 CUGGCCAGGAGUUGCCACU 11616 CUGGCcAGGAGUUGCcACUdTsdT antis 1742-1761  9617 GCCAAACUUUGUGAUUCUG 11617 GccAAAcuuuGuGAuucuGdTsdT sense 1742-1761  9618 CAGAAUCACAAAGUUUGGC 11618 cAGAAUcAcAAAGUUUGGCdTsdT antis 1778-1797  9619 AAGAAAGUUCUACAGGACA 11619 AAGAAAGuucuAcAGGAcAdTsdT sense 1778-1797  9620 UGUCCUGUAGAACUUUCUU 11620 UGUCCUGuAGAACUUUCUUdTsdT antis 1920-1939  9621 UGGACUAUGUUCCGGAGAC 11621 uGGAcuAuGuuccGGAGAcdTsdT sense 1920-1939  9622 GUCUCCGGAACAUAGUCCA 11622 GUCUCCGGAAcAuAGUCcAdTsdT antis 1973-1992  9623 AAGCAGACACUCCCUGUGA 11623 AAGcAGAcAcucccuGuGAdTsdT sense 1973-1992  9624 UCACAGGGAGUGUCUGCUU 11624 UcAcAGGGAGUGUCUGCUUdTsdT antis 1984-2003  9625 CCCUGUGAUCUAUGUCAAG 11625 cccuGuGAucuAuGucAAGdTsdT sense 1984-2003  9626 CUUGACAUAGAUCACAGGG 11626 CUUGAcAuAGAUcAcAGGGdTsdT antis 2085-2104  9627 UCUUGUUGGAUCCUGAUAC 11627 ucuuGuuGGAuccuGAuAcdTsdT sense 2085-2104  9628 GUAUCAGGAUCCAACAAGA 11628 GuAUcAGGAUCcAAcAAGAdTsdT antis 2090-2109  9629 UUGGAUCCUGAUACAGCUG 11629 uuGGAuccuGAuAcAGcuGdTsdT sense 2090-2109  9630 CAGCUGUAUCAGGAUCCAA 11630 cAGCUGuAUcAGGAUCcAAdTsdT antis 2170-2189  9631 AUAUAUCUGUUCUCGGUAC 11631 AuAuAucuGuucucGGuAcdTsdT sense 2170-2189  9632 GUACCGAGAACAGAUAUAU 11632 GuACCGAGAAcAGAuAuAUdTsdT antis 2200-2219  9633 AGAGUUGAUCUUUGGAGCC 11633 AGAGuuGAucuuuGGAGccdTsdT sense 2200-2219  9634 GGCUCCAAAGAUCAACUCU 11634 GGCUCcAAAGAUcAACUCUdTsdT antis 2253-2272  9635 CAGGCUGUGUGUUGGCUGA 11635 cAGGcuGuGuGuuGGcuGAdTsdT sense 2253-2272  9636 UCAGCCAACACACAGCCUG 11636 UcAGCcAAcAcAcAGCCUGdTsdT antis 2264-2283  9637 UUGGCUGAAUUGUUGCUAG 11637 uuGGcuGAAuuGuuGcuAGdTsdT sense 2264-2283  9638 CUAGCAACAAUUCAGCCAA 11638 CuAGcAAcAAUUcAGCcAAdTsdT antis 2285-2304  9639 CAACCAAUAUUUCCUGGGG 11639 cAAccAAuAuuuccuGGGGdTsdT sense 2285-2304  9640 CCCCAGGAAAUAUUGGUUG 11640 CCCcAGGAAAuAUUGGUUGdTsdT antis 2315-2334  9641 GAUCAGUUGGUGGAAAUAA 11641 GAucAGuuGGuGGAAAuAAdTsdT sense 2315-2334  9642 UUAUUUCCACCAACUGAUC 11642 UuAUUUCcACcAACUGAUCdTsdT antis 2452-2471  9643 UCCACCAGAGGCAAUUGCA 11643 uccAccAGAGGcAAuuGcAdTsdT sense 2452-2471  9644 UGCAAUUGCCUCUGGUGGA 11644 UGcAAUUGCCUCUGGUGGAdTsdT antis 2503-2522  9645 CGCCCGGCUAACACCACUG 11645 cGcccGGcuAAcAccAcuGdTsdT sense 2503-2522  9646 CAGUGGUGUUAGCCGGGCG 11646 cAGUGGUGUuAGCCGGGCGdTsdT antis 2504-2523  9647 GCCCGGCUAACACCACUGG 11647 GcccGGcuAAcAccAcuGGdTsdT sense 2504-2523  9648 CCAGUGGUGUUAGCCGGGC 11648 CcAGUGGUGUuAGCCGGGCdTsdT antis 1961-1980  9649 UAUAGUCGAGCCAAGCAGA 11649 uAuAGucGAGccAAGcAGAdTsdT sense 1961-1980  9650 UCUGCUUGGCUCGACUAUA 11650 UCUGCUUGGCUCGACuAuAdTsdT antis 1699-1718  9651 CACGAAAGUGAUUGGAAAU 11651 cAcGAAAGuGAuuGGAAAudTsdT sense 1699-1718  9652 AUUUCCAAUCACUUUCGUG 11652 AUUUCcAAUcACUUUCGUGdTsdT antis 1791-1810  9653 AGGACAAGCGAUUUAAGAA 11653 AGGAcAAGcGAuuuAAGAAdTsdT sense 1791-1810  9654 UUCUUAAAUCGCUUGUCCU 11654 UUCUuAAAUCGCUUGUCCUdTsdT antis 1534-1553  9655 GCGACCGAGAACCACCUCC 11655 GcGAccGAGAAccAccuccdTsdT sense 1534-1553  9656 GGAGGUGGUUCUCGGUCGC 11656 GGAGGUGGUUCUCGGUCGCdTsdT antis 1899-1918  9657 AGGUCUACCUUAACCUGGU 11657 AGGucuAccuuAAccuGGudTsdT sense 1899-1918  9658 ACCAGGUUAAGGUAGACCU 11658 ACcAGGUuAAGGuAGACCUdTsdT antis 1931-1950  9659 CCGGAGACAGUGUACAGAG 11659 ccGGAGAcAGuGuAcAGAGdTsdT sense 1931-1950  9660 CUCUGUACACUGUCUCCGG 11660 CUCUGuAcACUGUCUCCGGdTsdT antis 1964-1983  9661 AGUCGAGCCAAGCAGACAC 11661 AGucGAGccAAGcAGAcAcdTsdT sense 1964-1983  9662 GUGUCUGCUUGGCUCGACU 11662 GUGUCUGCUUGGCUCGACUdTsdT antis 2056-2075  9663 CUGCCAUCGAGACAUUAAA 11663 cuGccAucGAGAcAuuAAAdTsdT sense 2056-2075  9664 UUUAAUGUCUCGAUGGCAG 11664 UUuAAUGUCUCGAUGGcAGdTsdT antis 2155-2174  9665 AGAGCCCAAUGUUUCAUAU 11665 AGAGcccAAuGuuucAuAudTsdT sense 2155-2174  9666 AUAUGAAACAUUGGGCUCU 11666 AuAUGAAAcAUUGGGCUCUdTsdT antis 2182-2201  9667 UCGGUACUACAGGGCACCA 11667 ucGGuAcuAcAGGGcAccAdTsdT sense 2182-2201  9668 UGGUGCCCUGUAGUACCGA 11668 UGGUGCCCUGuAGuACCGAdTsdT antis 2329-2348  9669 AAUAAUAAAGGUCCUAGGA 11669 AAuAAuAAAGGuccuAGGAdTsdT sense 2329-2348  9670 UCCUAGGACCUUUAUUAUU 11670 UCCuAGGACCUUuAUuAUUdTsdT antis 2360-2379  9671 GAGCAAAUUAGAGAAAUGA 11671 GAGcAAAuuAGAGAAAuGAdTsdT sense 2360-2379  9672 UCAUUUCUCUAAUUUGCUC 11672 UcAUUUCUCuAAUUUGCUCdTsdT antis 2500-2519  9673 UACCGCCCGGCUAACACCA 11673 uAccGcccGGcuAAcAccAdTsdT sense 2500-2519  9674 UGGUGUUAGCCGGGCGGUA 11674 UGGUGUuAGCCGGGCGGuAdTsdT antis 1526-1545  9675 AUGUCGGGGCGACCGAGAA 11675 AuGucGGGGcGAccGAGAAdTsdT sense 1526-1545  9676 UUCUCGGUCGCCCCGACAU 11676 UUCUCGGUCGCCCCGAcAUdTsdT antis 1535-1554  9677 CGACCGAGAACCACCUCCU 11677 cGAccGAGAAccAccuccudTsdT sense 1535-1554  9678 AGGAGGUGGUUCUCGGUCG 11678 AGGAGGUGGUUCUCGGUCGdTsdT antis 1553-1572  9679 UUUGCGGAGAGCUGCAAGC 11679 uuuGcGGAGAGcuGcAAGcdTsdT sense 1553-1572  9680 GCUUGCAGCUCUCCGCAAA 11680 GCUUGcAGCUCUCCGcAAAdTsdT antis 1628-1647  9681 AGCAAGGUAACCACAGUAG 11681 AGcAAGGuAAccAcAGuAGdTsdT sense 1628-1647  9682 CUACUGUGGUUACCUUGCU 11682 CuACUGUGGUuACCUUGCUdTsdT antis 1633-1652  9683 GGUAACCACAGUAGUGGCA 11683 GGuAAccAcAGuAGuGGcAdTsdT sense 1633-1652  9684 UGCCACUACUGUGGUUACC 11684 UGCcACuACUGUGGUuACCdTsdT antis 1682-1701  9685 GAAGUCAGUUAUACAGACA 11685 GAAGucAGuuAuAcAGAcAdTsdT sense 1682-1701  9686 UGUCUGUAUAACUGACUUC 11686 UGUCUGuAuAACUGACUUCdTsdT antis 1684-1703  9687 AGUCAGUUAUACAGACACG 11687 AGucAGuuAuAcAGAcAcGdTsdT sense 1684-1703  9688 CGUGUCUGUAUAACUGACU 11688 CGUGUCUGuAuAACUGACUdTsdT antis 1698-1717  9689 ACACGAAAGUGAUUGGAAA 11689 AcAcGAAAGuGAuuGGAAAdTsdT sense 1698-1717  9690 UUUCCAAUCACUUUCGUGU 11690 UUUCcAAUcACUUUCGUGUdTsdT antis 1700-1719  9691 ACGAAAGUGAUUGGAAAUG 11691 AcGAAAGuGAuuGGAAAuGdTsdT sense 1700-1719  9692 CAUUUCCAAUCACUUUCGU 11692 cAUUUCcAAUcACUUUCGUdTsdT antis 1703-1722  9693 AAAGUGAUUGGAAAUGGAU 11693 AAAGuGAuuGGAAAuGGAudTsdT sense 1703-1722  9694 AUCCAUUUCCAAUCACUUU 11694 AUCcAUUUCcAAUcACUUUdTsdT antis 1735-1754  9695 AUAUCAAGCCAAACUUUGU 11695 AuAucAAGccAAAcuuuGudTsdT sense 1735-1754  9696 ACAAAGUUUGGCUUGAUAU 11696 AcAAAGUUUGGCUUGAuAUdTsdT antis 1741-1760  9697 AGCCAAACUUUGUGAUUCU 11697 AGccAAAcuuuGuGAuucudTsdT sense 1741-1760  9698 AGAAUCACAAAGUUUGGCU 11698 AGAAUcAcAAAGUUUGGCUdTsdT antis 1773-1792  9699 CCAUCAAGAAAGUUCUACA 11699 ccAucAAGAAAGuucuAcAdTsdT sense 1773-1792  9700 UGUAGAACUUUCUUGAUGG 11700 UGuAGAACUUUCUUGAUGGdTsdT antis 1774-1793  9701 CAUCAAGAAAGUUCUACAG 11701 cAucAAGAAAGuucuAcAGdTsdT sense 1774-1793  9702 CUGUAGAACUUUCUUGAUG 11702 CUGuAGAACUUUCUUGAUGdTsdT antis 1784-1803  9703 GUUCUACAGGACAAGCGAU 11703 GuucuAcAGGAcAAGcGAudTsdT sense 1784-1803  9704 AUCGCUUGUCCUGUAGAAC 11704 AUCGCUUGUCCUGuAGAACdTsdT antis 1823-1842  9705 AUCAUGAGAAAGCUAGACC 11705 AucAuGAGAAAGcuAGAccdTsdT sense 1823-1842  9706 GGUCUAGCUUUCUCAUGAU 11706 GGUCuAGCUUUCUcAUGAUdTsdT antis 1868-1887  9707 UUCUUCUACUCGAGUGGUG 11707 uucuucuAcucGAGuGGuGdTsdT sense 1868-1887  9708 CACCACUCGAGUAGAAGAA 11708 cACcACUCGAGuAGAAGAAdTsdT antis 1876-1895  9709 CUCGAGUGGUGAGAAGAAA 11709 cucGAGuGGuGAGAAGAAAdTsdT sense 1876-1895  9710 UUUCUUCUCACCACUCGAG 11710 UUUCUUCUcACcACUCGAGdTsdT antis 1907-1926  9711 CUUAACCUGGUGCUGGACU 11711 cuuAAccuGGuGcuGGAcudTsdT sense 1907-1926  9712 AGUCCAGCACCAGGUUAAG 11712 AGUCcAGcACcAGGUuAAGdTsdT antis 1910-1929  9713 AACCUGGUGCUGGACUAUG 11713 AAccuGGuGcuGGAcuAuGdTsdT sense 1910-1929  9714 CAUAGUCCAGCACCAGGUU 11714 cAuAGUCcAGcACcAGGUUdTsdT antis 1930-1949  9715 UCCGGAGACAGUGUACAGA 11715 uccGGAGAcAGuGuAcAGAdTsdT sense 1930-1949  9716 UCUGUACACUGUCUCCGGA 11716 UCUGuAcACUGUCUCCGGAdTsdT antis 1939-1958  9717 AGUGUACAGAGUCGCCAGA 11717 AGuGuAcAGAGucGccAGAdTsdT sense 1939-1958  9718 UCUGGCGACUCUGUACACU 11718 UCUGGCGACUCUGuAcACUdTsdT antis 1940-1959  9719 GUGUACAGAGUCGCCAGAC 11719 GuGuAcAGAGucGccAGAcdTsdT sense 1940-1959  9720 GUCUGGCGACUCUGUACAC 11720 GUCUGGCGACUCUGuAcACdTsdT antis 1943-1962  9721 UACAGAGUCGCCAGACACU 11721 uAcAGAGucGccAGAcAcudTsdT sense 1943-1962  9722 AGUGUCUGGCGACUCUGUA 11722 AGUGUCUGGCGACUCUGuAdTsdT antis 1946-1965  9723 AGAGUCGCCAGACACUAUA 11723 AGAGucGccAGAcAcuAuAdTsdT sense 1946-1965  9724 UAUAGUGUCUGGCGACUCU 11724 uAuAGUGUCUGGCGACUCUdTsdT antis 1948-1967  9725 AGUCGCCAGACACUAUAGU 11725 AGucGccAGAcAcuAuAGudTsdT sense 1948-1967  9726 ACUAUAGUGUCUGGCGACU 11726 ACuAuAGUGUCUGGCGACUdTsdT antis 1963-1982  9727 UAGUCGAGCCAAGCAGACA 11727 uAGucGAGccAAGcAGAcAdTsdT sense 1963-1982  9728 UGUCUGCUUGGCUCGACUA 11728 UGUCUGCUUGGCUCGACuAdTsdT antis 1987-2006  9729 UGUGAUCUAUGUCAAGUUG 11729 uGuGAucuAuGucAAGuuGdTsdT sense 1987-2006  9730 CAACUUGACAUAGAUCACA 11730 cAACUUGAcAuAGAUcAcAdTsdT antis 1991-2010  9731 AUCUAUGUCAAGUUGUAUA 11731 AucuAuGucAAGuuGuAuAdTsdT sense 1991-2010  9732 UAUACAACUUGACAUAGAU 11732 uAuAcAACUUGAcAuAGAUdTsdT antis 1992-2011  9733 UCUAUGUCAAGUUGUAUAU 11733 ucuAuGucAAGuuGuAuAudTsdT sense 1992-2011  9734 AUAUACAACUUGACAUAGA 11734 AuAuAcAACUUGAcAuAGAdTsdT antis 2000-2019  9735 AAGUUGUAUAUGUAUCAGC 11735 AAGuuGuAuAuGuAucAGcdTsdT sense 2000-2019  9736 GCUGAUACAUAUACAACUU 11736 GCUGAuAcAuAuAcAACUUdTsdT antis 2001-2020  9737 AGUUGUAUAUGUAUCAGCU 11737 AGuuGuAuAuGuAucAGcudTsdT sense 2001-2020  9738 AGCUGAUACAUAUACAACU 11738 AGCUGAuAcAuAuAcAACUdTsdT antis 2004-2023  9739 UGUAUAUGUAUCAGCUGUU 11739 uGuAuAuGuAucAGcuGuudTsdT sense 2004-2023  9740 AACAGCUGAUACAUAUACA 11740 AAcAGCUGAuAcAuAuAcAdTsdT antis 2007-2026  9741 AUAUGUAUCAGCUGUUCAG 11741 AuAuGuAucAGcuGuucAGdTsdT sense 2007-2026  9742 CUGAACAGCUGAUACAUAU 11742 CUGAAcAGCUGAuAcAuAUdTsdT antis 2048-2067  9743 UUUGGAAUCUGCCAUCGAG 11743 uuuGGAAucuGccAucGAGdTsdT sense 2048-2067  9744 CUCGAUGGCAGAUUCCAAA 11744 CUCGAUGGcAGAUUCcAAAdTsdT antis 2100-2119  9745 AUACAGCUGUAUUAAAACU 11745 AuAcAGcuGuAuuAAAAcudTsdT sense 2100-2119  9746 AGUUUUAAUACAGCUGUAU 11746 AGUUUuAAuAcAGCUGuAUdTsdT antis 2107-2126  9747 UGUAUUAAAACUCUGUGAC 11747 uGuAuuAAAAcucuGuGAcdTsdT sense 2107-2126  9748 GUCACAGAGUUUUAAUACA 11748 GUcAcAGAGUUUuAAuAcAdTsdT antis 2151-2170  9749 GAGGAGAGCCCAAUGUUUC 11749 GAGGAGAGcccAAuGuuucdTsdT sense 2151-2170  9750 GAAACAUUGGGCUCUCCUC 11750 GAAAcAUUGGGCUCUCCUCdTsdT antis 2158-2177  9751 GCCCAAUGUUUCAUAUAUC 11751 GcccAAuGuuucAuAuAucdTsdT sense 2158-2177  9752 GAUAUAUGAAACAUUGGGC 11752 GAuAuAUGAAAcAUUGGGCdTsdT antis 2166-2185  9753 UUUCAUAUAUCUGUUCUCG 11753 uuucAuAuAucuGuucucGdTsdT sense 2166-2185  9754 CGAGAACAGAUAUAUGAAA 11754 CGAGAAcAGAuAuAUGAAAdTsdT antis 2172-2191  9755 AUAUCUGUUCUCGGUACUA 11755 AuAucuGuucucGGuAcuAdTsdT sense 2172-2191  9756 UAGUACCGAGAACAGAUAU 11756 uAGuACCGAGAAcAGAuAUdTsdT antis 2183-2202  9757 CGGUACUACAGGGCACCAG 11757 cGGuAcuAcAGGGcAccAGdTsdT sense 2183-2202  9758 CUGGUGCCCUGUAGUACCG 11758 CUGGUGCCCUGuAGuACCGdTsdT antis 2232-2251  9759 CCAGUAUAGAUGUAUGGUC 11759 ccAGuAuAGAuGuAuGGucdTsdT sense 2232-2251  9760 GACCAUACAUCUAUACUGG 11760 GACcAuAcAUCuAuACUGGdTsdT antis 2273-2292  9761 UUGUUGCUAGGACAACCAA 11761 uuGuuGcuAGGAcAAccAAdTsdT sense 2273-2292  9762 UUGGUUGUCCUAGCAACAA 11762 UUGGUUGUCCuAGcAAcAAdTsdT antis 2274-2293  9763 UGUUGCUAGGACAACCAAU 11763 uGuuGcuAGGAcAAccAAudTsdT sense 2274-2293  9764 AUUGGUUGUCCUAGCAACA 11764 AUUGGUUGUCCuAGcAAcAdTsdT antis 2318-2337  9765 CAGUUGGUGGAAAUAAUAA 11765 cAGuuGGuGGAAAuAAuAAdTsdT sense 2318-2337  9766 UUAUUAUUUCCACCAACUG 11766 UuAUuAUUUCcACcAACUGdTsdT antis 2361-2380  9767 AGCAAAUUAGAGAAAUGAA 11767 AGcAAAuuAGAGAAAuGAAdTsdT sense 2361-2380  9768 UUCAUUUCUCUAAUUUGCU 11768 UUcAUUUCUCuAAUUUGCUdTsdT antis 2380-2399  9769 CCCAAAUUAUACAGAAUUC 11769 cccAAAuuAuAcAGAAuucdTsdT sense 2380-2399  9770 GAAUUCUGUAUAAUUUGGG 11770 GAAUUCUGuAuAAUUUGGGdTsdT antis 2400-2419  9771 AAUUCCCUCAAAUCAAGGC 11771 AAuucccucAAAucAAGGcdTsdT sense 2400-2419  9772 GCCUUGAUUUGAGGGAAUU 11772 GCCUUGAUUUGAGGGAAUUdTsdT antis 2409-2428  9773 AAAUCAAGGCACAUCCUUG 11773 AAAucAAGGcAcAuccuuGdTsdT sense 2409-2428  9774 CAAGGAUGUGCCUUGAUUU 11774 cAAGGAUGUGCCUUGAUUUdTsdT antis 2445-2464  9775 CCCGAACUCCACCAGAGGC 11775 cccGAAcuccAccAGAGGcdTsdT sense 2445-2464  9776 GCCUCUGGUGGAGUUCGGG 11776 GCCUCUGGUGGAGUUCGGGdTsdT antis 2479-2498  9777 CCGUCUGCUGGAGUACACA 11777 ccGucuGcuGGAGuAcAcAdTsdT sense 2479-2498  9778 UGUGUACUCCAGCAGACGG 11778 UGUGuACUCcAGcAGACGGdTsdT antis 2489-2508  9779 GAGUACACACCUACCGCCC 11779 GAGuAcAcAccuAccGcccdTsdT sense 2489-2508  9780 GGGCGGUAGGUGUGUACUC 11780 GGGCGGuAGGUGUGuACUCdTsdT antis 1819-1838  9781 CCAGAUCAUGAGAAAGCUA 11781 ccAGAucAuGAGAAAGcuAdTsdT sense 1819-1838  9782 UAGCUUUCUCAUGAUCUGG 11782 uAGCUUUCUcAUGAUCUGGdTsdT antis 2030-2049  9783 CUAGCCUAUAUCCAUUCCU 11783 cuAGccuAuAuccAuuccudTsdT sense 2030-2049  9784 AGGAAUGGAUAUAGGCUAG 11784 AGGAAUGGAuAuAGGCuAGdTsdT antis 2154-2173  9785 GAGAGCCCAAUGUUUCAUA 11785 GAGAGcccAAuGuuucAuAdTsdT sense 2154-2173  9786 UAUGAAACAUUGGGCUCUC 11786 uAUGAAAcAUUGGGCUCUCdTsdT antis 2184-2203  9787 GGUACUACAGGGCACCAGA 11787 GGuAcuAcAGGGcAccAGAdTsdT sense 2184-2203  9788 UCUGGUGCCCUGUAGUACC 11788 UCUGGUGCCCUGuAGuACCdTsdT antis 2190-2209  9789 ACAGGGCACCAGAGUUGAU 11789 AcAGGGcAccAGAGuuGAudTsdT sense 2190-2209  9790 AUCAACUCUGGUGCCCUGU 11790 AUcAACUCUGGUGCCCUGUdTsdT antis 2314-2333  9791 GGAUCAGUUGGUGGAAAUA 11791 GGAucAGuuGGuGGAAAuAdTsdT sense 2314-2333  9792 UAUUUCCACCAACUGAUCC 11792 uAUUUCcACcAACUGAUCCdTsdT antis 2428-2447  9793 GACAAAGGUCUUCCGGCCC 11793 GAcAAAGGucuuccGGcccdTsdT sense 2428-2447  9794 GGGCCGGAAGACCUUUGUC 11794 GGGCCGGAAGACCUUUGUCdTsdT antis 1913-1932  9795 CUGGUGCUGGACUAUGUUC 11795 cuGGuGcuGGAcuAuGuucdTsdT sense 1913-1932  9796 GAACAUAGUCCAGCACCAG 11796 GAAcAuAGUCcAGcACcAGdTsdT antis 1530-1549  9797 CGGGGCGACCGAGAACCAC 11797 cGGGGcGAccGAGAAccAcdTsdT sense 1530-1549  9798 GUGGUUCUCGGUCGCCCCG 11798 GUGGUUCUCGGUCGCCCCGdTsdT antis 1549-1568  9799 CUCCUUUGCGGAGAGCUGC 11799 cuccuuuGcGGAGAGcuGcdTsdT sense 1549-1568  9800 GCAGCUCUCCGCAAAGGAG 11800 GcAGCUCUCCGcAAAGGAGdTsdT antis 1550-1569  9801 UCCUUUGCGGAGAGCUGCA 11801 uccuuuGcGGAGAGcuGcAdTsdT sense 1550-1569  9802 UGCAGCUCUCCGCAAAGGA 11802 UGcAGCUCUCCGcAAAGGAdTsdT antis 1610-1629  9803 AGCAGAGAUAAAGAUGGCA 11803 AGcAGAGAuAAAGAuGGcAdTsdT sense 1610-1629  9804 UGCCAUCUUUAUCUCUGCU 11804 UGCcAUCUUuAUCUCUGCUdTsdT antis 1642-1661  9805 AGUAGUGGCAACUCCUGGC 11805 AGuAGuGGcAAcuccuGGcdTsdT sense 1642-1661  9806 GCCAGGAGUUGCCACUACU 11806 GCcAGGAGUUGCcACuACUdTsdT antis 1643-1662  9807 GUAGUGGCAACUCCUGGCC 11807 GuAGuGGcAAcuccuGGccdTsdT sense 1643-1662  9808 GGCCAGGAGUUGCCACUAC 11808 GGCcAGGAGUUGCcACuACdTsdT antis 1696-1715  9809 AGACACGAAAGUGAUUGGA 11809 AGAcAcGAAAGuGAuuGGAdTsdT sense 1696-1715  9810 UCCAAUCACUUUCGUGUCU 11810 UCcAAUcACUUUCGUGUCUdTsdT antis 1704-1723  9811 AAGUGAUUGGAAAUGGAUC 11811 AAGuGAuuGGAAAuGGAucdTsdT sense 1704-1723  9812 GAUCCAUUUCCAAUCACUU 11812 GAUCcAUUUCcAAUcACUUdTsdT antis 1719-1738  9813 GAUCAUUUGGUGUGGUAUA 11813 GAucAuuuGGuGuGGuAuAdTsdT sense 1719-1738  9814 UAUACCACACCAAAUGAUC 11814 uAuACcAcACcAAAUGAUCdTsdT antis 1728-1747  9815 GUGUGGUAUAUCAAGCCAA 11815 GuGuGGuAuAucAAGccAAdTsdT sense 1728-1747  9816 UUGGCUUGAUAUACCACAC 11816 UUGGCUUGAuAuACcAcACdTsdT antis 1731-1750  9817 UGGUAUAUCAAGCCAAACU 11817 uGGuAuAucAAGccAAAcudTsdT sense 1731-1750  9818 AGUUUGGCUUGAUAUACCA 11818 AGUUUGGCUUGAuAuACcAdTsdT antis 1732-1751  9819 GGUAUAUCAAGCCAAACUU 11819 GGuAuAucAAGccAAAcuudTsdT sense 1732-1751  9820 AAGUUUGGCUUGAUAUACC 11820 AAGUUUGGCUUGAuAuACCdTsdT antis 1733-1752  9821 GUAUAUCAAGCCAAACUUU 11821 GuAuAucAAGccAAAcuuudTsdT sense 1733-1752  9822 AAAGUUUGGCUUGAUAUAC 11822 AAAGUUUGGCUUGAuAuACdTsdT antis 1768-1787  9823 GGUUGCCAUCAAGAAAGUU 11823 GGuuGccAucAAGAAAGuudTsdT sense 1768-1787  9824 AACUUUCUUGAUGGCAACC 11824 AACUUUCUUGAUGGcAACCdTsdT antis 1800-1819  9825 GAUUUAAGAACCGAGAGCU 11825 GAuuuAAGAAccGAGAGcudTsdT sense 1800-1819  9826 AGCUCUCGGUUCUUAAAUC 11826 AGCUCUCGGUUCUuAAAUCdTsdT antis 1802-1821  9827 UUUAAGAACCGAGAGCUCC 11827 uuuAAGAAccGAGAGcuccdTsdT sense 1802-1821  9828 GGAGCUCUCGGUUCUUAAA 11828 GGAGCUCUCGGUUCUuAAAdTsdT antis 1821-1840  9829 AGAUCAUGAGAAAGCUAGA 11829 AGAucAuGAGAAAGcuAGAdTsdT sense 1821-1840  9830 UCUAGCUUUCUCAUGAUCU 11830 UCuAGCUUUCUcAUGAUCUdTsdT antis 1830-1849  9831 GAAAGCUAGACCACUGUAA 11831 GAAAGcuAGAccAcuGuAAdTsdT sense 1830-1849  9832 UUACAGUGGUCUAGCUUUC 11832 UuAcAGUGGUCuAGCUUUCdTsdT antis 1831-1850  9833 AAAGCUAGACCACUGUAAC 11833 AAAGcuAGAccAcuGuAAcdTsdT sense 1831-1850  9834 GUUACAGUGGUCUAGCUUU 11834 GUuAcAGUGGUCuAGCUUUdTsdT antis 1856-1875  9835 CGACUGCGGUAUUUCUUCU 11835 cGAcuGcGGuAuuucuucudTsdT sense 1856-1875  9836 AGAAGAAAUACCGCAGUCG 11836 AGAAGAAAuACCGcAGUCGdTsdT antis 1857-1876  9837 GACUGCGGUAUUUCUUCUA 11837 GAcuGcGGuAuuucuucuAdTsdT sense 1857-1876  9838 UAGAAGAAAUACCGCAGUC 11838 uAGAAGAAAuACCGcAGUCdTsdT antis 1875-1894  9839 ACUCGAGUGGUGAGAAGAA 11839 AcucGAGuGGuGAGAAGAAdTsdT sense 1875-1894  9840 UUCUUCUCACCACUCGAGU 11840 UUCUUCUcACcACUCGAGUdTsdT antis 1877-1896  9841 UCGAGUGGUGAGAAGAAAG 11841 ucGAGuGGuGAGAAGAAAGdTsdT sense 1877-1896  9842 CUUUCUUCUCACCACUCGA 11842 CUUUCUUCUcACcACUCGAdTsdT antis 1897-1916  9843 UGAGGUCUACCUUAACCUG 11843 uGAGGucuAccuuAAccuGdTsdT sense 1897-1916  9844 CAGGUUAAGGUAGACCUCA 11844 cAGGUuAAGGuAGACCUcAdTsdT antis 1908-1927  9845 UUAACCUGGUGCUGGACUA 11845 uuAAccuGGuGcuGGAcuAdTsdT sense 1908-1927  9846 UAGUCCAGCACCAGGUUAA 11846 uAGUCcAGcACcAGGUuAAdTsdT antis 1923-1942  9847 ACUAUGUUCCGGAGACAGU 11847 AcuAuGuuccGGAGAcAGudTsdT sense 1923-1942  9848 ACUGUCUCCGGAACAUAGU 11848 ACUGUCUCCGGAAcAuAGUdTsdT antis 1928-1947  9849 GUUCCGGAGACAGUGUACA 11849 GuuccGGAGAcAGuGuAcAdTsdT sense 1928-1947  9850 UGUACACUGUCUCCGGAAC 11850 UGuAcACUGUCUCCGGAACdTsdT antis 1934-1953  9851 GAGACAGUGUACAGAGUCG 11851 GAGAcAGuGuAcAGAGucGdTsdT sense 1934-1953  9852 CGACUCUGUACACUGUCUC 11852 CGACUCUGuAcACUGUCUCdTsdT antis 1951-1970  9853 CGCCAGACACUAUAGUCGA 11853 cGccAGAcAcuAuAGucGAdTsdT sense 1951-1970  9854 UCGACUAUAGUGUCUGGCG 11854 UCGACuAuAGUGUCUGGCGdTsdT antis 1981-2000  9855 ACUCCCUGUGAUCUAUGUC 11855 AcucccuGuGAucuAuGucdTsdT sense 1981-2000  9856 GACAUAGAUCACAGGGAGU 11856 GAcAuAGAUcAcAGGGAGUdTsdT antis 1983-2002  9857 UCCCUGUGAUCUAUGUCAA 11857 ucccuGuGAucuAuGucAAdTsdT sense 1983-2002  9858 UUGACAUAGAUCACAGGGA 11858 UUGAcAuAGAUcAcAGGGAdTsdT antis 1994-2013  9859 UAUGUCAAGUUGUAUAUGU 11859 uAuGucAAGuuGuAuAuGudTsdT sense 1994-2013  9860 ACAUAUACAACUUGACAUA 11860 AcAuAuAcAACUUGAcAuAdTsdT antis 2003-2022  9861 UUGUAUAUGUAUCAGCUGU 11861 uuGuAuAuGuAucAGcuGudTsdT sense 2003-2022  9862 ACAGCUGAUACAUAUACAA 11862 AcAGCUGAuAcAuAuAcAAdTsdT antis 2067-2086  9863 ACAUUAAACCACAGAACCU 11863 AcAuuAAAccAcAGAAccudTsdT sense 2067-2086  9864 AGGUUCUGUGGUUUAAUGU 11864 AGGUUCUGUGGUUuAAUGUdTsdT antis 2077-2096  9865 ACAGAACCUCUUGUUGGAU 11865 AcAGAAccucuuGuuGGAudTsdT sense 2077-2096  9866 AUCCAACAAGAGGUUCUGU 11866 AUCcAAcAAGAGGUUCUGUdTsdT antis 2079-2098  9867 AGAACCUCUUGUUGGAUCC 11867 AGAAccucuuGuuGGAuccdTsdT sense 2079-2098  9868 GGAUCCAACAAGAGGUUCU 11868 GGAUCcAAcAAGAGGUUCUdTsdT antis 2087-2106  9869 UUGUUGGAUCCUGAUACAG 11869 uuGuuGGAuccuGAuAcAGdTsdT sense 2087-2106  9870 CUGUAUCAGGAUCCAACAA 11870 CUGuAUcAGGAUCcAAcAAdTsdT antis 2093-2112  9871 GAUCCUGAUACAGCUGUAU 11871 GAuccuGAuAcAGcuGuAudTsdT sense 2093-2112  9872 AUACAGCUGUAUCAGGAUC 11872 AuAcAGCUGuAUcAGGAUCdTsdT antis 2099-2118  9873 GAUACAGCUGUAUUAAAAC 11873 GAuAcAGcuGuAuuAAAAcdTsdT sense 2099-2118  9874 GUUUUAAUACAGCUGUAUC 11874 GUUUuAAuAcAGCUGuAUCdTsdT antis 2135-2154  9875 GCAAAGCAGCUGGUCCGAG 11875 GcAAAGcAGcuGGuccGAGdTsdT sense 2135-2154  9876 CUCGGACCAGCUGCUUUGC 11876 CUCGGACcAGCUGCUUUGCdTsdT antis 2150-2169  9877 CGAGGAGAGCCCAAUGUUU 11877 cGAGGAGAGcccAAuGuuudTsdT sense 2150-2169  9878 AAACAUUGGGCUCUCCUCG 11878 AAAcAUUGGGCUCUCCUCGdTsdT antis 2157-2176  9879 AGCCCAAUGUUUCAUAUAU 11879 AGcccAAuGuuucAuAuAudTsdT sense 2157-2176  9880 AUAUAUGAAACAUUGGGCU 11880 AuAuAUGAAAcAUUGGGCUdTsdT antis 2198-2217  9881 CCAGAGUUGAUCUUUGGAG 11881 ccAGAGuuGAucuuuGGAGdTsdT sense 2198-2217  9882 CUCCAAAGAUCAACUCUGG 11882 CUCcAAAGAUcAACUCUGGdTsdT antis 2199-2218  9883 CAGAGUUGAUCUUUGGAGC 11883 cAGAGuuGAucuuuGGAGcdTsdT sense 2199-2218  9884 GCUCCAAAGAUCAACUCUG 11884 GCUCcAAAGAUcAACUCUGdTsdT antis 2216-2235  9885 GCCACUGAUUACACGUCCA 11885 GccAcuGAuuAcAcGuccAdTsdT sense 2216-2235  9886 UGGACGUGUAAUCAGUGGC 11886 UGGACGUGuAAUcAGUGGCdTsdT antis 2237-2256  9887 AUAGAUGUAUGGUCUGCAG 11887 AuAGAuGuAuGGucuGcAGdTsdT sense 2237-2256  9888 CUGCAGACCAUACAUCUAU 11888 CUGcAGACcAuAcAUCuAUdTsdT antis 2243-2262  9889 GUAUGGUCUGCAGGCUGUG 11889 GuAuGGucuGcAGGcuGuGdTsdT sense 2243-2262  9890 CACAGCCUGCAGACCAUAC 11890 cAcAGCCUGcAGACcAuACdTsdT antis 2272-2291  9891 AUUGUUGCUAGGACAACCA 11891 AuuGuuGcuAGGAcAAccAdTsdT sense 2272-2291  9892 UGGUUGUCCUAGCAACAAU 11892 UGGUUGUCCuAGcAAcAAUdTsdT antis 2283-2302  9893 GACAACCAAUAUUUCCUGG 11893 GAcAAccAAuAuuuccuGGdTsdT sense 2283-2302  9894 CCAGGAAAUAUUGGUUGUC 11894 CcAGGAAAuAUUGGUUGUCdTsdT antis 2291-2310  9895 AUAUUUCCUGGGGACAGUG 11895 AuAuuuccuGGGGAcAGuGdTsdT sense 2291-2310  9896 CACUGUCCCCAGGAAAUAU 11896 cACUGUCCCcAGGAAAuAUdTsdT antis 2311-2330  9897 UGUGGAUCAGUUGGUGGAA 11897 uGuGGAucAGuuGGuGGAAdTsdT sense 2311-2330  9898 UUCCACCAACUGAUCCACA 11898 UUCcACcAACUGAUCcAcAdTsdT antis 2353-2372  9899 AACAAGGGAGCAAAUUAGA 11899 AAcAAGGGAGcAAAuuAGAdTsdT sense 2353-2372  9900 UCUAAUUUGCUCCCUUGUU 11900 UCuAAUUUGCUCCCUUGUUdTsdT antis 2359-2378  9901 GGAGCAAAUUAGAGAAAUG 11901 GGAGcAAAuuAGAGAAAuGdTsdT sense 2359-2378  9902 CAUUUCUCUAAUUUGCUCC 11902 cAUUUCUCuAAUUUGCUCCdTsdT antis 2379-2398  9903 ACCCAAAUUAUACAGAAUU 11903 AcccAAAuuAuAcAGAAuudTsdT sense 2379-2398  9904 AAUUCUGUAUAAUUUGGGU 11904 AAUUCUGuAuAAUUUGGGUdTsdT antis 2408-2427  9905 CAAAUCAAGGCACAUCCUU 11905 cAAAucAAGGcAcAuccuudTsdT sense 2408-2427  9906 AAGGAUGUGCCUUGAUUUG 11906 AAGGAUGUGCCUUGAUUUGdTsdT antis 2412-2431  9907 UCAAGGCACAUCCUUGGAC 11907 ucAAGGcAcAuccuuGGAcdTsdT sense 2412-2431  9908 GUCCAAGGAUGUGCCUUGA 11908 GUCcAAGGAUGUGCCUUGAdTsdT antis 2438-2457  9909 UUCCGGCCCCGAACUCCAC 11909 uuccGGccccGAAcuccAcdTsdT sense 2438-2457  9910 GUGGAGUUCGGGGCCGGAA 11910 GUGGAGUUCGGGGCCGGAAdTsdT antis 2476-2495  9911 CAGCCGUCUGCUGGAGUAC 11911 cAGccGucuGcuGGAGuAcdTsdT sense 2476-2495  9912 GUACUCCAGCAGACGGCUG 11912 GuACUCcAGcAGACGGCUGdTsdT antis 2477-2496  9913 AGCCGUCUGCUGGAGUACA 11913 AGccGucuGcuGGAGuAcAdTsdT sense 2477-2496  9914 UGUACUCCAGCAGACGGCU 11914 UGuACUCcAGcAGACGGCUdTsdT antis 2478-2497  9915 GCCGUCUGCUGGAGUACAC 11915 GccGucuGcuGGAGuAcAcdTsdT sense 2478-2497  9916 GUGUACUCCAGCAGACGGC 11916 GUGuACUCcAGcAGACGGCdTsdT antis 2484-2503  9917 UGCUGGAGUACACACCUAC 11917 uGcuGGAGuAcAcAccuAcdTsdT sense 2484-2503  9918 GUAGGUGUGUACUCCAGCA 11918 GuAGGUGUGuACUCcAGcAdTsdT antis 1527-1546  9919 UGUCGGGGCGACCGAGAAC 11919 uGucGGGGcGAccGAGAAcdTsdT sense 1527-1546  9920 GUUCUCGGUCGCCCCGACA 11920 GUUCUCGGUCGCCCCGAcAdTsdT antis 1531-1550  9921 GGGGCGACCGAGAACCACC 11921 GGGGcGAccGAGAAccAccdTsdT sense 1531-1550  9922 GGUGGUUCUCGGUCGCCCC 11922 GGUGGUUCUCGGUCGCCCCdTsdT antis 1536-1555  9923 GACCGAGAACCACCUCCUU 11923 GAccGAGAAccAccuccuudTsdT sense 1536-1555  9924 AAGGAGGUGGUUCUCGGUC 11924 AAGGAGGUGGUUCUCGGUCdTsdT antis 1542-1561  9925 GAACCACCUCCUUUGCGGA 11925 GAAccAccuccuuuGcGGAdTsdT sense 1542-1561  9926 UCCGCAAAGGAGGUGGUUC 11926 UCCGcAAAGGAGGUGGUUCdTsdT antis 1552-1571  9927 CUUUGCGGAGAGCUGCAAG 11927 cuuuGcGGAGAGcuGcAAGdTsdT sense 1552-1571  9928 CUUGCAGCUCUCCGCAAAG 11928 CUUGcAGCUCUCCGcAAAGdTsdT antis 1556-1575  9929 GCGGAGAGCUGCAAGCCAG 11929 GcGGAGAGcuGcAAGccAGdTsdT sense 1556-1575  9930 CUGGCUUGCAGCUCUCCGC 11930 CUGGCUUGcAGCUCUCCGCdTsdT antis 1564-1583  9931 CUGCAAGCCAGUGCAGCAG 11931 cuGcAAGccAGuGcAGcAGdTsdT sense 1564-1583  9932 CUGCUGCACUGGCUUGCAG 11932 CUGCUGcACUGGCUUGcAGdTsdT antis 1572-1591  9933 CAGUGCAGCAGCCUUCAGC 11933 cAGuGcAGcAGccuucAGcdTsdT sense 1572-1591  9934 GCUGAAGGCUGCUGCACUG 11934 GCUGAAGGCUGCUGcACUGdTsdT antis 1578-1597  9935 AGCAGCCUUCAGCUUUUGG 11935 AGcAGccuucAGcuuuuGGdTsdT sense 1578-1597  9936 CCAAAAGCUGAAGGCUGCU 11936 CcAAAAGCUGAAGGCUGCUdTsdT antis 1579-1598  9937 GCAGCCUUCAGCUUUUGGU 11937 GcAGccuucAGcuuuuGGudTsdT sense 1579-1598  9938 ACCAAAAGCUGAAGGCUGC 11938 ACcAAAAGCUGAAGGCUGCdTsdT antis 1581-1600  9939 AGCCUUCAGCUUUUGGUAG 11939 AGccuucAGcuuuuGGuAGdTsdT sense 1581-1600  9940 CUACCAAAAGCUGAAGGCU 11940 CuACcAAAAGCUGAAGGCUdTsdT antis 1582-1601  9941 GCCUUCAGCUUUUGGUAGC 11941 GccuucAGcuuuuGGuAGcdTsdT sense 1582-1601  9942 GCUACCAAAAGCUGAAGGC 11942 GCuACcAAAAGCUGAAGGCdTsdT antis 1585-1604  9943 UUCAGCUUUUGGUAGCAUG 11943 uucAGcuuuuGGuAGcAuGdTsdT sense 1585-1604  9944 CAUGCUACCAAAAGCUGAA 11944 cAUGCuACcAAAAGCUGAAdTsdT antis 1587-1606  9945 CAGCUUUUGGUAGCAUGAA 11945 cAGcuuuuGGuAGcAuGAAdTsdT sense 1587-1606  9946 UUCAUGCUACCAAAAGCUG 11946 UUcAUGCuACcAAAAGCUGdTsdT antis 1588-1607  9947 AGCUUUUGGUAGCAUGAAA 11947 AGcuuuuGGuAGcAuGAAAdTsdT sense 1588-1607  9948 UUUCAUGCUACCAAAAGCU 11948 UUUcAUGCuACcAAAAGCUdTsdT antis 1598-1617  9949 AGCAUGAAAGUUAGCAGAG 11949 AGcAuGAAAGuuAGcAGAGdTsdT sense 1598-1617  9950 CUCUGCUAACUUUCAUGCU 11950 CUCUGCuAACUUUcAUGCUdTsdT antis 1602-1621  9951 UGAAAGUUAGCAGAGAUAA 11951 uGAAAGuuAGcAGAGAuAAdTsdT sense 1602-1621  9952 UUAUCUCUGCUAACUUUCA 11952 UuAUCUCUGCuAACUUUcAdTsdT antis 1618-1637  9953 UAAAGAUGGCAGCAAGGUA 11953 uAAAGAuGGcAGcAAGGuAdTsdT sense 1618-1637  9954 UACCUUGCUGCCAUCUUUA 11954 uACCUUGCUGCcAUCUUuAdTsdT antis 1619-1638  9955 AAAGAUGGCAGCAAGGUAA 11955 AAAGAuGGcAGcAAGGuAAdTsdT sense 1619-1638  9956 UUACCUUGCUGCCAUCUUU 11956 UuACCUUGCUGCcAUCUUUdTsdT antis 1625-1644  9957 GGCAGCAAGGUAACCACAG 11957 GGcAGcAAGGuAAccAcAGdTsdT sense 1625-1644  9958 CUGUGGUUACCUUGCUGCC 11958 CUGUGGUuACCUUGCUGCCdTsdT antis 1627-1646  9959 CAGCAAGGUAACCACAGUA 11959 cAGcAAGGuAAccAcAGuAdTsdT sense 1627-1646  9960 UACUGUGGUUACCUUGCUG 11960 uACUGUGGUuACCUUGCUGdTsdT antis 1636-1655  9961 AACCACAGUAGUGGCAACU 11961 AAccAcAGuAGuGGcAAcudTsdT sense 1636-1655  9962 AGUUGCCACUACUGUGGUU 11962 AGUUGCcACuACUGUGGUUdTsdT antis 1637-1656  9963 ACCACAGUAGUGGCAACUC 11963 AccAcAGuAGuGGcAAcucdTsdT sense 1637-1656  9964 GAGUUGCCACUACUGUGGU 11964 GAGUUGCcACuACUGUGGUdTsdT antis 1646-1665  9965 GUGGCAACUCCUGGCCAGG 11965 GuGGcAAcuccuGGccAGGdTsdT sense 1646-1665  9966 CCUGGCCAGGAGUUGCCAC 11966 CCUGGCcAGGAGUUGCcACdTsdT antis 1648-1667  9967 GGCAACUCCUGGCCAGGGU 11967 GGcAAcuccuGGccAGGGudTsdT sense 1648-1667  9968 ACCCUGGCCAGGAGUUGCC 11968 ACCCUGGCcAGGAGUUGCCdTsdT antis 1649-1668  9969 GCAACUCCUGGCCAGGGUC 11969 GcAAcuccuGGccAGGGucdTsdT sense 1649-1668  9970 GACCCUGGCCAGGAGUUGC 11970 GACCCUGGCcAGGAGUUGCdTsdT antis 1651-1670  9971 AACUCCUGGCCAGGGUCCU 11971 AAcuccuGGccAGGGuccudTsdT sense 1651-1670  9972 AGGACCCUGGCCAGGAGUU 11972 AGGACCCUGGCcAGGAGUUdTsdT antis 1666-1685  9973 UCCUGACAGGCCACAGGAA 11973 uccuGAcAGGccAcAGGAAdTsdT sense 1666-1685  9974 UUCCUGUGGCCUGUCAGGA 11974 UUCCUGUGGCCUGUcAGGAdTsdT antis 1667-1686  9975 CCUGACAGGCCACAGGAAG 11975 ccuGAcAGGccAcAGGAAGdTsdT sense 1667-1686  9976 CUUCCUGUGGCCUGUCAGG 11976 CUUCCUGUGGCCUGUcAGGdTsdT antis 1669-1688  9977 UGACAGGCCACAGGAAGUC 11977 uGAcAGGccAcAGGAAGucdTsdT sense 1669-1688  9978 GACUUCCUGUGGCCUGUCA 11978 GACUUCCUGUGGCCUGUcAdTsdT antis 1670-1689  9979 GACAGGCCACAGGAAGUCA 11979 GAcAGGccAcAGGAAGucAdTsdT sense 1670-1689  9980 UGACUUCCUGUGGCCUGUC 11980 UGACUUCCUGUGGCCUGUCdTsdT antis 1685-1704  9981 GUCAGUUAUACAGACACGA 11981 GucAGuuAuAcAGAcAcGAdTsdT sense 1685-1704  9982 UCGUGUCUGUAUAACUGAC 11982 UCGUGUCUGuAuAACUGACdTsdT antis 1687-1706  9983 CAGUUAUACAGACACGAAA 11983 cAGuuAuAcAGAcAcGAAAdTsdT sense 1687-1706  9984 UUUCGUGUCUGUAUAACUG 11984 UUUCGUGUCUGuAuAACUGdTsdT antis 1689-1708  9985 GUUAUACAGACACGAAAGU 11985 GuuAuAcAGAcAcGAAAGudTsdT sense 1689-1708  9986 ACUUUCGUGUCUGUAUAAC 11986 ACUUUCGUGUCUGuAuAACdTsdT antis 1691-1710  9987 UAUACAGACACGAAAGUGA 11987 uAuAcAGAcAcGAAAGuGAdTsdT sense 1691-1710  9988 UCACUUUCGUGUCUGUAUA 11988 UcACUUUCGUGUCUGuAuAdTsdT antis 1693-1712  9989 UACAGACACGAAAGUGAUU 11989 uAcAGAcAcGAAAGuGAuudTsdT sense 1693-1712  9990 AAUCACUUUCGUGUCUGUA 11990 AAUcACUUUCGUGUCUGuAdTsdT antis 1701-1720  9991 CGAAAGUGAUUGGAAAUGG 11991 cGAAAGuGAuuGGAAAuGGdTsdT sense 1701-1720  9992 CCAUUUCCAAUCACUUUCG 11992 CcAUUUCcAAUcACUUUCGdTsdT antis 1707-1726  9993 UGAUUGGAAAUGGAUCAUU 11993 uGAuuGGAAAuGGAucAuudTsdT sense 1707-1726  9994 AAUGAUCCAUUUCCAAUCA 11994 AAUGAUCcAUUUCcAAUcAdTsdT antis 1717-1736  9995 UGGAUCAUUUGGUGUGGUA 11995 uGGAucAuuuGGuGuGGuAdTsdT sense 1717-1736  9996 UACCACACCAAAUGAUCCA 11996 uACcAcACcAAAUGAUCcAdTsdT antis 1721-1740  9997 UCAUUUGGUGUGGUAUAUC 11997 ucAuuuGGuGuGGuAuAucdTsdT sense 1721-1740  9998 GAUAUACCACACCAAAUGA 11998 GAuAuACcAcACcAAAUGAdTsdT antis 1729-1748  9999 UGUGGUAUAUCAAGCCAAA 11999 uGuGGuAuAucAAGccAAAdTsdT sense 1729-1748 10000 UUUGGCUUGAUAUACCACA 12000 UUUGGCUUGAuAuACcAcAdTsdT antis 1734-1753 10001 UAUAUCAAGCCAAACUUUG 12001 uAuAucAAGccAAAcuuuGdTsdT sense 1734-1753 10002 CAAAGUUUGGCUUGAUAUA 12002 cAAAGUUUGGCUUGAuAuAdTsdT antis 1736-1755 10003 UAUCAAGCCAAACUUUGUG 12003 uAucAAGccAAAcuuuGuGdTsdT sense 1736-1755 10004 CACAAAGUUUGGCUUGAUA 12004 cAcAAAGUUUGGCUUGAuAdTsdT antis 1737-1756 10005 AUCAAGCCAAACUUUGUGA 12005 AucAAGccAAAcuuuGuGAdTsdT sense 1737-1756 10006 UCACAAAGUUUGGCUUGAU 12006 UcAcAAAGUUUGGCUUGAUdTsdT antis 1749-1768 10007 UUUGUGAUUCUGGAGAACU 12007 uuuGuGAuucuGGAGAAcudTsdT sense 1749-1768 10008 AGUUCUCCAGAAUCACAAA 12008 AGUUCUCcAGAAUcAcAAAdTsdT antis 1759-1778 10009 UGGAGAACUGGUUGCCAUC 12009 uGGAGAAcuGGuuGccAucdTsdT sense 1759-1778 10010 GAUGGCAACCAGUUCUCCA 12010 GAUGGcAACcAGUUCUCcAdTsdT antis 1760-1779 10011 GGAGAACUGGUUGCCAUCA 12011 GGAGAAcuGGuuGccAucAdTsdT sense 1760-1779 10012 UGAUGGCAACCAGUUCUCC 12012 UGAUGGcAACcAGUUCUCCdTsdT antis 1767-1786 10013 UGGUUGCCAUCAAGAAAGU 12013 uGGuuGccAucAAGAAAGudTsdT sense 1767-1786 10014 ACUUUCUUGAUGGCAACCA 12014 ACUUUCUUGAUGGcAACcAdTsdT antis 1769-1788 10015 GUUGCCAUCAAGAAAGUUC 12015 GuuGccAucAAGAAAGuucdTsdT sense 1769-1788 10016 GAACUUUCUUGAUGGCAAC 12016 GAACUUUCUUGAUGGcAACdTsdT antis 1770-1789 10017 UUGCCAUCAAGAAAGUUCU 12017 uuGccAucAAGAAAGuucudTsdT sense 1770-1789 10018 AGAACUUUCUUGAUGGCAA 12018 AGAACUUUCUUGAUGGcAAdTsdT antis 1775-1794 10019 AUCAAGAAAGUUCUACAGG 12019 AucAAGAAAGuucuAcAGGdTsdT sense 1775-1794 10020 CCUGUAGAACUUUCUUGAU 12020 CCUGuAGAACUUUCUUGAUdTsdT antis 1783-1802 10021 AGUUCUACAGGACAAGCGA 12021 AGuucuAcAGGAcAAGcGAdTsdT sense 1783-1802 10022 UCGCUUGUCCUGUAGAACU 12022 UCGCUUGUCCUGuAGAACUdTsdT antis 1787-1806 10023 CUACAGGACAAGCGAUUUA 12023 cuAcAGGAcAAGcGAuuuAdTsdT sense 1787-1806 10024 UAAAUCGCUUGUCCUGUAG 12024 uAAAUCGCUUGUCCUGuAGdTsdT antis 1806-1825 10025 AGAACCGAGAGCUCCAGAU 12025 AGAAccGAGAGcuccAGAudTsdT sense 1806-1825 10026 AUCUGGAGCUCUCGGUUCU 12026 AUCUGGAGCUCUCGGUUCUdTsdT antis 1810-1829 10027 CCGAGAGCUCCAGAUCAUG 12027 ccGAGAGcuccAGAucAuGdTsdT sense 1810-1829 10028 CAUGAUCUGGAGCUCUCGG 12028 cAUGAUCUGGAGCUCUCGGdTsdT antis 1815-1834 10029 AGCUCCAGAUCAUGAGAAA 12029 AGcuccAGAucAuGAGAAAdTsdT sense 1815-1834 10030 UUUCUCAUGAUCUGGAGCU 12030 UUUCUcAUGAUCUGGAGCUdTsdT antis 1816-1835 10031 GCUCCAGAUCAUGAGAAAG 12031 GcuccAGAucAuGAGAAAGdTsdT sense 1816-1835 10032 CUUUCUCAUGAUCUGGAGC 12032 CUUUCUcAUGAUCUGGAGCdTsdT antis 1817-1836 10033 CUCCAGAUCAUGAGAAAGC 12033 cuccAGAucAuGAGAAAGcdTsdT sense 1817-1836 10034 GCUUUCUCAUGAUCUGGAG 12034 GCUUUCUcAUGAUCUGGAGdTsdT antis 1820-1839 10035 CAGAUCAUGAGAAAGCUAG 12035 cAGAucAuGAGAAAGcuAGdTsdT sense 1820-1839 10036 CUAGCUUUCUCAUGAUCUG 12036 CuAGCUUUCUcAUGAUCUGdTsdT antis 1824-1843 10037 UCAUGAGAAAGCUAGACCA 12037 ucAuGAGAAAGcuAGAccAdTsdT sense 1824-1843 10038 UGGUCUAGCUUUCUCAUGA 12038 UGGUCuAGCUUUCUcAUGAdTsdT antis 1825-1844 10039 CAUGAGAAAGCUAGACCAC 12039 cAuGAGAAAGcuAGAccAcdTsdT sense 1825-1844 10040 GUGGUCUAGCUUUCUCAUG 12040 GUGGUCuAGCUUUCUcAUGdTsdT antis 1826-1845 10041 AUGAGAAAGCUAGACCACU 12041 AuGAGAAAGcuAGAccAcudTsdT sense 1826-1845 10042 AGUGGUCUAGCUUUCUCAU 12042 AGUGGUCuAGCUUUCUcAUdTsdT antis 1858-1877 10043 ACUGCGGUAUUUCUUCUAC 12043 AcuGcGGuAuuucuucuAcdTsdT sense 1858-1877 10044 GUAGAAGAAAUACCGCAGU 12044 GuAGAAGAAAuACCGcAGUdTsdT antis 1866-1885 10045 AUUUCUUCUACUCGAGUGG 12045 AuuucuucuAcucGAGuGGdTsdT sense 1866-1885 10046 CCACUCGAGUAGAAGAAAU 12046 CcACUCGAGuAGAAGAAAUdTsdT antis 1869-1888 10047 UCUUCUACUCGAGUGGUGA 12047 ucuucuAcucGAGuGGuGAdTsdT sense 1869-1888 10048 UCACCACUCGAGUAGAAGA 12048 UcACcACUCGAGuAGAAGAdTsdT antis 1878-1897 10049 CGAGUGGUGAGAAGAAAGA 12049 cGAGuGGuGAGAAGAAAGAdTsdT sense 1878-1897 10050 UCUUUCUUCUCACCACUCG 12050 UCUUUCUUCUcACcACUCGdTsdT antis 1890-1909 10051 AGAAAGAUGAGGUCUACCU 12051 AGAAAGAuGAGGucuAccudTsdT sense 1890-1909 10052 AGGUAGACCUCAUCUUUCU 12052 AGGuAGACCUcAUCUUUCUdTsdT antis 1891-1910 10053 GAAAGAUGAGGUCUACCUU 12053 GAAAGAuGAGGucuAccuudTsdT sense 1891-1910 10054 AAGGUAGACCUCAUCUUUC 12054 AAGGuAGACCUcAUCUUUCdTsdT antis 1898-1917 10055 GAGGUCUACCUUAACCUGG 12055 GAGGucuAccuuAAccuGGdTsdT sense 1898-1917 10056 CCAGGUUAAGGUAGACCUC 12056 CcAGGUuAAGGuAGACCUCdTsdT antis 1903-1922 10057 CUACCUUAACCUGGUGCUG 12057 cuAccuuAAccuGGuGcuGdTsdT sense 1903-1922 10058 CAGCACCAGGUUAAGGUAG 12058 cAGcACcAGGUuAAGGuAGdTsdT antis 1911-1930 10059 ACCUGGUGCUGGACUAUGU 12059 AccuGGuGcuGGAcuAuGudTsdT sense 1911-1930 10060 ACAUAGUCCAGCACCAGGU 12060 AcAuAGUCcAGcACcAGGUdTsdT antis 1912-1931 10061 CCUGGUGCUGGACUAUGUU 12061 ccuGGuGcuGGAcuAuGuudTsdT sense 1912-1931 10062 AACAUAGUCCAGCACCAGG 12062 AAcAuAGUCcAGcACcAGGdTsdT antis 1915-1934 10063 GGUGCUGGACUAUGUUCCG 12063 GGuGcuGGAcuAuGuuccGdTsdT sense 1915-1934 10064 CGGAACAUAGUCCAGCACC 12064 CGGAAcAuAGUCcAGcACCdTsdT antis 1929-1948 10065 UUCCGGAGACAGUGUACAG 12065 uuccGGAGAcAGuGuAcAGdTsdT sense 1929-1948 10066 CUGUACACUGUCUCCGGAA 12066 CUGuAcACUGUCUCCGGAAdTsdT antis 1933-1952 10067 GGAGACAGUGUACAGAGUC 12067 GGAGAcAGuGuAcAGAGucdTsdT sense 1933-1952 10068 GACUCUGUACACUGUCUCC 12068 GACUCUGuAcACUGUCUCCdTsdT antis 1935-1954 10069 AGACAGUGUACAGAGUCGC 12069 AGAcAGuGuAcAGAGucGcdTsdT sense 1935-1954 10070 GCGACUCUGUACACUGUCU 12070 GCGACUCUGuAcACUGUCUdTsdT antis 1941-1960 10071 UGUACAGAGUCGCCAGACA 12071 uGuAcAGAGucGccAGAcAdTsdT sense 1941-1960 10072 UGUCUGGCGACUCUGUACA 12072 UGUCUGGCGACUCUGuAcAdTsdT antis 1944-1963 10073 ACAGAGUCGCCAGACACUA 12073 AcAGAGucGccAGAcAcuAdTsdT sense 1944-1963 10074 UAGUGUCUGGCGACUCUGU 12074 uAGUGUCUGGCGACUCUGUdTsdT antis 1945-1964 10075 CAGAGUCGCCAGACACUAU 12075 cAGAGucGccAGAcAcuAudTsdT sense 1945-1964 10076 AUAGUGUCUGGCGACUCUG 12076 AuAGUGUCUGGCGACUCUGdTsdT antis 1965-1984 10077 GUCGAGCCAAGCAGACACU 12077 GucGAGccAAGcAGAcAcudTsdT sense 1965-1984 10078 AGUGUCUGCUUGGCUCGAC 12078 AGUGUCUGCUUGGCUCGACdTsdT antis 1966-1985 10079 UCGAGCCAAGCAGACACUC 12079 ucGAGccAAGcAGAcAcucdTsdT sense 1966-1985 10080 GAGUGUCUGCUUGGCUCGA 12080 GAGUGUCUGCUUGGCUCGAdTsdT antis 1967-1986 10081 CGAGCCAAGCAGACACUCC 12081 cGAGccAAGcAGAcAcuccdTsdT sense 1967-1986 10082 GGAGUGUCUGCUUGGCUCG 12082 GGAGUGUCUGCUUGGCUCGdTsdT antis 1970-1989 10083 GCCAAGCAGACACUCCCUG 12083 GccAAGcAGAcAcucccuGdTsdT sense 1970-1989 10084 CAGGGAGUGUCUGCUUGGC 12084 cAGGGAGUGUCUGCUUGGCdTsdT antis 1971-1990 10085 CCAAGCAGACACUCCCUGU 12085 ccAAGcAGAcAcucccuGudTsdT sense 1971-1990 10086 ACAGGGAGUGUCUGCUUGG 12086 AcAGGGAGUGUCUGCUUGGdTsdT antis 1974-1993 10087 AGCAGACACUCCCUGUGAU 12087 AGcAGAcAcucccuGuGAudTsdT sense 1974-1993 10088 AUCACAGGGAGUGUCUGCU 12088 AUcAcAGGGAGUGUCUGCUdTsdT antis 1975-1994 10089 GCAGACACUCCCUGUGAUC 12089 GcAGAcAcucccuGuGAucdTsdT sense 1975-1994 10090 GAUCACAGGGAGUGUCUGC 12090 GAUcAcAGGGAGUGUCUGCdTsdT antis 1986-2005 10091 CUGUGAUCUAUGUCAAGUU 12091 cuGuGAucuAuGucAAGuudTsdT sense 1986-2005 10092 AACUUGACAUAGAUCACAG 12092 AACUUGAcAuAGAUcAcAGdTsdT antis 1993-2012 10093 CUAUGUCAAGUUGUAUAUG 12093 cuAuGucAAGuuGuAuAuGdTsdT sense 1993-2012 10094 CAUAUACAACUUGACAUAG 12094 cAuAuAcAACUUGAcAuAGdTsdT antis 1995-2014 10095 AUGUCAAGUUGUAUAUGUA 12095 AuGucAAGuuGuAuAuGuAdTsdT sense 1995-2014 10096 UACAUAUACAACUUGACAU 12096 uAcAuAuAcAACUUGAcAUdTsdT antis 1996-2015 10097 UGUCAAGUUGUAUAUGUAU 12097 uGucAAGuuGuAuAuGuAudTsdT sense 1996-2015 10098 AUACAUAUACAACUUGACA 12098 AuAcAuAuAcAACUUGAcAdTsdT antis 1999-2018 10099 CAAGUUGUAUAUGUAUCAG 12099 cAAGuuGuAuAuGuAucAGdTsdT sense 1999-2018 10100 CUGAUACAUAUACAACUUG 12100 CUGAuAcAuAuAcAACUUGdTsdT antis 2009-2028 10101 AUGUAUCAGCUGUUCAGAA 12101 AuGuAucAGcuGuucAGAAdTsdT sense 2009-2028 10102 UUCUGAACAGCUGAUACAU 12102 UUCUGAAcAGCUGAuAcAUdTsdT antis 2010-2029 10103 UGUAUCAGCUGUUCAGAAG 12103 uGuAucAGcuGuucAGAAGdTsdT sense 2010-2029 10104 CUUCUGAACAGCUGAUACA 12104 CUUCUGAAcAGCUGAuAcAdTsdT antis 2016-2035 10105 AGCUGUUCAGAAGUCUAGC 12105 AGcuGuucAGAAGucuAGcdTsdT sense 2016-2035 10106 GCUAGACUUCUGAACAGCU 12106 GCuAGACUUCUGAAcAGCUdTsdT antis 2035-2054 10107 CUAUAUCCAUUCCUUUGGA 12107 cuAuAuccAuuccuuuGGAdTsdT sense 2035-2054 10108 UCCAAAGGAAUGGAUAUAG 12108 UCcAAAGGAAUGGAuAuAGdTsdT antis 2036-2055 10109 UAUAUCCAUUCCUUUGGAA 12109 uAuAuccAuuccuuuGGAAdTsdT sense 2036-2055 10110 UUCCAAAGGAAUGGAUAUA 12110 UUCcAAAGGAAUGGAuAuAdTsdT antis 2046-2065 10111 CCUUUGGAAUCUGCCAUCG 12111 ccuuuGGAAucuGccAucGdTsdT sense 2046-2065 10112 CGAUGGCAGAUUCCAAAGG 12112 CGAUGGcAGAUUCcAAAGGdTsdT antis 2049-2068 10113 UUGGAAUCUGCCAUCGAGA 12113 uuGGAAucuGccAucGAGAdTsdT sense 2049-2068 10114 UCUCGAUGGCAGAUUCCAA 12114 UCUCGAUGGcAGAUUCcAAdTsdT antis 2051-2070 10115 GGAAUCUGCCAUCGAGACA 12115 GGAAucuGccAucGAGAcAdTsdT sense 2051-2070 10116 UGUCUCGAUGGCAGAUUCC 12116 UGUCUCGAUGGcAGAUUCCdTsdT antis 2068-2087 10117 CAUUAAACCACAGAACCUC 12117 cAuuAAAccAcAGAAccucdTsdT sense 2068-2087 10118 GAGGUUCUGUGGUUUAAUG 12118 GAGGUUCUGUGGUUuAAUGdTsdT antis 2070-2089 10119 UUAAACCACAGAACCUCUU 12119 uuAAAccAcAGAAccucuudTsdT sense 2070-2089 10120 AAGAGGUUCUGUGGUUUAA 12120 AAGAGGUUCUGUGGUUuAAdTsdT antis 2071-2090 10121 UAAACCACAGAACCUCUUG 12121 uAAAccAcAGAAccucuuGdTsdT sense 2071-2090 10122 CAAGAGGUUCUGUGGUUUA 12122 cAAGAGGUUCUGUGGUUuAdTsdT antis 2073-2092 10123 AACCACAGAACCUCUUGUU 12123 AAccAcAGAAccucuuGuudTsdT sense 2073-2092 10124 AACAAGAGGUUCUGUGGUU 12124 AAcAAGAGGUUCUGUGGUUdTsdT antis 2075-2094 10125 CCACAGAACCUCUUGUUGG 12125 ccAcAGAAccucuuGuuGGdTsdT sense 2075-2094 10126 CCAACAAGAGGUUCUGUGG 12126 CcAAcAAGAGGUUCUGUGGdTsdT antis 2076-2095 10127 CACAGAACCUCUUGUUGGA 12127 cAcAGAAccucuuGuuGGAdTsdT sense 2076-2095 10128 UCCAACAAGAGGUUCUGUG 12128 UCcAAcAAGAGGUUCUGUGdTsdT antis 2078-2097 10129 CAGAACCUCUUGUUGGAUC 12129 cAGAAccucuuGuuGGAucdTsdT sense 2078-2097 10130 GAUCCAACAAGAGGUUCUG 12130 GAUCcAAcAAGAGGUUCUGdTsdT antis 2084-2103 10131 CUCUUGUUGGAUCCUGAUA 12131 cucuuGuuGGAuccuGAuAdTsdT sense 2084-2103 10132 UAUCAGGAUCCAACAAGAG 12132 uAUcAGGAUCcAAcAAGAGdTsdT antis 2086-2105 10133 CUUGUUGGAUCCUGAUACA 12133 cuuGuuGGAuccuGAuAcAdTsdT sense 2086-2105 10134 UGUAUCAGGAUCCAACAAG 12134 UGuAUcAGGAUCcAAcAAGdTsdT antis 2095-2114 10135 UCCUGAUACAGCUGUAUUA 12135 uccuGAuAcAGcuGuAuuAdTsdT sense 2095-2114 10136 UAAUACAGCUGUAUCAGGA 12136 uAAuAcAGCUGuAUcAGGAdTsdT antis 2102-2121 10137 ACAGCUGUAUUAAAACUCU 12137 AcAGcuGuAuuAAAAcucudTsdT sense 2102-2121 10138 AGAGUUUUAAUACAGCUGU 12138 AGAGUUUuAAuAcAGCUGUdTsdT antis 2103-2122 10139 CAGCUGUAUUAAAACUCUG 12139 cAGcuGuAuuAAAAcucuGdTsdT sense 2103-2122 10140 CAGAGUUUUAAUACAGCUG 12140 cAGAGUUUuAAuAcAGCUGdTsdT antis 2105-2124 10141 GCUGUAUUAAAACUCUGUG 12141 GcuGuAuuAAAAcucuGuGdTsdT sense 2105-2124 10142 CACAGAGUUUUAAUACAGC 12142 cAcAGAGUUUuAAuAcAGCdTsdT antis 2106-2125 10143 CUGUAUUAAAACUCUGUGA 12143 cuGuAuuAAAAcucuGuGAdTsdT sense 2106-2125 10144 UCACAGAGUUUUAAUACAG 12144 UcAcAGAGUUUuAAuAcAGdTsdT antis 2108-2127 10145 GUAUUAAAACUCUGUGACU 12145 GuAuuAAAAcucuGuGAcudTsdT sense 2108-2127 10146 AGUCACAGAGUUUUAAUAC 12146 AGUcAcAGAGUUUuAAuACdTsdT antis 2115-2134 10147 AACUCUGUGACUUUGGAAG 12147 AAcucuGuGAcuuuGGAAGdTsdT sense 2115-2134 10148 CUUCCAAAGUCACAGAGUU 12148 CUUCcAAAGUcAcAGAGUUdTsdT antis 2120-2139 10149 UGUGACUUUGGAAGUGCAA 12149 uGuGAcuuuGGAAGuGcAAdTsdT sense 2120-2139 10150 UUGCACUUCCAAAGUCACA 12150 UUGcACUUCcAAAGUcAcAdTsdT antis 2124-2143 10151 ACUUUGGAAGUGCAAAGCA 12151 AcuuuGGAAGuGcAAAGcAdTsdT sense 2124-2143 10152 UGCUUUGCACUUCCAAAGU 12152 UGCUUUGcACUUCcAAAGUdTsdT antis 2132-2151 10153 AGUGCAAAGCAGCUGGUCC 12153 AGuGcAAAGcAGcuGGuccdTsdT sense 2132-2151 10154 GGACCAGCUGCUUUGCACU 12154 GGACcAGCUGCUUUGcACUdTsdT antis 2134-2153 10155 UGCAAAGCAGCUGGUCCGA 12155 uGcAAAGcAGcuGGuccGAdTsdT sense 2134-2153 10156 UCGGACCAGCUGCUUUGCA 12156 UCGGACcAGCUGCUUUGcAdTsdT antis 2136-2155 10157 CAAAGCAGCUGGUCCGAGG 12157 cAAAGcAGcuGGuccGAGGdTsdT sense 2136-2155 10158 CCUCGGACCAGCUGCUUUG 12158 CCUCGGACcAGCUGCUUUGdTsdT antis 2139-2158 10159 AGCAGCUGGUCCGAGGAGA 12159 AGcAGcuGGuccGAGGAGAdTsdT sense 2139-2158 10160 UCUCCUCGGACCAGCUGCU 12160 UCUCCUCGGACcAGCUGCUdTsdT antis 2140-2159 10161 GCAGCUGGUCCGAGGAGAG 12161 GcAGcuGGuccGAGGAGAGdTsdT sense 2140-2159 10162 CUCUCCUCGGACCAGCUGC 12162 CUCUCCUCGGACcAGCUGCdTsdT antis 2141-2160 10163 CAGCUGGUCCGAGGAGAGC 12163 cAGcuGGuccGAGGAGAGcdTsdT sense 2141-2160 10164 GCUCUCCUCGGACCAGCUG 12164 GCUCUCCUCGGACcAGCUGdTsdT antis 2142-2161 10165 AGCUGGUCCGAGGAGAGCC 12165 AGcuGGuccGAGGAGAGccdTsdT sense 2142-2161 10166 GGCUCUCCUCGGACCAGCU 12166 GGCUCUCCUCGGACcAGCUdTsdT antis 2146-2165 10167 GGUCCGAGGAGAGCCCAAU 12167 GGuccGAGGAGAGcccAAudTsdT sense 2146-2165 10168 AUUGGGCUCUCCUCGGACC 12168 AUUGGGCUCUCCUCGGACCdTsdT antis 2147-2166 10169 GUCCGAGGAGAGCCCAAUG 12169 GuccGAGGAGAGcccAAuGdTsdT sense 2147-2166 10170 CAUUGGGCUCUCCUCGGAC 12170 cAUUGGGCUCUCCUCGGACdTsdT antis 2160-2179 10171 CCAAUGUUUCAUAUAUCUG 12171 ccAAuGuuucAuAuAucuGdTsdT sense 2160-2179 10172 CAGAUAUAUGAAACAUUGG 12172 cAGAuAuAUGAAAcAUUGGdTsdT antis 2189-2208 10173 UACAGGGCACCAGAGUUGA 12173 uAcAGGGcAccAGAGuuGAdTsdT sense 2189-2208 10174 UCAACUCUGGUGCCCUGUA 12174 UcAACUCUGGUGCCCUGuAdTsdT antis 2191-2210 10175 CAGGGCACCAGAGUUGAUC 12175 cAGGGcAccAGAGuuGAucdTsdT sense 2191-2210 10176 GAUCAACUCUGGUGCCCUG 12176 GAUcAACUCUGGUGCCCUGdTsdT antis 2194-2213 10177 GGCACCAGAGUUGAUCUUU 12177 GGcAccAGAGuuGAucuuudTsdT sense 2194-2213 10178 AAAGAUCAACUCUGGUGCC 12178 AAAGAUcAACUCUGGUGCCdTsdT antis 2195-2214 10179 GCACCAGAGUUGAUCUUUG 12179 GcAccAGAGuuGAucuuuGdTsdT sense 2195-2214 10180 CAAAGAUCAACUCUGGUGC 12180 cAAAGAUcAACUCUGGUGCdTsdT antis 2196-2215 10181 CACCAGAGUUGAUCUUUGG 12181 cAccAGAGuuGAucuuuGGdTsdT sense 2196-2215 10182 CCAAAGAUCAACUCUGGUG 12182 CcAAAGAUcAACUCUGGUGdTsdT antis 2201-2220 10183 GAGUUGAUCUUUGGAGCCA 12183 GAGuuGAucuuuGGAGccAdTsdT sense 2201-2220 10184 UGGCUCCAAAGAUCAACUC 12184 UGGCUCcAAAGAUcAACUCdTsdT antis 2211-2230 10185 UUGGAGCCACUGAUUACAC 12185 uuGGAGccAcuGAuuAcAcdTsdT sense 2211-2230 10186 GUGUAAUCAGUGGCUCCAA 12186 GUGuAAUcAGUGGCUCcAAdTsdT antis 2234-2253 10187 AGUAUAGAUGUAUGGUCUG 12187 AGuAuAGAuGuAuGGucuGdTsdT sense 2234-2253 10188 CAGACCAUACAUCUAUACU 12188 cAGACcAuAcAUCuAuACUdTsdT antis 2238-2257 10189 UAGAUGUAUGGUCUGCAGG 12189 uAGAuGuAuGGucuGcAGGdTsdT sense 2238-2257 10190 CCUGCAGACCAUACAUCUA 12190 CCUGcAGACcAuAcAUCuAdTsdT antis 2240-2259 10191 GAUGUAUGGUCUGCAGGCU 12191 GAuGuAuGGucuGcAGGcudTsdT sense 2240-2259 10192 AGCCUGCAGACCAUACAUC 12192 AGCCUGcAGACcAuAcAUCdTsdT antis 2241-2260 10193 AUGUAUGGUCUGCAGGCUG 12193 AuGuAuGGucuGcAGGcuGdTsdT sense 2241-2260 10194 CAGCCUGCAGACCAUACAU 12194 cAGCCUGcAGACcAuAcAUdTsdT antis 2242-2261 10195 UGUAUGGUCUGCAGGCUGU 12195 uGuAuGGucuGcAGGcuGudTsdT sense 2242-2261 10196 ACAGCCUGCAGACCAUACA 12196 AcAGCCUGcAGACcAuAcAdTsdT antis 2249-2268 10197 UCUGCAGGCUGUGUGUUGG 12197 ucuGcAGGcuGuGuGuuGGdTsdT sense 2249-2268 10198 CCAACACACAGCCUGCAGA 12198 CcAAcAcAcAGCCUGcAGAdTsdT antis 2255-2274 10199 GGCUGUGUGUUGGCUGAAU 12199 GGcuGuGuGuuGGcuGAAudTsdT sense 2255-2274 10200 AUUCAGCCAACACACAGCC 12200 AUUcAGCcAAcAcAcAGCCdTsdT antis 2256-2275 10201 GCUGUGUGUUGGCUGAAUU 12201 GcuGuGuGuuGGcuGAAuudTsdT sense 2256-2275 10202 AAUUCAGCCAACACACAGC 12202 AAUUcAGCcAAcAcAcAGCdTsdT antis 2257-2276 10203 CUGUGUGUUGGCUGAAUUG 12203 cuGuGuGuuGGcuGAAuuGdTsdT sense 2257-2276 10204 CAAUUCAGCCAACACACAG 12204 cAAUUcAGCcAAcAcAcAGdTsdT antis 2259-2278 10205 GUGUGUUGGCUGAAUUGUU 12205 GuGuGuuGGcuGAAuuGuudTsdT sense 2259-2278 10206 AACAAUUCAGCCAACACAC 12206 AAcAAUUcAGCcAAcAcACdTsdT antis 2260-2279 10207 UGUGUUGGCUGAAUUGUUG 12207 uGuGuuGGcuGAAuuGuuGdTsdT sense 2260-2279 10208 CAACAAUUCAGCCAACACA 12208 cAAcAAUUcAGCcAAcAcAdTsdT antis 2271-2290 10209 AAUUGUUGCUAGGACAACC 12209 AAuuGuuGcuAGGAcAAccdTsdT sense 2271-2290 10210 GGUUGUCCUAGCAACAAUU 12210 GGUUGUCCuAGcAAcAAUUdTsdT antis 2280-2299 10211 UAGGACAACCAAUAUUUCC 12211 uAGGAcAAccAAuAuuuccdTsdT sense 2280-2299 10212 GGAAAUAUUGGUUGUCCUA 12212 GGAAAuAUUGGUUGUCCuAdTsdT antis 2284-2303 10213 ACAACCAAUAUUUCCUGGG 12213 AcAAccAAuAuuuccuGGGdTsdT sense 2284-2303 10214 CCCAGGAAAUAUUGGUUGU 12214 CCcAGGAAAuAUUGGUUGUdTsdT antis 2287-2306 10215 ACCAAUAUUUCCUGGGGAC 12215 AccAAuAuuuccuGGGGAcdTsdT sense 2287-2306 10216 GUCCCCAGGAAAUAUUGGU 12216 GUCCCcAGGAAAuAUUGGUdTsdT antis 2288-2307 10217 CCAAUAUUUCCUGGGGACA 12217 ccAAuAuuuccuGGGGAcAdTsdT sense 2288-2307 10218 UGUCCCCAGGAAAUAUUGG 12218 UGUCCCcAGGAAAuAUUGGdTsdT antis 2289-2308 10219 CAAUAUUUCCUGGGGACAG 12219 cAAuAuuuccuGGGGAcAGdTsdT sense 2289-2308 10220 CUGUCCCCAGGAAAUAUUG 12220 CUGUCCCcAGGAAAuAUUGdTsdT antis 2290-2309 10221 AAUAUUUCCUGGGGACAGU 12221 AAuAuuuccuGGGGAcAGudTsdT sense 2290-2309 10222 ACUGUCCCCAGGAAAUAUU 12222 ACUGUCCCcAGGAAAuAUUdTsdT antis 2292-2311 10223 UAUUUCCUGGGGACAGUGG 12223 uAuuuccuGGGGAcAGuGGdTsdT sense 2292-2311 10224 CCACUGUCCCCAGGAAAUA 12224 CcACUGUCCCcAGGAAAuAdTsdT antis 2299-2318 10225 UGGGGACAGUGGUGUGGAU 12225 uGGGGAcAGuGGuGuGGAudTsdT sense 2299-2318 10226 AUCCACACCACUGUCCCCA 12226 AUCcAcACcACUGUCCCcAdTsdT antis 2303-2322 10227 GACAGUGGUGUGGAUCAGU 12227 GAcAGuGGuGuGGAucAGudTsdT sense 2303-2322 10228 ACUGAUCCACACCACUGUC 12228 ACUGAUCcAcACcACUGUCdTsdT antis 2310-2329 10229 GUGUGGAUCAGUUGGUGGA 12229 GuGuGGAucAGuuGGuGGAdTsdT sense 2310-2329 10230 UCCACCAACUGAUCCACAC 12230 UCcACcAACUGAUCcAcACdTsdT antis 2316-2335 10231 AUCAGUUGGUGGAAAUAAU 12231 AucAGuuGGuGGAAAuAAudTsdT sense 2316-2335 10232 AUUAUUUCCACCAACUGAU 12232 AUuAUUUCcACcAACUGAUdTsdT antis 2324-2343 10233 GUGGAAAUAAUAAAGGUCC 12233 GuGGAAAuAAuAAAGGuccdTsdT sense 2324-2343 10234 GGACCUUUAUUAUUUCCAC 12234 GGACCUUuAUuAUUUCcACdTsdT antis 2327-2346 10235 GAAAUAAUAAAGGUCCUAG 12235 GAAAuAAuAAAGGuccuAGdTsdT sense 2327-2346 10236 CUAGGACCUUUAUUAUUUC 12236 CuAGGACCUUuAUuAUUUCdTsdT antis 2333-2352 10237 AUAAAGGUCCUAGGAACAC 12237 AuAAAGGuccuAGGAAcAcdTsdT sense 2333-2352 10238 GUGUUCCUAGGACCUUUAU 12238 GUGUUCCuAGGACCUUuAUdTsdT antis 2335-2354 10239 AAAGGUCCUAGGAACACCA 12239 AAAGGuccuAGGAAcAccAdTsdT sense 2335-2354 10240 UGGUGUUCCUAGGACCUUU 12240 UGGUGUUCCuAGGACCUUUdTsdT antis 2341-2360 10241 CCUAGGAACACCAACAAGG 12241 ccuAGGAAcAccAAcAAGGdTsdT sense 2341-2360 10242 CCUUGUUGGUGUUCCUAGG 12242 CCUUGUUGGUGUUCCuAGGdTsdT antis 2345-2364 10243 GGAACACCAACAAGGGAGC 12243 GGAAcAccAAcAAGGGAGcdTsdT sense 2345-2364 10244 GCUCCCUUGUUGGUGUUCC 12244 GCUCCCUUGUUGGUGUUCCdTsdT antis 2356-2375 10245 AAGGGAGCAAAUUAGAGAA 12245 AAGGGAGcAAAuuAGAGAAdTsdT sense 2356-2375 10246 UUCUCUAAUUUGCUCCCUU 12246 UUCUCuAAUUUGCUCCCUUdTsdT antis 2358-2377 10247 GGGAGCAAAUUAGAGAAAU 12247 GGGAGcAAAuuAGAGAAAudTsdT sense 2358-2377 10248 AUUUCUCUAAUUUGCUCCC 12248 AUUUCUCuAAUUUGCUCCCdTsdT antis 2364-2383 10249 AAAUUAGAGAAAUGAACCC 12249 AAAuuAGAGAAAuGAAcccdTsdT sense 2364-2383 10250 GGGUUCAUUUCUCUAAUUU 12250 GGGUUcAUUUCUCuAAUUUdTsdT antis 2365-2384 10251 AAUUAGAGAAAUGAACCCA 12251 AAuuAGAGAAAuGAAcccAdTsdT sense 2365-2384 10252 UGGGUUCAUUUCUCUAAUU 12252 UGGGUUcAUUUCUCuAAUUdTsdT antis 2368-2387 10253 UAGAGAAAUGAACCCAAAU 12253 uAGAGAAAuGAAcccAAAudTsdT sense 2368-2387 10254 AUUUGGGUUCAUUUCUCUA 12254 AUUUGGGUUcAUUUCUCuAdTsdT antis 2369-2388 10255 AGAGAAAUGAACCCAAAUU 12255 AGAGAAAuGAAcccAAAuudTsdT sense 2369-2388 10256 AAUUUGGGUUCAUUUCUCU 12256 AAUUUGGGUUcAUUUCUCUdTsdT antis 2371-2390 10257 AGAAAUGAACCCAAAUUAU 12257 AGAAAuGAAcccAAAuuAudTsdT sense 2371-2390 10258 AUAAUUUGGGUUCAUUUCU 12258 AuAAUUUGGGUUcAUUUCUdTsdT antis 2372-2391 10259 GAAAUGAACCCAAAUUAUA 12259 GAAAuGAAcccAAAuuAuAdTsdT sense 2372-2391 10260 UAUAAUUUGGGUUCAUUUC 12260 uAuAAUUUGGGUUcAUUUCdTsdT antis 2374-2393 10261 AAUGAACCCAAAUUAUACA 12261 AAuGAAcccAAAuuAuAcAdTsdT sense 2374-2393 10262 UGUAUAAUUUGGGUUCAUU 12262 UGuAuAAUUUGGGUUcAUUdTsdT antis 2375-2394 10263 AUGAACCCAAAUUAUACAG 12263 AuGAAcccAAAuuAuAcAGdTsdT sense 2375-2394 10264 CUGUAUAAUUUGGGUUCAU 12264 CUGuAuAAUUUGGGUUcAUdTsdT antis 2381-2400 10265 CCAAAUUAUACAGAAUUCA 12265 ccAAAuuAuAcAGAAuucAdTsdT sense 2381-2400 10266 UGAAUUCUGUAUAAUUUGG 12266 UGAAUUCUGuAuAAUUUGGdTsdT antis 2386-2405 10267 UUAUACAGAAUUCAAAUUC 12267 uuAuAcAGAAuucAAAuucdTsdT sense 2386-2405 10268 GAAUUUGAAUUCUGUAUAA 12268 GAAUUUGAAUUCUGuAuAAdTsdT antis 2387-2406 10269 UAUACAGAAUUCAAAUUCC 12269 uAuAcAGAAuucAAAuuccdTsdT sense 2387-2406 10270 GGAAUUUGAAUUCUGUAUA 12270 GGAAUUUGAAUUCUGuAuAdTsdT antis 2388-2407 10271 AUACAGAAUUCAAAUUCCC 12271 AuAcAGAAuucAAAuucccdTsdT sense 2388-2407 10272 GGGAAUUUGAAUUCUGUAU 12272 GGGAAUUUGAAUUCUGuAUdTsdT antis 2396-2415 10273 UUCAAAUUCCCUCAAAUCA 12273 uucAAAuucccucAAAucAdTsdT sense 2396-2415 10274 UGAUUUGAGGGAAUUUGAA 12274 UGAUUUGAGGGAAUUUGAAdTsdT antis 2398-2417 10275 CAAAUUCCCUCAAAUCAAG 12275 cAAAuucccucAAAucAAGdTsdT sense 2398-2417 10276 CUUGAUUUGAGGGAAUUUG 12276 CUUGAUUUGAGGGAAUUUGdTsdT antis 2399-2418 10277 AAAUUCCCUCAAAUCAAGG 12277 AAAuucccucAAAucAAGGdTsdT sense 2399-2418 10278 CCUUGAUUUGAGGGAAUUU 12278 CCUUGAUUUGAGGGAAUUUdTsdT antis 2406-2425 10279 CUCAAAUCAAGGCACAUCC 12279 cucAAAucAAGGcAcAuccdTsdT sense 2406-2425 10280 GGAUGUGCCUUGAUUUGAG 12280 GGAUGUGCCUUGAUUUGAGdTsdT antis 2407-2426 10281 UCAAAUCAAGGCACAUCCU 12281 ucAAAucAAGGcAcAuccudTsdT sense 2407-2426 10282 AGGAUGUGCCUUGAUUUGA 12282 AGGAUGUGCCUUGAUUUGAdTsdT antis 2410-2429 10283 AAUCAAGGCACAUCCUUGG 12283 AAucAAGGcAcAuccuuGGdTsdT sense 2410-2429 10284 CCAAGGAUGUGCCUUGAUU 12284 CcAAGGAUGUGCCUUGAUUdTsdT antis 2411-2430 10285 AUCAAGGCACAUCCUUGGA 12285 AucAAGGcAcAuccuuGGAdTsdT sense 2411-2430 10286 UCCAAGGAUGUGCCUUGAU 12286 UCcAAGGAUGUGCCUUGAUdTsdT antis 2413-2432 10287 CAAGGCACAUCCUUGGACA 12287 cAAGGcAcAuccuuGGAcAdTsdT sense 2413-2432 10288 UGUCCAAGGAUGUGCCUUG 12288 UGUCcAAGGAUGUGCCUUGdTsdT antis 2415-2434 10289 AGGCACAUCCUUGGACAAA 12289 AGGcAcAuccuuGGAcAAAdTsdT sense 2415-2434 10290 UUUGUCCAAGGAUGUGCCU 12290 UUUGUCcAAGGAUGUGCCUdTsdT antis 2416-2435 10291 GGCACAUCCUUGGACAAAG 12291 GGcAcAuccuuGGAcAAAGdTsdT sense 2416-2435 10292 CUUUGUCCAAGGAUGUGCC 12292 CUUUGUCcAAGGAUGUGCCdTsdT antis 2417-2436 10293 GCACAUCCUUGGACAAAGG 12293 GcAcAuccuuGGAcAAAGGdTsdT sense 2417-2436 10294 CCUUUGUCCAAGGAUGUGC 12294 CCUUUGUCcAAGGAUGUGCdTsdT antis 2418-2437 10295 CACAUCCUUGGACAAAGGU 12295 cAcAuccuuGGAcAAAGGudTsdT sense 2418-2437 10296 ACCUUUGUCCAAGGAUGUG 12296 ACCUUUGUCcAAGGAUGUGdTsdT antis 2420-2439 10297 CAUCCUUGGACAAAGGUCU 12297 cAuccuuGGAcAAAGGucudTsdT sense 2420-2439 10298 AGACCUUUGUCCAAGGAUG 12298 AGACCUUUGUCcAAGGAUGdTsdT antis 2422-2441 10299 UCCUUGGACAAAGGUCUUC 12299 uccuuGGAcAAAGGucuucdTsdT sense 2422-2441 10300 GAAGACCUUUGUCCAAGGA 12300 GAAGACCUUUGUCcAAGGAdTsdT antis 2426-2445 10301 UGGACAAAGGUCUUCCGGC 12301 uGGAcAAAGGucuuccGGcdTsdT sense 2426-2445 10302 GCCGGAAGACCUUUGUCCA 12302 GCCGGAAGACCUUUGUCcAdTsdT antis 2430-2449 10303 CAAAGGUCUUCCGGCCCCG 12303 cAAAGGucuuccGGccccGdTsdT sense 2430-2449 10304 CGGGGCCGGAAGACCUUUG 12304 CGGGGCCGGAAGACCUUUGdTsdT antis 2439-2458 10305 UCCGGCCCCGAACUCCACC 12305 uccGGccccGAAcuccAccdTsdT sense 2439-2458 10306 GGUGGAGUUCGGGGCCGGA 12306 GGUGGAGUUCGGGGCCGGAdTsdT antis 2443-2462 10307 GCCCCGAACUCCACCAGAG 12307 GccccGAAcuccAccAGAGdTsdT sense 2443-2462 10308 CUCUGGUGGAGUUCGGGGC 12308 CUCUGGUGGAGUUCGGGGCdTsdT antis 2444-2463 10309 CCCCGAACUCCACCAGAGG 12309 ccccGAAcuccAccAGAGGdTsdT sense 2444-2463 10310 CCUCUGGUGGAGUUCGGGG 12310 CCUCUGGUGGAGUUCGGGGdTsdT antis 2446-2465 10311 CCGAACUCCACCAGAGGCA 12311 ccGAAcuccAccAGAGGcAdTsdT sense 2446-2465 10312 UGCCUCUGGUGGAGUUCGG 12312 UGCCUCUGGUGGAGUUCGGdTsdT antis 2447-2466 10313 CGAACUCCACCAGAGGCAA 12313 cGAAcuccAccAGAGGcAAdTsdT sense 2447-2466 10314 UUGCCUCUGGUGGAGUUCG 12314 UUGCCUCUGGUGGAGUUCGdTsdT antis 2448-2467 10315 GAACUCCACCAGAGGCAAU 12315 GAAcuccAccAGAGGcAAudTsdT sense 2448-2467 10316 AUUGCCUCUGGUGGAGUUC 12316 AUUGCCUCUGGUGGAGUUCdTsdT antis 2458-2477 10317 AGAGGCAAUUGCACUGUGC 12317 AGAGGcAAuuGcAcuGuGcdTsdT sense 2458-2477 10318 GCACAGUGCAAUUGCCUCU 12318 GcAcAGUGcAAUUGCCUCUdTsdT antis 2459-2478 10319 GAGGCAAUUGCACUGUGCA 12319 GAGGcAAuuGcAcuGuGcAdTsdT sense 2459-2478 10320 UGCACAGUGCAAUUGCCUC 12320 UGcAcAGUGcAAUUGCCUCdTsdT antis 2461-2480 10321 GGCAAUUGCACUGUGCAGC 12321 GGcAAuuGcAcuGuGcAGcdTsdT sense 2461-2480 10322 GCUGCACAGUGCAAUUGCC 12322 GCUGcAcAGUGcAAUUGCCdTsdT antis 2462-2481 10323 GCAAUUGCACUGUGCAGCC 12323 GcAAuuGcAcuGuGcAGccdTsdT sense 2462-2481 10324 GGCUGCACAGUGCAAUUGC 12324 GGCUGcAcAGUGcAAUUGCdTsdT antis 2464-2483 10325 AAUUGCACUGUGCAGCCGU 12325 AAuuGcAcuGuGcAGccGudTsdT sense 2464-2483 10326 ACGGCUGCACAGUGCAAUU 12326 ACGGCUGcAcAGUGcAAUUdTsdT antis 2465-2484 10327 AUUGCACUGUGCAGCCGUC 12327 AuuGcAcuGuGcAGccGucdTsdT sense 2465-2484 10328 GACGGCUGCACAGUGCAAU 12328 GACGGCUGcAcAGUGcAAUdTsdT antis 2471-2490 10329 CUGUGCAGCCGUCUGCUGG 12329 cuGuGcAGccGucuGcuGGdTsdT sense 2471-2490 10330 CCAGCAGACGGCUGCACAG 12330 CcAGcAGACGGCUGcAcAGdTsdT antis 2485-2504 10331 GCUGGAGUACACACCUACC 12331 GcuGGAGuAcAcAccuAccdTsdT sense 2485-2504 10332 GGUAGGUGUGUACUCCAGC 12332 GGuAGGUGUGuACUCcAGCdTsdT antis 2507-2526 10333 CGGCUAACACCACUGGAAG 12333 cGGcuAAcAccAcuGGAAGdTsdT sense 2507-2526 10334 CUUCCAGUGGUGUUAGCCG 12334 CUUCcAGUGGUGUuAGCCGdTsdT antis 2509-2528 10335 GCUAACACCACUGGAAGCU 12335 GcuAAcAccAcuGGAAGcudTsdT sense 2509-2528 10336 AGCUUCCAGUGGUGUUAGC 12336 AGCUUCcAGUGGUGUuAGCdTsdT antis 2510-2529 10337 CUAACACCACUGGAAGCUU 12337 cuAAcAccAcuGGAAGcuudTsdT sense 2510-2529 10338 AAGCUUCCAGUGGUGUUAG 12338 AAGCUUCcAGUGGUGUuAGdTsdT antis 2512-2531 10339 AACACCACUGGAAGCUUGU 12339 AAcAccAcuGGAAGcuuGudTsdT sense 2512-2531 10340 ACAAGCUUCCAGUGGUGUU 12340 AcAAGCUUCcAGUGGUGUUdTsdT antis 2513-2532 10341 ACACCACUGGAAGCUUGUG 12341 AcAccAcuGGAAGcuuGuGdTsdT sense 2513-2532 10342 CACAAGCUUCCAGUGGUGU 12342 cAcAAGCUUCcAGUGGUGUdTsdT antis 2514-2533 10343 CACCACUGGAAGCUUGUGC 12343 cAccAcuGGAAGcuuGuGcdTsdT sense 2514-2533 10344 GCACAAGCUUCCAGUGGUG 12344 GcAcAAGCUUCcAGUGGUGdTsdT antis 2515-2534 10345 ACCACUGGAAGCUUGUGCA 12345 AccAcuGGAAGcuuGuGcAdTsdT sense 2515-2534 10346 UGCACAAGCUUCCAGUGGU 12346 UGcAcAAGCUUCcAGUGGUdTsdT antis 2517-2536 10347 CACUGGAAGCUUGUGCACA 12347 cAcuGGAAGcuuGuGcAcAdTsdT sense 2517-2536 10348 UGUGCACAAGCUUCCAGUG 12348 UGUGcAcAAGCUUCcAGUGdTsdT antis 2519-2538 10349 CUGGAAGCUUGUGCACAUU 12349 cuGGAAGcuuGuGcAcAuudTsdT sense 2519-2538 10350 AAUGUGCACAAGCUUCCAG 12350 AAUGUGcAcAAGCUUCcAGdTsdT antis 2520-2539 10351 UGGAAGCUUGUGCACAUUC 12351 uGGAAGcuuGuGcAcAuucdTsdT sense 2520-2539 10352 GAAUGUGCACAAGCUUCCA 12352 GAAUGUGcAcAAGCUUCcAdTsdT antis 2521-2540 10353 GGAAGCUUGUGCACAUUCA 12353 GGAAGcuuGuGcAcAuucAdTsdT sense 2521-2540 10354 UGAAUGUGCACAAGCUUCC 12354 UGAAUGUGcAcAAGCUUCCdTsdT antis 2522-2541 10355 GAAGCUUGUGCACAUUCAU 12355 GAAGcuuGuGcAcAuucAudTsdT sense 2522-2541 10356 AUGAAUGUGCACAAGCUUC 12356 AUGAAUGUGcAcAAGCUUCdTsdT antis 2524-2543 10357 AGCUUGUGCACAUUCAUUU 12357 AGcuuGuGcAcAuucAuuudTsdT sense 2524-2543 10358 AAAUGAAUGUGCACAAGCU 12358 AAAUGAAUGUGcAcAAGCUdTsdT antis 1560-1579 10359 AGAGCUGCAAGCCAGUGCA 12359 AGAGcuGcAAGccAGuGcAdTsdT sense 1560-1579 10360 UGCACUGGCUUGCAGCUCU 12360 UGcACUGGCUUGcAGCUCUdTsdT antis 1561-1580 10361 GAGCUGCAAGCCAGUGCAG 12361 GAGcuGcAAGccAGuGcAGdTsdT sense 1561-1580 10362 CUGCACUGGCUUGCAGCUC 12362 CUGcACUGGCUUGcAGCUCdTsdT antis 1575-1594 10363 UGCAGCAGCCUUCAGCUUU 12363 uGcAGcAGccuucAGcuuudTsdT sense 1575-1594 10364 AAAGCUGAAGGCUGCUGCA 12364 AAAGCUGAAGGCUGCUGcAdTsdT antis 1611-1630 10365 GCAGAGAUAAAGAUGGCAG 12365 GcAGAGAuAAAGAuGGcAGdTsdT sense 1611-1630 10366 CUGCCAUCUUUAUCUCUGC 12366 CUGCcAUCUUuAUCUCUGCdTsdT antis 1661-1680 10367 CAGGGUCCUGACAGGCCAC 12367 cAGGGuccuGAcAGGccAcdTsdT sense 1661-1680 10368 GUGGCCUGUCAGGACCCUG 12368 GUGGCCUGUcAGGACCCUGdTsdT antis 1779-1798 10369 AGAAAGUUCUACAGGACAA 12369 AGAAAGuucuAcAGGAcAAdTsdT sense 1779-1798 10370 UUGUCCUGUAGAACUUUCU 12370 UUGUCCUGuAGAACUUUCUdTsdT antis 1917-1936 10371 UGCUGGACUAUGUUCCGGA 12371 uGcuGGAcuAuGuuccGGAdTsdT sense 1917-1936 10372 UCCGGAACAUAGUCCAGCA 12372 UCCGGAAcAuAGUCcAGcAdTsdT antis 2012-2031 10373 UAUCAGCUGUUCAGAAGUC 12373 uAucAGcuGuucAGAAGucdTsdT sense 2012-2031 10374 GACUUCUGAACAGCUGAUA 12374 GACUUCUGAAcAGCUGAuAdTsdT antis 2042-2061 10375 CAUUCCUUUGGAAUCUGCC 12375 cAuuccuuuGGAAucuGccdTsdT sense 2042-2061 10376 GGCAGAUUCCAAAGGAAUG 12376 GGcAGAUUCcAAAGGAAUGdTsdT antis 2053-2072 10377 AAUCUGCCAUCGAGACAUU 12377 AAucuGccAucGAGAcAuudTsdT sense 2053-2072 10378 AAUGUCUCGAUGGCAGAUU 12378 AAUGUCUCGAUGGcAGAUUdTsdT antis 2066-2085 10379 GACAUUAAACCACAGAACC 12379 GAcAuuAAAccAcAGAAccdTsdT sense 2066-2085 10380 GGUUCUGUGGUUUAAUGUC 12380 GGUUCUGUGGUUuAAUGUCdTsdT antis 2149-2168 10381 CCGAGGAGAGCCCAAUGUU 12381 ccGAGGAGAGcccAAuGuudTsdT sense 2149-2168 10382 AACAUUGGGCUCUCCUCGG 12382 AAcAUUGGGCUCUCCUCGGdTsdT antis 2248-2267 10383 GUCUGCAGGCUGUGUGUUG 12383 GucuGcAGGcuGuGuGuuGdTsdT sense 2248-2267 10384 CAACACACAGCCUGCAGAC 12384 cAAcAcAcAGCCUGcAGACdTsdT antis 2302-2321 10385 GGACAGUGGUGUGGAUCAG 12385 GGAcAGuGGuGuGGAucAGdTsdT sense 2302-2321 10386 CUGAUCCACACCACUGUCC 12386 CUGAUCcAcACcACUGUCCdTsdT antis 2330-2349 10387 AUAAUAAAGGUCCUAGGAA 12387 AuAAuAAAGGuccuAGGAAdTsdT sense 2330-2349 10388 UUCCUAGGACCUUUAUUAU 12388 UUCCuAGGACCUUuAUuAUdTsdT antis 2362-2381 10389 GCAAAUUAGAGAAAUGAAC 12389 GcAAAuuAGAGAAAuGAAcdTsdT sense 2362-2381 10390 GUUCAUUUCUCUAAUUUGC 12390 GUUcAUUUCUCuAAUUUGCdTsdT antis 2366-2385 10391 AUUAGAGAAAUGAACCCAA 12391 AuuAGAGAAAuGAAcccAAdTsdT sense 2366-2385 10392 UUGGGUUCAUUUCUCUAAU 12392 UUGGGUUcAUUUCUCuAAUdTsdT antis 2378-2397 10393 AACCCAAAUUAUACAGAAU 12393 AAcccAAAuuAuAcAGAAudTsdT sense 2378-2397 10394 AUUCUGUAUAAUUUGGGUU 12394 AUUCUGuAuAAUUUGGGUUdTsdT antis 2432-2451 10395 AAGGUCUUCCGGCCCCGAA 12395 AAGGucuuccGGccccGAAdTsdT sense 2432-2451 10396 UUCGGGGCCGGAAGACCUU 12396 UUCGGGGCCGGAAGACCUUdTsdT antis 2441-2460 10397 CGGCCCCGAACUCCACCAG 12397 cGGccccGAAcuccAccAGdTsdT sense 2441-2460 10398 CUGGUGGAGUUCGGGGCCG 12398 CUGGUGGAGUUCGGGGCCGdTsdT antis 2456-2475 10399 CCAGAGGCAAUUGCACUGU 12399 ccAGAGGcAAuuGcAcuGudTsdT sense 2456-2475 10400 ACAGUGCAAUUGCCUCUGG 12400 AcAGUGcAAUUGCCUCUGGdTsdT antis 2472-2491 10401 UGUGCAGCCGUCUGCUGGA 12401 uGuGcAGccGucuGcuGGAdTsdT sense 2472-2491 10402 UCCAGCAGACGGCUGCACA 12402 UCcAGcAGACGGCUGcAcAdTsdT antis 1538-1557 10403 CCGAGAACCACCUCCUUUG 12403 ccGAGAAccAccuccuuuGdTsdT sense 1538-1557 10404 CAAAGGAGGUGGUUCUCGG 12404 cAAAGGAGGUGGUUCUCGGdTsdT antis 1539-1558 10405 CGAGAACCACCUCCUUUGC 12405 cGAGAAccAccuccuuuGcdTsdT sense 1539-1558 10406 GCAAAGGAGGUGGUUCUCG 12406 GcAAAGGAGGUGGUUCUCGdTsdT antis 1547-1566 10407 ACCUCCUUUGCGGAGAGCU 12407 AccuccuuuGcGGAGAGcudTsdT sense 1547-1566 10408 AGCUCUCCGCAAAGGAGGU 12408 AGCUCUCCGcAAAGGAGGUdTsdT antis 1551-1570 10409 CCUUUGCGGAGAGCUGCAA 12409 ccuuuGcGGAGAGcuGcAAdTsdT sense 1551-1570 10410 UUGCAGCUCUCCGCAAAGG 12410 UUGcAGCUCUCCGcAAAGGdTsdT antis 1558-1577 10411 GGAGAGCUGCAAGCCAGUG 12411 GGAGAGcuGcAAGccAGuGdTsdT sense 1558-1577 10412 CACUGGCUUGCAGCUCUCC 12412 cACUGGCUUGcAGCUCUCCdTsdT antis 1573-1592 10413 AGUGCAGCAGCCUUCAGCU 12413 AGuGcAGcAGccuucAGcudTsdT sense 1573-1592 10414 AGCUGAAGGCUGCUGCACU 12414 AGCUGAAGGCUGCUGcACUdTsdT antis 1574-1593 10415 GUGCAGCAGCCUUCAGCUU 12415 GuGcAGcAGccuucAGcuudTsdT sense 1574-1593 10416 AAGCUGAAGGCUGCUGCAC 12416 AAGCUGAAGGCUGCUGcACdTsdT antis 1584-1603 10417 CUUCAGCUUUUGGUAGCAU 12417 cuucAGcuuuuGGuAGcAudTsdT sense 1584-1603 10418 AUGCUACCAAAAGCUGAAG 12418 AUGCuACcAAAAGCUGAAGdTsdT antis 1594-1613 10419 UGGUAGCAUGAAAGUUAGC 12419 uGGuAGcAuGAAAGuuAGcdTsdT sense 1594-1613 10420 GCUAACUUUCAUGCUACCA 12420 GCuAACUUUcAUGCuACcAdTsdT antis 1599-1618 10421 GCAUGAAAGUUAGCAGAGA 12421 GcAuGAAAGuuAGcAGAGAdTsdT sense 1599-1618 10422 UCUCUGCUAACUUUCAUGC 12422 UCUCUGCuAACUUUcAUGCdTsdT antis 1600-1619 10423 CAUGAAAGUUAGCAGAGAU 12423 cAuGAAAGuuAGcAGAGAudTsdT sense 1600-1619 10424 AUCUCUGCUAACUUUCAUG 12424 AUCUCUGCuAACUUUcAUGdTsdT antis 1613-1632 10425 AGAGAUAAAGAUGGCAGCA 12425 AGAGAuAAAGAuGGcAGcAdTsdT sense 1613-1632 10426 UGCUGCCAUCUUUAUCUCU 12426 UGCUGCcAUCUUuAUCUCUdTsdT antis 1614-1633 10427 GAGAUAAAGAUGGCAGCAA 12427 GAGAuAAAGAuGGcAGcAAdTsdT sense 1614-1633 10428 UUGCUGCCAUCUUUAUCUC 12428 UUGCUGCcAUCUUuAUCUCdTsdT antis 1630-1649 10429 CAAGGUAACCACAGUAGUG 12429 cAAGGuAAccAcAGuAGuGdTsdT sense 1630-1649 10430 CACUACUGUGGUUACCUUG 12430 cACuACUGUGGUuACCUUGdTsdT antis 1650-1669 10431 CAACUCCUGGCCAGGGUCC 12431 cAAcuccuGGccAGGGuccdTsdT sense 1650-1669 10432 GGACCCUGGCCAGGAGUUG 12432 GGACCCUGGCcAGGAGUUGdTsdT antis 1652-1671 10433 ACUCCUGGCCAGGGUCCUG 12433 AcuccuGGccAGGGuccuGdTsdT sense 1652-1671 10434 CAGGACCCUGGCCAGGAGU 12434 cAGGACCCUGGCcAGGAGUdTsdT antis 1653-1672 10435 CUCCUGGCCAGGGUCCUGA 12435 cuccuGGccAGGGuccuGAdTsdT sense 1653-1672 10436 UCAGGACCCUGGCCAGGAG 12436 UcAGGACCCUGGCcAGGAGdTsdT antis 1654-1673 10437 UCCUGGCCAGGGUCCUGAC 12437 uccuGGccAGGGuccuGAcdTsdT sense 1654-1673 10438 GUCAGGACCCUGGCCAGGA 12438 GUcAGGACCCUGGCcAGGAdTsdT antis 1665-1684 10439 GUCCUGACAGGCCACAGGA 12439 GuccuGAcAGGccAcAGGAdTsdT sense 1665-1684 10440 UCCUGUGGCCUGUCAGGAC 12440 UCCUGUGGCCUGUcAGGACdTsdT antis 1673-1692 10441 AGGCCACAGGAAGUCAGUU 12441 AGGccAcAGGAAGucAGuudTsdT sense 1673-1692 10442 AACUGACUUCCUGUGGCCU 12442 AACUGACUUCCUGUGGCCUdTsdT antis 1688-1707 10443 AGUUAUACAGACACGAAAG 12443 AGuuAuAcAGAcAcGAAAGdTsdT sense 1688-1707 10444 CUUUCGUGUCUGUAUAACU 12444 CUUUCGUGUCUGuAuAACUdTsdT antis 1743-1762 10445 CCAAACUUUGUGAUUCUGG 12445 ccAAAcuuuGuGAuucuGGdTsdT sense 1743-1762 10446 CCAGAAUCACAAAGUUUGG 12446 CcAGAAUcAcAAAGUUUGGdTsdT antis 1744-1763 10447 CAAACUUUGUGAUUCUGGA 12447 cAAAcuuuGuGAuucuGGAdTsdT sense 1744-1763 10448 UCCAGAAUCACAAAGUUUG 12448 UCcAGAAUcAcAAAGUUUGdTsdT antis 1745-1764 10449 AAACUUUGUGAUUCUGGAG 12449 AAAcuuuGuGAuucuGGAGdTsdT sense 1745-1764 10450 CUCCAGAAUCACAAAGUUU 12450 CUCcAGAAUcAcAAAGUUUdTsdT antis 1746-1765 10451 AACUUUGUGAUUCUGGAGA 12451 AAcuuuGuGAuucuGGAGAdTsdT sense 1746-1765 10452 UCUCCAGAAUCACAAAGUU 12452 UCUCcAGAAUcAcAAAGUUdTsdT antis 1780-1799 10453 GAAAGUUCUACAGGACAAG 12453 GAAAGuucuAcAGGAcAAGdTsdT sense 1780-1799 10454 CUUGUCCUGUAGAACUUUC 12454 CUUGUCCUGuAGAACUUUCdTsdT antis 1781-1800 10455 AAAGUUCUACAGGACAAGC 12455 AAAGuucuAcAGGAcAAGcdTsdT sense 1781-1800 10456 GCUUGUCCUGUAGAACUUU 12456 GCUUGUCCUGuAGAACUUUdTsdT antis 1782-1801 10457 AAGUUCUACAGGACAAGCG 12457 AAGuucuAcAGGAcAAGcGdTsdT sense 1782-1801 10458 CGCUUGUCCUGUAGAACUU 12458 CGCUUGUCCUGuAGAACUUdTsdT antis 1809-1828 10459 ACCGAGAGCUCCAGAUCAU 12459 AccGAGAGcuccAGAucAudTsdT sense 1809-1828 10460 AUGAUCUGGAGCUCUCGGU 12460 AUGAUCUGGAGCUCUCGGUdTsdT antis 1880-1899 10461 AGUGGUGAGAAGAAAGAUG 12461 AGuGGuGAGAAGAAAGAuGdTsdT sense 1880-1899 10462 CAUCUUUCUUCUCACCACU 12462 cAUCUUUCUUCUcACcACUdTsdT antis 1885-1904 10463 UGAGAAGAAAGAUGAGGUC 12463 uGAGAAGAAAGAuGAGGucdTsdT sense 1885-1904 10464 GACCUCAUCUUUCUUCUCA 12464 GACCUcAUCUUUCUUCUcAdTsdT antis 1889-1908 10465 AAGAAAGAUGAGGUCUACC 12465 AAGAAAGAuGAGGucuAccdTsdT sense 1889-1908 10466 GGUAGACCUCAUCUUUCUU 12466 GGuAGACCUcAUCUUUCUUdTsdT antis 2043-2062 10467 AUUCCUUUGGAAUCUGCCA 12467 AuuccuuuGGAAucuGccAdTsdT sense 2043-2062 10468 UGGCAGAUUCCAAAGGAAU 12468 UGGcAGAUUCcAAAGGAAUdTsdT antis 2050-2069 10469 UGGAAUCUGCCAUCGAGAC 12469 uGGAAucuGccAucGAGAcdTsdT sense 2050-2069 10470 GUCUCGAUGGCAGAUUCCA 12470 GUCUCGAUGGcAGAUUCcAdTsdT antis 2092-2111 10471 GGAUCCUGAUACAGCUGUA 12471 GGAuccuGAuAcAGcuGuAdTsdT sense 2092-2111 10472 UACAGCUGUAUCAGGAUCC 12472 uAcAGCUGuAUcAGGAUCCdTsdT antis 2116-2135 10473 ACUCUGUGACUUUGGAAGU 12473 AcucuGuGAcuuuGGAAGudTsdT sense 2116-2135 10474 ACUUCCAAAGUCACAGAGU 12474 ACUUCcAAAGUcAcAGAGUdTsdT antis 2143-2162 10475 GCUGGUCCGAGGAGAGCCC 12475 GcuGGuccGAGGAGAGcccdTsdT sense 2143-2162 10476 GGGCUCUCCUCGGACCAGC 12476 GGGCUCUCCUCGGACcAGCdTsdT antis 2159-2178 10477 CCCAAUGUUUCAUAUAUCU 12477 cccAAuGuuucAuAuAucudTsdT sense 2159-2178 10478 AGAUAUAUGAAACAUUGGG 12478 AGAuAuAUGAAAcAUUGGGdTsdT antis 2163-2182 10479 AUGUUUCAUAUAUCUGUUC 12479 AuGuuucAuAuAucuGuucdTsdT sense 2163-2182 10480 GAACAGAUAUAUGAAACAU 12480 GAAcAGAuAuAUGAAAcAUdTsdT antis 2207-2226 10481 AUCUUUGGAGCCACUGAUU 12481 AucuuuGGAGccAcuGAuudTsdT sense 2207-2226 10482 AAUCAGUGGCUCCAAAGAU 12482 AAUcAGUGGCUCcAAAGAUdTsdT antis 2247-2266 10483 GGUCUGCAGGCUGUGUGUU 12483 GGucuGcAGGcuGuGuGuudTsdT sense 2247-2266 10484 AACACACAGCCUGCAGACC 12484 AAcAcAcAGCCUGcAGACCdTsdT antis 2251-2270 10485 UGCAGGCUGUGUGUUGGCU 12485 uGcAGGcuGuGuGuuGGcudTsdT sense 2251-2270 10486 AGCCAACACACAGCCUGCA 12486 AGCcAAcAcAcAGCCUGcAdTsdT antis 2261-2280 10487 GUGUUGGCUGAAUUGUUGC 12487 GuGuuGGcuGAAuuGuuGcdTsdT sense 2261-2280 10488 GCAACAAUUCAGCCAACAC 12488 GcAAcAAUUcAGCcAAcACdTsdT antis 2298-2317 10489 CUGGGGACAGUGGUGUGGA 12489 cuGGGGAcAGuGGuGuGGAdTsdT sense 2298-2317 10490 UCCACACCACUGUCCCCAG 12490 UCcAcACcACUGUCCCcAGdTsdT antis 2300-2319 10491 GGGGACAGUGGUGUGGAUC 12491 GGGGAcAGuGGuGuGGAucdTsdT sense 2300-2319 10492 GAUCCACACCACUGUCCCC 12492 GAUCcAcACcACUGUCCCCdTsdT antis 2301-2320 10493 GGGACAGUGGUGUGGAUCA 12493 GGGAcAGuGGuGuGGAucAdTsdT sense 2301-2320 10494 UGAUCCACACCACUGUCCC 12494 UGAUCcAcACcACUGUCCCdTsdT antis 2319-2338 10495 AGUUGGUGGAAAUAAUAAA 12495 AGuuGGuGGAAAuAAuAAAdTsdT sense 2319-2338 10496 UUUAUUAUUUCCACCAACU 12496 UUuAUuAUUUCcACcAACUdTsdT antis 2323-2342 10497 GGUGGAAAUAAUAAAGGUC 12497 GGuGGAAAuAAuAAAGGucdTsdT sense 2323-2342 10498 GACCUUUAUUAUUUCCACC 12498 GACCUUuAUuAUUUCcACCdTsdT antis 2325-2344 10499 UGGAAAUAAUAAAGGUCCU 12499 uGGAAAuAAuAAAGGuccudTsdT sense 2325-2344 10500 AGGACCUUUAUUAUUUCCA 12500 AGGACCUUuAUuAUUUCcAdTsdT antis 2363-2382 10501 CAAAUUAGAGAAAUGAACC 12501 cAAAuuAGAGAAAuGAAccdTsdT sense 2363-2382 10502 GGUUCAUUUCUCUAAUUUG 12502 GGUUcAUUUCUCuAAUUUGdTsdT antis 2376-2395 10503 UGAACCCAAAUUAUACAGA 12503 uGAAcccAAAuuAuAcAGAdTsdT sense 2376-2395 10504 UCUGUAUAAUUUGGGUUCA 12504 UCUGuAuAAUUUGGGUUcAdTsdT antis 2377-2396 10505 GAACCCAAAUUAUACAGAA 12505 GAAcccAAAuuAuAcAGAAdTsdT sense 2377-2396 10506 UUCUGUAUAAUUUGGGUUC 12506 UUCUGuAuAAUUUGGGUUCdTsdT antis 2383-2402 10507 AAAUUAUACAGAAUUCAAA 12507 AAAuuAuAcAGAAuucAAAdTsdT sense 2383-2402 10508 UUUGAAUUCUGUAUAAUUU 12508 UUUGAAUUCUGuAuAAUUUdTsdT antis 2391-2410 10509 CAGAAUUCAAAUUCCCUCA 12509 cAGAAuucAAAuucccucAdTsdT sense 2391-2410 10510 UGAGGGAAUUUGAAUUCUG 12510 UGAGGGAAUUUGAAUUCUGdTsdT antis 2394-2413 10511 AAUUCAAAUUCCCUCAAAU 12511 AAuucAAAuucccucAAAudTsdT sense 2394-2413 10512 AUUUGAGGGAAUUUGAAUU 12512 AUUUGAGGGAAUUUGAAUUdTsdT antis 2436-2455 10513 UCUUCCGGCCCCGAACUCC 12513 ucuuccGGccccGAAcuccdTsdT sense 2436-2455 10514 GGAGUUCGGGGCCGGAAGA 12514 GGAGUUCGGGGCCGGAAGAdTsdT antis 2442-2461 10515 GGCCCCGAACUCCACCAGA 12515 GGccccGAAcuccAccAGAdTsdT sense 2442-2461 10516 UCUGGUGGAGUUCGGGGCC 12516 UCUGGUGGAGUUCGGGGCCdTsdT antis 2449-2468 10517 AACUCCACCAGAGGCAAUU 12517 AAcuccAccAGAGGcAAuudTsdT sense 2449-2468 10518 AAUUGCCUCUGGUGGAGUU 12518 AAUUGCCUCUGGUGGAGUUdTsdT antis 2450-2469 10519 ACUCCACCAGAGGCAAUUG 12519 AcuccAccAGAGGcAAuuGdTsdT sense 2450-2469 10520 CAAUUGCCUCUGGUGGAGU 12520 cAAUUGCCUCUGGUGGAGUdTsdT antis 2457-2476 10521 CAGAGGCAAUUGCACUGUG 12521 cAGAGGcAAuuGcAcuGuGdTsdT sense 2457-2476 10522 CACAGUGCAAUUGCCUCUG 12522 cAcAGUGcAAUUGCCUCUGdTsdT antis 2470-2489 10523 ACUGUGCAGCCGUCUGCUG 12523 AcuGuGcAGccGucuGcuGdTsdT sense 2470-2489 10524 CAGCAGACGGCUGCACAGU 12524 cAGcAGACGGCUGcAcAGUdTsdT antis 2473-2492 10525 GUGCAGCCGUCUGCUGGAG 12525 GuGcAGccGucuGcuGGAGdTsdT sense 2473-2492 10526 CUCCAGCAGACGGCUGCAC 12526 CUCcAGcAGACGGCUGcACdTsdT antis 2475-2494 10527 GCAGCCGUCUGCUGGAGUA 12527 GcAGccGucuGcuGGAGuAdTsdT sense 2475-2494 10528 UACUCCAGCAGACGGCUGC 12528 uACUCcAGcAGACGGCUGCdTsdT antis 1612-1631 10529 CAGAGAUAAAGAUGGCAGC 12529 cAGAGAuAAAGAuGGcAGcdTsdT sense 1612-1631 10530 GCUGCCAUCUUUAUCUCUG 12530 GCUGCcAUCUUuAUCUCUGdTsdT antis 1804-1823 10531 UAAGAACCGAGAGCUCCAG 12531 uAAGAAccGAGAGcuccAGdTsdT sense 1804-1823 10532 CUGGAGCUCUCGGUUCUUA 12532 CUGGAGCUCUCGGUUCUuAdTsdT antis 1805-1824 10533 AAGAACCGAGAGCUCCAGA 12533 AAGAAccGAGAGcuccAGAdTsdT sense 1805-1824 10534 UCUGGAGCUCUCGGUUCUU 12534 UCUGGAGCUCUCGGUUCUUdTsdT antis 1888-1907 10535 GAAGAAAGAUGAGGUCUAC 12535 GAAGAAAGAuGAGGucuAcdTsdT sense 1888-1907 10536 GUAGACCUCAUCUUUCUUC 12536 GuAGACCUcAUCUUUCUUCdTsdT antis 2165-2184 10537 GUUUCAUAUAUCUGUUCUC 12537 GuuucAuAuAucuGuucucdTsdT sense 2165-2184 10538 GAGAACAGAUAUAUGAAAC 12538 GAGAAcAGAuAuAUGAAACdTsdT antis 2332-2351 10539 AAUAAAGGUCCUAGGAACA 12539 AAuAAAGGuccuAGGAAcAdTsdT sense 2332-2351 10540 UGUUCCUAGGACCUUUAUU 12540 UGUUCCuAGGACCUUuAUUdTsdT antis 2518-2537 10541 ACUGGAAGCUUGUGCACAU 12541 AcuGGAAGcuuGuGcAcAudTsdT sense 2518-2537 10542 AUGUGCACAAGCUUCCAGU 12542 AUGUGcAcAAGCUUCcAGUdTsdT antis 1565-1584 10543 UGCAAGCCAGUGCAGCAGC 12543 uGcAAGccAGuGcAGcAGcdTsdT sense 1565-1584 10544 GCUGCUGCACUGGCUUGCA 12544 GCUGCUGcACUGGCUUGcAdTsdT antis 1569-1588 10545 AGCCAGUGCAGCAGCCUUC 12545 AGccAGuGcAGcAGccuucdTsdT sense 1569-1588 10546 GAAGGCUGCUGCACUGGCU 12546 GAAGGCUGCUGcACUGGCUdTsdT antis 1631-1650 10547 AAGGUAACCACAGUAGUGG 12547 AAGGuAAccAcAGuAGuGGdTsdT sense 1631-1650 10548 CCACUACUGUGGUUACCUU 12548 CcACuACUGUGGUuACCUUdTsdT antis 1659-1678 10549 GCCAGGGUCCUGACAGGCC 12549 GccAGGGuccuGAcAGGccdTsdT sense 1659-1678 10550 GGCCUGUCAGGACCCUGGC 12550 GGCCUGUcAGGACCCUGGCdTsdT antis 1711-1730 10551 UGGAAAUGGAUCAUUUGGU 12551 uGGAAAuGGAucAuuuGGudTsdT sense 1711-1730 10552 ACCAAAUGAUCCAUUUCCA 12552 ACcAAAUGAUCcAUUUCcAdTsdT antis 1756-1775 10553 UUCUGGAGAACUGGUUGCC 12553 uucuGGAGAAcuGGuuGccdTsdT sense 1756-1775 10554 GGCAACCAGUUCUCCAGAA 12554 GGcAACcAGUUCUCcAGAAdTsdT antis 1761-1780 10555 GAGAACUGGUUGCCAUCAA 12555 GAGAAcuGGuuGccAucAAdTsdT sense 1761-1780 10556 UUGAUGGCAACCAGUUCUC 12556 UUGAUGGcAACcAGUUCUCdTsdT antis 1762-1781 10557 AGAACUGGUUGCCAUCAAG 12557 AGAAcuGGuuGccAucAAGdTsdT sense 1762-1781 10558 CUUGAUGGCAACCAGUUCU 12558 CUUGAUGGcAACcAGUUCUdTsdT antis 1997-2016 10559 GUCAAGUUGUAUAUGUAUC 12559 GucAAGuuGuAuAuGuAucdTsdT sense 1997-2016 10560 GAUACAUAUACAACUUGAC 12560 GAuAcAuAuAcAACUUGACdTsdT antis 2040-2059 10561 UCCAUUCCUUUGGAAUCUG 12561 uccAuuccuuuGGAAucuGdTsdT sense 2040-2059 10562 CAGAUUCCAAAGGAAUGGA 12562 cAGAUUCcAAAGGAAUGGAdTsdT antis 2133-2152 10563 GUGCAAAGCAGCUGGUCCG 12563 GuGcAAAGcAGcuGGuccGdTsdT sense 2133-2152 10564 CGGACCAGCUGCUUUGCAC 12564 CGGACcAGCUGCUUUGcACdTsdT antis 2186-2205 10565 UACUACAGGGCACCAGAGU 12565 uAcuAcAGGGcAccAGAGudTsdT sense 2186-2205 10566 ACUCUGGUGCCCUGUAGUA 12566 ACUCUGGUGCCCUGuAGuAdTsdT antis 2250-2269 10567 CUGCAGGCUGUGUGUUGGC 12567 cuGcAGGcuGuGuGuuGGcdTsdT sense 2250-2269 10568 GCCAACACACAGCCUGCAG 12568 GCcAAcAcAcAGCCUGcAGdTsdT antis 2466-2485 10569 UUGCACUGUGCAGCCGUCU 12569 uuGcAcuGuGcAGccGucudTsdT sense 2466-2485 10570 AGACGGCUGCACAGUGCAA 12570 AGACGGCUGcAcAGUGcAAdTsdT antis 2523-2542 10571 AAGCUUGUGCACAUUCAUU 12571 AAGcuuGuGcAcAuucAuudTsdT sense 2523-2542 10572 AAUGAAUGUGCACAAGCUU 12572 AAUGAAUGUGcAcAAGCUUdTsdT antis 1548-1567 10573 CCUCCUUUGCGGAGAGCUG 12573 ccuccuuuGcGGAGAGcuGdTsdT sense 1548-1567 10574 CAGCUCUCCGCAAAGGAGG 12574 cAGCUCUCCGcAAAGGAGGdTsdT antis 1566-1585 10575 GCAAGCCAGUGCAGCAGCC 12575 GcAAGccAGuGcAGcAGccdTsdT sense 1566-1585 10576 GGCUGCUGCACUGGCUUGC 12576 GGCUGCUGcACUGGCUUGCdTsdT antis 1656-1675 10577 CUGGCCAGGGUCCUGACAG 12577 cuGGccAGGGuccuGAcAGdTsdT sense 1656-1675 10578 CUGUCAGGACCCUGGCCAG 12578 CUGUcAGGACCCUGGCcAGdTsdT antis 1763-1782 10579 GAACUGGUUGCCAUCAAGA 12579 GAAcuGGuuGccAucAAGAdTsdT sense 1763-1782 10580 UCUUGAUGGCAACCAGUUC 12580 UCUUGAUGGcAACcAGUUCdTsdT antis 2185-2204 10581 GUACUACAGGGCACCAGAG 12581 GuAcuAcAGGGcAccAGAGdTsdT sense 2185-2204 10582 CUCUGGUGCCCUGUAGUAC 12582 CUCUGGUGCCCUGuAGuACdTsdT antis 2212-2231 10583 UGGAGCCACUGAUUACACG 12583 uGGAGccAcuGAuuAcAcGdTsdT sense 2212-2231 10584 CGUGUAAUCAGUGGCUCCA 12584 CGUGuAAUcAGUGGCUCcAdTsdT antis 2265-2284 10585 UGGCUGAAUUGUUGCUAGG 12585 uGGcuGAAuuGuuGcuAGGdTsdT sense 2265-2284 10586 CCUAGCAACAAUUCAGCCA 12586 CCuAGcAAcAAUUcAGCcAdTsdT antis 2326-2345 10587 GGAAAUAAUAAAGGUCCUA 12587 GGAAAuAAuAAAGGuccuAdTsdT sense 2326-2345 10588 UAGGACCUUUAUUAUUUCC 12588 uAGGACCUUuAUuAUUUCCdTsdT antis 2425-2444 10589 UUGGACAAAGGUCUUCCGG 12589 uuGGAcAAAGGucuuccGGdTsdT sense 2425-2444 10590 CCGGAAGACCUUUGUCCAA 12590 CCGGAAGACCUUUGUCcAAdTsdT antis 1962-1981 10591 AUAGUCGAGCCAAGCAGAC 12591 AuAGucGAGccAAGcAGAcdTsdT sense 1962-1981 10592 GUCUGCUUGGCUCGACUAU 12592 GUCUGCUUGGCUCGACuAUdTsdT antis 1803-1822 10593 UUAAGAACCGAGAGCUCCA 12593 uuAAGAAccGAGAGcuccAdTsdT sense 1803-1822 10594 UGGAGCUCUCGGUUCUUAA 12594 UGGAGCUCUCGGUUCUuAAdTsdT antis 1808-1827 10595 AACCGAGAGCUCCAGAUCA 12595 AAccGAGAGcuccAGAucAdTsdT sense 1808-1827 10596 UGAUCUGGAGCUCUCGGUU 12596 UGAUCUGGAGCUCUCGGUUdTsdT antis 1603-1622 10597 GAAAGUUAGCAGAGAUAAA 12597 GAAAGuuAGcAGAGAuAAAdTsdT sense 1603-1622 10598 UUUAUCUCUGCUAACUUUC 12598 UUuAUCUCUGCuAACUUUCdTsdT antis 1640-1659 10599 ACAGUAGUGGCAACUCCUG 12599 AcAGuAGuGGcAAcuccuGdTsdT sense 1640-1659 10600 CAGGAGUUGCCACUACUGU 12600 cAGGAGUUGCcACuACUGUdTsdT antis 1718-1737 10601 GGAUCAUUUGGUGUGGUAU 12601 GGAucAuuuGGuGuGGuAudTsdT sense 1718-1737 10602 AUACCACACCAAAUGAUCC 12602 AuACcAcACcAAAUGAUCCdTsdT antis 1807-1826 10603 GAACCGAGAGCUCCAGAUC 12603 GAAccGAGAGcuccAGAucdTsdT sense 1807-1826 10604 GAUCUGGAGCUCUCGGUUC 12604 GAUCUGGAGCUCUCGGUUCdTsdT antis 1904-1923 10605 UACCUUAACCUGGUGCUGG 12605 uAccuuAAccuGGuGcuGGdTsdT sense 1904-1923 10606 CCAGCACCAGGUUAAGGUA 12606 CcAGcACcAGGUuAAGGuAdTsdT antis 1905-1924 10607 ACCUUAACCUGGUGCUGGA 12607 AccuuAAccuGGuGcuGGAdTsdT sense 1905-1924 10608 UCCAGCACCAGGUUAAGGU 12608 UCcAGcACcAGGUuAAGGUdTsdT antis 1906-1925 10609 CCUUAACCUGGUGCUGGAC 12609 ccuuAAccuGGuGcuGGAcdTsdT sense 1906-1925 10610 GUCCAGCACCAGGUUAAGG 12610 GUCcAGcACcAGGUuAAGGdTsdT antis 2015-2034 10611 CAGCUGUUCAGAAGUCUAG 12611 cAGcuGuucAGAAGucuAGdTsdT sense 2015-2034 10612 CUAGACUUCUGAACAGCUG 12612 CuAGACUUCUGAAcAGCUGdTsdT antis 2057-2076 10613 UGCCAUCGAGACAUUAAAC 12613 uGccAucGAGAcAuuAAAcdTsdT sense 2057-2076 10614 GUUUAAUGUCUCGAUGGCA 12614 GUUuAAUGUCUCGAUGGcAdTsdT antis 2109-2128 10615 UAUUAAAACUCUGUGACUU 12615 uAuuAAAAcucuGuGAcuudTsdT sense 2109-2128 10616 AAGUCACAGAGUUUUAAUA 12616 AAGUcAcAGAGUUUuAAuAdTsdT antis 2126-2145 10617 UUUGGAAGUGCAAAGCAGC 12617 uuuGGAAGuGcAAAGcAGcdTsdT sense 2126-2145 10618 GCUGCUUUGCACUUCCAAA 12618 GCUGCUUUGcACUUCcAAAdTsdT antis 2129-2148 10619 GGAAGUGCAAAGCAGCUGG 12619 GGAAGuGcAAAGcAGcuGGdTsdT sense 2129-2148 10620 CCAGCUGCUUUGCACUUCC 12620 CcAGCUGCUUUGcACUUCCdTsdT antis 2312-2331 10621 GUGGAUCAGUUGGUGGAAA 12621 GuGGAucAGuuGGuGGAAAdTsdT sense 2312-2331 10622 UUUCCACCAACUGAUCCAC 12622 UUUCcACcAACUGAUCcACdTsdT antis 2313-2332 10623 UGGAUCAGUUGGUGGAAAU 12623 uGGAucAGuuGGuGGAAAudTsdT sense 2313-2332 10624 AUUUCCACCAACUGAUCCA 12624 AUUUCcACcAACUGAUCcAdTsdT antis 2347-2366 10625 AACACCAACAAGGGAGCAA 12625 AAcAccAAcAAGGGAGcAAdTsdT sense 2347-2366 10626 UUGCUCCCUUGUUGGUGUU 12626 UUGCUCCCUUGUUGGUGUUdTsdT antis 2373-2392 10627 AAAUGAACCCAAAUUAUAC 12627 AAAuGAAcccAAAuuAuAcdTsdT sense 2373-2392 10628 GUAUAAUUUGGGUUCAUUU 12628 GuAuAAUUUGGGUUcAUUUdTsdT antis 2431-2450 10629 AAAGGUCUUCCGGCCCCGA 12629 AAAGGucuuccGGccccGAdTsdT sense 2431-2450 10630 UCGGGGCCGGAAGACCUUU 12630 UCGGGGCCGGAAGACCUUUdTsdT antis 1632-1651 10631 AGGUAACCACAGUAGUGGC 12631 AGGuAAccAcAGuAGuGGcdTsdT sense 1632-1651 10632 GCCACUACUGUGGUUACCU 12632 GCcACuACUGUGGUuACCUdTsdT antis 2031-2050 10633 UAGCCUAUAUCCAUUCCUU 12633 uAGccuAuAuccAuuccuudTsdT sense 2031-2050 10634 AAGGAAUGGAUAUAGGCUA 12634 AAGGAAUGGAuAuAGGCuAdTsdT antis 1604-1623 10635 AAAGUUAGCAGAGAUAAAG 12635 AAAGuuAGcAGAGAuAAAGdTsdT sense 1604-1623 10636 CUUUAUCUCUGCUAACUUU 12636 CUUuAUCUCUGCuAACUUUdTsdT antis 1605-1624 10637 AAGUUAGCAGAGAUAAAGA 12637 AAGuuAGcAGAGAuAAAGAdTsdT sense 1605-1624 10638 UCUUUAUCUCUGCUAACUU 12638 UCUUuAUCUCUGCuAACUUdTsdT antis 1634-1653 10639 GUAACCACAGUAGUGGCAA 12639 GuAAccAcAGuAGuGGcAAdTsdT sense 1634-1653 10640 UUGCCACUACUGUGGUUAC 12640 UUGCcACuACUGUGGUuACdTsdT antis 1662-1681 10641 AGGGUCCUGACAGGCCACA 12641 AGGGuccuGAcAGGccAcAdTsdT sense 1662-1681 10642 UGUGGCCUGUCAGGACCCU 12642 UGUGGCCUGUcAGGACCCUdTsdT antis 1663-1682 10643 GGGUCCUGACAGGCCACAG 12643 GGGuccuGAcAGGccAcAGdTsdT sense 1663-1682 10644 CUGUGGCCUGUCAGGACCC 12644 CUGUGGCCUGUcAGGACCCdTsdT antis 1702-1721 10645 GAAAGUGAUUGGAAAUGGA 12645 GAAAGuGAuuGGAAAuGGAdTsdT sense 1702-1721 10646 UCCAUUUCCAAUCACUUUC 12646 UCcAUUUCcAAUcACUUUCdTsdT antis 1772-1791 10647 GCCAUCAAGAAAGUUCUAC 12647 GccAucAAGAAAGuucuAcdTsdT sense 1772-1791 10648 GUAGAACUUUCUUGAUGGC 12648 GuAGAACUUUCUUGAUGGCdTsdT antis 1776-1795 10649 UCAAGAAAGUUCUACAGGA 12649 ucAAGAAAGuucuAcAGGAdTsdT sense 1776-1795 10650 UCCUGUAGAACUUUCUUGA 12650 UCCUGuAGAACUUUCUUGAdTsdT antis 1792-1811 10651 GGACAAGCGAUUUAAGAAC 12651 GGAcAAGcGAuuuAAGAAcdTsdT sense 1792-1811 10652 GUUCUUAAAUCGCUUGUCC 12652 GUUCUuAAAUCGCUUGUCCdTsdT antis 1801-1820 10653 AUUUAAGAACCGAGAGCUC 12653 AuuuAAGAAccGAGAGcucdTsdT sense 1801-1820 10654 GAGCUCUCGGUUCUUAAAU 12654 GAGCUCUCGGUUCUuAAAUdTsdT antis 1813-1832 10655 AGAGCUCCAGAUCAUGAGA 12655 AGAGcuccAGAucAuGAGAdTsdT sense 1813-1832 10656 UCUCAUGAUCUGGAGCUCU 12656 UCUcAUGAUCUGGAGCUCUdTsdT antis 1859-1878 10657 CUGCGGUAUUUCUUCUACU 12657 cuGcGGuAuuucuucuAcudTsdT sense 1859-1878 10658 AGUAGAAGAAAUACCGCAG 12658 AGuAGAAGAAAuACCGcAGdTsdT antis 1860-1879 10659 UGCGGUAUUUCUUCUACUC 12659 uGcGGuAuuucuucuAcucdTsdT sense 1860-1879 10660 GAGUAGAAGAAAUACCGCA 12660 GAGuAGAAGAAAuACCGcAdTsdT antis 1900-1919 10661 GGUCUACCUUAACCUGGUG 12661 GGucuAccuuAAccuGGuGdTsdT sense 1900-1919 10662 CACCAGGUUAAGGUAGACC 12662 cACcAGGUuAAGGuAGACCdTsdT antis 1909-1928 10663 UAACCUGGUGCUGGACUAU 12663 uAAccuGGuGcuGGAcuAudTsdT sense 1909-1928 10664 AUAGUCCAGCACCAGGUUA 12664 AuAGUCcAGcACcAGGUuAdTsdT antis 1982-2001 10665 CUCCCUGUGAUCUAUGUCA 12665 cucccuGuGAucuAuGucAdTsdT sense 1982-2001 10666 UGACAUAGAUCACAGGGAG 12666 UGAcAuAGAUcAcAGGGAGdTsdT antis 2125-2144 10667 CUUUGGAAGUGCAAAGCAG 12667 cuuuGGAAGuGcAAAGcAGdTsdT sense 2125-2144 10668 CUGCUUUGCACUUCCAAAG 12668 CUGCUUUGcACUUCcAAAGdTsdT antis 2137-2156 10669 AAAGCAGCUGGUCCGAGGA 12669 AAAGcAGcuGGuccGAGGAdTsdT sense 2137-2156 10670 UCCUCGGACCAGCUGCUUU 12670 UCCUCGGACcAGCUGCUUUdTsdT antis 2156-2175 10671 GAGCCCAAUGUUUCAUAUA 12671 GAGcccAAuGuuucAuAuAdTsdT sense 2156-2175 10672 UAUAUGAAACAUUGGGCUC 12672 uAuAUGAAAcAUUGGGCUCdTsdT antis 2174-2193 10673 AUCUGUUCUCGGUACUACA 12673 AucuGuucucGGuAcuAcAdTsdT sense 2174-2193 10674 UGUAGUACCGAGAACAGAU 12674 UGuAGuACCGAGAAcAGAUdTsdT antis 2281-2300 10675 AGGACAACCAAUAUUUCCU 12675 AGGAcAAccAAuAuuuccudTsdT sense 2281-2300 10676 AGGAAAUAUUGGUUGUCCU 12676 AGGAAAuAUUGGUUGUCCUdTsdT antis 2282-2301 10677 GGACAACCAAUAUUUCCUG 12677 GGAcAAccAAuAuuuccuGdTsdT sense 2282-2301 10678 CAGGAAAUAUUGGUUGUCC 12678 cAGGAAAuAUUGGUUGUCCdTsdT antis 2317-2336 10679 UCAGUUGGUGGAAAUAAUA 12679 ucAGuuGGuGGAAAuAAuAdTsdT sense 2317-2336 10680 UAUUAUUUCCACCAACUGA 12680 uAUuAUUUCcACcAACUGAdTsdT antis 2346-2365 10681 GAACACCAACAAGGGAGCA 12681 GAAcAccAAcAAGGGAGcAdTsdT sense 2346-2365 10682 UGCUCCCUUGUUGGUGUUC 12682 UGCUCCCUUGUUGGUGUUCdTsdT antis 2401-2420 10683 AUUCCCUCAAAUCAAGGCA 12683 AuucccucAAAucAAGGcAdTsdT sense 2401-2420 10684 UGCCUUGAUUUGAGGGAAU 12684 UGCCUUGAUUUGAGGGAAUdTsdT antis 2402-2421 10685 UUCCCUCAAAUCAAGGCAC 12685 uucccucAAAucAAGGcAcdTsdT sense 2402-2421 10686 GUGCCUUGAUUUGAGGGAA 12686 GUGCCUUGAUUUGAGGGAAdTsdT antis 2463-2482 10687 CAAUUGCACUGUGCAGCCG 12687 cAAuuGcAcuGuGcAGccGdTsdT sense 2463-2482 10688 CGGCUGCACAGUGCAAUUG 12688 CGGCUGcAcAGUGcAAUUGdTsdT antis 1537-1556 10689 ACCGAGAACCACCUCCUUU 12689 AccGAGAAccAccuccuuudTsdT sense 1537-1556 10690 AAAGGAGGUGGUUCUCGGU 12690 AAAGGAGGUGGUUCUCGGUdTsdT antis 1554-1573 10691 UUGCGGAGAGCUGCAAGCC 12691 uuGcGGAGAGcuGcAAGccdTsdT sense 1554-1573 10692 GGCUUGCAGCUCUCCGCAA 12692 GGCUUGcAGCUCUCCGcAAdTsdT antis 1555-1574 10693 UGCGGAGAGCUGCAAGCCA 12693 uGcGGAGAGcuGcAAGccAdTsdT sense 1555-1574 10694 UGGCUUGCAGCUCUCCGCA 12694 UGGCUUGcAGCUCUCCGcAdTsdT antis 1562-1581 10695 AGCUGCAAGCCAGUGCAGC 12695 AGcuGcAAGccAGuGcAGcdTsdT sense 1562-1581 10696 GCUGCACUGGCUUGCAGCU 12696 GCUGcACUGGCUUGcAGCUdTsdT antis 1563-1582 10697 GCUGCAAGCCAGUGCAGCA 12697 GcuGcAAGccAGuGcAGcAdTsdT sense 1563-1582 10698 UGCUGCACUGGCUUGCAGC 12698 UGCUGcACUGGCUUGcAGCdTsdT antis 1570-1589 10699 GCCAGUGCAGCAGCCUUCA 12699 GccAGuGcAGcAGccuucAdTsdT sense 1570-1589 10700 UGAAGGCUGCUGCACUGGC 12700 UGAAGGCUGCUGcACUGGCdTsdT antis 1571-1590 10701 CCAGUGCAGCAGCCUUCAG 12701 ccAGuGcAGcAGccuucAGdTsdT sense 1571-1590 10702 CUGAAGGCUGCUGCACUGG 12702 CUGAAGGCUGCUGcACUGGdTsdT antis 1589-1608 10703 GCUUUUGGUAGCAUGAAAG 12703 GcuuuuGGuAGcAuGAAAGdTsdT sense 1589-1608 10704 CUUUCAUGCUACCAAAAGC 12704 CUUUcAUGCuACcAAAAGCdTsdT antis 1595-1614 10705 GGUAGCAUGAAAGUUAGCA 12705 GGuAGcAuGAAAGuuAGcAdTsdT sense 1595-1614 10706 UGCUAACUUUCAUGCUACC 12706 UGCuAACUUUcAUGCuACCdTsdT antis 1596-1615 10707 GUAGCAUGAAAGUUAGCAG 12707 GuAGcAuGAAAGuuAGcAGdTsdT sense 1596-1615 10708 CUGCUAACUUUCAUGCUAC 12708 CUGCuAACUUUcAUGCuACdTsdT antis 1597-1616 10709 UAGCAUGAAAGUUAGCAGA 12709 uAGcAuGAAAGuuAGcAGAdTsdT sense 1597-1616 10710 UCUGCUAACUUUCAUGCUA 12710 UCUGCuAACUUUcAUGCuAdTsdT antis 1606-1625 10711 AGUUAGCAGAGAUAAAGAU 12711 AGuuAGcAGAGAuAAAGAudTsdT sense 1606-1625 10712 AUCUUUAUCUCUGCUAACU 12712 AUCUUuAUCUCUGCuAACUdTsdT antis 1607-1626 10713 GUUAGCAGAGAUAAAGAUG 12713 GuuAGcAGAGAuAAAGAuGdTsdT sense 1607-1626 10714 CAUCUUUAUCUCUGCUAAC 12714 cAUCUUuAUCUCUGCuAACdTsdT antis 1608-1627 10715 UUAGCAGAGAUAAAGAUGG 12715 uuAGcAGAGAuAAAGAuGGdTsdT sense 1608-1627 10716 CCAUCUUUAUCUCUGCUAA 12716 CcAUCUUuAUCUCUGCuAAdTsdT antis 1616-1635 10717 GAUAAAGAUGGCAGCAAGG 12717 GAuAAAGAuGGcAGcAAGGdTsdT sense 1616-1635 10718 CCUUGCUGCCAUCUUUAUC 12718 CCUUGCUGCcAUCUUuAUCdTsdT antis 1617-1636 10719 AUAAAGAUGGCAGCAAGGU 12719 AuAAAGAuGGcAGcAAGGudTsdT sense 1617-1636 10720 ACCUUGCUGCCAUCUUUAU 12720 ACCUUGCUGCcAUCUUuAUdTsdT antis 1638-1657 10721 CCACAGUAGUGGCAACUCC 12721 ccAcAGuAGuGGcAAcuccdTsdT sense 1638-1657 10722 GGAGUUGCCACUACUGUGG 12722 GGAGUUGCcACuACUGUGGdTsdT antis 1647-1666 10723 UGGCAACUCCUGGCCAGGG 12723 uGGcAAcuccuGGccAGGGdTsdT sense 1647-1666 10724 CCCUGGCCAGGAGUUGCCA 12724 CCCUGGCcAGGAGUUGCcAdTsdT antis 1657-1676 10725 UGGCCAGGGUCCUGACAGG 12725 uGGccAGGGuccuGAcAGGdTsdT sense 1657-1676 10726 CCUGUCAGGACCCUGGCCA 12726 CCUGUcAGGACCCUGGCcAdTsdT antis 1660-1679 10727 CCAGGGUCCUGACAGGCCA 12727 ccAGGGuccuGAcAGGccAdTsdT sense 1660-1679 10728 UGGCCUGUCAGGACCCUGG 12728 UGGCCUGUcAGGACCCUGGdTsdT antis 1664-1683 10729 GGUCCUGACAGGCCACAGG 12729 GGuccuGAcAGGccAcAGGdTsdT sense 1664-1683 10730 CCUGUGGCCUGUCAGGACC 12730 CCUGUGGCCUGUcAGGACCdTsdT antis 1668-1687 10731 CUGACAGGCCACAGGAAGU 12731 cuGAcAGGccAcAGGAAGudTsdT sense 1668-1687 10732 ACUUCCUGUGGCCUGUCAG 12732 ACUUCCUGUGGCCUGUcAGdTsdT antis 1692-1711 10733 AUACAGACACGAAAGUGAU 12733 AuAcAGAcAcGAAAGuGAudTsdT sense 1692-1711 10734 AUCACUUUCGUGUCUGUAU 12734 AUcACUUUCGUGUCUGuAUdTsdT antis 1694-1713 10735 ACAGACACGAAAGUGAUUG 12735 AcAGAcAcGAAAGuGAuuGdTsdT sense 1694-1713 10736 CAAUCACUUUCGUGUCUGU 12736 cAAUcACUUUCGUGUCUGUdTsdT antis 1716-1735 10737 AUGGAUCAUUUGGUGUGGU 12737 AuGGAucAuuuGGuGuGGudTsdT sense 1716-1735 10738 ACCACACCAAAUGAUCCAU 12738 ACcAcACcAAAUGAUCcAUdTsdT antis 1730-1749 10739 GUGGUAUAUCAAGCCAAAC 12739 GuGGuAuAucAAGccAAAcdTsdT sense 1730-1749 10740 GUUUGGCUUGAUAUACCAC 12740 GUUUGGCUUGAuAuACcACdTsdT antis 1764-1783 10741 AACUGGUUGCCAUCAAGAA 12741 AAcuGGuuGccAucAAGAAdTsdT sense 1764-1783 10742 UUCUUGAUGGCAACCAGUU 12742 UUCUUGAUGGcAACcAGUUdTsdT antis 1765-1784 10743 ACUGGUUGCCAUCAAGAAA 12743 AcuGGuuGccAucAAGAAAdTsdT sense 1765-1784 10744 UUUCUUGAUGGCAACCAGU 12744 UUUCUUGAUGGcAACcAGUdTsdT antis 1766-1785 10745 CUGGUUGCCAUCAAGAAAG 12745 cuGGuuGccAucAAGAAAGdTsdT sense 1766-1785 10746 CUUUCUUGAUGGCAACCAG 12746 CUUUCUUGAUGGcAACcAGdTsdT antis 1771-1790 10747 UGCCAUCAAGAAAGUUCUA 12747 uGccAucAAGAAAGuucuAdTsdT sense 1771-1790 10748 UAGAACUUUCUUGAUGGCA 12748 uAGAACUUUCUUGAUGGcAdTsdT antis 1777-1796 10749 CAAGAAAGUUCUACAGGAC 12749 cAAGAAAGuucuAcAGGAcdTsdT sense 1777-1796 10750 GUCCUGUAGAACUUUCUUG 12750 GUCCUGuAGAACUUUCUUGdTsdT antis 1811-1830 10751 CGAGAGCUCCAGAUCAUGA 12751 cGAGAGcuccAGAucAuGAdTsdT sense 1811-1830 10752 UCAUGAUCUGGAGCUCUCG 12752 UcAUGAUCUGGAGCUCUCGdTsdT antis 1814-1833 10753 GAGCUCCAGAUCAUGAGAA 12753 GAGcuccAGAucAuGAGAAdTsdT sense 1814-1833 10754 UUCUCAUGAUCUGGAGCUC 12754 UUCUcAUGAUCUGGAGCUCdTsdT antis 1835-1854 10755 CUAGACCACUGUAACAUAG 12755 cuAGAccAcuGuAAcAuAGdTsdT sense 1835-1854 10756 CUAUGUUACAGUGGUCUAG 12756 CuAUGUuAcAGUGGUCuAGdTsdT antis 1881-1900 10757 GUGGUGAGAAGAAAGAUGA 12757 GuGGuGAGAAGAAAGAuGAdTsdT sense 1881-1900 10758 UCAUCUUUCUUCUCACCAC 12758 UcAUCUUUCUUCUcACcACdTsdT antis 1882-1901 10759 UGGUGAGAAGAAAGAUGAG 12759 uGGuGAGAAGAAAGAuGAGdTsdT sense 1882-1901 10760 CUCAUCUUUCUUCUCACCA 12760 CUcAUCUUUCUUCUcACcAdTsdT antis 1902-1921 10761 UCUACCUUAACCUGGUGCU 12761 ucuAccuuAAccuGGuGcudTsdT sense 1902-1921 10762 AGCACCAGGUUAAGGUAGA 12762 AGcACcAGGUuAAGGuAGAdTsdT antis 1914-1933 10763 UGGUGCUGGACUAUGUUCC 12763 uGGuGcuGGAcuAuGuuccdTsdT sense 1914-1933 10764 GGAACAUAGUCCAGCACCA 12764 GGAAcAuAGUCcAGcACcAdTsdT antis 1932-1951 10765 CGGAGACAGUGUACAGAGU 12765 cGGAGAcAGuGuAcAGAGudTsdT sense 1932-1951 10766 ACUCUGUACACUGUCUCCG 12766 ACUCUGuAcACUGUCUCCGdTsdT antis 1968-1987 10767 GAGCCAAGCAGACACUCCC 12767 GAGccAAGcAGAcAcucccdTsdT sense 1968-1987 10768 GGGAGUGUCUGCUUGGCUC 12768 GGGAGUGUCUGCUUGGCUCdTsdT antis 1969-1988 10769 AGCCAAGCAGACACUCCCU 12769 AGccAAGcAGAcAcucccudTsdT sense 1969-1988 10770 AGGGAGUGUCUGCUUGGCU 12770 AGGGAGUGUCUGCUUGGCUdTsdT antis 1976-1995 10771 CAGACACUCCCUGUGAUCU 12771 cAGAcAcucccuGuGAucudTsdT sense 1976-1995 10772 AGAUCACAGGGAGUGUCUG 12772 AGAUcAcAGGGAGUGUCUGdTsdT antis 2002-2021 10773 GUUGUAUAUGUAUCAGCUG 12773 GuuGuAuAuGuAucAGcuGdTsdT sense 2002-2021 10774 CAGCUGAUACAUAUACAAC 12774 cAGCUGAuAcAuAuAcAACdTsdT antis 2013-2032 10775 AUCAGCUGUUCAGAAGUCU 12775 AucAGcuGuucAGAAGucudTsdT sense 2013-2032 10776 AGACUUCUGAACAGCUGAU 12776 AGACUUCUGAAcAGCUGAUdTsdT antis 2014-2033 10777 UCAGCUGUUCAGAAGUCUA 12777 ucAGcuGuucAGAAGucuAdTsdT sense 2014-2033 10778 UAGACUUCUGAACAGCUGA 12778 uAGACUUCUGAAcAGCUGAdTsdT antis 2032-2051 10779 AGCCUAUAUCCAUUCCUUU 12779 AGccuAuAuccAuuccuuudTsdT sense 2032-2051 10780 AAAGGAAUGGAUAUAGGCU 12780 AAAGGAAUGGAuAuAGGCUdTsdT antis 2033-2052 10781 GCCUAUAUCCAUUCCUUUG 12781 GccuAuAuccAuuccuuuGdTsdT sense 2033-2052 10782 CAAAGGAAUGGAUAUAGGC 12782 cAAAGGAAUGGAuAuAGGCdTsdT antis 2034-2053 10783 CCUAUAUCCAUUCCUUUGG 12783 ccuAuAuccAuuccuuuGGdTsdT sense 2034-2053 10784 CCAAAGGAAUGGAUAUAGG 12784 CcAAAGGAAUGGAuAuAGGdTsdT antis 2037-2056 10785 AUAUCCAUUCCUUUGGAAU 12785 AuAuccAuuccuuuGGAAudTsdT sense 2037-2056 10786 AUUCCAAAGGAAUGGAUAU 12786 AUUCcAAAGGAAUGGAuAUdTsdT antis 2038-2057 10787 UAUCCAUUCCUUUGGAAUC 12787 uAuccAuuccuuuGGAAucdTsdT sense 2038-2057 10788 GAUUCCAAAGGAAUGGAUA 12788 GAUUCcAAAGGAAUGGAuAdTsdT antis 2041-2060 10789 CCAUUCCUUUGGAAUCUGC 12789 ccAuuccuuuGGAAucuGcdTsdT sense 2041-2060 10790 GCAGAUUCCAAAGGAAUGG 12790 GcAGAUUCcAAAGGAAUGGdTsdT antis 2045-2064 10791 UCCUUUGGAAUCUGCCAUC 12791 uccuuuGGAAucuGccAucdTsdT sense 2045-2064 10792 GAUGGCAGAUUCCAAAGGA 12792 GAUGGcAGAUUCcAAAGGAdTsdT antis 2069-2088 10793 AUUAAACCACAGAACCUCU 12793 AuuAAAccAcAGAAccucudTsdT sense 2069-2088 10794 AGAGGUUCUGUGGUUUAAU 12794 AGAGGUUCUGUGGUUuAAUdTsdT antis 2110-2129 10795 AUUAAAACUCUGUGACUUU 12795 AuuAAAAcucuGuGAcuuudTsdT sense 2110-2129 10796 AAAGUCACAGAGUUUUAAU 12796 AAAGUcAcAGAGUUUuAAUdTsdT antis 2111-2130 10797 UUAAAACUCUGUGACUUUG 12797 uuAAAAcucuGuGAcuuuGdTsdT sense 2111-2130 10798 CAAAGUCACAGAGUUUUAA 12798 cAAAGUcAcAGAGUUUuAAdTsdT antis 2114-2133 10799 AAACUCUGUGACUUUGGAA 12799 AAAcucuGuGAcuuuGGAAdTsdT sense 2114-2133 10800 UUCCAAAGUCACAGAGUUU 12800 UUCcAAAGUcAcAGAGUUUdTsdT antis 2121-2140 10801 GUGACUUUGGAAGUGCAAA 12801 GuGAcuuuGGAAGuGcAAAdTsdT sense 2121-2140 10802 UUUGCACUUCCAAAGUCAC 12802 UUUGcACUUCcAAAGUcACdTsdT antis 2122-2141 10803 UGACUUUGGAAGUGCAAAG 12803 uGAcuuuGGAAGuGcAAAGdTsdT sense 2122-2141 10804 CUUUGCACUUCCAAAGUCA 12804 CUUUGcACUUCcAAAGUcAdTsdT antis 2127-2146 10805 UUGGAAGUGCAAAGCAGCU 12805 uuGGAAGuGcAAAGcAGcudTsdT sense 2127-2146 10806 AGCUGCUUUGCACUUCCAA 12806 AGCUGCUUUGcACUUCcAAdTsdT antis 2128-2147 10807 UGGAAGUGCAAAGCAGCUG 12807 uGGAAGuGcAAAGcAGcuGdTsdT sense 2128-2147 10808 CAGCUGCUUUGCACUUCCA 12808 cAGCUGCUUUGcACUUCcAdTsdT antis 2130-2149 10809 GAAGUGCAAAGCAGCUGGU 12809 GAAGuGcAAAGcAGcuGGudTsdT sense 2130-2149 10810 ACCAGCUGCUUUGCACUUC 12810 ACcAGCUGCUUUGcACUUCdTsdT antis 2144-2163 10811 CUGGUCCGAGGAGAGCCCA 12811 cuGGuccGAGGAGAGcccAdTsdT sense 2144-2163 10812 UGGGCUCUCCUCGGACCAG 12812 UGGGCUCUCCUCGGACcAGdTsdT antis 2145-2164 10813 UGGUCCGAGGAGAGCCCAA 12813 uGGuccGAGGAGAGcccAAdTsdT sense 2145-2164 10814 UUGGGCUCUCCUCGGACCA 12814 UUGGGCUCUCCUCGGACcAdTsdT antis 2152-2171 10815 AGGAGAGCCCAAUGUUUCA 12815 AGGAGAGcccAAuGuuucAdTsdT sense 2152-2171 10816 UGAAACAUUGGGCUCUCCU 12816 UGAAAcAUUGGGCUCUCCUdTsdT antis 2173-2192 10817 UAUCUGUUCUCGGUACUAC 12817 uAucuGuucucGGuAcuAcdTsdT sense 2173-2192 10818 GUAGUACCGAGAACAGAUA 12818 GuAGuACCGAGAAcAGAuAdTsdT antis 2244-2263 10819 UAUGGUCUGCAGGCUGUGU 12819 uAuGGucuGcAGGcuGuGudTsdT sense 2244-2263 10820 ACACAGCCUGCAGACCAUA 12820 AcAcAGCCUGcAGACcAuAdTsdT antis 2293-2312 10821 AUUUCCUGGGGACAGUGGU 12821 AuuuccuGGGGAcAGuGGudTsdT sense 2293-2312 10822 ACCACUGUCCCCAGGAAAU 12822 ACcACUGUCCCcAGGAAAUdTsdT antis 2296-2315 10823 UCCUGGGGACAGUGGUGUG 12823 uccuGGGGAcAGuGGuGuGdTsdT sense 2296-2315 10824 CACACCACUGUCCCCAGGA 12824 cAcACcACUGUCCCcAGGAdTsdT antis 2297-2316 10825 CCUGGGGACAGUGGUGUGG 12825 ccuGGGGAcAGuGGuGuGGdTsdT sense 2297-2316 10826 CCACACCACUGUCCCCAGG 12826 CcAcACcACUGUCCCcAGGdTsdT antis 2320-2339 10827 GUUGGUGGAAAUAAUAAAG 12827 GuuGGuGGAAAuAAuAAAGdTsdT sense 2320-2339 10828 CUUUAUUAUUUCCACCAAC 12828 CUUuAUuAUUUCcACcAACdTsdT antis 2321-2340 10829 UUGGUGGAAAUAAUAAAGG 12829 uuGGuGGAAAuAAuAAAGGdTsdT sense 2321-2340 10830 CCUUUAUUAUUUCCACCAA 12830 CCUUuAUuAUUUCcACcAAdTsdT antis 2322-2341 10831 UGGUGGAAAUAAUAAAGGU 12831 uGGuGGAAAuAAuAAAGGudTsdT sense 2322-2341 10832 ACCUUUAUUAUUUCCACCA 12832 ACCUUuAUuAUUUCcACcAdTsdT antis 2348-2367 10833 ACACCAACAAGGGAGCAAA 12833 AcAccAAcAAGGGAGcAAAdTsdT sense 2348-2367 10834 UUUGCUCCCUUGUUGGUGU 12834 UUUGCUCCCUUGUUGGUGUdTsdT antis 2349-2368 10835 CACCAACAAGGGAGCAAAU 12835 cAccAAcAAGGGAGcAAAudTsdT sense 2349-2368 10836 AUUUGCUCCCUUGUUGGUG 12836 AUUUGCUCCCUUGUUGGUGdTsdT antis 2389-2408 10837 UACAGAAUUCAAAUUCCCU 12837 uAcAGAAuucAAAuucccudTsdT sense 2389-2408 10838 AGGGAAUUUGAAUUCUGUA 12838 AGGGAAUUUGAAUUCUGuAdTsdT antis 2414-2433 10839 AAGGCACAUCCUUGGACAA 12839 AAGGcAcAuccuuGGAcAAdTsdT sense 2414-2433 10840 UUGUCCAAGGAUGUGCCUU 12840 UUGUCcAAGGAUGUGCCUUdTsdT antis 2419-2438 10841 ACAUCCUUGGACAAAGGUC 12841 AcAuccuuGGAcAAAGGucdTsdT sense 2419-2438 10842 GACCUUUGUCCAAGGAUGU 12842 GACCUUUGUCcAAGGAUGUdTsdT antis 2429-2448 10843 ACAAAGGUCUUCCGGCCCC 12843 AcAAAGGucuuccGGccccdTsdT sense 2429-2448 10844 GGGGCCGGAAGACCUUUGU 12844 GGGGCCGGAAGACCUUUGUdTsdT antis 2460-2479 10845 AGGCAAUUGCACUGUGCAG 12845 AGGcAAuuGcAcuGuGcAGdTsdT sense 2460-2479 10846 CUGCACAGUGCAAUUGCCU 12846 CUGcAcAGUGcAAUUGCCUdTsdT antis 2474-2493 10847 UGCAGCCGUCUGCUGGAGU 12847 uGcAGccGucuGcuGGAGudTsdT sense 2474-2493 10848 ACUCCAGCAGACGGCUGCA 12848 ACUCcAGcAGACGGCUGcAdTsdT antis 2480-2499 10849 CGUCUGCUGGAGUACACAC 12849 cGucuGcuGGAGuAcAcAcdTsdT sense 2480-2499 10850 GUGUGUACUCCAGCAGACG 12850 GUGUGuACUCcAGcAGACGdTsdT antis 2481-2500 10851 GUCUGCUGGAGUACACACC 12851 GucuGcuGGAGuAcAcAccdTsdT sense 2481-2500 10852 GGUGUGUACUCCAGCAGAC 12852 GGUGUGuACUCcAGcAGACdTsdT antis 2511-2530 10853 UAACACCACUGGAAGCUUG 12853 uAAcAccAcuGGAAGcuuGdTsdT sense 2511-2530 10854 CAAGCUUCCAGUGGUGUUA 12854 cAAGCUUCcAGUGGUGUuAdTsdT antis 1540-1559 10855 GAGAACCACCUCCUUUGCG 12855 GAGAAccAccuccuuuGcGdTsdT sense 1540-1559 10856 CGCAAAGGAGGUGGUUCUC 12856 CGcAAAGGAGGUGGUUCUCdTsdT antis 1883-1902 10857 GGUGAGAAGAAAGAUGAGG 12857 GGuGAGAAGAAAGAuGAGGdTsdT sense 1883-1902 10858 CCUCAUCUUUCUUCUCACC 12858 CCUcAUCUUUCUUCUcACCdTsdT antis 2044-2063 10859 UUCCUUUGGAAUCUGCCAU 12859 uuccuuuGGAAucuGccAudTsdT sense 2044-2063 10860 AUGGCAGAUUCCAAAGGAA 12860 AUGGcAGAUUCcAAAGGAAdTsdT antis 2205-2224 10861 UGAUCUUUGGAGCCACUGA 12861 uGAucuuuGGAGccAcuGAdTsdT sense 2205-2224 10862 UCAGUGGCUCCAAAGAUCA 12862 UcAGUGGCUCcAAAGAUcAdTsdT antis 2331-2350 10863 UAAUAAAGGUCCUAGGAAC 12863 uAAuAAAGGuccuAGGAAcdTsdT sense 2331-2350 10864 GUUCCUAGGACCUUUAUUA 12864 GUUCCuAGGACCUUuAUuAdTsdT antis 2384-2403 10865 AAUUAUACAGAAUUCAAAU 12865 AAuuAuAcAGAAuucAAAudTsdT sense 2384-2403 10866 AUUUGAAUUCUGUAUAAUU 12866 AUUUGAAUUCUGuAuAAUUdTsdT antis 1557-1576 10867 CGGAGAGCUGCAAGCCAGU 12867 cGGAGAGcuGcAAGccAGudTsdT sense 1557-1576 10868 ACUGGCUUGCAGCUCUCCG 12868 ACUGGCUUGcAGCUCUCCGdTsdT antis 1567-1586 10869 CAAGCCAGUGCAGCAGCCU 12869 cAAGccAGuGcAGcAGccudTsdT sense 1567-1586 10870 AGGCUGCUGCACUGGCUUG 12870 AGGCUGCUGcACUGGCUUGdTsdT antis 1568-1587 10871 AAGCCAGUGCAGCAGCCUU 12871 AAGccAGuGcAGcAGccuudTsdT sense 1568-1587 10872 AAGGCUGCUGCACUGGCUU 12872 AAGGCUGCUGcACUGGCUUdTsdT antis 1580-1599 10873 CAGCCUUCAGCUUUUGGUA 12873 cAGccuucAGcuuuuGGuAdTsdT sense 1580-1599 10874 UACCAAAAGCUGAAGGCUG 12874 uACcAAAAGCUGAAGGCUGdTsdT antis 1583-1602 10875 CCUUCAGCUUUUGGUAGCA 12875 ccuucAGcuuuuGGuAGcAdTsdT sense 1583-1602 10876 UGCUACCAAAAGCUGAAGG 12876 UGCuACcAAAAGCUGAAGGdTsdT antis 1590-1609 10877 CUUUUGGUAGCAUGAAAGU 12877 cuuuuGGuAGcAuGAAAGudTsdT sense 1590-1609 10878 ACUUUCAUGCUACCAAAAG 12878 ACUUUcAUGCuACcAAAAGdTsdT antis 1609-1628 10879 UAGCAGAGAUAAAGAUGGC 12879 uAGcAGAGAuAAAGAuGGcdTsdT sense 1609-1628 10880 GCCAUCUUUAUCUCUGCUA 12880 GCcAUCUUuAUCUCUGCuAdTsdT antis 1615-1634 10881 AGAUAAAGAUGGCAGCAAG 12881 AGAuAAAGAuGGcAGcAAGdTsdT sense 1615-1634 10882 CUUGCUGCCAUCUUUAUCU 12882 CUUGCUGCcAUCUUuAUCUdTsdT antis 1655-1674 10883 CCUGGCCAGGGUCCUGACA 12883 ccuGGccAGGGuccuGAcAdTsdT sense 1655-1674 10884 UGUCAGGACCCUGGCCAGG 12884 UGUcAGGACCCUGGCcAGGdTsdT antis 1671-1690 10885 ACAGGCCACAGGAAGUCAG 12885 AcAGGccAcAGGAAGucAGdTsdT sense 1671-1690 10886 CUGACUUCCUGUGGCCUGU 12886 CUGACUUCCUGUGGCCUGUdTsdT antis 1672-1691 10887 CAGGCCACAGGAAGUCAGU 12887 cAGGccAcAGGAAGucAGudTsdT sense 1672-1691 10888 ACUGACUUCCUGUGGCCUG 12888 ACUGACUUCCUGUGGCCUGdTsdT antis 1747-1766 10889 ACUUUGUGAUUCUGGAGAA 12889 AcuuuGuGAuucuGGAGAAdTsdT sense 1747-1766 10890 UUCUCCAGAAUCACAAAGU 12890 UUCUCcAGAAUcAcAAAGUdTsdT antis 1748-1767 10891 CUUUGUGAUUCUGGAGAAC 12891 cuuuGuGAuucuGGAGAAcdTsdT sense 1748-1767 10892 GUUCUCCAGAAUCACAAAG 12892 GUUCUCcAGAAUcAcAAAGdTsdT antis 1750-1769 10893 UUGUGAUUCUGGAGAACUG 12893 uuGuGAuucuGGAGAAcuGdTsdT sense 1750-1769 10894 CAGUUCUCCAGAAUCACAA 12894 cAGUUCUCcAGAAUcAcAAdTsdT antis 1751-1770 10895 UGUGAUUCUGGAGAACUGG 12895 uGuGAuucuGGAGAAcuGGdTsdT sense 1751-1770 10896 CCAGUUCUCCAGAAUCACA 12896 CcAGUUCUCcAGAAUcAcAdTsdT antis 1752-1771 10897 GUGAUUCUGGAGAACUGGU 12897 GuGAuucuGGAGAAcuGGudTsdT sense 1752-1771 10898 ACCAGUUCUCCAGAAUCAC 12898 ACcAGUUCUCcAGAAUcACdTsdT antis 1753-1772 10899 UGAUUCUGGAGAACUGGUU 12899 uGAuucuGGAGAAcuGGuudTsdT sense 1753-1772 10900 AACCAGUUCUCCAGAAUCA 12900 AACcAGUUCUCcAGAAUcAdTsdT antis 2117-2136 10901 CUCUGUGACUUUGGAAGUG 12901 cucuGuGAcuuuGGAAGuGdTsdT sense 2117-2136 10902 CACUUCCAAAGUCACAGAG 12902 cACUUCcAAAGUcAcAGAGdTsdT antis 2118-2137 10903 UCUGUGACUUUGGAAGUGC 12903 ucuGuGAcuuuGGAAGuGcdTsdT sense 2118-2137 10904 GCACUUCCAAAGUCACAGA 12904 GcACUUCcAAAGUcAcAGAdTsdT antis 2148-2167 10905 UCCGAGGAGAGCCCAAUGU 12905 uccGAGGAGAGcccAAuGudTsdT sense 2148-2167 10906 ACAUUGGGCUCUCCUCGGA 12906 AcAUUGGGCUCUCCUCGGAdTsdT antis 2202-2221 10907 AGUUGAUCUUUGGAGCCAC 12907 AGuuGAucuuuGGAGccAcdTsdT sense 2202-2221 10908 GUGGCUCCAAAGAUCAACU 12908 GUGGCUCcAAAGAUcAACUdTsdT antis 2203-2222 10909 GUUGAUCUUUGGAGCCACU 12909 GuuGAucuuuGGAGccAcudTsdT sense 2203-2222 10910 AGUGGCUCCAAAGAUCAAC 12910 AGUGGCUCcAAAGAUcAACdTsdT antis 2204-2223 10911 UUGAUCUUUGGAGCCACUG 12911 uuGAucuuuGGAGccAcuGdTsdT sense 2204-2223 10912 CAGUGGCUCCAAAGAUCAA 12912 cAGUGGCUCcAAAGAUcAAdTsdT antis 2206-2225 10913 GAUCUUUGGAGCCACUGAU 12913 GAucuuuGGAGccAcuGAudTsdT sense 2206-2225 10914 AUCAGUGGCUCCAAAGAUC 12914 AUcAGUGGCUCcAAAGAUCdTsdT antis 2245-2264 10915 AUGGUCUGCAGGCUGUGUG 12915 AuGGucuGcAGGcuGuGuGdTsdT sense 2245-2264 10916 CACACAGCCUGCAGACCAU 12916 cAcAcAGCCUGcAGACcAUdTsdT antis 2252-2271 10917 GCAGGCUGUGUGUUGGCUG 12917 GcAGGcuGuGuGuuGGcuGdTsdT sense 2252-2271 10918 CAGCCAACACACAGCCUGC 12918 cAGCcAAcAcAcAGCCUGCdTsdT antis 2266-2285 10919 GGCUGAAUUGUUGCUAGGA 12919 GGcuGAAuuGuuGcuAGGAdTsdT sense 2266-2285 10920 UCCUAGCAACAAUUCAGCC 12920 UCCuAGcAAcAAUUcAGCCdTsdT antis 2294-2313 10921 UUUCCUGGGGACAGUGGUG 12921 uuuccuGGGGAcAGuGGuGdTsdT sense 2294-2313 10922 CACCACUGUCCCCAGGAAA 12922 cACcACUGUCCCcAGGAAAdTsdT antis 2295-2314 10923 UUCCUGGGGACAGUGGUGU 12923 uuccuGGGGAcAGuGGuGudTsdT sense 2295-2314 10924 ACACCACUGUCCCCAGGAA 12924 AcACcACUGUCCCcAGGAAdTsdT antis 2350-2369 10925 ACCAACAAGGGAGCAAAUU 12925 AccAAcAAGGGAGcAAAuudTsdT sense 2350-2369 10926 AAUUUGCUCCCUUGUUGGU 12926 AAUUUGCUCCCUUGUUGGUdTsdT antis 2382-2401 10927 CAAAUUAUACAGAAUUCAA 12927 cAAAuuAuAcAGAAuucAAdTsdT sense 2382-2401 10928 UUGAAUUCUGUAUAAUUUG 12928 UUGAAUUCUGuAuAAUUUGdTsdT antis 1543-1562 10929 AACCACCUCCUUUGCGGAG 12929 AAccAccuccuuuGcGGAGdTsdT sense 1543-1562 10930 CUCCGCAAAGGAGGUGGUU 12930 CUCCGcAAAGGAGGUGGUUdTsdT antis 1544-1563 10931 ACCACCUCCUUUGCGGAGA 12931 AccAccuccuuuGcGGAGAdTsdT sense 1544-1563 10932 UCUCCGCAAAGGAGGUGGU 12932 UCUCCGcAAAGGAGGUGGUdTsdT antis 1545-1564 10933 CCACCUCCUUUGCGGAGAG 12933 ccAccuccuuuGcGGAGAGdTsdT sense 1545-1564 10934 CUCUCCGCAAAGGAGGUGG 12934 CUCUCCGcAAAGGAGGUGGdTsdT antis 1712-1731 10935 GGAAAUGGAUCAUUUGGUG 12935 GGAAAuGGAucAuuuGGuGdTsdT sense 1712-1731 10936 CACCAAAUGAUCCAUUUCC 12936 cACcAAAUGAUCcAUUUCCdTsdT antis 1879-1898 10937 GAGUGGUGAGAAGAAAGAU 12937 GAGuGGuGAGAAGAAAGAudTsdT sense 1879-1898 10938 AUCUUUCUUCUCACCACUC 12938 AUCUUUCUUCUcACcACUCdTsdT antis 2060-2079 10939 CAUCGAGACAUUAAACCAC 12939 cAucGAGAcAuuAAAccAcdTsdT sense 2060-2079 10940 GUGGUUUAAUGUCUCGAUG 12940 GUGGUUuAAUGUCUCGAUGdTsdT antis 2062-2081 10941 UCGAGACAUUAAACCACAG 12941 ucGAGAcAuuAAAccAcAGdTsdT sense 2062-2081 10942 CUGUGGUUUAAUGUCUCGA 12942 CUGUGGUUuAAUGUCUCGAdTsdT antis 2061-2080 10943 AUCGAGACAUUAAACCACA 12943 AucGAGAcAuuAAAccAcAdTsdT sense 2061-2080 10944 UGUGGUUUAAUGUCUCGAU 12944 UGUGGUUuAAUGUCUCGAUdTsdT antis 2058-2077 10945 GCCAUCGAGACAUUAAACC 12945 GccAucGAGAcAuuAAAccdTsdT sense 2058-2077 10946 GGUUUAAUGUCUCGAUGGC 12946 GGUUuAAUGUCUCGAUGGCdTsdT antis 2059-2078 10947 CCAUCGAGACAUUAAACCA 12947 ccAucGAGAcAuuAAAccAdTsdT sense 2059-2078 10948 UGGUUUAAUGUCUCGAUGG 12948 UGGUUuAAUGUCUCGAUGGdTsdT antis 1639-1658 10949 CACAGUAGUGGCAACUCCU 12949 cAcAGuAGuGGcAAcuccudTsdT sense 1639-1658 10950 AGGAGUUGCCACUACUGUG 12950 AGGAGUUGCcACuACUGUGdTsdT antis 2064-2083 10951 GAGACAUUAAACCACAGAA 12951 GAGAcAuuAAAccAcAGAAdTsdT sense 2064-2083 10952 UUCUGUGGUUUAAUGUCUC 12952 UUCUGUGGUUuAAUGUCUCdTsdT antis 1641-1660 10953 CAGUAGUGGCAACUCCUGG 12953 cAGuAGuGGcAAcuccuGGdTsdT sense 1641-1660 10954 CCAGGAGUUGCCACUACUG 12954 CcAGGAGUUGCcACuACUGdTsdT antis 1812-1831 10955 GAGAGCUCCAGAUCAUGAG 12955 GAGAGcuccAGAucAuGAGdTsdT sense 1812-1831 10956 CUCAUGAUCUGGAGCUCUC 12956 CUcAUGAUCUGGAGCUCUCdTsdT antis 2063-2082 10957 CGAGACAUUAAACCACAGA 12957 cGAGAcAuuAAAccAcAGAdTsdT sense 2063-2082 10958 UCUGUGGUUUAAUGUCUCG 12958 UCUGUGGUUuAAUGUCUCGdTsdT antis 2065-2084 10959 AGACAUUAAACCACAGAAC 12959 AGAcAuuAAAccAcAGAAcdTsdT sense 2065-2084 10960 GUUCUGUGGUUUAAUGUCU 12960 GUUCUGUGGUUuAAUGUCUdTsdT antis 2112-2131 10961 UAAAACUCUGUGACUUUGG 12961 uAAAAcucuGuGAcuuuGGdTsdT sense 2112-2131 10962 CCAAAGUCACAGAGUUUUA 12962 CcAAAGUcAcAGAGUUUuAdTsdT antis 2119-2138 10963 CUGUGACUUUGGAAGUGCA 12963 cuGuGAcuuuGGAAGuGcAdTsdT sense 2119-2138 10964 UGCACUUCCAAAGUCACAG 12964 UGcACUUCcAAAGUcAcAGdTsdT antis 2123-2142 10965 GACUUUGGAAGUGCAAAGC 12965 GAcuuuGGAAGuGcAAAGcdTsdT sense 2123-2142 10966 GCUUUGCACUUCCAAAGUC 12966 GCUUUGcACUUCcAAAGUCdTsdT antis 2131-2150 10967 AAGUGCAAAGCAGCUGGUC 12967 AAGuGcAAAGcAGcuGGucdTsdT sense 2131-2150 10968 GACCAGCUGCUUUGCACUU 12968 GACcAGCUGCUUUGcACUUdTsdT antis 1715-1734 10969 AAUGGAUCAUUUGGUGUGG 12969 AAuGGAucAuuuGGuGuGGdTsdT sense 1715-1734 10970 CCACACCAAAUGAUCCAUU 12970 CcAcACcAAAUGAUCcAUUdTsdT antis 2482-2501 10971 UCUGCUGGAGUACACACCU 12971 ucuGcuGGAGuAcAcAccudTsdT sense 2482-2501 10972 AGGUGUGUACUCCAGCAGA 12972 AGGUGUGuACUCcAGcAGAdTsdT antis 1714-1733 10973 AAAUGGAUCAUUUGGUGUG 12973 AAAuGGAucAuuuGGuGuGdTsdT sense 1714-1733 10974 CACACCAAAUGAUCCAUUU 12974 cAcACcAAAUGAUCcAUUUdTsdT antis 1884-1903 10975 GUGAGAAGAAAGAUGAGGU 12975 GuGAGAAGAAAGAuGAGGudTsdT sense 1884-1903 10976 ACCUCAUCUUUCUUCUCAC 12976 ACCUcAUCUUUCUUCUcACdTsdT antis 2039-2058 10977 AUCCAUUCCUUUGGAAUCU 12977 AuccAuuccuuuGGAAucudTsdT sense 2039-2058 10978 AGAUUCCAAAGGAAUGGAU 12978 AGAUUCcAAAGGAAUGGAUdTsdT antis 2113-2132 10979 AAAACUCUGUGACUUUGGA 12979 AAAAcucuGuGAcuuuGGAdTsdT sense 2113-2132 10980 UCCAAAGUCACAGAGUUUU 12980 UCcAAAGUcAcAGAGUUUUdTsdT antis 2246-2265 10981 UGGUCUGCAGGCUGUGUGU 12981 uGGucuGcAGGcuGuGuGudTsdT sense 2246-2265 10982 ACACACAGCCUGCAGACCA 12982 AcAcAcAGCCUGcAGACcAdTsdT antis 1713-1732 10983 GAAAUGGAUCAUUUGGUGU 12983 GAAAuGGAucAuuuGGuGudTsdT sense 1713-1732 10984 ACACCAAAUGAUCCAUUUC 12984 AcACcAAAUGAUCcAUUUCdTsdT antis

TABLE 4 Sequences of duplexes targeting Mouse GSK3-alpha Target sequence start identifies first nucleotide in target sequence in mouse GSK3-alpha mRNA NM_001031667.1. Unmodified sense strand is identical to target sequence. Unmodified antisense strand is complementary to target sequence. Target SEQ SEQ sequence ID ID Duplex start NO: NO: unmodified unmodified sense strand antisense strand 5′ to 3′ 5′ to 3′ AD-18821  670 12985 AACUGCAGAUUAUGCGUAA 12996  UUACGCAUAAUCUGCAGUU AD-18823  330 12986 GGCGGCGGGAAAGCGUCAG 12997 CUGACGCUUUCCCGCCGCC AD-18824  239 12987 GGCGCGGACCAGCUCGUUC 12998 GAACGAGCUGGUCCGCGCC AD-18825 1340 12988 CCUACUGGAGUACACGCCA 12999 UGGCGUGUACUCCAGUAGG AD-18826 1342 12989 UACUGGAGUACACGCCAUC 13000 GAUGGCGUGUACUCCAGUA AD-18827 1073 12990 CACAGAUUACACCUCGUCC 13001 GGACGAGGUGUAAUCUGUG AD-18828 1236 12991 CCUAACUAUACGGAGUUCA 13002 UGAACUCCGUAUAGUUAGG AD-18829  435 12992 GCGGGCACUAGCUUCCCGC 13003 GCGGGAAGCUAGUGCCCGC AD-18830 1231 12993 UGAACCCUAACUAUACGGA 13004 UCCGUAUAGUUAGGGUUCA AD-18831 1234 12994 ACCCUAACUAUACGGAGUU 13005 AACUCCGUAUAGUUAGGGU AD-18832 1235 12995 CCCUAACUAUACGGAGUUC 13006 GAACUCCGUAUAGUUAGGG modified modified sense strand antisense strand 5′ to 3′ 5′ to 3′ AD-18821-b1  670 13007 AAcuGcAGAuuAuGcGuAAdTsdT 13018 UuACGcAuAAUCUGcAGUUdTsdT AD-18823-b1  330 13008 GGcGGcGGGAAAGcGucAGdTsdT 13019 CUGACGCUUUCCCGCCGCCdTsdT AD-18824-b1  239 13009 GGcGcGGAccAGcucGuucdTsdT 13020 GAACGAGCUGGUCCGCGCCdTsdT AD-18825-b1 1340 13010 ccuAcuGGAGuAcAcGccAdTsdT 13021 UGGCGUGuACUCcAGuAGGdTsdT AD-18826-b1 1342 13011 uAcuGGAGuAcAcGccAucdTsdT 13022 GAUGGCGUGuACUCcAGuAdTsdT AD-18827-b1 1073 13012 cAcAGAuuAcAccucGuccdTsdT 13023 GGACGAGGUGuAAUCUGUGdTsdT AD-18828-b1 1236 13013 ccuAAcuAuAcGGAGuucAdTsdT 13024 UGAACUCCGuAuAGUuAGGdTsdT AD-18829-b1  435 13014 GcGGGcAcuAGcuucccGcdTsdT 13025 GCGGGAAGCuAGUGCCCGCdTsdT AD-18830-b1 1231 13015 uGAAcccuAAcuAuAcGGAdTsdT 13026 UCCGuAuAGUuAGGGUUcAdTsdT AD-18831-b1 1234 13016 AcccuAAcuAuAcGGAGuudTsdT 13027 AACUCCGuAuAGUuAGGGUdTsdT AD-18832-b1 1235 13017 cccuAAcuAuAcGGAGuucdTsdT 13028 GAACUCCGuAuAGUuAGGGdTsdT

TABLE 5 Sequences of duplexes targeting Mouse GSK3-beta Target sequence start identifies first nucleotide in target sequence in mouse GSK3-beta mRNA NM_019827.6. Unmodified sense strand is identical to target sequence. Unmodified antisense strand is complementary to target sequence. Target SEQ SEQ sequence ID ID Duplex start NO: NO: unmodified unmodified sense strand antisense strand 5′ to 3′ 5′ to 3′ AD-18833 1842 13029 ACUGUAACAUAGUCCGACU 13040 AGUCGGACUAUGUUACAGU AD-18834 1843 13030 CUGUAACAUAGUCCGACUG 13041 CAGUCGGACUAUGUUACAG AD-18835 1952 13031 GCCAGACACUAUAGUCGAG 13042 CUCGACUAUAGUGUCUGGC AD-18836 1847 13032 AACAUAGUCCGACUGCGGU 13043 ACCGCAGUCGGACUAUGUU AD-18837 1838 13033 GACCACUGUAACAUAGUCC 13044 GGACUAUGUUACAGUGGUC AD-18838 1846 13034 UAACAUAGUCCGACUGCGG 13045 CCGCAGUCGGACUAUGUUA AD-18839 1849 13035 CAUAGUCCGACUGCGGUAU 13046 AUACCGCAGUCGGACUAUG AD-18841 1957 13036 ACACUAUAGUCGAGCCAAG 13047 CUUGGCUCGACUAUAGUGU AD-18842 2169 13037 CAUAUAUCUGUUCUCGGUA 13048 UACCGAGAACAGAUAUAUG AD-18843 1788 13038 UACAGGACAAGCGAUUUAA 13049 UUAAAUCGCUUGUCCUGUA AD-18844 1862 13039 ACUGUAACAUAGUCCGACU 13050 UCGAGUAGAAGAAAUACCG modified modified sense strand antisense strand 5′ to 3′ 5′ to 3′ AD-18833-b1 1842 13051 AcuGuAAcAuAGuccGAcudTsdT 13062 AGUCGGACuAUGUuAcAGUdTsdT AD-18834-b1 1843 13052 cuGuAAcAuAGuccGAcuGdTsdT 13063 cAGUCGGACuAUGUuAcAGdTsdT AD-18835-b1 1952 13053 GccAGAcAcuAuAGucGAGdTsdT 13064 CUCGACuAuAGUGUCUGGCdTsdT AD-18836-b1 1847 13054 AAcAuAGuccGAcuGcGGudTsdT 13065 ACCGcAGUCGGACuAUGUUdTsdT AD-18837-b1 1838 13055 GAccAcuGuAAcAuAGuccdTsdT 13066 GGACuAUGUuAcAGUGGUCdTsdT AD-18838-b1 1846 13056 uAAcAuAGuccGAcuGcGGdTsdT 13067 CCGcAGUCGGACuAUGUuAdTsdT AD-18839-b1 1849 13057 cAuAGuccGAcuGcGGuAudTsdT 13068 AuACCGcAGUCGGACuAUGdTsdT AD-18841-b1 1957 13058 AcAcuAuAGucGAGccAAGdTsdT 13069 CUUGGCUCGACuAuAGUGUdTsdT AD-18842-b1 2169 13059 cAuAuAucuGuucucGGuAdTsdT 13070 uACCGAGAAcAGAuAuAUGdTsdT AD-18843-b1 1788 13060 uAcAGGAcAAGcGAuuuAAdTsdT 13071 UuAAAUCGCUUGUCCUGuAdTsdT AD-18844-b1 1862 13061 cGGuAuuucuucuAcucGAdTsdT 13072 UCGAGuAGAAGAAAuACCGdTsdT

TABLE 6 Sequences of duplexes targeting Human GSK3-alpha Target sequence start identifies first nucleotide in target sequence in human GSK3-alpha mRNA NM_002093. Unmodified sense strand is identical to target sequence. Unmodified antisense strand is complementary to target sequence. Target SEQ unmodified SEQ unmodified sequence ID sense strand ID antisense strand Duplex start NO: 5′ to 3′ NO: 5′ to 3′ huGSKA-1 1273 13073 AGCUCCAGAUCAUGAGAAA 13081 UUUCUCAUGAUCUGGAGCU huGSKA-2 1979 13074 UCUGCUGGAGUAUACACCA 13082 UGGUGUAUACUCCAGCAGA huGSKA-3 1981 13075 UGCUGGAGUAUACACCAAC 13083 GUUGGUGUAUACUCCAGCA huGSKA-4 1676 13076 CACUGAUUAUACCUCUAGU 13084 ACUAGAGGUAUAAUCAGUG huGSKA-5 1839 13077 CCAAACUACACAGAAUUUA 13085 UAAAUUCUGUGUAGUUUGG huGSKA-6 1834 13078 UGAACCCAAACUACACAGA 13086 UCUGUGUAGUUUGGGUUCA huGSKA-7 1837 13079 ACCCAAACUACACAGAAUU 13087 AAUUCUGUGUAGUUUGGGU huGSKA-8 1838 13080 CCCAAACUACACAGAAUUU 13088 AAAUUCUGUGUAGUUUGGG Human GSK alpha duplexes correspond to the mouse GSK alpha duplexes as follows:

Mouse duplex Human duplex AD-18821 huGSKA-1 AD-18825 huGSKA-2 AD-18826 huGSKA-3 AD-18827 huGSKA-4 AD-18828 huGSKA-5 AD-18830 huGSKA-6 AD-18831 huGSKA-7 AD-18832 huGSKA-8

TABLE 7 Sequences of duplexes targeting Human GSK3-beta Target sequence start identifies first nucleotide in target sequence in human GSK3-beta mRNA NM_019884. Unmodified sense strand is identical to target sequence. Unmodified antisense strand is complementary to target sequence. Target SEQ unmodified SEQ unmodified sequence ID antisense strand ID sense strand Duplex start NO: 5′ to 3′ NO: 5′ to 3′ huGSKB-1 625 13088 ACUGCAAUAUUGUGAGGCU 13099 AGCCUCACAAUAUUGCAGU huGSKB-2 626 13089 CUGCAAUAUUGUGAGGCUG 13100 CAGCCUCACAAUAUUGCAG huGSKB-3 735 13090 GCCCGCCACUUCACCAAGG 13101 CCUUGGUGAAGUGGCGGGC huGSKB-4 630 13091 AAUAUUGUGAGGCUGAGAU 13102 AUCUCAGCCUCACAAUAUU huGSKB-5 621 13092 GACCACUGCAAUAUUGUGA 13103 UCACAAUAUUGCAGUGGUC huGSKB-6 629 13093 CAAUAUUGUGAGGCUGAGA 13104 UCUCAGCCUCACAAUAUUG huGSKB-7 632 13094 UAUUGUGAGGCUGAGAUAC 13105 GUAUCUCAGCCUCACAAUA huGSKB-8 740 13095 CCACUUCACCAAGGCCAAG 13106 CUUGGCCUUGGUGAAGUGG huGSKB-9 952 13096 CCUACAUCUGUUCUCGCUA 13107 UAGCGAGAACAGAUGUAGG huGSKB-10 571 13097 UCCAGGACAAGAGGUUCAA 13108 UUGAACCUCUUGUCCUGGA huGSKB-11 645 13098 AGAUACUUUUUCUACUCCA 13109 UGGAGUAGAAAAAGUAUCU Human GSK beta duplexes correspond to the mouse GSK beta duplexes as follows:

Mouse Duplex Human Duplex AD-18833 huGSKB-1 AD-18834 huGSKB-2 AD-18835 huGSKB-3 AD-18836 huGSKB-4 AD-18837 huGSKB-5 AD-18838 huGSKB-6 AD-18839 huGSKB-7 AD-18841 huGSKB-8 AD-18842 huGSKB-9 AD-18843 huGSKB-10 AD-18844 huGSKB-11 

1. A double-stranded ribonucleic acid (dsRNA), comprising a sense strand and an antisense strand, the sense strand comprising a first sequence and the antisense strand comprising a second sequence, the second sequence comprising a region complementary to an mRNA encoding a GSK-3, and wherein said region of complementarity is less than 30 nucleotides in length.
 2. The dsRNA of claim 1, the second sequence comprising a region complementary to NM_(—)019884, NM_(—)00103166, :NM_(—)002093, or NM_(—)019827. 3-10. (canceled)
 11. The dsRNA of claim 1, the sense strand comprising at least 15 nucleotides of one of the sense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table 7 and the antisense strand comprising at least 15 nucleotides of one of the antisense strand sequences in Table 1 or Table 2 or Table 4 or Table 5 or Table 6 or Table
 7. 12-15. (canceled)
 16. The dsRNA of claim 1, wherein said dsRNA comprises at least one modified nucleotide.
 17. The dsRNA of claim 16, wherein at least one of said modified nucleotides is chosen from the group of: a 2′-O-methyl modified nucleotide, a nucleotide comprising a 5′-phosphorothioate group, and a terminal nucleotide linked to a cholesteryl derivative or dodecanoic acid bisdecylamide group.
 18. The dsRNA of claim 16, wherein said modified nucleotide is chosen from the group of: a 2′-deoxy-2′-fluoro modified nucleotide, a 2′-deoxy-modified nucleotide, a locked nucleotide, an abasic nucleotide, 2′-amino-modified nucleotide, 2′-alkyl-modified nucleotide, morpholino nucleotide, a phosphoramidate, and a non-natural base comprising nucleotide.
 19. The dsRNA of claim 16, comprising at least one 2′-O-methyl modified nucleotide and at least one nucleotide comprising a 5′-phosphorothioate group.
 20. The dsRNA of claim 1, wherein the region of complementary is at least 15 nucleotides in length.
 21. The dsRNA of claim 1, wherein the region of complementarity is between 19 and 21 nucleotides in length.
 22. The dsRNA of claim 1, wherein the region of complementarity is 19 nucleotides in length.
 23. The dsRNA of claim 1, wherein administration of the dsRNA inhibits expression of GSK3 by more than 40%.
 24. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of less than or equal to 10 nM in suppressing GSK3.
 25. The dsRNA of claim 1, wherein the dsRNA exhibits an 1050 of less than or equal to 1.0 nM in suppressing GSK3.
 26. A cell comprising the dsRNA of claim
 1. 27. A vector comprising at least one strand of the dsRNA of claim
 1. 28. A cell comprising the vector of claim
 27. 29. A pharmaceutical composition for inhibiting expression of an GSK-3 gene comprising the dsRNA of claim
 1. 30. A method of inhibiting GSK-3 expression in a cell, the method comprising: (a) introducing into the cell the dsRNA of claim 1; and (b) maintaining the cell produced in step (a) for a time sufficient to obtain degradation of the mRNA transcript of a GSK-3 gene, thereby inhibiting expression of a GSK-3 gene in the cell.
 31. A method of treating a disorder mediated by GSK-3 expression comprising administering to a human in need of such treatment a therapeutically effective amount of the dsRNA of claim
 1. 32. The method of claim 31, wherein the human has manic depression. 